Abstract: Medicines regulatory authorities expect pharmaceutical companies and contract research organizations to seek ways to certify that their laboratory control measurements are reliable. Establishing and maintaining laboratory quality standards are essential in ensuring the accuracy of test results. ‘ISO/IEC 17025:2017’ and ‘WHO Good Practices for Pharmaceutical Quality Control Laboratories (GPPQCL)’ are two quality standards commonly employed in developing laboratory quality systems. A review was conducted on the two standards to elaborate on areas on convergence and divergence. The goal was to understand how differences in each standard's requirements may influence laboratories' choices as to which document is easier to adopt for quality systems. A qualitative review method compared similar items in the two standards while mapping out areas where there were specific differences in the requirements of the two documents. The review also provided a detailed description of the clauses and parts covering management and technical requirements in these laboratory standards. The review showed that both documents share requirements for over ten critical areas covering objectives, infrastructure, management systems, and laboratory processes. There were, however, differences in standard expectations where GPPQCL emphasizes system procedures for planning and future budgets that will ensure continuity. Conversely, ISO 17025 was more focused on the risk management approach to establish laboratory quality systems. Elements in the two documents form common standard requirements to assure the validity of laboratory test results that promote mutual recognition. The ISO standard currently has more global patronage than GPPQCL.
Abstract: Sightseeing glass bridges located in steep valley area are being built on a large scale owing to the development of tourism. Consequently, their aerostatic stability is seriously affected by the wind field characteristics created by strong wind and special terrain, such as wind speed and wind attack angle. For instance, a cable-stayed pedestrian bridge without backstays comprised of a 60-m cantilever girder and the glass bridge deck is located in an abrupt valley, acting as a viewing platform. The bridge’s nonlinear aerostatic stability was analyzed by the segmental model test and numerical simulation in this paper. Based on aerostatic coefficients of the main girder measured in wind tunnel tests, nonlinear influences caused by the structure and aerostatic load, inhomogeneous distribution of torsion angle along the bridge axis, and the influence of initial attack angle were analyzed by using the incremental double iteration method. The results show that the aerostatic response varying with speed shows an obvious nonlinearity, and the aerostatic instability mode is of the characteristic of space deformation of bending-twisting coupling mode. The vertical and torsional deformation of the main girder is larger than its lateral deformation, with the wind speed approaching the critical wind speed. The flow of negative attack angle will reduce the bridges’ critical stability wind speed, but the influence of the negative attack angle on the aerostatic stability is more significant than that of the positive attack angle. The critical wind speeds of torsional divergence and lateral buckling are both larger than 200 m/s; namely, the bridge will not occur aerostatic instability under the action of various wind attack angles.
Abstract: The universe of aesthetic perception entails impasses about sensitive divergences that each text or visual object may be subjected to. If approached through intertextuality that is not based on the misleading notion of kinships or similarities a priori admissible, the possibility of anachronistic, heterogeneous - and non-diachronic - assemblies can enhance the emergence of interval movements, intermediate, and conflicting, conducive to a method of reading, interpreting, and assigning meaning that escapes the rigid antinomies of the mere being and non-being of things. In negative, they operate in a relationship built by the lack of an adjusted meaning set by their positive existences, with no remainders; the generated interval becomes the remnant of each of them; it is the opening that obscures the stable positions of each one. Without the negative of absence, of that which is always missing or must be missing in a text, concept, or image made positive by history, nothing is perceived beyond what has been already given. Pairings or binary oppositions cannot lead only to functional syntheses; on the contrary, methodological disturbances accumulated by the approximation of signs and entities can initiate a process of becoming as an opening to an unforeseen other, transformation until a moment when the difficulties of [re]conciliation become the mainstay of a future of that sign/entity, not envisioned a priori. A counter-history can emerge from these unprecedented, misadjusted approaches, beginnings of unassigned injunctions and disjunctions, in short, difficult alliances that open cracks in a supposedly cohesive history, chained in its apparent linearity with no remains, understood as a categorical historical imperative. Interstices are minority fields that, because of their opening, are capable of causing opacity in that which, apparently, presents itself with irreducible clarity. Resulting from an incomplete and maladjusted [at the least dual] marriage between the signs/entities that originate them, this interval may destabilize and cause disorder in these entities and their own meanings. The interstitials offer a hyphenated relationship: a simultaneous union and separation, a spacing between the entity’s identity and its otherness or, alterity. One and the other may no longer be seen without the crack or fissure that now separates them, uniting, by a space-time lapse. Ontological, semantic shifts are caused by this fissure, an absence between one and the other, one with and against the other. Based on an improbable approximation between some conceptual and semantic shifts within the design production of architect Rem Koolhaas and the textual production of the philosopher Jacques Derrida, this article questions the notion of unity, coherence, affinity, and complementarity in the process of construction of thought from these ontological, epistemological, and semiological fissures that rattle the signs/entities and their stable meanings. Fissures in a thought that is considered coherent, cohesive, formatted are the negativity that constitutes the interstices that allow us to move towards what still remains as non-identity, which allows us to begin another story.
Abstract: In recent years, electricity trade between neighboring countries has become increasingly intense. Increasing power transmission over long distances has resulted in an increase in the oscillations of the transmitted power. The damping of the oscillations can be carried out with the reconfiguration of the network or the replacement of generators, but such solution is not economically reasonable. The only cost-effective solution to improve the damping of power oscillations is to use power system stabilizers. Power system stabilizer represents a part of synchronous generator control system. It utilizes semiconductor’s excitation system connected to the rotor field excitation winding to increase the damping of the power system. The majority of the synchronous generators are equipped with the conventional power system stabilizers with fixed parameters. The control structure of the conventional power system stabilizers and the tuning procedure are based on the linear control theory. Conventional power system stabilizers are simple to realize, but they show non-sufficient damping improvement in the entire operating conditions. This is the reason that advanced control theories are used for development of better power system stabilizers. In this paper, the adaptive control theory for power system stabilizers design and synthesis is studied. The presented work is focused on the use of model reference adaptive control approach. Control signal, which assures that the controlled plant output will follow the reference model output, is generated by the adaptive algorithm. Adaptive gains are obtained as a combination of the "proportional" term and with the σ-term extended "integral" term. The σ-term is introduced to avoid divergence of the integral gains. The necessary condition for asymptotic tracking is derived by means of hyperstability theory. The benefits of the proposed model reference adaptive power system stabilizer were evaluated as objectively as possible by means of a theoretical analysis, numerical simulations and laboratory realizations. Damping of the synchronous generator oscillations in the entire operating range was investigated. Obtained results show the improved damping in the entire operating area and the increase of the power system stability. The results of the presented work will help by the development of the model reference power system stabilizer which should be able to replace the conventional stabilizers in power systems.
Abstract: Yi is an ethnic group mainly living in mainland China, with its own spoken and written language systems, after development of thousands of years. Ancient Yi is one of the six ancient languages in the world, which keeps a record of the history of the Yi people and offers documents valuable for research into human civilization. Recognition of the characters in ancient Yi helps to transform the documents into an electronic form, making their storage and spreading convenient. Due to historical and regional limitations, research on recognition of ancient characters is still inadequate. Thus, deep learning technology was applied to the recognition of such characters. Five models were developed on the basis of the four-layer convolutional neural network (CNN). Alpha-Beta divergence was taken as a penalty term to re-encode output neurons of the five models. Two fully connected layers fulfilled the compression of the features. Finally, at the softmax layer, the orthographic features of ancient Yi characters were re-evaluated, their probability distributions were obtained, and characters with features of the highest probability were recognized. Tests conducted show that the method has achieved higher precision compared with the traditional CNN model for handwriting recognition of the ancient Yi.
Abstract: Frequency diverse array (FDA) beamforming is a technology developed in recent years, and its antenna pattern has a unique angle-distance-dependent characteristic. However, the beam is always required to have strong concentration, high resolution and low sidelobe level to form the point-to-point interference in the concentrated set. In order to eliminate the angle-distance coupling of the traditional FDA and to make the beam energy more concentrated, this paper adopts a multi-carrier FDA structure based on proposed power exponential frequency offset to improve the array structure and frequency offset of the traditional FDA. The simulation results show that the beam pattern of the array can form a dot-shape beam with more concentrated energy, and its resolution and sidelobe level performance are improved. However, the covariance matrix of the signal in the traditional adaptive beamforming algorithm is estimated by the finite-time snapshot data. When the number of snapshots is limited, the algorithm has an underestimation problem, which leads to the estimation error of the covariance matrix to cause beam distortion, so that the output pattern cannot form a dot-shape beam. And it also has main lobe deviation and high sidelobe level problems in the case of limited snapshot. Aiming at these problems, an adaptive beamforming technique based on exponential correction for multi-carrier FDA is proposed to improve beamforming robustness. The steps are as follows: first, the beamforming of the multi-carrier FDA is formed under linear constrained minimum variance (LCMV) criteria. Then the eigenvalue decomposition of the covariance matrix is performed to obtain the diagonal matrix composed of the interference subspace, the noise subspace and the corresponding eigenvalues. Finally, the correction index is introduced to exponentially correct the small eigenvalues of the noise subspace, improve the divergence of small eigenvalues in the noise subspace, and improve the performance of beamforming. The theoretical analysis and simulation results show that the proposed algorithm can make the multi-carrier FDA form a dot-shape beam at limited snapshots, reduce the sidelobe level, improve the robustness of beamforming, and have better performance.
Abstract: Software-defined networking (SDN) provides a solution
for scalable network framework with decoupled control and data
plane. However, this architecture also induces a particular distributed
denial-of-service (DDoS) attack that can affect or even overwhelm
the SDN network. DDoS attack detection problem has to date been
mostly researched as entropy comparison problem. However, this
problem lacks the utilization of SDN, and the results are not accurate.
In this paper, we propose a DDoS attack detection method, which
interprets DDoS detection as a signature matching problem and is
formulated as Earth Mover’s Distance (EMD) model. Considering
the feasibility and accuracy, we further propose to define the cost
function of EMD to be a generalized Kullback-Leibler divergence.
Simulation results show that our proposed method can detect DDoS
attacks by comparing EMD values with the ones computed in the case
without attacks. Moreover, our method can significantly increase the
true positive rate of detection.
Abstract: Traditionally in sensor networks and recently in the
Internet of Things, numerous heterogeneous sensors are deployed
in distributed manner to monitor a phenomenon that often can be
model by an underlying stochastic process. The big time-series
data collected by the sensors must be analyzed to detect change
in the stochastic process as quickly as possible with tolerable
false alarm rate. However, sensors may have different accuracy
and sensitivity range, and they decay along time. As a result,
the big time-series data collected by the sensors will contain
uncertainties and sometimes they are conflicting. In this study, we
present a framework to take advantage of Evidence Theory (a.k.a.
Dempster-Shafer and Dezert-Smarandache Theories) capabilities of
representing and managing uncertainty and conflict to fast change
detection and effectively deal with complementary hypotheses.
Specifically, Kullback-Leibler divergence is used as the similarity
metric to calculate the distances between the estimated current
distribution with the pre- and post-change distributions. Then mass
functions are calculated and related combination rules are applied to
combine the mass values among all sensors. Furthermore, we applied
the method to estimate the minimum number of sensors needed to
combine, so computational efficiency could be improved. Cumulative
sum test is then applied on the ratio of pignistic probability to detect
and declare the change for decision making purpose. Simulation
results using both synthetic data and real data from experimental
setup demonstrate the effectiveness of the presented schemes.
Abstract: In this paper, we present a simple effective numerical geometric method to estimate the divergence of a vector field over a curved surface. The conservation law is an important principle in physics and mathematics. However, many well-known numerical methods for solving diffusion equations do not obey conservation laws. Our presented method in this paper combines the divergence theorem with a generalized finite difference method and obeys the conservation law on discrete closed surfaces. We use the similar method to solve the Cahn-Hilliard equations on evolving spherical surfaces and observe stability results in our numerical simulations.
Abstract: Over the past three decades, free and open source software (FOSS) programmers have developed new, innovative and legally binding licences that have in turn enabled the creation of innumerable pieces of everyday software, including Linux, Mozilla Firefox and Open Office. That FOSS has been highly successful in competing with 'closed source software' (e.g. Microsoft Office) is now undeniable, but in noting this success, it is important to examine in detail why this system of FOSS has been so successful. One key reason is the existence of networks or communities of programmers, who are bound together by a key shared social norm of 'reciprocity'. At the same time, these FOSS networks are not unitary – they are highly diverse and there are large divergences of opinion between members regarding which licences are generally preferable: some members favour the flexible ‘free’ or 'no copyleft' licences, such as BSD and MIT, while other members favour the ‘strong open’ or 'strong copyleft' licences such as GPL. This paper argues that without both the existence of the shared norm of reciprocity and the diversity of licences, it is unlikely that the innovative legal framework provided by FOSS would have succeeded to the extent that it has.
Abstract: The customers use the best compromise criterion
between price and quality of service (QoS) to select or change
their Service Provider (SP). The SPs share the same market and
are competing to attract more customers to gain more profit. Due
to the divergence of SPs interests, we believe that this situation is a
non-cooperative game of price and QoS. The game converges to an
equilibrium position known Nash Equilibrium (NE). In this work, we
formulate a game theoretic framework for the dynamical behaviors
of SPs. We use Genetic Algorithms (GAs) to find the price and
QoS strategies that maximize the profit for each SP and illustrate
the corresponding strategy in NE. In order to quantify how this NE
point is performant, we perform a detailed analysis of the price of
anarchy induced by the NE solution. Finally, we provide an extensive
numerical study to point out the importance of considering price and
QoS as a joint decision parameter.
Abstract: Development of a method to estimate gene functions is
an important task in bioinformatics. One of the approaches for the
annotation is the identification of the metabolic pathway that genes are
involved in. Since gene expression data reflect various intracellular
phenomena, those data are considered to be related with genes’
functions. However, it has been difficult to estimate the gene function
with high accuracy. It is considered that the low accuracy of the
estimation is caused by the difficulty of accurately measuring a gene
expression. Even though they are measured under the same condition,
the gene expressions will vary usually. In this study, we proposed a
feature extraction method focusing on the variability of gene
expressions to estimate the genes' metabolic pathway accurately. First,
we estimated the distribution of each gene expression from replicate
data. Next, we calculated the similarity between all gene pairs by KL
divergence, which is a method for calculating the similarity between
distributions. Finally, we utilized the similarity vectors as feature
vectors and trained the multiclass SVM for identifying the genes'
metabolic pathway. To evaluate our developed method, we applied the
method to budding yeast and trained the multiclass SVM for
identifying the seven metabolic pathways. As a result, the accuracy
that calculated by our developed method was higher than the one that
calculated from the raw gene expression data. Thus, our developed
method combined with KL divergence is useful for identifying the
genes' metabolic pathway.
Abstract: Steganography is the art and science that hides the information in an appropriate cover carrier like image, text, audio and video media. In this work the authors propose a new image based steganographic method for hiding information within the complex bit planes of the image. After slicing into bit planes the cover image is analyzed to extract the most complex planes in decreasing order based on their bit plane complexity. The complexity function next determines the complex noisy blocks of the chosen bit plane and finally pixel mapping method (PMM) has been used to embed secret bits into those regions of the bit plane. The novel approach of using pixel mapping method (PMM) in bit plane domain adaptively embeds data on most complex regions of image, provides high embedding capacity, better imperceptibility and resistance to steganalysis attack.
Abstract: This article is deal with the experimental
investigations of the laser diode matrixes (LDM) based on the
AlGaAs/GaAs heterostructures (lasing wavelength 790-880 nm) to
find optimal LDM parameters for active vision systems. In particular,
the dependence of LDM radiation pulse power on the pulse duration
and LDA active layer heating as well as the LDM radiation
divergence are discussed.
Abstract: Thermal radiation plays a very important role in the heat transfer combination through the various components of the SOFC fuel cell operating at high temperatures. Lattice Boltzmann method is used for treating conduction-radiation heat transfer in the electrolyte. The thermal radiation heat transfer is coupled to the overall energy conservation equations through the divergence of the local radiative flux. The equation of energy in one dimension is numerically resolved by using the Lattice Boltzmann method. A computing program (FORTRAN) is developed locally for this purpose in order to obtain fields of temperature in every element of the cell. The parameters investigated are: functioning temperature, cell voltages and electrolyte thickness. The results show that the radiation effect increases with increasing the electrolyte thickness, also increases with increasing the functioning temperature and decreases with the increase of the voltage of the cell.
Abstract: Due to adverse pressure gradient along the diverging
walls of wide-angled diffusers, the attached flow separates from
one wall and remains attached permanently to the other wall in a
process called stalling. Stalled diffusers render the whole fluid flow
system, in which they are part of, very inefficient. There is then an
engineering need to try to understand the whole process of diffuser
stall if any meaningful attempts to improve on diffuser efficiency
are to be made. In this regard, this paper provides a data bank
contribution for the mean flow-field in wide-angled diffusers where
the complete velocity and static pressure fields, and pressure recovery
data for diffusers in the fully stalled flow regime are experimentally
measured. The measurements were carried out at Reynolds numbers
between 1.07×105 and 2.14×105 based on inlet hydraulic diameter
and centreline velocity for diffusers whose divergence angles were
between 30Ôùª and 50Ôùª. Variation of Reynolds number did not significantly
affect the velocity and static pressure profiles. The wall static
pressure recovery was found to be more sensitive to changes in the
Reynolds number. By increasing the velocity from 10 m/s to 20 m/s,
the wall static pressure recovery increased by 8.31%. However, as the
divergence angle was increased, a similar increase in the Reynolds
number resulted in a higher percentage increase in pressure recovery.
Experimental results showed that regardless of the wall to which
the flow was attached, both the velocity and pressure fields were
replicated with discrepancies below 2%.
Abstract: People usually have a telephone voice, which means
they adjust their speech to fit particular situations and to blend in with
other interlocutors. The question is: Do we speak differently to
different people? This possibility has been suggested by social
psychologists within Accommodation Theory [1]. Converging toward
the speech of another person can be regarded as a polite speech
strategy while choosing a language not used by the other interlocutor
can be considered as the clearest example of speech divergence [2].
The present study sets out to investigate such processes in the course
of everyday telephone conversations. Using Joos-s [3] model of
formality in spoken English, the researchers try to explore
convergence to or divergence from the addressee. The results
propound the actuality that lexical choice, and subsequently, patterns
of style vary intriguingly in concordance with the person being
addressed.
Abstract: The article deals with experimental and numerical
investigation of axi-symmetric subsonic air to air ejector with
diffuser adapted for boundary layer suction. The diffuser, which is
placed behind the mixing chamber of the ejector, has high divergence
angle and therefore low efficiency. To increase the efficiency, the
diffuser is equipped with slot enabling boundary layer suction. The
effect of boundary layer suction on flow in ejector, static pressure
distribution on the mixing chamber wall and characteristic were
measured and studied numerically. Both diffuser and ejector
efficiency were evaluated. The diffuser efficiency was increased,
however, the efficiency of ejector itself remained low.
Abstract: The role of corporate governance is to reduce the
divergence of interests between shareholders and managers. The role
of corporate governance is more useful when managers have an
incentive to deviate from shareholders- interests. One example of
management-s deviation from shareholders- interests is the
management of earnings through the use of accounting accruals. This
paper examines the association between corporate governance
internal mechanisms ownership concentration, board independence,
the existence of CEO-Chairman duality and earnings management.
Firm size and leverage are control variables. The population used in
this study comprises firms listed on the Tehran Stock Exchange
(TSE) between 2004 and 2008, the sample comprises 196 firms.
Panel Data method is employed as technique to estimate the model.
We find that there is negative significant association between
ownership concentration and board independence manage earnings
with earnings management, there is negative significant association
between the existence of CEO-Chairman duality and earnings
management. This study also found a positive significant association
between control variable (firm size and leverage) and earnings
management.
Abstract: Recently many research has been conducted to
retrieve pertinent parameters and adequate models for automatic
music genre classification. In this paper, two measures based upon
information theory concepts are investigated for mapping the features
space to decision space. A Gaussian Mixture Model (GMM) is used
as a baseline and reference system. Various strategies are proposed
for training and testing sessions with matched or mismatched
conditions, long training and long testing, long training and short
testing. For all experiments, the file sections used for testing are
never been used during training. With matched conditions all
examined measures yield the best and similar scores (almost 100%).
With mismatched conditions, the proposed measures yield better
scores than the GMM baseline system, especially for the short testing
case. It is also observed that the average discrimination information
measure is most appropriate for music category classifications and on
the other hand the divergence measure is more suitable for music
subcategory classifications.