Abstract: The characteristics of physiological blood flow in human carotid arterial bifurcation model have been numerically studied using a fully coupled fluid-structure interaction (FSI) analysis. This computational model with the fluid-structure interaction is constructed to investigate the flow characteristics and wall shear stress in the carotid artery. As the flow begins to decelerate after the peak flow, a large recirculation zone develops at the non-divider wall of both internal carotid artery (ICA) and external carotid artery (ECA) in FSI model due to the elastic energy stored in the expanding compliant wall. The calculated difference in wall shear stress (WSS) in both Non-FSI and FSI models is a range of between 5 and 11% at the mean WSS. The low WSS corresponds to regions of carotid artery that are more susceptible to atherosclerosis.
Abstract: In this paper, we study the pulsatile flow of blood through stenotic arteries. The inner layer of arterial walls is modeled as a porous medium and human blood is assumed as an incompressible fluid. A numerical algorithm based on the finite element method is developed to simulate the blood flow through both the lumen region and the porous wall. The algorithm is then applied to study the flow behaviour and to investigate the significance of the non-Newtonian effect.
Abstract: A three-dimensional and pulsatile blood flow in the left ventricle of heart model has been studied numerically. The geometry was derived from a simple approximation of the left ventricle model and the numerical simulations were obtained using a formulation of the Navier-Stokes equations. In this study, simulation was used to investigate the pattern of flow velocity in 3D model of heart with consider the left ventricle based on critical parameter of blood under steady condition. Our results demonstrate that flow velocity focused from mitral valve channel and continuous linearly to left ventricle wall but this skewness progresses into outside wall in atrium through aortic valve with random distribution that is irregular due to force subtract from ventricle wall during cardiac cycle. The findings are the prediction of the behavior of the blood flow velocity pattern in steady flow condition which can assist the medical practitioners in their decision on the patients- treatments.
Abstract: To improve the characterization of blood flows, we propose a method which makes it possible to use the spectral analysis
of the Doppler signals. Our calculation induces a reasonable approximation, the error made on estimated speed reflects the fact
that speed depends on the flow conditions as well as on measurement parameters like the bore and the volume flow rate. The estimate of the Doppler signal frequency enables us to determine the maximum Doppler frequencie Fd max as well as the maximum flow speed. The
results show that the difference between the estimated frequencies
( Fde ) and the Doppler frequencies ( Fd ) is small, this variation tends to zero for important θ angles and it is proportional to the diameter D. The description of the speed of friction and the
coefficient of friction justify the error rate obtained.
Abstract: Nowadays, cardiac disease is one of the most common
cause of death. Each year almost one million of angioplasty interventions and stents implantations are made all over the world.
Unfortunately, in 20-30% of cases neointimal proliferations leads to
restenosis occurring within the following period of 3-6 months. Three major factors are believed to contribute mostly to the edge
restenosis: (a) mechanical damage of the artery-s wall caused by the
stent implantation, (b) interaction between the stent and the blood constituents and (c) endothelial growth stimulation by small (lower
that 1.5 Pa) and oscillating wall shear stress. Assuming that this last actor is particularly important, a numerical model of restenosis
basing on wall shear stress distribution in the stented artery was elaborated. A numerical simulations of the development of in-stent
restenosis have been performed and realistic geometric patterns of a
progressing lumen reduction have been obtained
Abstract: Microcirculation is essential for the proper supply of
oxygen and nutritive substances to the biological tissue and the
removal of waste products of metabolism. The determination of
blood flow in the capillaries is therefore of great interest to clinicians.
A comparison has been carried out using the developed non-invasive,
non-contact and whole field laser speckle contrast imaging (LSCI)
based technique and as well as a commercially available laser
Doppler blood flowmeter (LDF) to evaluate blood flow at the finger
tip and elbow and is presented here. The LSCI technique gives more
quantitative information on the velocity of blood when compared to
the perfusion values obtained using the LDF. Measurement of blood
flow in capillaries can be of great interest to clinicians in the
diagnosis of vascular diseases of the upper extremities.
Abstract: A numerical method is developed for simulating
the motion of particles with arbitrary shapes in an effectively
infinite or bounded viscous flow. The particle translational and
angular motions are numerically investigated using a fluid-structure
interaction (FSI) method based on the Arbitrary-Lagrangian-Eulerian
(ALE) approach and the dynamic mesh method (smoothing and
remeshing) in FLUENT ( ANSYS Inc., USA). Also, the effects of
arbitrary shapes on the dynamics are studied using the FSI method
which could be applied to the motions and deformations of a single
blood cell and multiple blood cells, and the primary thrombogenesis
caused by platelet aggregation. It is expected that, combined with a
sophisticated large-scale computational technique, the simulation
method will be useful for understanding the overall properties of blood
flow from blood cellular level (microscopic) to the resulting
rheological properties of blood as a mass (macroscopic).
Abstract: Blood pulse is an important human physiological signal commonly used for the understanding of the individual physical health. Current methods of non-invasive blood pulse sensing require direct contact or access to the human skin. As such, the performances of these devices tend to vary with time and are subjective to human body fluids (e.g. blood, perspiration and skin-oil) and environmental contaminants (e.g. mud, water, etc). This paper proposes a simulation model for the novel method of non-invasive acquisition of blood pulse using the disturbance created by blood flowing through a localized magnetic field. The simulation model geometry represents a blood vessel, a permanent magnet, a magnetic sensor, surrounding tissues and air in 2-dimensional. In this model, the velocity and pressure fields in the blood stream are described based on Navier-Stroke equations and the walls of the blood vessel are assumed to have no-slip condition. The blood assumes a parabolic profile considering a laminar flow for blood in major artery near the skin. And the inlet velocity follows a sinusoidal equation. This will allow the computational software to compute the interactions between the magnetic vector potential generated by the permanent magnet and the magnetic nanoparticles in the blood. These interactions are simulated based on Maxwell equations at the location where the magnetic sensor is placed. The simulated magnetic field at the sensor location is found to assume similar sinusoidal waveform characteristics as the inlet velocity of the blood. The amplitude of the simulated waveforms at the sensor location are compared with physical measurements on human subjects and found to be highly correlated.
Abstract: CFD simulations are carried out in arterial stenoses
with 48 % areal occlusion. Non-newtonian fluid model is selected for
the blood flow as the same problem has been solved before with
Newtonian fluid model. Studies on flow resistance with the presence
of surface irregularities are carried out. Investigations are also
performed on the pressure drop at various Reynolds numbers. The
present study revealed that the pressure drop across a stenosed artery
is practically unaffected by surface irregularities at low Reynolds
numbers, while flow features are observed and discussed at higher
Reynolds numbers.
Abstract: The cardiovascular system has become the most
important subject of clinical research, particularly measurement of
arterial blood flow. Therefore correct determination of arterial
diameter is crucial. We propose a novel, semi-automatic method for
artery lumen detection. The method is based on Gaussian probability
function. Usability of our proposed method was assessed by
analyzing ultrasound B-mode CFA video sequences acquired from
eleven healthy volunteers. The correlation coefficient between the
manual and semi-automatic measurement of arterial diameter was
0.996. Our proposed method for detecting artery boundary is novel
and accurate enough for the measurement of artery diameter.
Abstract: Recurrence of aneurysm rupture can be attributed to
coil migration and compaction. In order to verify the effects of
hemodynamics on coil compaction and migration, we analyze the
forces and displacements on the coil bundle using a computational
method. Lateral aneurysms partially filled coils are modeled, and
blood flow fields and coil deformations are simulated considering
fluid and solid interaction. Effects of aneurysm neck size and parent
vessel geometry are also investigated. The results showed that coil
deformation was larger in the aneurysms with a wider neck. Parent
vessel geometry and aneurysm neck size also affected mean pressure
force profiles on the coil surface. Pressure forces were higher in wide
neck models with curved parent vessel geometry. Simulation results
showed that coils in the wide neck aneurysm with a curved parent
vessel may be displaced and compacted more easily.
Abstract: Differentiated impact of team sports (basketball, indoor soccer, handball) on general haemodynamics and aerobic potential of students who specialize in technical subjects is detected only on the fourth year of studies in the institute of higher education. Those who play basketball and indoor soccer have shown increase of stroke and minute volume of blood indices, pumping and contractile function of the heart, oxygenation of blood and oxygen delivery to tissues, aerobic energy supply and balance of sympathetic and parasympathetic activity of the nervous regulation mechanism of the circulatory system. Those who play handball have shown these indices statistically decreased. On the whole playing basketball and indoor soccer optimizes the strategy for adaptation of students to the studying process, but playing handball does the opposite thing. The leading factor for adaptation of students is: those who play basketball have increase of minute blood volume which stipulates velocity of the system blood circulation and well-timed oxygen delivery to tissues; those who play indoor soccer have increase of power and velocity of contractile function of the heart; those who play handball have increase of resistance of thorax to the system blood flow which minimizes contractile function of the heart, blood oxygen saturation and delivery of oxygen to tissues.
Abstract: Phase-Contrast MR imaging methods are widely used
for measurement of blood flow velocity components. Also there are
some other tools such as CT and Ultrasound for velocity map
detection in intravascular studies. These data are used in deriving
flow characteristics. Some clinical applications are investigated
which use pressure distribution in diagnosis of intravascular disorders
such as vascular stenosis. In this paper an approach to the problem of
measurement of intravascular pressure field by using velocity field
obtained from flow images is proposed. The method presented in this
paper uses an algorithm to calculate nonlinear equations of Navier-
Stokes, assuming blood as an incompressible and Newtonian fluid.
Flow images usually suffer the lack of spatial resolution. Our
attempt is to consider the effect of spatial resolution on the pressure
distribution estimated from this method. In order to achieve this aim,
velocity map of a numerical phantom is derived at six different
spatial resolutions. To determine the effects of vascular stenoses on
pressure distribution, a stenotic phantom geometry is considered. A
comparison between the pressure distribution obtained from the
phantom and the pressure resulted from the algorithm is presented. In
this regard we also compared the effects of collocated and staggered
computational grids on the pressure distribution resulted from this
algorithm.