Abstract: Platinum oxide nanoparticles were prepared by a
simple hydrothermal route and chemical reduction using
carbohydrates (Fructose and sucrose) as the reducing and
stabilizing agents. The crystallite size of these nanoparticles was
evaluated from X-ray diffraction (XRD), atomic force microscopy
(AFM) and transmission electron microscopy (TEM) and was
found to be 10 nm as shown in figure 1, which is the
demonstration of EM bright field and transmission electron
microscopy. The effect of carbohydrates on the morphology of the
nanoparticles was studied using TEM (Figure 1). The
nanoparticles (100 μg/ml) were administered to the Pseudomonas
Stutzeri and Lactobacillus cultures and the incubation was done at
35 oC for 24 hours. The nanocomposites exhibited interesting
inhibitory as well as bactericidal activity against P. Stutzeri and
and Lactobacillus species. Incorporation of nanoparticles also
increased the thermal stability of the carbohydrates.
Abstract: This study determines the effect of naked and heparinbased
super-paramagnetic iron oxide nanoparticles on the human
cancer cell lines of A2780. Doxorubicin was used as the anticancer
drug, entrapped in the SPIO-NPs. This study aimed to decorate
nanoparticles with heparin, a molecular ligand for 'active' targeting
of cancerous cells and the application of modified-nanoparticles in
cancer treatment. The nanoparticles containing the anticancer drug
DOX were prepared by a solvent evaporation and emulsification
cross-linking method. The physicochemical properties of the
nanoparticles were characterized by various techniques, and uniform
nanoparticles with an average particle size of 110±15 nm with high
encapsulation efficiencies (EE) were obtained. Additionally, a
sustained release of DOX from the SPIO-NPs was successful.
Cytotoxicity tests showed that the SPIO-DOX-HP had higher cell
toxicity than the individual HP and confocal microscopy analysis
confirmed excellent cellular uptake efficiency. These results indicate
that HP based SPIO-NPs have potential uses as anticancer drug
carriers and also have an enhanced anticancer effect.