Abstract: P16/INK4A is tumor suppressor protein that plays a critical role in cell cycle regulation. Loss of P16 protein expression has been implicated in pathogenesis of many cancers, including lymphoma. Therefore, we sought to investigate if loss of P16 protein expression is associated with lymphoma and/or any specific lymphoma subtypes (Hodgkin-s lymphoma (HL) and nonHodgkin-s lymphoma (NHL)). Fifty-five lymphoma cases consisted of 30 cases of HL and 25 cases of NHL, with an age range of 3 to 78 years, were examined for loss of P16 by immunohistochemical technique using a specific antibody reacting against P16. In total, P16 loss was seen in 33% of all lymphoma cases. P16 loss was identified in 47.7% of HL cases. In contrast, only 16% of NHL showed loss of P16. Loss of P16 was seen in 67% of HL patients with 50 years of age or older, whereas P16 loss was found in only 42% of HL patients with less than 50 years of age. P16 loss in HL is somewhat higher in male (55%) than in female (30%). In subtypes of HL, P16 loss was found exclusively in all cases of lymphocyte depletion, lymphocyte predominance and unclassified cases, whereas P16 loss was seen in 39% of mixed cellularity and 29% of nodular sclerosis cases. In low grade NHL patients, P16 loss was seen in approximately one-third of cases, whereas no or very rare of P16 loss was found in intermediate and high grade cases. P16 loss did not show any correlation with age or gender of NHL patients. In conclusion, the high rate of P16 loss seen in our study suggests that loss of P16 expression plays a critical role in the pathogenesis of lymphoma, particularly with HL.
Abstract: MOC (method of cell) is a new method of investigating
wave propagating in material with periodic microstructure, and can
reflect the effect of microstructure. Wave propagation in periodically
laminated medium consisting of linearly elastic layers can be treated
as a special application of this method. In this paper, it was used to
simulate the dynamic response of carbon-phenolic to impulsive
loading under certain boundary conditions. From the comparison
between the results obtained from this method and the exact results
based on propagator matrix theory, excellent agreement is achieved.
Conclusion can be made that the oscillation periodicity is decided by
the thickness of sub-cells. In the end, the NHDMOC method, which
permits studying stress wave propagation with one dimensional strain,
was applied to study the one-dimensional stress wave propagation. In
this paper, the ZWT nonlinear visco-elastic constitutive relationship
with 7 parameters, NHDMOC, and corresponding equations were
deduced. The equations were verified, comparing the elastic stress
wave propagation in SHPB with, respectively, the elastic and the
visco-elastic bar. Finally the dispersion and attenuation of stress wave
in SHPB with visco-elastic bar was studied.