Abstract: A new approach to predict the 3D structures of proteins by combining the knowledge-based method and Molecular Dynamics Simulation is presented on the chicken villin headpiece subdomain (HP-36). Comparative modeling is employed as the knowledge-based method to predict the core region (Ala9-Asn28) of the protein while the remaining residues are built as extended regions (Met1-Lys8; Leu29-Phe36) which then further refined using Molecular Dynamics Simulation for 120 ns. Since the core region is built based on a high sequence identity to the template (65%) resulting in RMSD of 1.39 Å from the native, it is believed that this well-developed core region can act as a 'nucleation center' for subsequent rapid downhill folding. Results also demonstrate that the formation of the non-native contact which tends to hamper folding rate can be avoided. The best 3D model that exhibits most of the native characteristics is identified using clustering method which then further ranked based on the conformational free energies. It is found that the backbone RMSD of the best model compared to the NMR-MDavg is 1.01 Å and 3.53 Å, for the core region and the complete protein, respectively. In addition to this, the conformational free energy of the best model is lower by 5.85 kcal/mol as compared to the NMR-MDavg. This structure prediction protocol is shown to be effective in predicting the 3D structure of small globular protein with a considerable accuracy in much shorter time compared to the conventional Molecular Dynamics simulation alone.
Abstract: There is a renewed interest in land use transport integration as a means of achieving sustainable accessibility. Such accessibility requires designing more than simply the transport network; it also requires attention to place (built form). Transitoriented development would appear to capture many of the criteria deemed important in land use transport integration. In Perth, Australia, there have been planning policies for the past 20 years requiring transit-oriented development around railway stations throughout the metropolitan area. While the policy intent, particularly at the State level, is clear the implementation of policy has been fairly ineffective. The first part of this paper provides an examination of state and local government planning and transport policies, evaluating them using a set of land use transport integration criteria considered all encompassing. This provides some insight into the extent of state and local government capacity to deliver land use transport integration. The second part of this paper examines the extent of implementation by examining existing and proposed land use around station precincts throughout metropolitan Perth. The findings of this research suggest that the capacity of state and local government to deliver land use transport integration is reasonable in a planning policy sense. Implementation, despite long policy lead times, has been lacking. It appears to be more effective where local planning controls have been suspended with new redevelopment authorities given powers to develop land around railway stations.
Abstract: Celiac disease is an immune-mediated disease, triggered in genetically susceptible individuals by ingested gluten from wheat, rye, barley and other closely related cereal grains. The only effective treatment is a strict gluten free diet for life. Latvian producers do not offer gluten-free products. In this research, use of extruded maize flour was tested for substituting rice, maize or buckwheat flour in gluten-free bread formulations at different ratios. Also the influence of extruded maize flour on the quality parameters of gluten-free bread was investigated. The aim of research was to study the influence of extruded maize flour on gluten-free bread quality. Addition of extruded maize flour affect gluten-free bread crumb color, structure of crumb, weight loss and dry off of bread.
Abstract: A statistical optimization was studied to design a media composition to produce optimum cellulolytic enzyme where palm oil mill effluent (POME) as a basal medium and filamentous fungus, Trichoderma reesei RUT-C30 were used in the liquid state bioconversion(LSB). 2% (w/v) total suspended solid, TSS, of the POME supplemented with 1% (w/v) cellulose, 0.5%(w/v) peptone and 0.02% (v/v) Tween 80 was estimated to produce the optimum CMCase activity of 18.53 U/ml through the statistical analysis followed by the faced centered central composite design(FCCCD). The probability values of cellulose (
Abstract: Polypropylene blended with natural oil and pigment additives has been studied. Different formulations for each compound were made into polybag used for cultivation of oil palm seedlings for strength and mechanical properties studies. One group of sample was exposed under normal sunlight to initiate degradation and another group of sample was placed under shaded area for five months. All samples were tested for tensile strength to determine the degradation effects. The tensile strength of directly exposed sunlight samples and shaded area showed up to 50% and 25% degradation respectively. However, similar reduction of Young’s modulus for all samples was found for both exposures. Structural investigations were done using FTIR to detect deformation. The natural additives that were used in the studies were all natural and environmental friendly
Abstract: Although the Vietnamese catfish farming has grown
at very high rates in recent years, the industry has also faced many
problems affecting its sustainability. This paper studies the
perceptions of catfish farmers regarding risk and risk management
strategies in their production activities. Specifically, the study aims
to measure the consequences, likelihoods, and levels of risks as well
as the efficacy of risk management in Vietnamese catfish farming.
Data for the study were collected through a sample of 261 catfish
farmers in the Mekong Delta, Vietnam using a questionnaire survey
in 2008. Results show that, in general, price and production risks
were perceived as the most important risks. Farm management and
technical measures were perceived more effective than other kinds of
risk management strategies in risk reduction. Although price risks
were rated as important risks, price risk management strategies were
not perceived as important measures for risk mitigation. The results
of the study are discussed to provide implications for various
industry stakeholders, including policy makers, processors, advisors,
and developers of new risk management strategies.
Abstract: In today-s competitive market, most companies
develop manufacturing systems that can help in cost reduction and
maximum quality. Human issues are an important part of
manufacturing systems, yet most companies ignore their effects on
production performance. This paper aims to developing an integrated
workforce planning system that incorporates the human being.
Therefore, a multi-objective mixed integer nonlinear programming
model is developed to determine the amount of hiring, firing,
training, overtime for each worker type. This paper considers a
workforce planning model including human aspects such as skills,
training, workers- personalities, capacity, motivation, and learning
rates. This model helps to minimize the hiring, firing, training and
overtime costs, and maximize the workers- performance. The results
indicate that the workers- differences should be considered in
workforce scheduling to generate realistic plans with minimum costs.
This paper also investigates the effects of human learning rates on the
performance of the production systems.
Abstract: The periodic mixed convection of a water-copper
nanofluid inside a rectangular cavity with aspect ratio of 3 is
investigated numerically. The temperature of the bottom wall of the
cavity is assumed greater than the temperature of the top lid which
oscillates horizontally with the velocity defined as u = u0 sin (ω t).
The effects of Richardson number, Ri, and volume fraction of
nanoparticles on the flow and thermal behavior of the nanofluid are
investigated. Velocity and temperature profiles, streamlines and
isotherms are presented. It is observed that when Ri < 1, heat transfer
rate is much greater than when Ri > 1. The higher value of Ri
corresponds to a lower value of the amplitude of the oscillation of
Num in the steady periodic state. Moreover, increasing the volume
fraction of the nanoparticles increases the heat transfer rate.
Abstract: An experiment was performed in the south of
Morocco in order to evaluate the effect of deficit irrigation by treated
wastewater on chickpea production. We applied six irrigation
treatments on a local variety of chickpea by supplying alternatively
50 or 100% of ETm in a completely randomized design.
We found a highly significant difference between treatments in
terms of biomass production. Drought stress during the vegetative
period showed highest yield with 6.5 t/ha which was more than the
yield obtained for the control (4.9 t/ha). The optimal crop stage in
which deficit irrigation can be applied is the vegetative growth stage,
as the crop has a chance to develop its root system, to be able to
cover the plant needs for water and nutrient supply during the rest of
cycle, and non stress conditions during the flowering and seed filling
stages allow the plant to optimize its photosynthesis and carbon
translocation, therefore increase its productivity.
Abstract: In this study the extracts of the Iraqi herb Tribulus
terrestris (Al-Hassage or Al-Kutub) was done by using of polar and
non polar solvents, then the biological activity of these extractants
was studied in three fields, First, the antibacterial activity (in vitro)
on gram positive bacteria (Staphylococcus aureus), and gram
negative bacteria (E. coli, Proteus vulgaris, Pseudomonas
aerugiuosa, and Klebsiella), all extracts showed considerable activity
against all bacteria. Second, the effect of extracts on free serum
testosterone level in male mice (in vivo), the alcoholic, and
acetonitrilic extracts showed significant (P < 0.05) increase in free
serum testosterone level, and we found that the extracts contained
compounds with less genotoxic effects in mice germ cells. 3rd, was to
study the effect of methanolic extract of T. terrestris in diabetes
management.
Abstract: The most important property of the Gene Ontology is
the terms. These control vocabularies are defined to provide
consistent descriptions of gene products that are shareable and
computationally accessible by humans, software agent, or other
machine-readable meta-data. Each term is associated with
information such as definition, synonyms, database references, amino
acid sequences, and relationships to other terms. This information has
made the Gene Ontology broadly applied in microarray and
proteomic analysis. However, the process of searching the terms is
still carried out using traditional approach which is based on keyword
matching. The weaknesses of this approach are: ignoring semantic
relationships between terms, and highly depending on a specialist to
find similar terms. Therefore, this study combines semantic similarity
measure and genetic algorithm to perform a better retrieval process
for searching semantically similar terms. The semantic similarity
measure is used to compute similitude strength between two terms.
Then, the genetic algorithm is employed to perform batch retrievals
and to handle the situation of the large search space of the Gene
Ontology graph. The computational results are presented to show the
effectiveness of the proposed algorithm.
Abstract: This paper predicts the effect of the user-s hand-hold
position on the Total Isotropic Sensitivity (TIS) of GSM900/1800
mobile phone antennas of realistic in-use conditions, where different
semi-realistic mobile phone models, i.e., candy bar and clamshell, as
well as different antenna types, i.e., external and internal, are
simulated using a FDTD-based platform. A semi-realistic hand model
consisting of three tissues and the SAM head are used in simulations.
The results show a considerable impact on TIS of the adopted mobile
phone models owing to the user-s hand presence at different
positions, where a maximum level of TIS is obtained while grasping
the upper part of the mobile phone against head. Maximum TIS
levels are recorded in talk position for mobile phones with external
antenna and maximum differences in TIS levels due to the hand-hold
alteration are recorded for clamshell-type phones.
Abstract: A new design approach for three-stage operational
amplifiers (op-amps) is proposed. It allows to actually implement a
symmetrical push-pull class-AB amplifier output stage for wellestablished
three-stage amplifiers using a feedforward
transconductance stage. Compared with the conventional design
practice, the proposed approach leads to a significant
improvement of the symmetry between the positive and the
negative op-amp step response, resulting in similar values of the
positive/negative settling time. The new approach proves to be very
useful in order to fully exploit the potentiality allowed by the op-amp
in terms of speed performances. Design examples in a commercial
0.35-μm CMOS prove the effectiveness of theproposed strategy.
Abstract: In this paper, different nonlinear dynamics analysis techniques are employed to unveil the rich nonlinear phenomena of the electromagnetic system. In particular, bifurcation diagrams, time responses, phase portraits, Poincare maps, power spectrum analysis, and the construction of basins of attraction are all powerful and effective tools for nonlinear dynamics problems. We also employ the method of Lyapunov exponents to show the occurrence of chaotic motion and to verify those numerical simulation results. Finally, two cases of a chaotic electromagnetic system being effectively controlled by a reference signal or being synchronized to another nonlinear electromagnetic system are presented.
Abstract: Hypericum perforatum L. is a member of the Hypericaceae (Guttiferae) family and commonly known as St. John’s wort. There is a growing interest in this medicinal plant because of the constituents of this genus. A number of species have been shown to possess various biological activities such as antiviral, wound healing, analgesic, hepatoprotective, antimicrobial and antioxidant activities and also have therapeutic effects on burns, bruises, swelling, anxiety and mild to moderate depression.
In this study, the aerial parts of Hypericum perforatum L. are extracted and the main and effective constituents are determined. The analysis of the extracts was performed by GC-MS and LC-MS. As a next step, it is aimed to investigate the usage of the main constituents of the medicinal plant.
Abstract: According to Rostler method (ASTM D 2006), saturates content of bitumen is determined based on its reactivity to sulphuric acid. While Corbett method (ASTM D 4124) based on its polarity level. This paper presents results from the study on the effect of saturates content determined by two different fractionation methods on the rheological and aging characteristics of bitumen. The result indicated that the increment of saturates content tended to reduce all the rheological characteristics concerned. Bitumen became less elastic, less viscous, and less resistant to plastic deformation, but became more resistant to fatigue cracking. After short and long term aging process, the treatment effect coefficients of saturates decreased, saturates became thicker due to aging process. This study concludes that saturates is not really stable or reactive in aging process. Therefore, the reactivity of saturates should be considered in bitumen aging index
Abstract: In this paper, a new design technique for enhancing
bandwidth that improves the performance of a conventional
microstrip patch antenna is proposed. This paper presents a novel
wideband probe fed inverted slotted microstrip patch antenna. The
design adopts contemporary techniques; coaxial probe feeding,
inverted patch structure and slotted patch. The composite effect of
integrating these techniques and by introducing the proposed patch,
offer a low profile, broadband, high gain, and low cross-polarization
level. The results for the VSWR, gain and co-and cross-polarization
patterns are presented. The antenna operating the band of 1.80-2.36
GHz shows an impedance bandwidth (2:1 VSWR) of 27% and a gain
of 10.18 dBi with a gain variation of 1.12 dBi. Good radiation
characteristics, including a cross-polarization level in xz-plane less
than -42 dB, have been obtained.
Abstract: Magnesium wastes are produced by many industrial activities. This waste problem is becoming a future problem for the world. Magnesium borates have many advantages such as; high corrosion resistance, heat resistance, high coefficient of elasticity and can also be used in the production of material against radiation. Addition, magnesium borates have great potential in sectors
including ceramic and detergents industry and superconducting materials.
In this study, using the starting materials of waste magnesium and H3BO3 the hydrothermal method was applied at a moderate
temperature of 70oC. Several mole ratios of waste magnesium to H3BO3 are selected as; 1:2, 1:4, 1:6, 1:8, 1:10. Reaction time was determined as 1 hour. After the synthesis, X-Ray Diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FT-IR) techniques are applied to products. As a result the forms of mcallisterite “Mg2(B6O7(OH)6)2.9(H2O)”, admontite “MgO(B2O3)3.7(H2O)” and magnesium boron hydrate (MgO(B2O3)3.6(H2O)” are obtained.
Abstract: The characterization and modeling of the dynamic
behavior of many built-up structures under vibration conditions is still
a subject of current research. The present study emphasizes the
theoretical investigation of slip damping in layered and jointed
welded cantilever structures using finite element approach.
Application of finite element method in damping analysis is relatively
recent, as such, some problems particularly slip damping analysis has
not received enough attention. To validate the finite element model
developed, experiments have been conducted on a number of mild
steel specimens under different initial conditions of vibration. Finite
element model developed affirms that the damping capacity of such
structures is influenced by a number of vital parameters such as;
pressure distribution, kinematic coefficient of friction and micro-slip
at the interfaces, amplitude, frequency of vibration, length and
thickness of the specimen. Finite element model developed can be
utilized effectively in the design of machine tools, automobiles,
aerodynamic and space structures, frames and machine members for
enhancing their damping capacity.
Abstract: Addition of an oily waste to a co-composting process of dairy cow manure with food waste, and the influence in the final product was evaluated. Three static composting piles with different substrates concentrations were assessed. Sawdust was also added to all composting piles to attain 60%, humidity at the beginning of the process. In pile 1, the co-substrates were the solid-phase of dairy cow manure, food waste and sawdust as bulking agent. In piles 2 and 3 there was an extra input of oily waste of 7 and 11% of the total volume, respectively, corresponding to 18 and 28% in dry weight. The results showed that the co-composting process was feasible even at the highest fat content. Another positive effect due to the oily waste addition was the requirement of extra humidity, due to the hydrophobic properties of this specific waste, which may imply reduced need of a bulking agent. Moreover, this study shows that composting can be a feasible way of adding value to fatty wastes. The three final composts presented very similar and suitable properties for land application.