Abstract: Mendelian Disease Genes represent a collection of single points of failure for the various systems they constitute. Such genes have been shown, on average, to encode longer proteins than 'non-disease' proteins. Existing models suggest that this results from the increased likeli-hood of longer genes undergoing mutations. Here, we show that in saturated mutagenesis experiments performed on model organisms, where the likelihood of each gene mutating is one, a similar relationship between length and the probability of a gene being lethal was observed. We thus suggest an extended model demonstrating that the likelihood of a mutated gene to produce a severe phenotype is length-dependent. Using the occurrence of conserved domains, we bring evidence that this dependency results from a correlation between protein length and the number of functions it performs. We propose that protein length thus serves as a proxy for protein cardinality in different networks required for the organism's survival and well-being. We use this example to argue that the collection of Mendelian Disease Genes can, and should, be used to study the rules governing systems vulnerability in living organisms.
Abstract: Application of Information Technology (IT) has
revolutionized the functioning of business all over the world. Its
impact has been felt mostly among the information of dependent
industries. Tourism is one of such industry. The conceptual
framework in this study represents an innovation of travel
information searching system on mobile devices which is used as
tools to deliver travel information (such as hotels, restaurants, tourist
attractions and souvenir shops) for each user by travelers
segmentation based on data mining technique to segment the tourists-
behavior patterns then match them with tourism products and
services. This system innovation is designed to be a knowledge
incremental learning. It is a marketing strategy to support business to
respond traveler-s demand effectively.
Abstract: This paper presents design and characterization of a
microaccelerometer designated for integration into cataract surgical
probe to detect hardness of different eye tissues during cataract
surgery. Soft posterior lens capsule of eye can be easily damaged in
comparison with hard opaque lens since the surgeon can not see
directly behind cutting needle during the surgery. Presence of
microsensor helps the surgeon to avoid rupturing posterior lens
capsule which if occurs leads to severe complications such as
glaucoma, infection, or even blindness. The microsensor having
overall dimensions of 480 μm x 395 μm is able to deliver significant
capacitance variations during encountered vibration situations which
makes it capable to distinguish between different types of tissue.
Integration of electronic components on chip ensures high level of
reliability and noise immunity while minimizes space and power
requirements. Physical characteristics and results on performance
testing, proves integration of microsensor as an effective tool to aid
the surgeon during this procedure.
Abstract: Supplementation of palm vitamin E has been reported
to prevent loss of bone density in ovariectomised female rats. The
mechanism by which palm vitamin E exerts these effects is still
unknown. We hypothesized that palm vitamin E may act by
preventing the protein expression changes. Two dimensional poly
acyrilamide gel electrophoresis (2-D PAGE) and PD Quest software
genomic solutions Investigator (proteomics) was used to analyze the
differential protein expression profile in femoral and humeri bones
harvested from three groups of rats; sham-operated rats (SO),
ovariectomised rats (Ovx) and ovariectomised rats supplemented for
2 months with palm vitamin E. The results showed that there were
over 300 valued spot on each of the groups PVE and OVX as
compared to about 200 in SO. Comparison between the differential
protein expression between OVX and PVE groups showed that ten
spots were down –regulated in OVX but up-regulated in PVE. The
ten differential spots were separately named P1-P10. The
identification and understanding of the pathway of the differential
protein expression among the groups is ongoing and may account for
the molecular mechanism through which palm vitamin E exert its
anti-osteoporotic effect.
Abstract: Dioscorea species or commonly named as yam is
reported to be one of the major food sources worldwide. This
ethnobotanical study was conducted to document local knowledge
and potentials of DioscoreahispidaDennst. and to investigate and
record its distribution in three districts of Terengganu. Information
was gathered from 23 villagers from three districts of Besut, Marang
and Setiu by using semi-structured questionnaire. The villagers were
randomly selected and no appointment was made prior to the visits.
For distribution, the location of Dioscoreahispida was recorded by
using the Global Positioning System (GPS). The villagers identified
Dioscoreahispida or locally named ubigadong by looking at the
physical characteristics that include its leaf shape, stem and the color
of the tuber-s flesh. The villagers used Dioscoreahispida in many
ways in their life such as for food, medicinal purposes and fish
poison.
Abstract: Texture information plays increasingly an important
role in remotely sensed imagery classification and many pattern
recognition applications. However, the selection of relevant textural
features to improve this classification accuracy is not a straightforward
task. This work investigates the effectiveness of two Mutual
Information Feature Selector (MIFS) algorithms to select salient
textural features that contain highly discriminatory information for
multispectral imagery classification. The input candidate features are
extracted from a SPOT High Resolution Visible(HRV) image using
Wavelet Transform (WT) at levels (l = 1,2).
The experimental results show that the selected textural features
according to MIFS algorithms make the largest contribution to
improve the classification accuracy than classical approaches such
as Principal Components Analysis (PCA) and Linear Discriminant
Analysis (LDA).
Abstract: A new OTA-based logarithmic-control variable gain
current amplifier (LCCA) is presented. It consists of two Operational
Transconductance Amplifier (OTA) and two PMOS transistors
biased in weak inversion region. The circuit operates from 0.6V DC
power supply and consumes 0.6 μW. The linear-dB controllable
output range is 43 dB with maximum error less than 0.5dB. The
functionality of the proposed design was confirmed using HSPICE in
0.35μm CMOS process technology.
Abstract: The prospective analysis is presented as an important tool to identify the most relevant opportunities and needs in research and development from planned interventions in innovation systems. This study chose Phyllanthus niruri, known as "stone break" to describe the knowledge about the specie, by using biotechnological forecasting through the software Vantage Point. It can be seen a considerable increase in studies on Phyllanthus niruri in recent years and that there are patents about this plant since twenty-five years ago. India was the country that most carried out research on the specie, showing interest, mainly in studies of hepatoprotection, antioxidant and anti-cancer activities. Brazil is in the second place, with special interest for anti-tumor studies. Given the identification of the Brazilian groups that exploit the species it is possible to mediate partnerships and cooperation aiming to help on the implementing of the Program of Herbal medicines (phytotherapics) in Brazil.
Abstract: The Globally Asynchronous Locally Synchronous Network on Chip (GALS NoC) is the most efficient solution that provides low latency transfers and power efficient System on Chip (SoC) interconnect. This study presents a GALS and generic NoC architecture based on a configurable router. This router integrates a sophisticated dynamic arbiter, the wormhole routing technique and can be configured in a manner that allows it to be used in many possible NoC topologies such as Mesh 2-D, Tree and Polygon architectures. This makes it possible to improve the quality of service (QoS) required by the proposed NoC. A comparative performances study of the proposed NoC architecture, Tore architecture and of the most used Mesh 2D architecture is performed. This study shows that Spidergon architecture is characterised by the lower latency and the later saturation. It is also shown that no matter what the number of used links is raised; the Links×Diameter product permitted by the Spidergon architecture remains always the lower. The only limitation of this architecture comes from it-s over cost in term of silicon area.
Abstract: In order to accelerate the similarity search in highdimensional database, we propose a new hierarchical indexing method. It is composed of offline and online phases. Our contribution concerns both phases. In the offline phase, after gathering the whole of the data in clusters and constructing a hierarchical index, the main originality of our contribution consists to develop a method to construct bounding forms of clusters to avoid overlapping. For the online phase, our idea improves considerably performances of similarity search. However, for this second phase, we have also developed an adapted search algorithm. Our method baptized NOHIS (Non-Overlapping Hierarchical Index Structure) use the Principal Direction Divisive Partitioning (PDDP) as algorithm of clustering. The principle of the PDDP is to divide data recursively into two sub-clusters; division is done by using the hyper-plane orthogonal to the principal direction derived from the covariance matrix and passing through the centroid of the cluster to divide. Data of each two sub-clusters obtained are including by a minimum bounding rectangle (MBR). The two MBRs are directed according to the principal direction. Consequently, the nonoverlapping between the two forms is assured. Experiments use databases containing image descriptors. Results show that the proposed method outperforms sequential scan and SRtree in processing k-nearest neighbors.
Abstract: Groundwater is one of the most important water resources in Fars province. Based on this study, 95 percent of the total annual water consumption in Fars is used for agriculture, whereas the percentages for domestic and industrial uses are 4 and 1 percent, respectively. Population growth, urban and industrial growth, and agricultural development in Fars have created a condition of water stress. In this province, farmers and other users are pumping groundwater faster than its natural replenishment rate, causing a continuous drop in groundwater tables and depletion of this resource. In this research variation of groundwater level , their effects and ways to help control groundwater levels in some plains of Fars were evaluated .Excessive exploitation of groundwater in Darab, Jahrom, Estahban, Arsanjan, Khir and Niriz plains of Fars caused the groundwater levels fall too fast or to unacceptable levels. The average drawdown of the water table in Arsanjan, Khir. Estahban and Niriz plain plains were 12,8, 9 and 6 meters during 16,11,11 and 13 years ago respectively. This not only reduces available water resources and well yields but also can saline water intrusion, reductions in river flow and in wetland areas , drying springs, and ground subsidence, considerable increase in pumping costs and a significant decline in crop yields as a result of the increasing salinity. Finally based on situation and condition of the aquifer some suggestions are recommended.
Abstract: As the demand and prices of various petroleum products have been on the rise in recent years, there is a growing need for alternative fuels. Biodiesel, which consists of alkyl monoesters of fatty acids from vegetable oils and animal fats, is considered as an alternative to petroleum diesel. Biodiesel has comparable performance with that of diesel and has lower brake specific fuel consumption than diesel with significant reduction in emissions of CO, hydrocarbons (HC) and smoke with however, a slight increase in NOx emissions. This paper analyzes the effect of cooled exhaust gas recirculation in the combustion characteristics of a direct injection compression ignition engine using biodiesel blended fuel as opposed to the conventional system. The combustion parameters such as cylinder pressure, heat release rate, delay period and peak pressure were analyzed at various loads. The maximum cylinder pressure reduces as the fraction of biodiesel increases in the blend the maximum rate of pressure rise was found to be higher for diesel at higher engine loads.
Abstract: This paper presents a spectroscopic study on doping
of Vanadyl pathalocyanine (VOPc) by [6,6]-phenyl C61 butyric acid
methyl ester (PCBM). The films are characterized by UV/Vis/NIR
spectroscopy. A drastic increase in the absorption coefficient has
been observed with increasing dopant concentration. Optical
properties of VOPc:PCBM films deposited by spin coating technique
were studied in detail. Optical band gap decreased with the PCBM
incorporation in the VOPc film. Optical band gap calculated from the
absorption spectra decreased from 3.32 eV to 3.26 eV with a
variation of 0–75 % of PCBM concentration in the VOPC films.
Abstract: Fatigue behaviors of Lead Zirconate Titanate (PZT)
ceramics under different amplitude of bipolar electrical loads have
been investigated. Fatigue behavior is represented by the change of
hysteresis loops and remnant polarization. Three levels of electrical
load amplitudes (1.00, 1.25 and 1.50 kV /mm) were applied in this
experimental. It was found that the remnant polarization decreased
significantly with the number of loading cycles. The degree of fatigue
degradation depends on the amplitude of electric field. The higher
amplitude exhibits the greater fatigue degradation.
Abstract: Although backpropagation ANNs generally predict
better than decision trees do for pattern classification problems, they
are often regarded as black boxes, i.e., their predictions cannot be
explained as those of decision trees. In many applications, it is
desirable to extract knowledge from trained ANNs for the users to
gain a better understanding of how the networks solve the problems.
A new rule extraction algorithm, called rule extraction from artificial
neural networks (REANN) is proposed and implemented to extract
symbolic rules from ANNs. A standard three-layer feedforward ANN
is the basis of the algorithm. A four-phase training algorithm is
proposed for backpropagation learning. Explicitness of the extracted
rules is supported by comparing them to the symbolic rules generated
by other methods. Extracted rules are comparable with other methods
in terms of number of rules, average number of conditions for a rule,
and predictive accuracy. Extensive experimental studies on several
benchmarks classification problems, such as breast cancer, iris,
diabetes, and season classification problems, demonstrate the
effectiveness of the proposed approach with good generalization
ability.
Abstract: The present paper discusses the basic concepts and the underlying principles of Multi-Agent Systems (MAS) along with an interdisciplinary exploitation of these principles. It has been found that they have been utilized for lots of research and studies on various systems spanning across diverse engineering and scientific realms showing the need of development of a proper generalized framework. Such framework has been developed for the Multi-Agent Systems and it has been generalized keeping in mind the diverse areas where they find application. All the related aspects have been categorized and a general definition has been given where ever possible.
Abstract: The cost of developing the software from scratch can
be saved by identifying and extracting the reusable components from
already developed and existing software systems or legacy systems
[6]. But the issue of how to identify reusable components from
existing systems has remained relatively unexplored. We have used
metric based approach for characterizing a software module. In this
present work, the metrics McCabe-s Cyclometric Complexity
Measure for Complexity measurement, Regularity Metric, Halstead
Software Science Indicator for Volume indication, Reuse Frequency
metric and Coupling Metric values of the software component are
used as input attributes to the different types of Neural Network
system and reusability of the software component is calculated. The
results are recorded in terms of Accuracy, Mean Absolute Error
(MAE) and Root Mean Squared Error (RMSE).
Abstract: In this paper, vapour-liquid critical locus for the
binary system acetone + chloroform was determined experimentally
over the whole range of composition. The critical property
measurements were carried out using a dynamic-synthetic apparatus,
employed in the dynamic mode. The critical points are visually
determined by observing the critical opalescence and the
simultaneous disappearance and reappearance of the meniscus in the
middle of a high-pressure view cell which withstands operations up
to 673K and 20MPa. The experimental critical points measured in
this work were compared to those available in literature.
Abstract: Ranong province has the best kaolin, and it is the most
useful of all the clay types used in ceramic making. Until recently,
there has been only one community business making ceramics in
Ranong province. And this business could not build the mix of body
and glaze from their raw material without assistance. Considering
these problems, this research is aimed to test the composition of
ceramic body and glaze which suit. Kaolin from Ranong is the raw
material which these search focuses on. All other raw materials use in
the investigation will come from southern Thailand, kaolin and
limestone from Ranong province, ball clay from Surat Thani
province, white sand from Songkhla province, and feldspar from
Nakhon Si Thammarat province. Results can be used to develop the
efficiency of industrial production which in return will enhance the
business process.
Abstract: The study of the Andaman Sea can be studied by
using the oceanic model; therefore the grid covering the study area
should be generated. This research aims to generate grid covering
the Andaman Sea, situated between longitudes 90◦E to 101◦E and
latitudes 1◦N to 18◦N. A horizontal grid is an orthogonal curvilinear
with 87 × 217 grid points. The methods used in this study are
cubic spline and bilinear interpolations. The boundary grid points
are generated by spline interpolation while the interior grid points
have to be specified by bilinear interpolation method. A vertical grid
is sigma coordinate with 15 layers of water column.