Abstract: This study determines the effect of naked and heparinbased
super-paramagnetic iron oxide nanoparticles on the human
cancer cell lines of A2780. Doxorubicin was used as the anticancer
drug, entrapped in the SPIO-NPs. This study aimed to decorate
nanoparticles with heparin, a molecular ligand for 'active' targeting
of cancerous cells and the application of modified-nanoparticles in
cancer treatment. The nanoparticles containing the anticancer drug
DOX were prepared by a solvent evaporation and emulsification
cross-linking method. The physicochemical properties of the
nanoparticles were characterized by various techniques, and uniform
nanoparticles with an average particle size of 110±15 nm with high
encapsulation efficiencies (EE) were obtained. Additionally, a
sustained release of DOX from the SPIO-NPs was successful.
Cytotoxicity tests showed that the SPIO-DOX-HP had higher cell
toxicity than the individual HP and confocal microscopy analysis
confirmed excellent cellular uptake efficiency. These results indicate
that HP based SPIO-NPs have potential uses as anticancer drug
carriers and also have an enhanced anticancer effect.
Abstract: For numerical prediction of the NOX in the exhaust of
a compression ignition engine a model was developed by considering
the parameter equivalence ratio. This model was validated by
comparing the predicted results of NOX with experimental ones. The
ultimate aim of the work was to access the applicability, robustness
and performance of the improved NOX model against other NOX
models.
Abstract: DNA shuffling is a powerful method used for in vitro
evolute molecules with specific functions and has application in areas
such as, for example, pharmaceutical, medical and agricultural
research. The success of such experiments is dependent on a variety
of parameters and conditions that, sometimes, can not be properly
pre-established. Here, two computational models predicting DNA
shuffling results is presented and their use and results are evaluated
against an empirical experiment. The in silico and in vitro results
show agreement indicating the importance of these two models and
motivating the study and development of new models.
Abstract: The conjugate gradient optimization algorithm
usually used for nonlinear least squares is presented and is
combined with the modified back propagation algorithm yielding
a new fast training multilayer perceptron (MLP) algorithm
(CGFR/AG). The approaches presented in the paper consist of
three steps: (1) Modification on standard back propagation
algorithm by introducing gain variation term of the activation
function, (2) Calculating the gradient descent on error with
respect to the weights and gains values and (3) the determination
of the new search direction by exploiting the information
calculated by gradient descent in step (2) as well as the previous
search direction. The proposed method improved the training
efficiency of back propagation algorithm by adaptively modifying
the initial search direction. Performance of the proposed method
is demonstrated by comparing to the conjugate gradient algorithm
from neural network toolbox for the chosen benchmark. The
results show that the number of iterations required by the
proposed method to converge is less than 20% of what is required
by the standard conjugate gradient and neural network toolbox
algorithm.
Abstract: Biometric techniques are gaining importance for
personal authentication and identification as compared to the
traditional authentication methods. Biometric templates are
vulnerable to variety of attacks due to their inherent nature. When a
person-s biometric is compromised his identity is lost. In contrast to
password, biometric is not revocable. Therefore, providing security
to the stored biometric template is very crucial. Crypto biometric
systems are authentication systems, which blends the idea of
cryptography and biometrics. Fuzzy vault is a proven crypto
biometric construct which is used to secure the biometric templates.
However fuzzy vault suffer from certain limitations like nonrevocability,
cross matching. Security of the fuzzy vault is affected
by the non-uniform nature of the biometric data. Fuzzy vault when
hardened with password overcomes these limitations. Password
provides an additional layer of security and enhances user privacy.
Retina has certain advantages over other biometric traits. Retinal
scans are used in high-end security applications like access control to
areas or rooms in military installations, power plants, and other high
risk security areas. This work applies the idea of fuzzy vault for
retinal biometric template. Multimodal biometric system
performance is well compared to single modal biometric systems.
The proposed multi modal biometric fuzzy vault includes combined
feature points from retina and fingerprint. The combined vault is
hardened with user password for achieving high level of security.
The security of the combined vault is measured using min-entropy.
The proposed password hardened multi biometric fuzzy vault is
robust towards stored biometric template attacks.
Abstract: Unified Modeling Language (UML) is a standard
language for modeling of a system. UML is used to visually specify
the structure and behavior of a system. The system requirements are
captured and then converted into UML specification. UML
specification uses a set of rules and notations, and diagrams to
specify the system requirements. In this paper, we present a tool for
developing the UML specification. The tool will ease the use of the
notations and diagrams for UML specification as well as increase the
understanding and familiarity of the UML specification. The tool will
also be able to check the conformance of the diagrams against each
other for basic compliance of UML specification.
Abstract: This paper is concerned with the application of small
rating Capacitive Energy Storage units for the improvement of
Automatic Generation Control of a multiunit multiarea power
system. Generation Rate Constraints are also considered in the
investigations. Integral Squared Error technique is used to obtain the
optimal integral gain settings by minimizing a quadratic performance
index. Simulation studies reveal that with CES units, the deviations
in area frequencies and inter-area tie-power are considerably
improved in terms of peak deviations and settling time as compared
to that obtained without CES units.
Abstract: This paper presents a new approach for image
segmentation by applying Pillar-Kmeans algorithm. This
segmentation process includes a new mechanism for clustering the
elements of high-resolution images in order to improve precision and
reduce computation time. The system applies K-means clustering to
the image segmentation after optimized by Pillar Algorithm. The
Pillar algorithm considers the pillars- placement which should be
located as far as possible from each other to withstand against the
pressure distribution of a roof, as identical to the number of centroids
amongst the data distribution. This algorithm is able to optimize the
K-means clustering for image segmentation in aspects of precision
and computation time. It designates the initial centroids- positions
by calculating the accumulated distance metric between each data
point and all previous centroids, and then selects data points which
have the maximum distance as new initial centroids. This algorithm
distributes all initial centroids according to the maximum
accumulated distance metric. This paper evaluates the proposed
approach for image segmentation by comparing with K-means and
Gaussian Mixture Model algorithm and involving RGB, HSV, HSL
and CIELAB color spaces. The experimental results clarify the
effectiveness of our approach to improve the segmentation quality in
aspects of precision and computational time.
Abstract: This paper investigates the problem of designing a robust state-feedback controller for a class of uncertain Markovian jump nonlinear systems that guarantees the L2-gain from an exogenous input to a regulated output is less than or equal to a prescribed value. First, we approximate this class of uncertain Markovian jump nonlinear systems by a class of uncertain Takagi-Sugeno fuzzy models with Markovian jumps. Then, based on an LMI approach, LMI-based sufficient conditions for the uncertain Markovian jump nonlinear systems to have an H performance are derived. An illustrative example is used to illustrate the effectiveness of the proposed design techniques.
Abstract: Market competition and a desire to gain advantages on globalized market, drives companies towards innovation efforts. Project overload is an unpleasant phenomenon, which is happening for employees inside those organizations trying to make the most efficient use of their resources to be innovative. But what are the impacts of project overload on organization-s innovation capabilities? Advanced engineering teams (AE) inside a major heavy equipment manufacturer are suffering from project overload in their quest for innovation. In this paper, Agent-based modeling (ABM) is used to examine the current reality of the company context, and of the AE team, where the opportunities and challenges for reducing the risk of project overload and moving towards innovation were identified. Project overload is more likely to stifle innovation and creativity inside teams. On the other hand, motivations on proper challenging goals are more likely to help individual to alleviate the negative aspects of low level of project overload.
Abstract: An alarming emergence of multidrug-resistant strains
of the tuberculosis pathogen Mycobacterium tuberculosis and
continuing high worldwide incidence of tuberculosis has invigorated
the search for novel drug targets. The enzyme glutamate racemase
(MurI) in bacteria catalyzes the stereoconversion of L-glutamate to
D-glutamate which is a component of the peptidoglycan cell wall of
the bacterium. The inhibitors targeted against MurI from several
bacterial species have been patented and are advocated as promising
antibacterial agents. However there are none available against MurI
from Mycobacterium tuberculosis, due to the lack of its threedimensional
structure. This work accomplished two major objectives.
First, the tertiary structure of MtMurI was deduced computationally
through homology modeling using the templates from bacterial
homologues. It is speculated that like in other Gram-positive bacteria,
MtMurI exists as a dimer and many of the protein interactions at the
dimer interface are also conserved. Second, potent candidate
inhibitors against MtMurI were identified through docking against
already known inhibitors in other organisms.
Abstract: Design for Disassembly (DfD) aims to reuse the
structural components instead of demolition followed by recycling of
the demolition debris. This concept preserves the invested embodied
energy of materials, thus reducing inputs of new embodied energy
during materials reprocessing or remanufacturing. Both analytical and
experimental research on a proposed DfD beam-column connection
for use in residential apartments is currently investigated at the
National University of Singapore in collaboration with the Housing
and Development Board of Singapore. The present study reports on
the results of a numerical analysis of the proposed connection utilizing
finite element analysis. The numerical model was calibrated and
validated by comparison against experimental results. Results of a
parametric study will also be presented and discussed.
Abstract: In this study, we experiment on precise control outlet
temperature of water from the water cooler with hot-gas bypass
method based on PI control logic for machine tool. Recently, technical
trend for machine tools is focused on enhancement of speed and
accuracy. High speedy processing causes thermal and structural
deformation of objects from the machine tools. Water cooler has to be
applied to machine tools to reduce the thermal negative influence with
accurate temperature controlling system. The goal of this study is to
minimize temperature error in steady state. In addition, control period
of an electronic expansion valve were considered to increment of
lifetime of the machine tools and quality of product with a water
cooler.
Abstract: Periodic vortex shedding in pulsating flow inside wavy
channel and the effect it has on heat transfer are studied using the
finite volume method. A sinusoidally-varying component is superimposed
on a uniform flow inside a sinusoidal wavy channel and
the effects on the Nusselt number is analyzed. It was found that a
unique optimum value of the pulsation frequency, represented by the
Strouhal number, exists for Reynolds numbers ranging from 125 to
1000. Results suggest that the gain in heat transfer is related to the
process of vortex formation, movement about the troughs of the wavy
channel, and subsequent ejection/destruction through the converging
section. Heat transfer is the highest when the frequencies of the
pulsation and vortex formation approach being in-phase. Analysis of
Strouhal number effect on Nu over a period of pulsation substantiates
the proposed physical mechanism for enhancement. The effect of
changing the amplitude of pulsation is also presented over a period
of pulsation, showing a monotonic increase in heat transfer with
increasing amplitude. The 60% increase in Nusselt number suggests
that sinusoidal fluid pulsation can an effective method for enhancing
heat transfer in laminar, wavy-channel flows.
Abstract: Gated community has gained its dominant in residential areas development that it has become the standard development pattern of the newly built residential areas in contemporary China. The form of gated community has its own advantages and rationality that meet the needs of quite a lot of residents, but it-s also believed by researchers that the form has great damage to the urban morphology and development, and has a negative impact on residents- living style. However, there is still a considerable controversy of the origins and outcomes. Though recognized as a global phenomenon, gated community developed in China is greatly to do with the specific local forces, respect to the unique historical, political and socio-cultural momentums. A historical review of the traditional settlements in China and the trends that how Gated community has gained its contemporary form, is indispensable for comprehending the local forces, and provide a new perspective to solve the controversy.
Abstract: The liberalization and privatization processes have
forced public utility companies to face new competitive challenges,
implementing strategies to gain market share and, at the same time,
keep the old customers. To this end, many companies have carried
out mergers, acquisitions and conglomerations in order to diversify
their business. This paper focuses on companies operating in the free
energy market in Italy. In the last decade, this sector has undergone
profound changes that have radically changed the competitive
scenario and have led companies to implement diversification
strategies of the business. Our work aims to evaluate the economic
and financial performances obtained by energy companies, following
the beginning of the liberalization process, verifying the possible
relationship with the implemented diversification strategies.
Abstract: Application of nanoparticles as additives in membrane
synthesis for improving the resistance of membranes against fouling
has triggered recent interest in new membrane types. However, most
nanoparticle-enhanced membranes suffer from the tradeoff between
permeability and selectivity. In this study, nano-WS2 was explored as
the additive in membrane synthesis by non-solvent induced phase
separation. Blended PES-WS2 flat-sheet membranes with the
incorporation of ultra-low concentrations of nanoparticles (from 0.025
to 0.25%, WS2/PES ratio) were manufactured and investigated in
terms of permeability, fouling resistance and solute rejection.
Remarkably, a significant enhancement in the permeability was
observed as a result of the incorporation of ultra-low fractions of
nano-WS2 to the membrane structure. Optimal permeability values
were obtained for modified membranes with 0.10%
nanoparticle/polymer concentration ratios. Furthermore, fouling
resistance and solute rejection were significantly improved by the
incorporation of nanoparticles into the membrane matrix. Specifically,
fouling resistance of modified membrane can increase by around 50%.
Abstract: The assessment of surface waters in Enugu metropolis
for fecal coliform bacteria was undertaken. Enugu urban was divided
into three areas (A1, A2 and A3), and fecal coliform bacteria
analysed in the surface waters found in these areas for four years
(2005-2008). The plate count method was used for the analyses. Data
generated were subjected to statistical tests involving; Normality test,
Homogeneity of variance test, correlation test, and tolerance limit
test. The influence of seasonality and pollution trends were
investigated using time series plots. Results from the tolerance limit
test at 95% coverage with 95% confidence, and with respect to EU
maximum permissible concentration show that the three areas suffer
from fecal coliform pollution. To this end, remediation procedure
involving the use of saw-dust extracts from three woods namely;
Chlorophora-Excelsa (C-Excelsa),Khayan-Senegalensis,(CSenegalensis)
and Erythrophylum-Ivorensis (E-Ivorensis) in
controlling the coliforms was studied. Results show that mixture of
the acetone extracts of the woods show the most effective
antibacterial inhibitory activities (26.00mm zone of inhibition)
against E-coli. Methanol extract mixture of the three woods gave best
inhibitory activity (26.00mm zone of inhibition) against S-areus, and
25.00mm zones of inhibition against E-Aerogenes. The aqueous
extracts mixture gave acceptable zones of inhibitions against the
three bacteria organisms.
Abstract: The article deals with technical support of intracranial single unit activity measurement. The parameters of the whole measuring set were tested in order to assure the optimal conditions of extracellular single-unit recording. Metal microelectrodes for measuring the single-unit were tested during animal experiments. From signals recorded during these experiments, requirements for the measuring set parameters were defined. The impedance parameters of the metal microelectrodes were measured. The frequency-gain and autonomous noise properties of preamplifier and amplifier were verified. The measurement and the description of the extracellular single unit activity could help in prognoses of brain tissue damage recovery.
Abstract: A simple impedance matching technique for inset feed
grooved microstrip patch antenna based on the concept of coplanar
waveguide feed line has been developed and investigated for a
printed antenna at X-Band frequency of 10GHz. The proposed
technique has been used in the design of Linear Grooved Microstrip
patch antenna array. The characteristics of the antenna are
determined in terms of Return loss, VSWR, gain, radiation pattern
etc. The measured and simulated results presented are found to be in
good agreement.