Abstract: The exposure to outdoor air pollution causes lung
cancer and increases the risk of bladder cancer. Because air pollution
in urban areas is mainly caused by transportation, it is necessary to
evaluate pollutant exhaust emissions from vehicles during their realworld
use. Nevertheless their evaluation and reduction is a key
problem, especially in the cities, that account for more than 50% of
world population.
A particular attention was given to the slope variability along the
streets during each journey performed by the instrumented vehicle.
In this paper we dealt with the problem of describing a
quantitatively approach for the reconstruction of GPS coordinates and
altitude, in the context of correlation study between driving cycles /
emission / geographical location, during an experimental campaign
realized with some instrumented cars.
Finally the slope analysis can be correlated to the emission and
consumption values in a specific road position, and it could be
evaluated its influence on their behaviour.
Abstract: In this work, we have used arrays of micromechanical piezoresistive cantilever with different geometries to detect carcinoembryonic antigen (CEA), which is known as an important biomarker associated with various cancers such as colorectal, lung, breast, pancreatic, and bladder cancer. The sensing principle is based on the surface stress changes induced by antigen–antibody interaction on the microcantilevers surfaces. Different concentrations of CEA in a human serum albumin (HSA) solution were detected as a function of deflection of the beams. According to the experiments, it was revealed that microcantilevers have surface stress sensitivities in the order of 8 (mJ/m). This matter allows them to detect CEA concentrations as low as 3 ng/mL or 18 pM. This indicates the fact that the self-sensing microcantilevers approach is beneficial for pathological tests.
Abstract: Bladder carcinoma is an important worldwide health problem. Both cystoscopy and urine cytology used in detecting bladder cancer suffer from drawbacks where cystoscopy is an invasive method and urine cytology shows low sensitivity in low grade tumors. This study validates easier and less time-consuming techniques to evaluate the value of combined use of angiogenin and clusterin in comparison and combination with voided urine cytology in the detection of bladder cancer patients. This study includes malignant (bladder cancer patients, n= 50), benign (n=20) and healthy (n=20) groups. The studied groups were subjected to cystoscopic examination, detection of bilharzial antibodies, urine cytology, and estimation of urinary angiogenin and clusterin by ELISA. The overall sensitivity and specificity were 66% and 75% for angiogenin, 70% and 82.5% for clusterin and 46% and 80% for voided urine cytology. Combined sensitivity of angiogenin and clusterin with urine cytology increased from 82 to 88%.
Abstract: The inhibition effect of brazilin to human bladder
tumor cell line T24 in vitro and in vivo was studied. The results of the
in vitro experiments showed that brazilin has strong inhibition activity
on the target cells. The inhibition ratio of 100 μg/mL brazilin and 100
μg/mL mitomycin to the target cells was 90.90 % and 63.24 %
respectively, which showed that brazilin has higher inhibition activity
than mitomycin under the same concentration. Brazilin could induce
cell apoptosis in T24 cells. Significant antitumor activity of brazilin
was also showed in the animals experiments. The life extention rate of
200 mg/mL, 300 mg/kg, and 400 mg/kg brazilin intraperitoneally
injected into Balb/c-nu-nu nude mice that with human bladder cancer
were 51.50 %, 56.90 %, and 58.42 %（P
Abstract: Nuclear matrix protein 22 (NMP22) is a FDA approved
biomarker for bladder cancer. The objective of this study is to develop
a simple NMP22 immumosensor (NMP22-IMS) for accurate
measurement of NMP22. The NMP22-IMS was constructed with
NMP22 antibody immobilized on screen-printed carbon electrodes.
The construction procedures and antibody immobilization are simple.
Results showed that the NMP22-IMS has an excellent (r2³0.95)
response range (20 – 100 ng/mL). In conclusion, a simple and reliable
NMP22-IMS was developed, capable of precisely determining urine
NMP22 level.
Abstract: Trihalomethanes (THMs) were among the first
disinfection byproducts to be discovered in chlorinated water. The
substances form during a reaction between chlorine and organic
matter in the water. Trihalomethanes are suspected to have negative
effects on birth such as, low birth weight, intrauterine growth
retardation in term births, as well as gestational age and preterm
delivery. There are also some evidences showing these by-products to
be mutagenic and carcinogenic, the greatest amount of evidence being
related to the bladder cancer. However, there exist inconsistencies
regarding such effects of THMs as different studies have provided
different results in this regard. The aim of the present study is to
provide a review of the related researches about the above mentioned
health effects of THMs.