Abstract: Bone growth factors, such as Bone Morphogenic
Protein-2 (BMP-2) have been approved by the FDA to replace grafting for some surgical interventions, but the high dose requirement limits its use in patients. Noggin, an extracellular protein, blocks the effect of BMP-2 by binding to BMP. Preventing
the BMP-2/noggin interaction will help increase the free
concentration of BMP-2 and therefore should enhance its efficacy to
induce bone formation. The work presented here involves
computational design of novel small molecule inhibitory agents of BMP-2/noggin interaction, based on our current understanding of
BMP-2, and its known putative ligands (receptors and antagonists). A
successful acquisition of such an inhibitory agent of BMP-2/noggin interaction would allow clinicians to reduce the dose required of
BMP-2 protein in clinical applications to promote osteogenesis. The
available crystal structures of the BMPs, its receptors, and the binding partner noggin were analyzed to identify the critical residues
involved in their interaction. In presenting this study, LUDI de novo design method was utilized to perform virtual screening of a large
number of compounds from a commercially available library against the binding sites of noggin to identify the lead chemical compounds
that could potentially block BMP-noggin interaction with a high specificity.
Abstract: The purpose of this paper is to provide an overview on methodological aspects of the information technology outsourcing (ITO) surveys, in an attempt to improve the data quality and reporting in survey research. It is based on a review of thirty articles on ITO surveys and focuses on two commonly explored dimensions of ITO, namely what are outsourced and why should there be ITO. This study highlights weaknesses in ITO surveys including lack of a clear definition of population, lack of information regarding the sampling method used, not citing the response rate, no information pertaining to pilot testing of survey instrument and absence of information on internal validity in the use or reporting of surveys. This study represents an attempt with a limited scope to point to shortfalls in the use survey methodology in ITO, and thus raise awareness among researchers in enhancing the reliability of survey findings.
Abstract: REY area has been located in Tehran Province and several archaeological ruins of this area indicate that the settlement in this area has been started since several thousand years ago. In this paper, the main investigation items consist of analysis of oil components and groundwater quality inside the wells. By finding the contents of oil in the well, it is possible to find out the pollution source by comparing the oil contents of well with other oil products that are used inside and outside of the oil farm. Investigation items consist of analysis of BTEX (Benzene, Toluene, Ethyl-benzene, Xylene), Gas chromatographic distillation characteristics, Water content, Density, Sulfur content, Lead content, Atmospheric distillation, MTBE(Methyl tertiary butyl ether). Analysis of polluting oil components showed that except MW(Monitoring Well)10 and MW 15 that oil with slightly heavy components was detected in them; with a high possibility the polluting oil is light oil.
Abstract: A total of 33,680 nuclear power plants (NPPs) workers were monitored and recorded from 1990 to 2007. According to the record, the average individual radiation dose has been decreasing continually from it 3.20 mSv/man in 1990 to 1.12 mSv/man at the end of 2007. After the International Commission on Radiological Protection (ICRP) 60 recommendation was generalized in South Korea, no nuclear power plant workers received above 20 mSv radiation, and the numbers of relatively highly exposed workers have been decreasing continuously. The age distribution of radiation workers in nuclear power plants was composed of mainly 20-30- year-olds (83%) for 1990 ~ 1994 and 30-40-year-olds (75%) for 2003 ~ 2007. The difference in individual average dose by age was not significant. Most (77%) of NPP radiation exposures from 1990 to 2007 occurred mostly during the refueling period. With regard to exposure type, the majority of exposures were external exposures, representing 95% of the total exposures, while internal exposures represented only 5%. External effective dose was affected mainly by gamma radiation exposure, with an insignificant amount of neutron exposure. As for internal effective dose, tritium (3H) in the pressurized heavy water reactor (PHWR) was the biggest cause of exposure.
Abstract: An electronic portal image device (EPID) has become
a method of patient-specific IMRT dose verification for radiotherapy.
Research studies have focused on pre and post-treatment verification,
however, there are currently no interventional procedures using EPID
dosimetry that measure the dose in real time as a mechanism to
ensure that overdoses do not occur and underdoses are detected as
soon as is practically possible. As a result, an EPID-based real time
dose verification system for dynamic IMRT was developed and was
implemented with MATLAB/Simulink. The EPID image acquisition
was set to continuous acquisition mode at 1.4 images per second. The
system defined the time constraint gap, or execution gap at the image
acquisition time, so that every calculation must be completed before
the next image capture is completed. In addition, the
Abstract: This paper presented a proposed design for
transcutaneous inductive powering links. The design used to transfer
power and data to the implanted devices such as implanted
Microsystems to stimulate and monitoring the nerves and muscles.
The system operated with low band frequency 13.56 MHZ according
to industrial- scientific – medical (ISM) band to avoid the tissue
heating. For external part, the modulation index is 13 % and the
modulation rate 7.3% with data rate 1 Mbit/s assuming Tbit=1us. The
system has been designed using 0.35-μm fabricated CMOS
technology. The mathematical model is given and the design is
simulated using OrCAD P Spice 16.2 software tool and for real-time
simulation the electronic workbench MULISIM 11 has been used.
The novel circular plane (pancake) coils was simulated using
ANSOFT- HFss software.
Abstract: This paper describes a UDP over IP based, server-oriented redundant host configuration protocol (RHCP) that can be used by collaborating embedded systems in an ad-hoc network to acquire a dynamic IP address. The service is provided by a single network device at a time and will be dynamically reassigned to one of the other network clients if the primary provider fails. The protocol also allows all participating clients to monitor the dynamic makeup of the network over time. So far the algorithm has been implemented and tested on an 8-bit embedded system architecture with a 10Mbit Ethernet interface.
Abstract: In this paper we present a technique to speed up
ICA based on the idea of reducing the dimensionality of the data
set preserving the quality of the results. In particular we refer to
FastICA algorithm which uses the Kurtosis as statistical property
to be maximized. By performing a particular Johnson-Lindenstrauss
like projection of the data set, we find the minimum dimensionality
reduction rate ¤ü, defined as the ratio between the size k of the reduced
space and the original one d, which guarantees a narrow confidence
interval of such estimator with high confidence level. The derived
dimensionality reduction rate depends on a system control parameter
β easily computed a priori on the basis of the observations only.
Extensive simulations have been done on different sets of real world
signals. They show that actually the dimensionality reduction is very
high, it preserves the quality of the decomposition and impressively
speeds up FastICA. On the other hand, a set of signals, on which the
estimated reduction rate is greater than 1, exhibits bad decomposition
results if reduced, thus validating the reliability of the parameter β.
We are confident that our method will lead to a better approach to
real time applications.
Abstract: Transferring information developed by other peoples is an ordinary event that happens during daily conversations, for example when employees sea each other in the organization, or when they are having lunch together, or attending a meeting, they use to talk about their experience, and discuss about their current projects, and talk about their successes over some specific problems. Despite the potential value of leveraging organizational memory and expertise by using OMS and ER, still small organizations haven-t been able to capitalize on its promised value. Each organization has its internal knowledge management system, in some of organizations the system face the lack of expert people to save their experience in the repository and in another hand on some other organizations there are lots of expert people but the organization doesn-t have the maximum use of their knowledge.
Abstract: One of object oriented software developing problem
is the difficulty of searching the appropriate and suitable objects for
starting the system. In this work, ontologies appear in the part of
supporting the object discovering in the initial of object oriented
software developing. There are many researches try to demonstrate
that there is a great potential between object model and ontologies.
Constructing ontology from object model is called ontology
engineering can be done; On the other hand, this research is aiming to
support the idea of building object model from ontology is also
promising and practical. Ontology classes are available online in any
specific areas, which can be searched by semantic search engine.
There are also many helping tools to do so; one of them which are
used in this research is Protégé ontology editor and Visual Paradigm.
To put them together give a great outcome. This research will be
shown how it works efficiently with the real case study by using
ontology classes in travel/tourism domain area. It needs to combine
classes, properties, and relationships from more than two ontologies
in order to generate the object model. In this paper presents a simple
methodology framework which explains the process of discovering
objects. The results show that this framework has great value while
there is possible for expansion. Reusing of existing ontologies offers
a much cheaper alternative than building new ones from scratch.
More ontologies are becoming available on the web, and online
ontologies libraries for storing and indexing ontologies are increasing
in number and demand. Semantic and Ontologies search engines have
also started to appear, to facilitate search and retrieval of online
ontologies.
Abstract: This paper describes the designs of a first and second
generation autonomous gas monitoring system and the successful
field trial of the final system (2nd generation). Infrared sensing
technology is used to detect and measure the greenhouse gases
methane (CH4) and carbon dioxide (CO2) at point sources. The
ability to monitor real-time events is further enhanced through the
implementation of both GSM and Bluetooth technologies to
communicate these data in real-time. These systems are robust,
reliable and a necessary tool where the monitoring of gas events in
real-time are needed.
Abstract: The objective of this paper is to design a model of human vital sign prediction for decreasing prediction error by using two states mapping based time series neural network BP (back-propagation) model. Normally, lot of industries has been applying the neural network model by training them in a supervised manner with the error back-propagation algorithm for time series prediction systems. However, it still has a residual error between real value and prediction output. Therefore, we designed two states of neural network model for compensation of residual error which is possible to use in the prevention of sudden death and metabolic syndrome disease such as hypertension disease and obesity. We found that most of simulations cases were satisfied by the two states mapping based time series prediction model compared to normal BP. In particular, small sample size of times series were more accurate than the standard MLP model. We expect that this algorithm can be available to sudden death prevention and monitoring AGENT system in a ubiquitous homecare environment.
Abstract: The result of process of territory-s development is the territory-s state of development (TSoD), which is pointed towards the provision and improvement of people-s life conditions. The authors offer to measure the TSoD according to their own developed model. Using the available statistical data regarding the values of model-s elements, the authors empirically show which element mainly determines the TSoD. The findings of the research showed that the key elements of the TSoD are the “Material welfare of people" and “People-s health". Performing a deeper statistical analysis of correlation between these elements, it turned out that it is not so necessary for a country to be bent on trying to increase the material growth of a territory, because a relatively high index of life expectancy at birth could be ensured also by much more modest material resources. On the other hand, the economical feedback of longer lifespan within countries with lower material performance is also relatively low.
Abstract: We examine the maximum theorem by Berge from the
point of view of Bishop style constructive mathematics. We will show
an approximate version of the maximum theorem and the maximum
theorem for functions with sequentially locally at most one maximum.
Abstract: In this study, an experimental investigation was carried
out to fix CO2 into the electronic arc furnace (EAF) reducing slag from
stainless steelmaking process under wet grinding. The slag was ground
by the vibrating ball mill with the CO2 and pure water. The reaction
behavior was monitored with constant pressure method, and the
change of CO2 volume in the experimental system with grinding time
was measured. It was found that the CO2 absorption occurred as soon
as the grinding started. The CO2 absorption under wet grinding was
significantly larger than that under dry grinding. Generally, the
amount of CO2 absorption increased as the amount of water, the
amount of slag, the diameter of alumina ball and the initial pressure of
CO2 increased. However, the initial absorption rate was scarcely
influenced by the experimental conditions except for the initial CO2
pressure. According to this research, the CO2 reacted with the CaO
inside the slag to form CaCO3.
Abstract: The proper selection of the AC-side passive filter
interconnecting the voltage source converter to the power supply is
essential to obtain satisfactory performances of an active power filter
system. The use of the LCL-type filter has the advantage of
eliminating the high frequency switching harmonics in the current
injected into the power supply. This paper is mainly focused on
analyzing the influence of the interface filter parameters on the active
filtering performances. Some design aspects are pointed out. Thus,
the design of the AC interface filter starts from transfer functions by
imposing the filter performance which refers to the significant current
attenuation of the switching harmonics without affecting the
harmonics to be compensated. A Matlab/Simulink model of the entire
active filtering system including a concrete nonlinear load has been
developed to examine the system performances. It is shown that a
gamma LC filter could accomplish the attenuation requirement of the
current provided by converter. Moreover, the existence of an optimal
value of the grid-side inductance which minimizes the total harmonic
distortion factor of the power supply current is pointed out.
Nevertheless, a small converter-side inductance and a damping
resistance in series with the filter capacitance are absolutely needed
in order to keep the ripple and oscillations of the current at the
converter side within acceptable limits. The effect of change in the
LCL-filter parameters is evaluated. It is concluded that good active
filtering performances can be achieved with small values of the
capacitance and converter-side inductance.
Abstract: The basis of this paper is the assumption, that graviton
is a measurable entity of molecular gravitational acceleration and this
is not a hypothetical entity. The adoption of this assumption as an
axiom is tantamount to fully opening the previously locked door to
the boundary theory between laminar and turbulent flows. It leads to
the theorem, that the division of flows of Newtonian (viscous) fluids
into laminar and turbulent is true only, if the fluid is influenced by a
powerful, external force field. The mathematical interpretation of this
theorem, presented in this paper shows, that the boundary between
laminar and turbulent flow can be determined theoretically. This is a
novelty, because thus far the said boundary was determined
empirically only and the reasons for its existence were unknown.
Abstract: Microorganisms isolated from water and soil of
Kazakhstan to identify potential high-effective producers of the
arachidonic acid, exhibiting a wide range of physiological activity
and having practical applications were screened. Based on the results
of two independent tests (the test on the sensitivity of the growth
processes of microorganisms to acetylsalicylic acid - an irreversible
inhibitor of PGH-synthase involved in the metabolism of arachidonic
acid and its derivatives, the test for inhibition of peroxidase activity
of membrane-bounding fraction of PGH - synthase by acetylsalicylic
acid) were selected microbial cultures which are potential highproducer
of arachidonic acid. They are characterized by a stable
strong growth in the laboratory conditions. Identification of
microorganism cultures based on morphological, physiological,
biochemical and molecular genetic characteristics was performed.
Abstract: This paper presents the results of preliminary
assessment of water quality along the coastal areas in the vicinity of
Left Bank Outfall Drainage (LBOD) and Tidal Link Drain (TLD) in
Sindh province after the cyclone 2A occurred in 1999. The water
samples were collected from various RDs of Tidal Link Drain and
lakes during September 2001 to April 2002 and were analysed for
salinity, nitrite, phosphate, ammonia, silicate and suspended material
in water. The results of the study showed considerable variations in
water quality depending upon the location along the coast in the
vicinity of LBOD and RDs. The salinity ranged between 4.39–65.25
ppt in Tidal Link Drain samples whereas 2.4–38.05 ppt in samples
collected from lakes. The values of suspended material at various
RDs of Tidal Link Drain ranged between 56.6–2134 ppm and at the
lakes between 68–297 ppm. The data of continuous monitoring at
RD–93 showed the range of PO4 (8.6–25.2 μg/l), SiO3 (554.96–1462
μg/l), NO2 (0.557.2–25.2 μg/l) and NH3 (9.38–23.62 μg/l). The
concentration of nutrients in water samples collected from different
RDs was found in the range of PO4 (10.85 to 11.47 μg/l), SiO3 (1624
to 2635.08 μg/l), NO2 (20.38 to 44.8 μg/l) and NH3 (24.08 to 26.6
μg/l). Sindh coastal areas which situated at the north-western
boundary the Arabian Sea are highly vulnerable to flood damages
due to flash floods during SW monsoon or impact of sea level rise
and storm surges coupled with cyclones passing through Arabian Sea
along Pakistan coast. It is hoped that the obtained data in this study
would act as a database for future investigations and monitoring of
LBOD and Tidal Link Drain coastal waters.
Abstract: Two indica varieties, IR36 and ‘Suweon 258’ (“S”)
are middle-heading in southern Japan. 36U, also middle-heading, is
an isogenic line of IR36 carrying Ur1 (Undulate rachis-1) gene.
However, late-heading plants segregated in the F2 population from
the F1 of S × 36U, and so did in the following generations. The
concerning lateness gene is designated as Ex. From the F8 generation,
isogenic-line pair of early-heading and late-heading lines, denoted by
“E” (ex/ex) and “L” (Ex/Ex), were developed. Genetic analyses of
heading time were conducted, using F1s and F2s among L, E, S and
36U. The following inferences were drawn from the experimental
results: 1) L, and both of E and 36U harbor Ex and ex, respectively;
2) Besides Ex, S harbors an inhibitor gene to it, i.e. I-Ex which is a
novel finding of the present study. 3) Ex is a dominant allele at the
E1 locus.