Abstract: MicroRNAs (miRNAs), a class of approximately 22 nucleotide long non coding RNAs which play critical role in different biological processes. The mature microRNA is usually 19–27 nucleotides long and is derived from a bigger precursor that folds into a flawed stem-loop structure. Mature micro RNAs are involved in many cellular processes that encompass development, proliferation, stress response, apoptosis, and fat metabolism by gene regulation. Resent finding reveals that certain viruses encode their own miRNA that processed by cellular RNAi machinery. In recent research indicate that cellular microRNA can target the genetic material of invading viruses. Cellular microRNA can be used in the virus life cycle; either to up regulate or down regulate viral gene expression Computational tools use in miRNA target prediction has been changing drastically in recent years. Many of the methods have been made available on the web and can be used by experimental researcher and scientist without expert knowledge of bioinformatics. With the development and ease of use of genomic technologies and computational tools in the field of microRNA biology has superior tremendously over the previous decade. This review attempts to give an overview over the genome wide approaches that have allow for the discovery of new miRNAs and development of new miRNA target prediction tools and databases.
Abstract: The study aimed to investigate whether cognitive emotion regulation in children varies with parenting style, family type and gender. Toward this end, cognitive emotion regulation and perceived parenting style of 206 school children were measured. Standard regression analyses of data revealed that the models were significant and explained 17.3% of the variance in adaptive emotion regulation (Adjusted R²=0.173; F=9.579, p
Abstract: The error monitoring and processing system, EMPS is
the system located in the substantia nigra of the midbrain, basal
ganglia and cortex of the forebrain, and plays a leading role in error
detection and correction. The main components of EMPS are the
dopaminergic system and anterior cingulate cortex. Although, recent
studies show that alcohol disrupts the EMPS, the ways in which
alcohol affects this system are poorly understood. Based on current
literature data, here we suggest a hypothesis of alcohol-related
glucose-dependent system of error monitoring and processing, which
holds that the disruption of the EMPS is related to the competency of
glucose homeostasis regulation, which in turn may determine the
dopamine level as a major component of EMPS. Alcohol may
indirectly disrupt the EMPS by affecting dopamine level through
disorders in blood glucose homeostasis regulation.
Abstract: The Czech Republic is a country whose economy has
undergone a transformation since 1989. Since joining the EU it has
been striving to reduce the differences in its economic standard and
the quality of its institutional environment in comparison with
developed countries. According to an assessment carried out by the
World Bank, the Czech Republic was long classed as a country
whose institutional development was seen as problematic. For many
years one of the things it was rated most poorly on was its bankruptcy
law. The new Insolvency Act, which is a modern law in terms of its
treatment of bankruptcy, was first adopted in the Czech Republic in
2006. This law, together with other regulatory measures, offers debtridden
Czech economic subjects legal instruments which are well
established and in common practice in developed market economies.
Since then, analyses performed by the World Bank and the London
EBRD have shown that there have been significant steps forward in
the quality of Czech bankruptcy law. The Czech Republic still lacks
an analytical apparatus which can offer a structured characterisation
of the general and specific conditions of Czech company and
household debt which is subject to current changes in the global
economy. This area has so far not been given the attention it
deserves. The lack of research is particularly clear as regards analysis
of household debt and householders- ability to settle their debts in a
reasonable manner using legal and other state means of regulation.
We assume that Czech households have recourse to a modern
insolvency law, yet the effective application of this law is hampered
by the inconsistencies in the formal and informal institutions
involved in resolving debt. This in turn is based on the assumption
that this lack of consistency is more marked in cases of personal
bankruptcy. Our aim is to identify the symptoms which indicate that
for some time the effective application of bankruptcy law in the
Czech Republic will be hindered by factors originating in
householders- relative inability to identify the risks of falling into
debt.
Abstract: The very nonlinear nature of the generator and system
behaviour following a severe disturbance precludes the use of
classical linear control technique. In this paper, a new approach of
nonlinear control is proposed for transient and steady state stability
analysis of a synchronous generator. The control law of the generator
excitation is derived from the basis of Lyapunov stability criterion.
The overall stability of the system is shown using Lyapunov
technique. The application of the proposed controller to simulated
generator excitation control under a large sudden fault and wide
range of operating conditions demonstrates that the new control
strategy is superior to conventional automatic voltage regulator
(AVR), and show very promising results.
Abstract: This paper presents a novel three-phase utility
frequency to high frequency soft switching power conversion circuit
with dual mode pulse width modulation and pulse density modulation
for high power induction heating applications as melting of steel and
non ferrous metals, annealing of metals, surface hardening of steel
and cast iron work pieces and hot water producers, steamers and
super heated steamers. This high frequency power conversion circuit
can operate from three-phase systems to produce high current for
high power induction heating applications under the principles of
ZVS and it can regulate its ac output power from the rated value to a
low power level. A dual mode modulation control scheme based on
high frequency PWM in synchronization with the utility frequency
positive and negative half cycles for the proposed high frequency
conversion circuit and utility frequency pulse density modulation is
produced to extend its soft switching operating range for wide ac
output power regulation. A dual packs heat exchanger assembly is
designed to be used in consumer and industrial fluid pipeline systems
and it is proved to be suitable for the hot water, steam and super
heated steam producers. Experiment and simulation results are given
in this paper to verify the operation principles of the proposed ac
conversion circuit and to evaluate its power regulation and
conversion efficiency. Also, the paper presents a mutual coupling
model of the induction heating load instead of equivalent transformer
circuit model.
Abstract: The purpose of this paper is to guide the effort in
improving the economic added value of Indonesian fisheries product
through post fishing program, which is cold storage program.
Indonesia's fisheries potential has been acknowledged by the world.
FAO (2009) stated that Indonesia is one of the tenth highest
producers of fishery products in the world. Based on BPS (Statistics
Indonesia data), the national fisheries production in 2011 reached
5.714 million tons, which 93.55% came from marine fisheries and
6.45% from open waters. Indonesian territory consist of 2/3 of
Indonesian waters, has given enormous benefits for Indonesia,
especially fishermen. To improve the economic level of fishermen
requires efforts to develop fisheries business unit. On of the efforts is
by improving the quality of products which are marketed in the
regional and international levels. It is certainly need the support of
the existence of various fishery facilities (infrastructure to
superstructure), one of which is cold storage. Given the many
benefits of cold storage as a means of processing of fishery resources,
Indonesia Maritime Security Coordinating Board (IMSCB) as one of
the maritime institutions for maritime security and safety, has a
program to empower the coastal community through encourages the
development of cold storage in the middle and lower fishery business
unit. The development of cold storage facilities which able to run its
maximum role requires synergistic efforts of various parties.
Abstract: A kind of crash energy absorption structure adopted by vehicle simulator crash testing equipment based on mechanical energy
storage was studied. Dynamic explicit finite element simulation was achieved for thin-walled tube structure under different conditions of
section shape, thickness and inducement groove style. Crash energy absorption property of the structure was obtained. After optimization,
a reasonable structure was given which can meet current vehicle crash regulation. And the optimized structure can be adopted in vehicle
simulator, which can increase the practicability of the testing
equipment.
Abstract: Horizontal platform system (HPS) is popularly applied
in offshore and earthquake technology, but it is difficult and
time-consuming for regulation. In order to understand the nonlinear
dynamic behavior of HPS and reduce the cost when using it, this paper
employs differential transformation method to study the bifurcation
behavior of HPS. The numerical results reveal a complex dynamic
behavior comprising periodic, sub-harmonic, and chaotic responses.
Furthermore, the results reveal the changes which take place in the
dynamic behavior of the HPS as the external torque is increased.
Therefore, the proposed method provides an effective means of
gaining insights into the nonlinear dynamics of horizontal platform
system.
Abstract: P16/INK4A is tumor suppressor protein that plays a critical role in cell cycle regulation. Loss of P16 protein expression has been implicated in pathogenesis of many cancers, including lymphoma. Therefore, we sought to investigate if loss of P16 protein expression is associated with lymphoma and/or any specific lymphoma subtypes (Hodgkin-s lymphoma (HL) and nonHodgkin-s lymphoma (NHL)). Fifty-five lymphoma cases consisted of 30 cases of HL and 25 cases of NHL, with an age range of 3 to 78 years, were examined for loss of P16 by immunohistochemical technique using a specific antibody reacting against P16. In total, P16 loss was seen in 33% of all lymphoma cases. P16 loss was identified in 47.7% of HL cases. In contrast, only 16% of NHL showed loss of P16. Loss of P16 was seen in 67% of HL patients with 50 years of age or older, whereas P16 loss was found in only 42% of HL patients with less than 50 years of age. P16 loss in HL is somewhat higher in male (55%) than in female (30%). In subtypes of HL, P16 loss was found exclusively in all cases of lymphocyte depletion, lymphocyte predominance and unclassified cases, whereas P16 loss was seen in 39% of mixed cellularity and 29% of nodular sclerosis cases. In low grade NHL patients, P16 loss was seen in approximately one-third of cases, whereas no or very rare of P16 loss was found in intermediate and high grade cases. P16 loss did not show any correlation with age or gender of NHL patients. In conclusion, the high rate of P16 loss seen in our study suggests that loss of P16 expression plays a critical role in the pathogenesis of lymphoma, particularly with HL.
Abstract: In this paper, we consider nested sliding mode control of SISO nonlinear systems, perturbed by bounded matched and unmatched uncertainties. The systems are assumed to be in strict-feedback form. A step wise procedure is introduced to obtain the controller. In each step, a continuous sliding mode controller is designed as virtual control law. Then the next step sliding surface is defined by using this virtual controller. These sliding surfaces are selected as nonlinear static functions of the system states. Finally in the last step, smooth static state feedback control law is determined such that the output reaches the desired set-point while the system is forced arbitrary close to the intersection of sliding surfaces and the states remain bounded.
Abstract: Heat pipes are two-phase heat transfer devices with
high effective thermal conductivity. Due to the high heat transport
capacity, heat exchanger with heat pipes has become much smaller
than traditional heat exchangers in handling high heat fluxes. With
the working fluid in a heat pipe, heat can be absorbed on the
evaporator region and transported to the condenser region where the
vapour condenses releasing the heat to the cooling media. Heat pipe
technology has found increasing applications in enhancing the
thermal performance of heat exchangers in microelectranics, energy
saving in HVAC systems for operating rooms,surgery centers, hotels,
cleanrooms etc, temperature regulation systems for the human body
and other industrial sectors. Development activity in heat pipe and
thermosyphon technology in asia in recent years is surveyed. Some
new results obtained in Australia and other countries are also
included.
Abstract: In the package design industry, there are a lot of tacit knowledge resided within each designer. The objectives are to capture them and compile it to be used as a teaching resource and to create a video clip of package design process as well as to evaluate its quality and learning effectiveness. Interview were used as a technique for capturing knowledge in brand design concept, differentiation, recognition, rank of recognition factor, consumer survey, knowledge about marketing, research, graphic design, the effect of color, and law and regulation. Video clip about package design were created. The clip consisted of both the speech and clip of actual process. The quality of the video in term of media was ranked as good while the content was ranked as excellent. The students- score on post-test was significantly greater than that of pretest (p>0.001).
Abstract: An on chip low drop out voltage regulator that
employs elegant compensation scheme is presented in this paper. The
novelty in this design is that the device parasitic capacitances are
exploited for compensation at different loads. The proposed LDO is
designed to provide a constant voltage of 1.2V and is implemented in
UMC 180 nano meter CMOS technology. The voltage regulator
presented improves stability even at lighter loads and enhances line
and load regulation.
Abstract: Expression and secretion of inflammation markers are
disturbed in obesity. Interleukin-6 reduces body fat mass. The
common G-174C polymorphism in the promoter of IL-6 gene has
been reported that effects on transcriptional regulation. The objective
was to investigate association of the common polymorphism G-174C
with obesity in Iranian population. The present study is cross
sectional association study that included 242 individuals (110 men
and 132 women). Serum IL-6 levels, C-reactive protein, fasting
blood glucose and blood lipids profile were measured .BMI and
WHR were calculated. Genotyping is carried out by PCR and RFLP.
The frequencies of G and C allele were 64.5% and 35.5%,
respectively. The G-174C polymorphism was not associated with
BMI and WHR. However in obese individual, fasting blood glucose
was significantly higher in carrier of C allele compared with the noncarrier.
The IL-6 G-174C polymorphism is not a risk factor for
obesity in Iranian population.
Abstract: This paper presents the DC voltage control design of D-STATCOM when the D-STATCOM is used for load voltage regulation. Although, the DC voltage can be controlled by active current of the D-STATCOM, reactive current still affects the DC voltage. To eliminate this effect, the control strategy with elimination effect of the reactive current is proposed and the results of the control with and without the elimination the effect of the reactive current are compared. For obtaining the proportional and integral gains of the PI controllers, the symmetrical optimum and genetic algorithms methods are applied. The stability margin of these methods are obtained and discussed in detail. In addition, the performance of the DC voltage control based on symmetrical optimum and genetic algorithms methods are compared. Effectiveness of the controllers designed was verified through computer simulation performed by using Power System Tool Block (PSB) in SIMULINK/MATLAB. The simulation results demonstrated that the DC voltage control proposed is effective in regulating DC voltage when the DSTATCOM is used for load voltage regulation.
Abstract: This paper presents a new method for the
implementation of a direct rotor flux control (DRFOC) of induction
motor (IM) drives. It is based on the rotor flux components
regulation. The d and q axis rotor flux components feed proportional
integral (PI) controllers. The outputs of which are the target stator
voltages (vdsref and vqsref). While, the synchronous speed is depicted at
the output of rotor speed controller. In order to accomplish variable
speed operation, conventional PI like controller is commonly used.
These controllers provide limited good performances over a wide
range of operations even under ideal field oriented conditions. An
alternate approach is to use the so called fuzzy logic controller. The
overall investigated system is implemented using dSpace system
based on digital signal processor (DSP). Simulation and experimental
results have been presented for a one kw IM drives to confirm the
validity of the proposed algorithms.
Abstract: A new power regulator controller with multiple-access
PID compensator is proposed, which can achieve a minimum memory
requirement for fully table look-up. The proposed regulator controller
employs hysteresis comparators, an error process unit (EPU) for
voltage regulation, a multiple-access PID compensator and a lowpower-
consumption digital PWM (DPWM). Based on the multipleaccess
mechanism, the proposed controller can alleviate the penalty of
large amount of memory employed for fully table look-up based PID
compensator in the applications of power regulation. The proposed
controller has been validated with simulation results.
Abstract: Utilities use operating reserve for frequency regulation.To ensure that the operating frequency and system security are well maintained, the operating grid codes always specify that the reserve quantity and response rate should meet some prescribed levels. This paper proposes a methodology to evaluate system's contingency reserve for an isolated power network. With the presented algorithm to estimate system's frequency response characteristic, an online allocation of contingency reserve would be feasible to meet the grid codes for contingency operation. Test results from the simulated conditions, and from the actual operating data verify the merits of the proposed methodology to system's frequency control, and security.
Abstract: This paper presents application artificial intelligent (AI) techniques, namely artificial neural network (ANN), adaptive neuro fuzzy interface system (ANFIS), to estimate the real power transfer between generators and loads. Since these AI techniques adopt supervised learning, it first uses modified nodal equation method (MNE) to determine real power contribution from each generator to loads. Then the results of MNE method and load flow information are utilized to estimate the power transfer using AI techniques. The 25-bus equivalent system of south Malaysia is utilized as a test system to illustrate the effectiveness of both AI methods compared to that of the MNE method. The mean squared error of the estimate of ANN and ANFIS power transfer allocation methods are 1.19E-05 and 2.97E-05, respectively. Furthermore, when compared to MNE method, ANN and ANFIS methods computes generator contribution to loads within 20.99 and 39.37msec respectively whereas the MNE method took 360msec for the calculation of same real power transfer allocation.