Abstract: The PAX6, a transcription factor, is essential for the morphogenesis of the eyes, brain, pituitary and pancreatic islets. In rodents, the loss of Pax6 function leads to central nervous system defects, anophthalmia, and nasal hypoplasia. The haplo-insufficiency of Pax6 causes microphthalmia, aggression and other behavioral abnormalities. It is also required in brain patterning and neuronal plasticity. In human, heterozygous mutation of Pax6 causes loss of iris [aniridia], mental retardation and glucose intolerance. The 3- deletion in Pax6 leads to autism and aniridia. The phenotypes are variable in peneterance and expressivity. However, mechanism of function and interaction of PAX6 with other proteins during development and associated disease are not clear. It is intended to explore interactors of PAX6 to elucidated biology of PAX6 function in the tissues where it is expressed and also in the central regulatory pathway. This report describes In-silico approaches to explore interacting proteins of PAX6. The models show several possible proteins interacting with PAX6 like MITF, SIX3, SOX2, SOX3, IPO13, TRIM, and OGT. Since the Pax6 is a critical transcriptional regulator and master control gene of eye and brain development it might be interacting with other protein involved in morphogenesis [TGIF, TGF, Ras etc]. It is also presumed that matricelluar proteins [SPARC, thrombospondin-1 and osteonectin etc] are likely to interact during transport and processing of PAX6 and are somewhere its cascade. The proteins involved in cell survival and cell proliferation can also not be ignored.
Abstract: In recent years, tuned mass damper (TMD) control systems for civil engineering structures have attracted considerable attention. This paper emphasizes on the application of particle swarm application (PSO) to design and optimize the parameters of the TMD control scheme for achieving the best results in the reduction of the building response under earthquake excitations. The Integral of the Time multiplied Absolute value of the Error (ITAE) based on relative displacement of all floors in the building is taken as a performance index of the optimization criterion. The problem of robustly TMD controller design is formatted as an optimization problem based on the ITAE performance index to be solved using the PSO technique which has a story ability to find the most optimistic results. An 11- story realistic building, located in the city of Rasht, Iran is considered as a test system to demonstrate effectiveness of the proposed method. The results analysis through the time-domain simulation and some performance indices reveals that the designed PSO based TMD controller has an excellent capability in reduction of the seismically excited example building.
Abstract: Natural disasters, including earthquake, kill many people around the world every year. Society rescue actions, which start after the earthquake and are called LAST in abbreviation, include locating, access, stabilization and transportation. In the present article, we have studied the process of local accessibility to the injured and transporting them to health care centers. With regard the heavy traffic load due to earthquake, the destruction of connecting roads and bridges and the heavy debris in alleys and street, which put the lives of the injured and the people buried under the debris in danger, accelerating the rescue actions and facilitating the accessibilities are of great importance, obviously. Tehran, the capital of Iran, is among the crowded cities in the world and is the center of extensive economic, political, cultural and social activities. Tehran has a population of about 9.5 millions and because of the immigration of people from the surrounding cities. Furthermore, considering the fact that Tehran is located on two important and large faults, a 6 Richter magnitude earthquake in this city could lead to the greatest catastrophe during the entire human history. The present study is a kind of review and a major part of the required information for it, has been obtained from libraries all of the rescue vehicles around the world, including rescue helicopters, ambulances, fire fighting vehicles and rescue boats, and their applied technology, and also the robots specifically designed for the rescue system and the advantages and disadvantages of them, have been investigated. The studies show that there is a significant relationship between the rescue team-s arrival time at the incident zone and the number of saved people; so that, if the duration of burial under debris 30 minutes, the probability of survival is %99.3, after a day is %81, after 2days is %19 and after 5days is %7.4. The exiting transport systems all have some defects. If these defects are removed, more people could be saved each hour and the preparedness against natural disasters is increased. In this study, transport system has been designed for the rescue team and the injured; which could carry the rescue team to the incident zone and the injured to the health care centers. In addition, this system is able to fly in the air and move on the earth as well; so that the destruction of roads and the heavy traffic load could not prevent the rescue team from arriving early at the incident zone. The system also has the equipment required firebird for debris removing, optimum transport of the injured and first aid.
Abstract: A cancelable palmprint authentication system
proposed in this paper is specifically designed to overcome the
limitations of the contemporary biometric authentication system. In
this proposed system, Geometric and pseudo Zernike moments are
employed as feature extractors to transform palmprint image into a
lower dimensional compact feature representation. Before moment
computation, wavelet transform is adopted to decompose palmprint
image into lower resolution and dimensional frequency subbands.
This reduces the computational load of moment calculation
drastically. The generated wavelet-moment based feature
representation is used to generate cancelable verification key with a
set of random data. This private binary key can be canceled and
replaced. Besides that, this key also possesses high data capture
offset tolerance, with highly correlated bit strings for intra-class
population. This property allows a clear separation of the genuine
and imposter populations, as well as zero Equal Error Rate
achievement, which is hardly gained in the conventional biometric
based authentication system.
Abstract: The methanolic extracts from seeds of tamarind
(Tamarindus indica) was prepared by Soxhlet apparatus extraction
and evaluated for total phenolic content by Folin-Ciocalteu method.
Then, methanolic extract was screened biological activities (In vitro)
for anti-melanogenic activity by tyrosinase inhibition test, antiinflammation
activity by cyclooxygenase 1 (COX-1) and
cyclooxygenase 2 (COX-2) inhibition test, and cytotoxic screening
test with Vero cells. The results showed that total phenolic content,
which contained in extract, was contained 27.72 mg of gallic acid
equivalent per g of dry weight. The ability to inhibit tyrosinase
enzyme, which exerted by Tamarind seed extracts (1 mg/ml) was
52.13 ± 0.42 %. The extract was not possessed inhibitory effect to
COX-1 and COX-2 enzymes and cytotoxic effect to Vero cells. The
finding is concludes that tested seed extract was possessed
antimelanogenic activity with non-toxic effects. However, there was
not exhibited anti-inflammatory activity. Further studies include the
use of advance biological models to confirm this biological activity,
as well as, the isolation and characterization of the purified
compounds that it was contained.
Abstract: Controlled release urea has become popular in agricultural industry as it helps to solve environmental issues and increase crop yield. Recently biomass was identified to replace the polymer used as a coating material in the conventional coated urea. In this paper spreading and contact angle of biomass droplet (lignin, cellulose and clay) on urea surface are investigated experimentally. There were two tests were conducted, sessile drop for contact angle measurement and pendant drop for contact angle measurement. A different concentration of biomass droplet was released from 30 mm above a substrate. Glass was used as a controlled substrate. Images were recorded as soon as the droplet impacted onto the urea before completely adsorb into the urea. Digitized droplets were then used to identify the droplet-s surface tension and contact angle. There is large difference observed between the low surface tension and high surface tension liquids, where the wetting and spreading diameter is higher for lower surface tension. From the contact angle results, the data showed that the biomass coating films were possible as wetting liquid (θ < 90º). Contact angle of biomass coating material gives good indication for the wettablity of a liquid on urea surface.
Abstract: In Algeria, some fruit trees produce fruits in free nature. Such trees are Celtis australis, Crataegus azarolus, Crataegus monogyna and Zizyphus lotus. In spite of their appreciable consumption, their nutritional value remains unknown. The objective of this study is the determination of sugars in the pulpe and almond of the above fruits. The biochemical analysis shows that these fruits present interesting contents of soluble sugars which confers significant caloric intakes to them. As well as significant fibres which give them therapeutic and industrial benefits? The analysis of the almonds shows that it contains considerable contents of sugars which enable them to be an energetic food.
Abstract: The p53 tumor suppressor gene plays two important
roles in genomic stability: blocking cell proliferation after DNA
damage until it has been repaired, and starting apoptosis if the
damage is too critical. Codon 72 exon4 polymorphism (Arg72Pro) of
the P53 gene has been implicated in cancer risk. Various studies have
been done to investigate the status of p53 at codon 72 for arginine
(Arg) and proline (Pro) alleles in different populations and also the
association of this codon 72 polymorphism with various tumors. Our
objective was to investigate the possible association between P53
Arg72Pro polymorphism and susceptibility to colorectal cancer
among Isfahan and Chaharmahal Va Bakhtiari (a part of south west
of Iran) population. We investigated the status of p53 at codon 72 for
Arg/Arg, Arg/Pro and Pro/Pro allele polymorphisms in blood
samples from 145 colorectal cancer patients and 140 controls by
Nested-PCR of p53 exon 4 and digestion with BstUI restriction
enzyme and the DNA fragments were then resolved by
electrophoresis in 2% agarose gel. The Pro allele was 279 bp, while
the Arg allele was restricted into two fragments of 160 and 119 bp.
Among the 145 colorectal cancer cases 49 cases (33.79%) were
homozygous for the Arg72 allele (Arg/Arg), 18 cases (12.41%) were
homozygous for the Pro72 allele (Pro/Pro) and 78 cases (53.8%)
found in heterozygous (Arg/Pro).
In conclusion, it can be said that p53Arg/Arg genotype may be
correlated with possible increased risk of this kind of cancers in south
west of Iran.
Abstract: Non-viral gene carriers composed of biodegradable
polymers or lipids have been considered as a safer alternative for gene
carriers over viral vectors. We have developed multi-functional
nano-micelles for both drug and gene delivery application.
Polyethyleneimine (PEI) was modified by grafting stearic acid (SA)
and formulated to polymeric micelles (PEI-SA) with positive surface
charge for gene and drug delivery. Our results showed that PEI-SA
micelles provided high siRNA binding efficiency. In addition, siRNA
delivered by PEI-SA carriers also demonstrated significantly high
cellular uptake even in the presence of serum proteins. The
post-transcriptional gene silencing efficiency was greatly improved by
the polyplex formulated by 10k PEI-SA/siRNA. The amphiphilic
structure of PEI-SA micelles provided advantages for multifunctional
tasks; where the hydrophilic shell modified with cationic charges can
electrostatically interact with DNA or siRNA, and the hydrophobic
core can serve as payloads for hydrophobic drugs, making it a
promising multifunctional vehicle for both genetic and chemotherapy
application.
Abstract: We aimed to investigate how can target and optimize
pulmonary delivery distribution by changing physicochemical
characteristics of instilled liquid.Therefore, we created a new liquids
group:
a. eligible for desired distribution within lung because of
assorted physicochemical characteristics
b. capable of being augmented with a broad range of
chemicals inertly
c. no interference on respiratory function
d. compatible with airway surface liquid
We developed forty types of new liquid,were composed of
Carboxymethylcellulose sodium,Glycerin and different types of
Polysorbates.Viscosity was measured using a Programmable
Rheometer and surface tension by KRUSS Tensiometer.We
subsequently examined the liquids and delivery protocols by simple
and branched glass capillary tube models of airways.Eventually,we
explored pulmonary distribution of liquids being augmented with
technetium-99m in mechanically ventilated rabbits.We used a single
head large field of view gamma camera.Kinematic viscosity between
0.265Stokes and 0.289Stokes,density between 1g/cm3 and 1.5g/cm3
and surface tension between 25dyn/cm and 35dyn/cm were the most
acceptable.
Abstract: Experimental investigations were carried out in the
Manchester Tidal flow Facility (MTF) to study the flow patterns in
the region around and adjacent to a hypothetical headland in tidal
(oscillatory) ambient flow. The Planar laser-induced fluorescence
(PLIF) technique was used for visualization, with fluorescent dye
released at specific points around the headland perimeter and in its
adjacent recirculation zone. The flow patterns can be generalized into
the acceleration, stable flow and deceleration stages for each halfcycle,
with small variations according to location, which are more
distinct for low Keulegan-Carpenter number (KC) cases. Flow
patterns in the mixing region are unstable and complex, especially in
the recirculation zone. The flow patterns are in agreement with
previous visualizations, and support previous results in steady
ambient flow. It is suggested that the headland lee could be a viable
location for siting of pollutant outfalls.
Abstract: Finding effective ways of improving university quality assurance requires, as well, a retraining of the staff. This article illustrates an Online Programme of Excellence Model (OPEM), based on the European quality assurance model, for improving participants- formative programme standards. The results of applying this OPEM indicate the necessity of quality policies that support the evaluators- competencies to improve formative programmes. The study concludes by outlining how faculty and agency staff can use OPEM for the internal and external quality assurance of formative programmes.
Abstract: Heat-inducible gene expression vectors are useful for hyperthermia-induced cancer gene therapy, because the combination
of hyperthermia and gene therapy can considerably improve the therapeutic effects. In the present study, we developed an enhanced
heat-inducible transgene expression system in which a heat-shock
protein (HSP) promoter and tetracycline-responsive transactivator
were combined. When the transactivator plasmid containing the
tetracycline-responsive transactivator gene was co-transfected with
the reporter gene expression plasmid, a high level of heat-induced gene expression was observed compared with that using the HSP
promoter without the transactivator. In vitro evaluation of the
therapeutic effect using HeLa cells showed that heat-induced therapeutic gene expression caused cell death in a high percentage of
these cells, indicating that this strategy is promising for cancer gene therapy.
Abstract: This study examines the possibility to apply the theory of multidimensional accounting (momentum accounting) in a Brazilian Navy-s Services Provider Military Organization (Organização Militar Prestadora de Serviços - OMPS). In general, the core of the said theory is the fact that Accounting does not recognize the inertia of transactions occurring in an entity, and that occur repeatedly in some cases, regardless of the implementation of new actions by its managers. The study evaluates the possibility of greater use of information recorded in the financial statements of the unit of analysis, within the strategic decisions of the organization. As a research strategy, we adopted the case study. The results infer that it is possible to use the theory in the context of a multidimensional OMPS, promoting useful information for decision-making and thereby contributing to the strengthening of the necessary alignment of its administration with the current desires of the Brazilian society.
Abstract: Recently, neural networks have shown good
results for detection of a certain pattern in a given image. In
our previous papers [1-5], a fast algorithm for pattern
detection using neural networks was presented. Such
algorithm was designed based on cross correlation in the
frequency domain between the input image and the weights
of neural networks. Image conversion into symmetric shape
was established so that fast neural networks can give the
same results as conventional neural networks. Another
configuration of symmetry was suggested in [3,4] to improve
the speed up ratio. In this paper, our previous algorithm for
fast neural networks is developed. The frequency domain
cross correlation is modified in order to compensate for the
symmetric condition which is required by the input image.
Two new ideas are introduced to modify the cross correlation
algorithm. Both methods accelerate the speed of the fast
neural networks as there is no need for converting the input
image into symmetric one as previous. Theoretical and
practical results show that both approaches provide faster
speed up ratio than the previous algorithm.
Abstract: This paper introduces an adiabatic register file based
on two-phase CPAL (Complementary Pass-Transistor Adiabatic
Logic circuits) with power-gating scheme, which can operate on a
single-phase power clock. A 32×32 single-phase adiabatic register file
with power-gating scheme has been implemented with TSMC 0.18μm
CMOS technology. All the circuits except for the storage cells employ
two-phase CPAL circuits, and the storage cell is based on the
conventional memory one. The two-phase non-overlap power-clock
generator with power-gating scheme is used to supply the proposed
adiabatic register file. Full-custom layouts are drawn. The energy and
functional simulations have been performed using the net-list
extracted from their layouts. Compared with the traditional static
CMOS register file, HSPICE simulations show that the proposed
adiabatic register file can work very well, and it attains about 73%
energy savings at 100 MHz.
Abstract: This paper describes a low-voltage and low-power
channel selection analog front end with continuous-time low pass
filters and highly linear programmable gain amplifier (PGA). The
filters were realized as balanced Gm-C biquadratic filters to achieve a
low current consumption. High linearity and a constant wide
bandwidth are achieved by using a new transconductance (Gm) cell.
The PGA has a voltage gain varying from 0 to 65dB, while
maintaining a constant bandwidth. A filter tuning circuit that requires
an accurate time base but no external components is presented.
With a 1-Vrms differential input and output, the filter achieves
-85dB THD and a 78dB signal-to-noise ratio. Both the filter and PGA
were implemented in a 0.18um 1P6M n-well CMOS process. They
consume 3.2mW from a 1.8V power supply and occupy an area of
0.19mm2.
Abstract: This paper presents a methodology towards the emulation of the electrical power consumption of the RF device during the cellular phone/handset transmission mode using the LTE technology. The emulation methodology takes the physical environmental variables and the logical interface between the baseband and the RF system as inputs to compute the emulated power dissipation of the RF device. The emulated power, in between the measured points corresponding to the discrete values of the logical interface parameters is computed as a polynomial interpolation using polynomial basis functions. The evaluation of polynomial and spline curve fitting models showed a respective divergence (test error) of 8% and 0.02% from the physically measured power consumption. The precisions of the instruments used for the physical measurements have been modeled as intervals. We have been able to model the power consumption of the RF device operating at 5MHz using homotopy between 2 continuous power consumptions of the RF device operating at the bandwidths 3MHz and 10MHz.
Abstract: Modular multiplication is the basic operation
in most public key cryptosystems, such as RSA, DSA, ECC,
and DH key exchange. Unfortunately, very large operands
(in order of 1024 or 2048 bits) must be used to provide
sufficient security strength. The use of such big numbers
dramatically slows down the whole cipher system, especially
when running on embedded processors.
So far, customized hardware accelerators - developed on
FPGAs or ASICs - were the best choice for accelerating
modular multiplication in embedded environments. On the
other hand, many algorithms have been developed to speed
up such operations. Examples are the Montgomery modular
multiplication and the interleaved modular multiplication
algorithms. Combining both customized hardware with
an efficient algorithm is expected to provide a much faster
cipher system.
This paper introduces an enhanced architecture for computing
the modular multiplication of two large numbers X
and Y modulo a given modulus M. The proposed design is
compared with three previous architectures depending on
carry save adders and look up tables. Look up tables should
be loaded with a set of pre-computed values. Our proposed
architecture uses the same carry save addition, but replaces
both look up tables and pre-computations with an enhanced
version of sign detection techniques. The proposed architecture
supports higher frequencies than other architectures.
It also has a better overall absolute time for a single operation.
Abstract: The present investigation aimed to study the
histomorphometric characterizations of the thyroid gland of the duck.
Five adult male and five adult female ducks were used in the
experiment. Results showed that the overall histological structure of
the thyroid gland of the duck were similar to those of the other
vertebrae. The gland consisted of roughly spherical randomly
distributed micro and macrofollicles with very little interstitial tissue
between them. Each follicle is lined by a single layer of epithelial
cells enclosing a cavity, the follicular cavity, which is filled with
colloid. Ultrastructural findings showed that the apical surface of the
follicular cells bears a variable number of short, irregularly
distributed microvilli which are apparently more numerous on the
columnar cells than on the lower, relatively inactive cells.
Mitochondria and rough endoplasmic reticulum occupy the
subnuclear region of the follicular cell, whereas the Golgi complex,
free ribosomes and colloid droplets were found in the apical
cytoplasm. At light or electron microscopic levels, there was no sex
difference in histomorphometric characteristics of the thyroid
glands.ls.