Abstract: In this work, we have used arrays of micromechanical piezoresistive cantilever with different geometries to detect carcinoembryonic antigen (CEA), which is known as an important biomarker associated with various cancers such as colorectal, lung, breast, pancreatic, and bladder cancer. The sensing principle is based on the surface stress changes induced by antigen–antibody interaction on the microcantilevers surfaces. Different concentrations of CEA in a human serum albumin (HSA) solution were detected as a function of deflection of the beams. According to the experiments, it was revealed that microcantilevers have surface stress sensitivities in the order of 8 (mJ/m). This matter allows them to detect CEA concentrations as low as 3 ng/mL or 18 pM. This indicates the fact that the self-sensing microcantilevers approach is beneficial for pathological tests.
Abstract: When the characteristic length of an elastic solid is
down to the nanometer level, its deformation behavior becomes size
dependent. Surface energy /surface stress have recently been applied
to explain such dependency. In this paper, the effect of
strain-independent surface stress on the deformation of an isotropic
elastic solid containing a nanosized elliptical hole is studied by the
finite element method. Two loading cases are considered, in the first
case, hoop stress along the rim of the elliptical hole induced by pure
surface stress is studied, in the second case, hoop stress around the
elliptical opening under combined remote tension and surface stress is
investigated. It has been shown that positive surface stress induces
compressive hoop stress along the hole, and negative surface stress has
opposite effect, maximum hoop stress occurs near the major semi-axes
of the ellipse. Under combined loading of remote tension and surface
stress, stress concentration around the hole can be either intensified or
weakened depending on the sign of the surface stress.