Abstract: Oxidative stress is considered to be the cause for onset
and the progression of type 2 diabetes mellitus (T2DM) and
complications including neuropathy. It is a deleterious process that
can be an important mediator of damage to cell structures: protein,
lipids and DNA. Data suggest that in patients with diabetes and
diabetic neuropathy DNA repair is impaired, which prevents effective
removal of lesions. Objective: The aim of our study was to evaluate
the association of the hOGG1 (326 Ser/Cys) and XRCC1 (194
Arg/Trp, 399 Arg/Gln) gene polymorphisms whose protein is
involved in the BER pathway with DNA repair efficiency in patients
with diabetes type 2 and diabetic neuropathy compared to the healthy
subjects. Genotypes were determined by PCR-RFLP analysis in 385
subjects, including 117 with type 2 diabetes, 56 with diabetic
neuropathy and 212 with normal glucose metabolism. The
polymorphisms studied include codon 326 of hOGG1 and 194, 399
of XRCC1 in the base excision repair (BER) genes. Comet assay was
carried out using peripheral blood lymphocytes from the patients and
controls. This test enabled the evaluation of DNA damage in cells
exposed to hydrogen peroxide alone and in the combination with the
endonuclease III (Nth). The results of the analysis of polymorphism
were statistically examination by calculating the odds ratio (OR) and
their 95% confidence intervals (95% CI) using the ¤ç2-tests. Our data
indicate that patients with diabetes mellitus type 2 (including those
with neuropathy) had higher frequencies of the XRCC1 399Arg/Gln
polymorphism in homozygote (GG) (OR: 1.85 [95% CI: 1.07-3.22],
P=0.3) and also increased frequency of 399Gln (G) allele (OR: 1.38
[95% CI: 1.03-1.83], P=0.3). No relation to other polymorphisms
with increased risk of diabetes or diabetic neuropathy. In T2DM
patients complicated by neuropathy, there was less efficient repair of
oxidative DNA damage induced by hydrogen peroxide in both the
presence and absence of the Nth enzyme. The results of our study
suggest that the XRCC1 399 Arg/Gln polymorphism is a significant
risk factor of T2DM in Polish population. Obtained data suggest a
decreased efficiency of DNA repair in cells from patients with
diabetes and neuropathy may be associated with oxidative stress.
Additionally, patients with neuropathy are characterized by even
greater sensitivity to oxidative damage than patients with diabetes,
which suggests participation of free radicals in the pathogenesis of
neuropathy.
Abstract: One of the purposes of the robust method of
estimation is to reduce the influence of outliers in the data, on the
estimates. The outliers arise from gross errors or contamination from
distributions with long tails. The trimmed mean is a robust estimate.
This means that it is not sensitive to violation of distributional
assumptions of the data. It is called an adaptive estimate when the
trimming proportion is determined from the data rather than being
fixed a “priori-.
The main objective of this study is to find out the robustness
properties of the adaptive trimmed means in terms of efficiency, high
breakdown point and influence function. Specifically, it seeks to find
out the magnitude of the trimming proportion of the adaptive
trimmed mean which will yield efficient and robust estimates of the
parameter for data which follow a modified Weibull distribution with
parameter λ = 1/2 , where the trimming proportion is determined by a
ratio of two trimmed means defined as the tail length. Secondly, the
asymptotic properties of the tail length and the trimmed means are
also investigated. Finally, a comparison is made on the efficiency of
the adaptive trimmed means in terms of the standard deviation for the
trimming proportions and when these were fixed a “priori".
The asymptotic tail lengths defined as the ratio of two trimmed
means and the asymptotic variances were computed by using the
formulas derived. While the values of the standard deviations for the
derived tail lengths for data of size 40 simulated from a Weibull
distribution were computed for 100 iterations using a computer
program written in Pascal language.
The findings of the study revealed that the tail lengths of the
Weibull distribution increase in magnitudes as the trimming
proportions increase, the measure of the tail length and the adaptive
trimmed mean are asymptotically independent as the number of
observations n becomes very large or approaching infinity, the tail
length is asymptotically distributed as the ratio of two independent
normal random variables, and the asymptotic variances decrease as
the trimming proportions increase. The simulation study revealed
empirically that the standard error of the adaptive trimmed mean
using the ratio of tail lengths is relatively smaller for different values
of trimming proportions than its counterpart when the trimming
proportions were fixed a 'priori'.
Abstract: In this article, by means of examination of Bolshevists
Turkistanskie Vedomosti" newspaper and “Erikti Oylar Organi" and
“Turkistanskyi Vestnik" newspapers which had been published
during 1917-1918, the fact that “Turkistan Governorship" established
in city of Kokand in November of 1917, within the framework of
former tsarist Russia Turkistan general-governorship, was the legal
government formed as a requisition of people of Turkistan was
proved. An examination of these two newspapers providing
information regarding history of “Turkistan Autonomy" but having
opposite to each other views makes it possible to obtain valuable data
concerning history of autonomy which was inappropriately
misrepresented during Soviet period.
Abstract: Tourists- eyes will often be attracted by the unique
phenomenon of the roadsides: betel nut beauties (pronounced as
binlang xishi in Mandarin), if they drive on the roads of Taiwan.
Sitting in the neon-lit glass stalls with attractive dress on the roadsides,
betel nut beauties usually sell betel nuts to the passing truckers or car
drivers with much of their efforts. Moreover, in order to attract
peoples- eyesight and increase the sales volume, the young girls are in
skimpy clothing to promote betel nuts or beverages to their customers.
Therefore, when the Chinese tourists come to Taiwan, to see the
unique betel nut beauty phenomenon has become one of their greatly
interested things or even a “must see". This paper describes betel but
beauties in Taiwan, explained why the Chinese tourists like to see
them in Taiwan and proposed propositions for examination.
Abstract: The sand production problem has led researchers into making various attempts to understand the phenomenon. The generally accepted concept is that the occurrence of sanding is due to the in-situ stress conditions and the induced changes in stress that results in the failure of the reservoir sandstone during hydrocarbon production from wellbores. By using a hypothetical cased (perforated) well, an approach to the problem is presented here by using Finite Element numerical modelling techniques. In addition to the examination of the erosion problem, the influence of certain key parameters is studied in order to ascertain their effect on the failure and subsequent erosion process. The major variables investigated include: drawdown, perforation depth, and the erosion criterion. Also included is the determination of the optimal mud pressure for given operational and reservoir conditions. The improved understanding between parameters enables the choice of optimal values to minimize sanding during oil production.
Abstract: This paper focuses on analyzing medical diagnostic data using classification rules in data mining and context reduction in formal concept analysis. It helps in finding redundancies among the various medical examination tests used in diagnosis of a disease. Classification rules have been derived from positive and negative association rules using the Concept lattice structure of the Formal Concept Analysis. Context reduction technique given in Formal Concept Analysis along with classification rules has been used to find redundancies among the various medical examination tests. Also it finds out whether expensive medical tests can be replaced by some cheaper tests.
Abstract: The purpose of this research is to study the concepts
of multiple Cartesian product, variety of multiple algebras and to
present some examples. In the theory of multiple algebras, like other
theories, deriving new things and concepts from the things and
concepts available in the context is important. For example, the first
were obtained from the quotient of a group modulo the equivalence
relation defined by a subgroup of it. Gratzer showed that every
multiple algebra can be obtained from the quotient of a universal
algebra modulo a given equivalence relation.
The purpose of this study is examination of multiple algebras and
basic relations defined on them as well as introduction to some
algebraic structures derived from multiple algebras. Among the
structures obtained from multiple algebras, this article studies submultiple
algebras, quotients of multiple algebras and the Cartesian
product of multiple algebras.
Abstract: In this paper, the optimum weight and cost of a laminated composite plate is seeked, while it undergoes the heaviest load prior to a complete failure. Various failure criteria are defined for such structures in the literature. In this work, the Tsai-Hill theory is used as the failure criterion. The theory of analysis was based on the Classical Lamination Theory (CLT). A newly type of Genetic Algorithm (GA) as an optimization technique with a direct use of real variables was employed. Yet, since the optimization via GAs is a long process, and the major time is consumed through the analysis, Radial Basis Function Neural Networks (RBFNN) was employed in predicting the output from the analysis. Thus, the process of optimization will be carried out through a hybrid neuro-GA environment, and the procedure will be carried out until a predicted optimum solution is achieved.
Abstract: Human skull is shown to exhibit numerous sexually dimorphic traits. Estimation of sex is a challenging task especially when a part of skull is brought for medicolegal investigation. The present research was planned to evaluate the sexing potential of the dimensions of foramen magnum in forensic identification by craniometric analysis. Length and breadth of the foramen magnum was measured using Vernier calipers and the area of foramen magnum was calculated. The length, breadth, and area of foramen magnum were found to be larger in males than females. Sexual dimorphism index was calculated to estimate the sexing potential of each variable. The study observations are suggestive of the limited utility of the craniometric analysis of foramen magnum during the examination of skull and its parts in estimation of sex.
Abstract: Thirty six samples from each (aerobic and anoxic)
activated sludge were collected from two wastewater treatment plants
with MBRs in Berlin, Germany. The samples were prepared for count
and definition of fungal isolates; these isolates were purified by
conventional techniques and identified by microscopic examination.
Sixty tow species belonging to 28 genera were isolated from
activated sludge samples under aerobic conditions (28 genera and 58
species) and anoxic conditions (26 genera and 52 species). The
obtained data show that, Aspergillus was found at 94.4% followed by
Penicillium 61.1 %, Fusarium (61.1 %), Trichoderma (44.4 %) and
Geotrichum candidum (41.6 %) species were the most prevalent in all
activated sludge samples. The study confirmed that fungi can thrive
in activated sludge and sporulation, but isolated in different numbers
depending on the effect of aeration system. Some fungal species in
our study are saprophytic, and other a pathogenic to plants and
animals.
Abstract: In this paper, the effect of modified clay on the
mechanical efficiency of epoxy resin is examined. Studies by X ray
diffraction and microscopic transient electron method show that
modified clay distribution in polymer area is intercalated kind.
Examination the results of mechanical tests shows that existence of
modified clay in epoxy area increases pressure yield strength, tension
module and nano composite fracture toughness in relate of pure
epoxy. By microscopic examinations it is recognized too that the
action of toughness growth of this kind of nano composite is due to
crack deflection, formation of new surfaces and fracture of clay piles.
Abstract: The heavy metal contamination of the technogenous
sediments and soils at the investigated dump-field show irregular
planar distribution. Also the heavy metal content in the surface water,
drainage water and in the groundwater was studied both in the dry as
well as during the rainy periods. The cementation process causes
substitution of iron by copper. Natural installation and development
of plant species was observed at the old mine waste dumps, specific
to the local chemical conditions such as low content of essential
nutrients and high content of heavy metals. The individual parts of
the plant tissues (roots, branches/stems, leaves/needles, flowers/
fruits) are contaminated by heavy metals and tissues are damaged
differently, respectively.
Abstract: An evaluation of the PCBs residues in the surface soils from Bacninh, Vietnam was carried out. Sixty representative soil samples were collected from the centre of Bacninh and three surrounding districts. The analyzed results indicated the wide extent of contamination of total PCBs in Bacninh. In industrial and urban zones, total PCBs concentrations ranged from ranged from
Abstract: Tourism industry is an important sector in Malaysia economy and this motivates the examination of long-run relationships between tourist arrivals from three selected European countries in Malaysia and four possible determinants; relative prices, exchange rates, transportation cost and relative prices of substitute destination. The study utilizes data from January 1999 to September 2008 and employs standard econometric techniques that include unit root test and cointegration test. The estimated demand model indicates that depreciation of local currency and increases in prices at substitute destination have positive impact on tourist arrivals while increase in transportation cost has negative impact on tourist arrivals. In addition, the model suggests that higher rate of increase in local prices relative to prices at tourist country of origin may not deter tourists from coming to Malaysia
Abstract: This study focuses on an evaluation of Hokkaido which
is the northernmost and largest prefecture by surface area in Japan and
particularly on two points: the rivalry between all kinds of land use
such as urban land and agricultural and forestry land in various cities
and their surrounding areas and the possibilities for forestry biomass in
areas other than those mentioned above and grasps which areas require
examination of the nature of land use control and guidance through
conducting land use analysis at the district level using GIS
(Geographic Information Systems). The results of analysis in this
study demonstrated that it is essential to divide the whole of Hokkaido
into two areas: those within delineated city planning areas and those
outside of delineated city planning areas and to conduct an evaluation
of each land use control.
In delineated urban areas, particularly urban areas, it is essential to
re-examine land use from the point of view of compact cities or smart
cities along with conducting an evaluation of land use control that
focuses on issues of rivalry between all kinds of land use such as urban
land and agricultural and forestry land. In areas outside of delineated
urban areas, it is desirable to aim to build a specific community
recycling range based on forest biomass utilization by conducting an
evaluation of land use control concerning the possibilities for forest
biomass focusing particularly on forests within and outside of city
planning areas.
Abstract: Asthma is a condition that causing chronic health problems in children. In addition to basic therapy against disease, we must try to reduce the impact of chronic health problems and also optimize their medical aspect of growth and development. A boy with mild asthma attack frequent episode did not showed any improvement with medical treatment and his asthma control test was 11. From radiologic examination he got hyperaerated lung and billateral sinusitis maxillaris; skin test results were house dust, food and pet allergy; an overweight body; bad school grades; psychological and environmental problem. We followed and evaluated this boy in 6 months, treated holistically. Even we could not do much on environmental but no more psychological and school problems, his on a good bodyweight and his asthma control test was 22. A case of a child with mild asthma attack frequent episode was reported. Asthma clinical course show no significant improvement when other predisposing factor is not well-controlled and a child’s growth and development may be affected. Improving condition of the patient can be created with the help of loving and caring way of nurturing from the parents and supportive peer group. Therefore, continuous and consistent monitoring is required because prognosis of asthma is generally good when regularly and properly controlled.
Abstract: Tanzania secondary schools in rural areas are geographically and socially isolated, hence face a number of problems in getting learning materials resulting in poor performance in National examinations. E-learning as defined to be the use of information and communication technology (ICT) for supporting the educational processes has motivated Tanzania to apply ICT in its education system. There has been effort to improve secondary school education using ICT through several projects. ICT for e-learning to Tanzania rural secondary school is one of the research projects conceived by the University of Dar-es-Salaam through its College of Engineering and Technology. The main objective of the project is to develop a tool to enable ICT support rural secondary school. The project is comprehensive with a number of components, one being development of e-learning management system (e-LMS) for Tanzania secondary schools. This paper presents strategies of developing e-LMS. It shows the importance of integrating action research methodology with the modeling methods as presented by model driven architecture (MDA) and the usefulness of Unified Modeling Language (UML) on the issue of modeling. The benefit of MDA will go along with the development based on software development life cycle (SDLC) process, from analysis and requirement phase through design and implementation stages as employed by object oriented system analysis and design approach. The paper also explains the employment of open source code reuse from open source learning platforms for the context sensitive development of the e-LMS for Tanzania secondary schools.
Abstract: Protecting is the sources of drinking water is the first
barrier of contamination of drinking water. The Feitsui Reservoir
watershed of Taiwan supplies domestic water for around 5 million
people in the Taipei metropolitan area. Understanding the spatial
patterns of water quality trends in this watershed is an important
agenda for management authorities. This study examined 7 sites in the
watershed for water quality parameters regulated in the standard for
drinking water source. The non-parametric seasonal Mann-Kendall-s
test was used to determine significant trends for each parameter.
Significant trends of increasing pH occurred at the sampling station in
the uppermost stream watershed, and in total phosphorus at 4 sampling
stations in the middle and downstream watershed. Additionally, the
multi-scale land cover assessment and average land slope were used to
explore the influence on the water quality in the watershed. Regression
models for predicting water quality were also developed.
Abstract: The coastal sediments of West Port of Malaysia was monitored from Nov. 2009 to Oct. 2010 to assess spatial distribution of heavy metals As, Cu, Cd, Cr, Hg, Ni, Zn and Pb. Sediment samples were collected from 10 stations in dry and rainy season in West Port. The range concentrations measured (Mg/g dry weight ) were from 23.4 to 98.3 for Zn, 22.3 to 80 for Pb, 7.4 to 27.6 Cu, 0.244 to 3.53 for Cd, 7.2 to 22.2 for Ni, 20.2 to 162 for As, 0.11 to 0.409 for Hg and 11.5 to 61.5 for Cr. The geochemical indexes used in this study were Geoaccumulation (Igeo), Contamination Factor (CF) and Pollution Load Index (PLI); these indexes were used to evaluate the levels of sediment contaminations. The results of these indexes show that, the status of West Port sediment quality are moderately polluted by heavy metals except in arsenic which shows the high level of pollution.
Abstract: The purpose of this study is to discuss the effect of the
intervention of exercise behavior change plan for high school students
on study subjects- social and psychological factors and exercise
stages. This research uses the transtheoretical model as the research
framework. One experiment group and one control group were used in
a quasi-experimental design research. The experimental group
accepted health-related physical fitness course and the traditional
course; the control group accepted traditional physical education
course. There is a significant difference before and after the
intervention in the experimental group. Karl-s test shows the
experimental group gained a better improvement than that in the
control group. The Analysis of Covariance had shown the exercise
stages (F=7.62, p