Abstract: This paper deals with the theoretical and numerical
investigation of magneto hydrodynamic boundary layer flow of a
nanofluid past a wedge shaped wick in heat pipe used for the cooling
of electronic components and different type of machines. To
incorporate the effect of nanoparticle diameter, concentration of
nanoparticles in the pure fluid, nanothermal layer formed around the
nanoparticle and Brownian motion of nanoparticles etc., appropriate
models are used for the effective thermal and physical properties of
nanofluids. To model the rotation of nanoparticles inside the base
fluid, microfluidics theory is used. In this investigation ethylene
glycol (EG) based nanofluids, are taken into account. The non-linear
equations governing the flow and heat transfer are solved by using a
very effective particle swarm optimization technique along with
Runge-Kutta method. The values of heat transfer coefficient are
found for different parameters involved in the formulation viz.
nanoparticle concentration, nanoparticle size, magnetic field and
wedge angle etc. It is found that, the wedge angle, presence of
magnetic field, nanoparticle size and nanoparticle concentration etc.
have prominent effects on fluid flow and heat transfer characteristics
for the considered configuration.
Abstract: To mimic the natural circumstances of cell growth in an organism, we present three-dimensional (3D) scaffolds fabricated by microfluidics for cultivation. This work investigates the cellular behaviors of rat cardiomyocytes in gelatin 3D scaffolds compared to those on 2D control, such as proliferation, viability and morphology. We found that the scaffolds may induce skeletal differentiation of H9c2 cells.
Abstract: This research presents the design, fabrication and application of a flavor sensor for an integrated electronic tongue and electronic nose that can allow rapid characterization of multi-component mixtures in a solution. The odor gas and liquid are separated using hydrophobic porous membrane in micro fluidic channel. The sensor uses an array composed of microbeads in micromachined cavities localized on silicon wafer. Sensing occurs via colorimetric and fluorescence changes to receptors and indicator molecules that are attached to termination sites on the polymeric microbeads. As a result, the sensor array system enables simultaneous and near-real-time analyses using small samples and reagent volumes with the capacity to incorporate significant redundancies. One of the key parts of the system is a passive pump driven only by capillary force. The hydrophilic surface of the fluidic structure draws the sample into the sensor array without any moving mechanical parts. Since there is no moving mechanical component in the structure, the size of the fluidic structure can be compact and the fabrication becomes simple when compared to the device including active microfluidic components. These factors should make the proposed system inexpensive to mass-produce, portable and compatible with biomedical applications.
Abstract: This paper presents a study on the effect of
second-order slip on forced convection through a long isoflux heated
or cooled planar microchannel. The fully developed solutions of flow
and thermal fields are analytically obtained on the basis of the
second-order Maxwell-Burnett slip and local heat flux boundary
conditions. Results reveal that when the average flow velocity
increases or the wall heat flux amount decreases, the role of thermal
creep becomes more insignificant, while the effect of second-order slip
becomes larger. The second-order term in the Deissler slip boundary
condition is found to contribute a positive velocity slip and then to lead
to a lower pressure drop as well as a lower temperature rise for the
heated-wall case or to a higher temperature rise for the cooled-wall
case. These findings are contrary to predictions made by the
Karniadakis slip model.
Abstract: We present an integration approach of a CMOS biosensor into a polymer based microfluidic environment suitable for mass production. It consists of a wafer-level-package for the silicon die and laser bonding process promoted by an intermediate hot melt foil to attach the sensor package to the microfluidic chip, without the need for dispensing of glues or underfiller. A very good condition of the sensing area was obtained after introducing a protection layer during packaging. A microfluidic flow cell was fabricated and shown to withstand pressures up to Δp = 780 kPa without leakage. The employed biosensors were electrically characterized in a dry environment.
Abstract: In this paper, a simple microfluidic device for monitoring algal cell behavior is proposed. An array of algal microwells is fabricated by PDMS soft-lithography using X-ray LIGA mold, placed on a glass substrate. Two layers of replicated PDMS and substrate are attached by oxygen plasma bonding, creating a microchannel for the microfluidic system. Algal cell are loaded into the microfluidic device, which provides positive charge on the bottom surface of wells. Algal cells, which are negative charged, can be attracted to the bottom of the wells via electrostatic interaction. By varying the concentration of algal cells in the loading suspension, it is possible to obtain wells with a single cell. Liquid medium for cells monitoring are flown continuously over the wells, providing nutrient and waste exchange between the well and the main flow. This device could lead to the uncovering of the quantitative biology of the algae, which is a key to effective and extensive algal utilizations in the field of biotechnology, food industry and bioenergy research and developments.
Abstract: The compatibility of optical resonators with microfluidic systems may be relevant for chemical and biological applications. Here, a fluorescent-core microcavity (FCM) is investigated as a refractometric sensor for heavy oils. A high-index film of silicon quantum dots (QDs) was formed inside the capillary, supporting cylindrical fluorescence whispering gallery modes (WGMs). A set of standard refractive index oils was injected into a capillary, causing a shift of the WGM resonances toward longer wavelengths. A maximum sensitivity of 240 nm/RIU (refractive index unit) was found for a nominal oil index of 1.74. As well, a sensitivity of 22 nm/RIU was obtained for a lower index of 1.48, more typical of fuel hydrocarbons. Furthermore, the observed spectra and sensitivities were compared to theoretical predictions and reproduced via FDTD simulations, showing in general an excellent agreement. This work demonstrates the potential use of FCMs for oil sensing applications and the more generally for detecting liquid solutions with a high refractive index or high viscosity.
Abstract: We developed an effective microfluidic device for photoreactions with low reflectance and good heat conductance. The performance of this microfluidic device was tested by carrying out a photoreactive synthesis of benzopinacol and acetone from benzophenone and 2-propanol. The yield reached 36% with an irradiation time of 469.2 s and was improved by more than 30% when compared to the values obtained by the batch method. Therefore, the microfluidic device was found to be effective for improving the yields of photoreactions.
Abstract: Equipment miniaturisation offers several opportunities such as an increased surface-to-volume ratio and higher heat transfer coefficients. However, moving towards small-diameter channels demands extra attention to fouling, reliability and stable operation of the system. The present investigation explores possibilities to enhance the stability of the once-through micro evaporator by reducing its flow boiling induced pressure fluctuations. Experimental comparison shows that the measured reduction factor approaches a theoretically derived value. Pressure fluctuations are reduced by a factor of ten in the solid conical channel and a factor of 15 in the porous conical channel. This presumably leads to less backflow and therefore to a better flow control.
Abstract: The electrokinetic flow resistance (electroviscous
effect) is predicted for steady state, pressure-driven liquid flow at
low Reynolds number in a microfluidic contraction of rectangular
cross-section. Calculations of the three dimensional flow are
performed in parallel using a finite volume numerical method. The
channel walls are assumed to carry a uniform charge density and the
liquid is taken to be a symmetric 1:1 electrolyte. Predictions are
presented for a single set of flow and electrokinetic parameters. It is
shown that the magnitude of the streaming potential gradient and the
charge density of counter-ions in the liquid is greater than that in
corresponding two-dimensional slit-like contraction geometry. The
apparent viscosity is found to be very close to the value for a
rectangular channel of uniform cross-section at the chosen Reynolds
number (Re = 0.1). It is speculated that the apparent viscosity for the
contraction geometry will increase as the Reynolds number is
reduced.
Abstract: The present microfluidic study is emphasizing the flow behavior within a Y shape micro-bifurcation in two similar flow configurations. We report here a numerical and experimental investigation on the velocity profiles evolution and secondary flows, manifested at different Reynolds numbers (Re) and for two different boundary conditions. The experiments are performed using special designed setup based on optical microscopic devices. With this setup, direct visualizations and quantitative measurements of the path-lines are obtained. A Micro-PIV measurement system is used to obtain velocity profiles distributions in a spatial evolution in the main flows domains. The experimental data is compared with numerical simulations performed with commercial computational code FLUENT in a 3D geometry with the same dimensions as the experimental one. The numerical flow patterns are found to be in good agreement with the experimental manifestations.
Abstract: In this paper, design, fabrication and coupled
multifield analysis of hollow out-of-plane silicon microneedle array
with piezoelectrically actuated microfluidic device for transdermal
drug delivery (TDD) applications is presented. The fabrication
process of silicon microneedle array is first done by series of
combined isotropic and anisotropic etching processes using
inductively coupled plasma (ICP) etching technology. Then coupled
multifield analysis of MEMS based piezoelectrically actuated device
with integrated 2×2 silicon microneedle array is presented. To predict
the stress distribution and model fluid flow in coupled field analysis,
finite element (FE) and computational fluid dynamic (CFD) analysis
using ANSYS rather than analytical systems has been performed.
Static analysis and transient CFD analysis were performed to predict
the fluid flow through the microneedle array. The inlet pressure from
10 kPa to 150 kPa was considered for static CFD analysis. In the
lumen region fluid flow rate 3.2946 μL/min is obtained at 150 V for
2×2 microneedle array. In the present study the authors have
performed simulation of structural, piezoelectric and CFD analysis
on three dimensional model of the piezoelectrically actuated
mcirofluidic device integrated with 2×2 microneedle array.
Abstract: In this work, we perform numerical simulation of fluid
mixing in a floor-grooved micro-channel with wavy sidewalls which
may impose perturbation on the helical flow induced by the slanted
grooves on the channel floor. The perturbation is caused by separation
vortices in the recesses of the wavy-walled channel as the Reynolds
number is large enough. The results show that the effects of the wavy
sidewalls of the present micromixer on the enhancement of fluid
mixing increase with the increase of Reynolds number. The degree of
mixing increases with the increase of the corrugation angle, until the
angle is greater than 45 degrees. Besides, the pumping pressure of the
micromixer increases with the increase of the corrugation angle
monotonically. Therefore, we would suggest setting the corrugation
angle of the wavy sidewalls to be 45 degrees.
Abstract: Micro droplet formation is considered as a growing
emerging area of research due to its wide-range application in
chemistry as well as biology. The mechanism of micro droplet
formation using two immiscible liquids running through a T-junction
has been widely studied.
We believe that the flow of these two immiscible phases can be of
greater important factor that could have an impact on out-flow
hydrodynamic behavior, the droplets generated and the size of the
droplets. In this study, the type of the capillary tubes used also
represents another important factor that can have an impact on the
generation of micro droplets.
The tygon capillary tubing with hydrophilic inner surface doesn't
allow regular out-flows due to the fact that the continuous phase
doesn't adhere to the wall of the capillary inner surface.
Teflon capillary tubing, presents better wettability than tygon
tubing, and allows to obtain steady and regular regimes of out-flow,
and the micro droplets are homogeneoussize.
The size of the droplets is directly dependent on the flows of the
continuous and dispersed phases. Thus, as increasing the flow of the
continuous phase, to flow of the dispersed phase stationary, the size
of the drops decreases. Inversely, while increasing the flow of the
dispersed phase, to flow of the continuous phase stationary, the size
of the droplet increases.
Abstract: We have developed a microfluidic device system for the continuous producting of nanoparticles, and we have clarified the relationship between the mixing performance of reactors and the particle size. First, we evaluated the mixing performance of reactors by carring out the Villermaux–Dushman reaction and determined the experimental conditions for producing AgCl nanoparticles. Next, we produced AgCl nanoparticles and evaluated the mixing performance and the particle size. We found that as the mixing performance improves the size of produced particles decreases and the particle size distribution becomes sharper. We produced AgCl nanoparticles with a size of 86 nm using the microfluidic device that had the best mixing performance among the three reactors we tested in this study; the coefficient of variation (Cv) of the size distribution of the produced nanoparticles was 26.1%.
Abstract: In this work, we examine fluid mixing in a full three-stream mixing channel with longitudinal vortex generators (LVGs) built on the channel bottom by numerical simulation and experiment. The effects of the asymmetrical arrangement and the attack angle of the LVGs on fluid mixing are investigated. The results show that the micromixer with LVGs at a small asymmetry index (defined by the ratio of the distance from the center plane of the gap between the winglets to the center plane of the main channel to the width of the main channel) is superior to the micromixer with symmetric LVGs and that with LVGs at a large asymmetry index. The micromixer using five mixing modules of the LVGs with an attack angle between 16.5 degrees and 22.5 degrees can achieve excellent mixing over a wide range of Reynolds numbers. Here, we call a section of channel with two pairs of staggered asymmetrical LVGs a mixing module. Besides, the micromixer with LVGs at a small attack angle is more efficient than that with a larger attack angle when pressure losses are taken into account.
Abstract: A portable sensor for the analysis of phosphate in
aqueous samples has been developed. The sensor incorporates
microfluidic technology, colorimetric detection, and wireless
communications into a compact and rugged portable device. The
detection method used is the molybdenum yellow method, in which a
phosphate-containing sample is mixed with a reagent containing
ammonium metavanadate and ammonium molybdate in an acidic
medium. A yellow-coloured compound is generated and the
absorption of this compound is measured using a light emitting diode
(LED) light source and a photodiode detector. The absorption is
directly proportional to the phosphate concentration in the original
sample. In this paper we describe the application of this phosphate
sensor to the analysis of wastewater at a municipal wastewater
treatment plant in Co. Kildare, Ireland.
Abstract: PDMS (Polydimethylsiloxane) polymer is a suitable material for biological and MEMS (Microelectromechanical systems) designers, because of its biocompatibility, transparency and high resistance under plasma treatment. PDMS round channel is always been of great interest due to its ability to confine the liquid with membrane type micro valves. In this paper we are presenting a very simple way to form round shapemicrofluidic channel, which is based on reflow of positive photoresist AZ® 40 XT. With this method, it is possible to obtain channel of different height simply by varying the spin coating parameters of photoresist.