Abstract: Mycophenolic acid “MPA" is a secondary metabolite
of Penicillium bervicompactum with antibiotic and
immunosuppressive properties. In this study, fermentation process
was established for production of mycophenolic acid by Penicillium
bervicompactum MUCL 19011 in shake flask. The maximum MPA
production, product yield and productivity were 1.379 g/L, 18.6 mg/g
glucose and 4.9 mg/L.h respectively. Glucose consumption, biomass
and MPA production profiles were investigated during fermentation
time. It was found that MPA production starts approximately after
180 hours and reaches to a maximum at 280 h. In the next step, the
effects of methionine and acetate concentrations on MPA production
were evaluated. Maximum MPA production, product yield and
productivity (1.763 g/L, 23.8 mg/g glucose and 6.30 mg/L. h
respectively) were obtained with using 2.5 g/L methionine in culture
medium. Further addition of methionine had not more positive effect
on MPA production. Finally, results showed that the addition of
acetate to the culture medium had not any observable effect on MPA
production
Abstract: This paper presents the experimental results of silicone rubber polymer insulators for 22 kV systems under salt water dip wheel test based on IEC 62217. Straight shed silicone rubber polymer insulators having leakage distance 685 mm were tested continuously 30,000 cycles. One test cycle includes 4 positions, energized, de-energized, salt water dip and deenergized, respectively. For one test cycle, each test specimen remains stationary for about 40 second in each position and takes 8 second for rotate to next position. By visual observation, sever surface erosion was observed on the trunk near the energized end of tested specimen. Puncture was observed on the upper shed near the energized end. In addition, decreasing in hydrophobicity and increasing in hardness were measured on tested specimen comparing with new specimen. Furthermore, chemical analysis by ATR-FTIR was conducted in order to elucidate the chemical change of tested specimens comparing with new specimen.
Abstract: A new concept for long-term reagent storage for Labon- a-Chip (LoC) devices is described. Here we present a polymer multilayer stack with integrated stick packs for long-term storage of several liquid reagents, which are necessary for many diagnostic applications. Stick packs are widely used in packaging industry for storing solids and liquids for long time. The storage concept fulfills two main requirements: First, a long-term storage of reagents in stick packs without significant losses and interaction with surroundings, second, on demand releasing of liquids, which is realized by pushing a membrane against the stick pack through pneumatic pressure. This concept enables long-term on-chip storage of liquid reagents at room temperature and allows an easy implementation in different LoC devices.
Abstract: If price and quantity are the fundamental building
blocks of any theory of market interactions, the importance of trading
volume in understanding the behavior of financial markets is clear.
However, while many economic models of financial markets have
been developed to explain the behavior of prices -predictability,
variability, and information content- far less attention has been
devoted to explaining the behavior of trading volume. In this article,
we hope to expand our understanding of trading volume by
developing a new measure of herding behavior based on a cross
sectional dispersion of volumes betas. We apply our measure to the
Toronto stock exchange using monthly data from January 2000 to
December 2002. Our findings show that the herd phenomenon
consists of three essential components: stationary herding, intentional
herding and the feedback herding.
Abstract: In this paper, we propose an algorithm to compute
initial cluster centers for K-means clustering. Data in a cell is
partitioned using a cutting plane that divides cell in two smaller cells.
The plane is perpendicular to the data axis with the highest variance
and is designed to reduce the sum squared errors of the two cells as
much as possible, while at the same time keep the two cells far apart
as possible. Cells are partitioned one at a time until the number of
cells equals to the predefined number of clusters, K. The centers of
the K cells become the initial cluster centers for K-means. The
experimental results suggest that the proposed algorithm is effective,
converge to better clustering results than those of the random
initialization method. The research also indicated the proposed
algorithm would greatly improve the likelihood of every cluster
containing some data in it.
Abstract: In most of the cases, natural disasters lead to the
necessity of evacuating people. The quality of evacuation
management is dramatically improved by the use of information
provided by decision support systems, which become indispensable
in case of large scale evacuation operations. This paper presents a
best practice case study. In November 2007, officers from the
Emergency Situations Inspectorate “Crisana" of Bihor County from
Romania participated to a cross-border evacuation exercise, when
700 people have been evacuated from Netherlands to Belgium. One
of the main objectives of the exercise was the test of four different
decision support systems. Afterwards, based on that experience,
software system called TEVAC (Trans Border Evacuation) has been
developed “in house" by the experts of this institution. This original
software system was successfully tested in September 2008, during
the deployment of the international exercise EU-HUROMEX 2008,
the scenario involving real evacuation of 200 persons from Hungary
to Romania. Based on the lessons learned and results, starting from
April 2009, the TEVAC software is used by all Emergency
Situations Inspectorates all over Romania.
Abstract: A major requirement for Grid application developers is ensuring performance and scalability of their applications. Predicting the performance of an application demands understanding its specific features. This paper discusses performance modeling and prediction of multi-agent based simulation (MABS) applications on the Grid. An experiment conducted using a synthetic MABS workload explains the key features to be included in the performance model. The results obtained from the experiment show that the prediction model developed for the synthetic workload can be used as a guideline to understand to estimate the performance characteristics of real world simulation applications.
Abstract: Measurement of competitiveness between countries or regions is an important topic of many economic analysis and scientific papers. In European Union (EU), there is no mainstream approach of competitiveness evaluation and measuring. There are many opinions and methods of measurement and evaluation of competitiveness between states or regions at national and European level. The methods differ in structure of using the indicators of competitiveness and ways of their processing. The aim of the paper is to analyze main sources of competitive potential of the EU Member States with the help of Factor analysis (FA) and to classify the EU Member States to homogeneous units (clusters) according to the similarity of selected indicators of competitiveness factors by Cluster analysis (CA) in reference years 2000 and 2011. The theoretical part of the paper is devoted to the fundamental bases of competitiveness and the methodology of FA and CA methods. The empirical part of the paper deals with the evaluation of competitiveness factors in the EU Member States and cluster comparison of evaluated countries by cluster analysis.
Abstract: Using neural network we try to model the unknown function f for given input-output data pairs. The connection strength of each neuron is updated through learning. Repeated simulations of crisp neural network produce different values of weight factors that are directly affected by the change of different parameters. We propose the idea that for each neuron in the network, we can obtain quasi-fuzzy weight sets (QFWS) using repeated simulation of the crisp neural network. Such type of fuzzy weight functions may be applied where we have multivariate crisp input that needs to be adjusted after iterative learning, like claim amount distribution analysis. As real data is subjected to noise and uncertainty, therefore, QFWS may be helpful in the simplification of such complex problems. Secondly, these QFWS provide good initial solution for training of fuzzy neural networks with reduced computational complexity.
Abstract: The inphase/quadrature (I/Q) amplitude and phase
imbalance effects are studied in coherent optical orthogonal
frequency division multiplexing (CO-OFDM) systems. An analytical
model for the I/Q imbalance is developed and supported by
simulation results. The results indicate that the I/Q imbalance degrades the BER performance considerably.
Abstract: HSDPA is a new feature which is introduced in
Release-5 specifications of the 3GPP WCDMA/UTRA standard to
realize higher speed data rate together with lower round-trip times.
Moreover, the HSDPA concept offers outstanding improvement of
packet throughput and also significantly reduces the packet call
transfer delay as compared to Release -99 DSCH. Till now the
HSDPA system uses turbo coding which is the best coding technique
to achieve the Shannon limit. However, the main drawbacks of turbo
coding are high decoding complexity and high latency which makes
it unsuitable for some applications like satellite communications,
since the transmission distance itself introduces latency due to
limited speed of light. Hence in this paper it is proposed to use LDPC
coding in place of Turbo coding for HSDPA system which decreases
the latency and decoding complexity. But LDPC coding increases the
Encoding complexity. Though the complexity of transmitter
increases at NodeB, the End user is at an advantage in terms of
receiver complexity and Bit- error rate. In this paper LDPC Encoder
is implemented using “sparse parity check matrix" H to generate a
codeword at Encoder and “Belief Propagation algorithm "for LDPC
decoding .Simulation results shows that in LDPC coding the BER
suddenly drops as the number of iterations increase with a small
increase in Eb/No. Which is not possible in Turbo coding. Also same
BER was achieved using less number of iterations and hence the
latency and receiver complexity has decreased for LDPC coding.
HSDPA increases the downlink data rate within a cell to a theoretical
maximum of 14Mbps, with 2Mbps on the uplink. The changes that
HSDPA enables includes better quality, more reliable and more
robust data services. In other words, while realistic data rates are
only a few Mbps, the actual quality and number of users achieved
will improve significantly.
Abstract: Results are presented from a combined experimental
and modeling study undertaken to understand the effect of fuel spray
angle on soot production in turbulent liquid spray flames. The
experimental work was conducted in a cylindrical laboratory furnace
at fuel spray cone angle of 30º, 45º and 60º. Soot concentrations
inside the combustor are measured by filter paper technique. The soot
concentration is modeled by using the soot particle number density
and the mass density based acetylene concentrations. Soot oxidation
occurred by both hydroxide radicals and oxygen molecules. The
comparison of calculated results against experimental measurements
shows good agreement. Both the numerical and experimental results
show that the peak value of soot and its location in the furnace
depend on fuel spray cone angle. An increase in spray angle enhances
the evaporating rate and peak temperature near the nozzle. Although
peak soot concentration increase with enhance of fuel spray angle but
soot emission from the furnace decreases.
Abstract: Proper orthogonal decomposition (POD) is used to reconstruct spatio-temporal data of a fully developed turbulent channel flow with density variation at Reynolds number of 150, based on the friction velocity and the channel half-width, and Prandtl number of 0.71. To apply POD to the fully developed turbulent channel flow with density variation, the flow field (velocities, density, and temperature) is scaled by the corresponding root mean square values (rms) so that the flow field becomes dimensionless. A five-vector POD problem is solved numerically. The reconstructed second-order moments of velocity, temperature, and density from POD eigenfunctions compare favorably to the original Direct Numerical Simulation (DNS) data.
Abstract: The cinema in Turkey during the 1940s was shaped
under the Second World War conditions. The amateur film makers
from different socioeconomic roots experienced movie production in
those years. Having similar socioeconomic characteristics and
autobiographies, each of them has a different understanding of
cinema. Nevertheless, they joined in making movies which address
native culture and audience. They narrated indigenous stories with
native music, amateur players and simple settings. Although the
martial law, censorship and economical deficiencies, they started to
produce films in the Second World War. The cinematographers of the
1940s usually called as thetransition period cinematographers in
Turkey, producing in the passage between the period of thetheatre
playersand the period of thenational cinema. But, 1940- 1950 period
of Turkish cinema should be defined not as a transition but a period
of forming the professional conscioussness in cinema.
Abstract: In this paper back-propagation artificial neural
network (BPANN) with Levenberg–Marquardt algorithm is
employed to predict the limiting drawing ratio (LDR) of the deep
drawing process. To prepare a training set for BPANN, some finite
element simulations were carried out. die and punch radius, die arc
radius, friction coefficient, thickness, yield strength of sheet and
strain hardening exponent were used as the input data and the LDR
as the specified output used in the training of neural network. As a
result of the specified parameters, the program will be able to
estimate the LDR for any new given condition. Comparing FEM and
BPANN results, an acceptable correlation was found.
Abstract: In this work we study the reflection of circularly
polarised light from a nano-structured biological material found in
the exocuticle of scarabus beetles. This material is made of a stack
of ultra-thin (~5 nm) uniaxial layers arranged in a left-handed
helicoidal stack, which resonantly reflects circularly polarized light.
A chirp in the layer thickness combined with a finite absorption
coefficient produce a broad smooth reflectance spectrum. By
comparing model calculations and electron microscopy with
measured spectra we can explain our observations and quantify most
relevant structural parameters.
Abstract: With today's fast lifestyles and busy schedule, nuclear
families are becoming popular. Thus, the elderly members of these
families are often neglected. This has lead to the popularity of the
concept of Community living for the aged. The elders reside at a
centre, which is controlled by the MANAGER. The manager takes
responsibility of the functioning of the centre which includes taking
care of 'residents' at the centre along with managing the daily chores
of the centre, which he accomplishes with the help of a number of
staff members and volunteers Often the Manager is not an employee
but a volunteer. In such cases especially, time is an important
constraint. A system, which provides an easy and efficient manner of
managing the working of an old age home in detail, will prove to be
of great benefit. We have developed a P.C. based organizer used to
monitor the various activities of an old age home. It is an effective
and easy-to-use system which will enable the manager to keep an
account of all the residents, their accounts, staff members, volunteers,
the centre-s logistic requirements etc. It is thus, a comprehensive
'Organizer' for Old Age Homes.
Abstract: The new optimization method for fiber orientation
angle optimization of symmetrical multilayer plates like plywood is
proposed. Optimization method consists of seeking for minimal
compliance by choosing appropriate fiber orientation angle in outer
layers of flexural plate. The discrete values of fiber orientation angles
are used in method. Optimization results of simply supported plate
and multispan plate with uniformly distributed load are provided.
Results show that stiffness could be increased up to 20% by changing
wood fiber orientation angle in one or two outer layers.
Abstract: Migration in breast cancer cell wound healing assay
had been studied using image fractal dimension analysis. The
migration of MDA-MB-231 cells (highly motile) in a wound healing
assay was captured using time-lapse phase contrast video microscopy
and compared to MDA-MB-468 cell migration (moderately motile).
The Higuchi fractal method was used to compute the fractal
dimension of the image intensity fluctuation along a single pixel
width region parallel to the wound. The near-wound region fractal
dimension was found to decrease three times faster in the MDA-MB-
231 cells initially as compared to the less cancerous MDA-MB-468
cells. The inner region fractal dimension was found to be fairly
constant for both cell types in time and suggests a wound influence
range of about 15 cell layer. The box-counting fractal dimension
method was also used to study region of interest (ROI). The MDAMB-
468 ROI area fractal dimension was found to decrease
continuously up to 7 hours. The MDA-MB-231 ROI area fractal
dimension was found to increase and is consistent with the behavior
of a HGF-treated MDA-MB-231 wound healing assay posted in the
public domain. A fractal dimension based capacity index has been
formulated to quantify the invasiveness of the MDA-MB-231 cells in
the perpendicular-to-wound direction. Our results suggest that image
intensity fluctuation fractal dimension analysis can be used as a tool
to quantify cell migration in terms of cancer severity and treatment
responses.
Abstract: Most CT reconstruction system x-ray computed
tomography (CT) is a well established visualization technique in
medicine and nondestructive testing. However, since CT scanning
requires sampling of radiographic projections from different viewing
angles, common CT systems with mechanically moving parts are too
slow for dynamic imaging, for instance of multiphase flows or live
animals. A large number of X-ray projections are needed to
reconstruct CT images, so the collection and calculation of the
projection data consume too much time and harmful for patient. For
the purpose of solving the problem, in this study, we proposed a
method for tomographic reconstruction of a sample from a limited
number of x-ray projections by using linear interpolation method. In
simulation, we presented reconstruction from an experimental x-ray
CT scan of a Aluminum phantom that follows to two steps: X-ray
projections will be interpolated using linear interpolation method and
using it for CT reconstruction based upon Ordered Subsets
Expectation Maximization (OSEM) method.