Abstract: The literature reports a large number of approaches for
measuring the similarity between protein sequences. Most of these
approaches estimate this similarity using alignment-based techniques
that do not necessarily yield biologically plausible results, for two
reasons.
First, for the case of non-alignable (i.e., not yet definitively aligned
and biologically approved) sequences such as multi-domain, circular
permutation and tandem repeat protein sequences, alignment-based
approaches do not succeed in producing biologically plausible results.
This is due to the nature of the alignment, which is based on the
matching of subsequences in equivalent positions, while non-alignable
proteins often have similar and conserved domains in non-equivalent
positions.
Second, the alignment-based approaches lead to similarity measures
that depend heavily on the parameters set by the user for the alignment
(e.g., gap penalties and substitution matrices). For easily alignable
protein sequences, it's possible to supply a suitable combination of
input parameters that allows such an approach to yield biologically
plausible results. However, for difficult-to-align protein sequences,
supplying different combinations of input parameters yields different
results. Such variable results create ambiguities and complicate the
similarity measurement task.
To overcome these drawbacks, this paper describes a novel and
effective approach for measuring the similarity between protein
sequences, called SAF for Substitution and Alignment Free. Without
resorting either to the alignment of protein sequences or to substitution
relations between amino acids, SAF is able to efficiently detect the
significant subsequences that best represent the intrinsic properties of
protein sequences, those underlying the chronological dependencies of
structural features and biochemical activities of protein sequences.
Moreover, by using a new efficient subsequence matching scheme,
SAF more efficiently handles protein sequences that contain similar
structural features with significant meaning in chronologically
non-equivalent positions. To show the effectiveness of SAF, extensive
experiments were performed on protein datasets from different
databases, and the results were compared with those obtained by
several mainstream algorithms.
Abstract: With data centers, end-users can realize the pervasiveness of services that will be one day the cornerstone of our lives. However, data centers are often classified as computing systems that consume the most amounts of power. To circumvent such a problem, we propose a self-adaptive weighted sum methodology that jointly optimizes the performance and power consumption of any given data center. Compared to traditional methodologies for multi-objective optimization problems, the proposed self-adaptive weighted sum technique does not rely on a systematical change of weights during the optimization procedure. The proposed technique is compared with the greedy and LR heuristics for large-scale problems, and the optimal solution for small-scale problems implemented in LINDO. the experimental results revealed that the proposed selfadaptive weighted sum technique outperforms both of the heuristics and projects a competitive performance compared to the optimal solution.
Abstract: We study in this paper the effect of the scene
changing on image sequences coding system using Embedded
Zerotree Wavelet (EZW). The scene changing considered here is the
full motion which may occurs. A special image sequence is generated
where the scene changing occurs randomly. Two scenarios are
considered: In the first scenario, the system must provide the
reconstruction quality as best as possible by the management of the
bit rate (BR) while the scene changing occurs. In the second scenario,
the system must keep the bit rate as constant as possible by the
management of the reconstruction quality. The first scenario may be
motivated by the availability of a large band pass transmission
channel where an increase of the bit rate may be possible to keep the
reconstruction quality up to a given threshold. The second scenario
may be concerned by the narrow band pass transmission channel
where an increase of the bit rate is not possible. In this last case,
applications for which the reconstruction quality is not a constraint
may be considered. The simulations are performed with five scales
wavelet decomposition using the 9/7-tap filter bank biorthogonal
wavelet. The entropy coding is performed using a specific defined
binary code book and EZW algorithm. Experimental results are
presented and compared to LEAD H263 EVAL. It is shown that if
the reconstruction quality is the constraint, the system increases the
bit rate to obtain the required quality. In the case where the bit rate
must be constant, the system is unable to provide the required quality
if the scene change occurs; however, the system is able to improve
the quality while the scene changing disappears.
Abstract: MATCH project [1] entitle the development of an
automatic diagnosis system that aims to support treatment of colon
cancer diseases by discovering mutations that occurs to tumour
suppressor genes (TSGs) and contributes to the development of
cancerous tumours. The constitution of the system is based on a)
colon cancer clinical data and b) biological information that will be
derived by data mining techniques from genomic and proteomic
sources The core mining module will consist of the popular, well
tested hybrid feature extraction methods, and new combined
algorithms, designed especially for the project. Elements of rough
sets, evolutionary computing, cluster analysis, self-organization maps
and association rules will be used to discover the annotations
between genes, and their influence on tumours [2]-[11].
The methods used to process the data have to address their high
complexity, potential inconsistency and problems of dealing with the
missing values. They must integrate all the useful information
necessary to solve the expert's question. For this purpose, the system
has to learn from data, or be able to interactively specify by a domain
specialist, the part of the knowledge structure it needs to answer a
given query. The program should also take into account the
importance/rank of the particular parts of data it analyses, and adjusts
the used algorithms accordingly.
Abstract: The major part of light weight timber constructions
consists of insulation. Mineral wool is the most commonly used
insulation due to its cost efficiency and easy handling. The fiber
orientation and porosity of this insulation material enables flowthrough.
The air flow resistance is low. If leakage occurs in the
insulated bay section, the convective flow may cause energy losses
and infiltration of the exterior wall with moisture and particles. In
particular the infiltrated moisture may lead to thermal bridges and
growth of health endangering mould and mildew. In order to prevent
this problem, different numerical calculation models have been
developed. All models developed so far have a potential for
completion. The implementation of the flow-through properties of
mineral wool insulation may help to improve the existing models.
Assuming that the real pressure difference between interior and
exterior surface is larger than the prescribed pressure difference in the
standard test procedure for mineral wool ISO 9053 / EN 29053,
measurements were performed using the measurement setup for
research on convective moisture transfer “MSRCMT".
These measurements show, that structural inhomogeneities of
mineral wool effect the permeability only at higher pressure
differences, as applied in MSRCMT. Additional microscopic
investigations show, that the location of a leak within the
construction has a crucial influence on the air flow-through and the
infiltration rate. The results clearly indicate that the empirical values
for the acoustic resistance of mineral wool should not be used for the
calculation of convective transfer mechanisms.
Abstract: In today's day and age, one of the important topics in
information security is authentication. There are several alternatives
to text-based authentication of which includes Graphical Password
(GP) or Graphical User Authentication (GUA). These methods stems
from the fact that humans recognized and remembers images better
than alphanumerical text characters. This paper will focus on the
security aspect of GP algorithms and what most researchers have
been working on trying to define these security features and
attributes. The goal of this study is to develop a fuzzy decision model
that allows automatic selection of available GP algorithms by taking
into considerations the subjective judgments of the decision makers
who are more than 50 postgraduate students of computer science. The
approach that is being proposed is based on the Fuzzy Analytic
Hierarchy Process (FAHP) which determines the criteria weight as a
linear formula.
Abstract: Literature reveals that many investors rely on technical trading rules when making investment decisions. If stock markets are efficient, one cannot achieve superior results by using these trading rules. However, if market inefficiencies are present, profitable opportunities may arise. The aim of this study is to investigate the effectiveness of technical trading rules in 34 emerging stock markets. The performance of the rules is evaluated by utilizing White-s Reality Check and the Superior Predictive Ability test of Hansen, along with an adjustment for transaction costs. These tests are able to evaluate whether the best model performs better than a buy-and-hold benchmark. Further, they provide an answer to data snooping problems, which is essential to obtain unbiased outcomes. Based on our results we conclude that technical trading rules are not able to outperform a naïve buy-and-hold benchmark on a consistent basis. However, we do find significant trading rule profits in 4 of the 34 investigated markets. We also present evidence that technical analysis is more profitable in crisis situations. Nevertheless, this result is relatively weak.
Abstract: This paper reports the tensile fracture location
characterizations of dissimilar friction stir welds between 5754
aluminium alloy and C11000 copper. The welds were produced using
three shoulder diameter tools; namely, 15, 18 and 25 mm by varying
the process parameters. The rotational speeds considered were 600,
950 and 1200 rpm while the feed rates employed were 50, 150 and
300 mm/min to represent the low, medium and high settings
respectively. The tensile fracture locations were evaluated using the
optical microscope to identify the fracture locations and were
characterized. It was observed that 70% of the tensile samples failed
in the Thermo Mechanically Affected Zone (TMAZ) of copper at the
weld joints. Further evaluation of the fracture surfaces of the pulled
tensile samples revealed that welds with low Ultimate Tensile
Strength either have defects or intermetallics present at their joint
interfaces.
Abstract: We have developed a database for membrane protein functions, which has more than 3000 experimental data on functionally important amino acid residues in membrane proteins along with sequence, structure and literature information. Further, we have proposed different methods for identifying membrane proteins based on their functions: (i) discrimination of membrane transport proteins from other globular and membrane proteins and classifying them into channels/pores, electrochemical and active transporters, and (ii) β-signal for the insertion of mitochondrial β-barrel outer membrane proteins and potential targets. Our method showed an accuracy of 82% in discriminating transport proteins and 68% to classify them into three different transporters. In addition, we have identified a motif for targeting β-signal and potential candidates for mitochondrial β-barrel membrane proteins. Our methods can be used as effective tools for genome-wide annotations.
Abstract: The new concept of two–dimensional (2D) image
processing implementation for auto-guiding system is shown in this
paper. It is dedicated to astrophotography and operates with
astronomy CCD guide cameras or with self-guided dual-detector
CCD cameras and ST4 compatible equatorial mounts. This idea was
verified by MATLAB model, which was used to test all procedures
and data conversions. Next the circuit prototype was implemented at
Altera MAX II CPLD device and tested for real astronomical object
images. The digital processing speed of CPLD prototype board was
sufficient for correct equatorial mount guiding in real-time system.
Abstract: The methanolic extracts from seeds of tamarind
(Tamarindus indica) was prepared by Soxhlet apparatus extraction
and evaluated for total phenolic content by Folin-Ciocalteu method.
Then, methanolic extract was screened biological activities (In vitro)
for anti-melanogenic activity by tyrosinase inhibition test, antiinflammation
activity by cyclooxygenase 1 (COX-1) and
cyclooxygenase 2 (COX-2) inhibition test, and cytotoxic screening
test with Vero cells. The results showed that total phenolic content,
which contained in extract, was contained 27.72 mg of gallic acid
equivalent per g of dry weight. The ability to inhibit tyrosinase
enzyme, which exerted by Tamarind seed extracts (1 mg/ml) was
52.13 ± 0.42 %. The extract was not possessed inhibitory effect to
COX-1 and COX-2 enzymes and cytotoxic effect to Vero cells. The
finding is concludes that tested seed extract was possessed
antimelanogenic activity with non-toxic effects. However, there was
not exhibited anti-inflammatory activity. Further studies include the
use of advance biological models to confirm this biological activity,
as well as, the isolation and characterization of the purified
compounds that it was contained.
Abstract: One of the major, difficult tasks in automated video
surveillance is the segmentation of relevant objects in the scene.
Current implementations often yield inconsistent results on average
from frame to frame when trying to differentiate partly occluding
objects. This paper presents an efficient block-based segmentation
algorithm which is capable of separating partly occluding objects and
detecting shadows. It has been proven to perform in real time with a
maximum duration of 47.48 ms per frame (for 8x8 blocks on a
720x576 image) with a true positive rate of 89.2%. The flexible
structure of the algorithm enables adaptations and improvements with
little effort. Most of the parameters correspond to relative differences
between quantities extracted from the image and should therefore not
depend on scene and lighting conditions. Thus presenting a
performance oriented segmentation algorithm which is applicable in
all critical real time scenarios.
Abstract: None of the processing models in the software
development has explained the software systems performance
evaluation and modeling; likewise, there exist uncertainty in the
information systems because of the natural essence of requirements,
and this may cause other challenges in the processing of software
development. By definition an extended version of UML (Fuzzy-
UML), the functional requirements of the software defined
uncertainly would be supported. In this study, the behavioral
description of uncertain information systems by the aid of fuzzy-state
diagram is crucial; moreover, the introduction of behavioral diagrams
role in F-UML is investigated in software performance modeling
process. To get the aim, a fuzzy sub-profile is used.
Abstract: Perturbed-Chain Statistical Association Fluid Theory (PC-SAFT) equation of state (EOS) is a modified SAFT EOS with three pure component specific parameters: segment number (m), diameter (σ) and energy (ε). These PC-SAFT parameters need to be determined for each component under the conditions of interest by fitting experimental data, such as vapor pressure, density or heat capacity. PC-SAFT parameters for propane, ethylene and hydrogen in supercritical region were successfully estimated by fitting experimental density data available in literature. The regressed PCSAFT parameters were compared with the literature values by means of estimating pure component density and calculating average absolute deviation between the estimated and experimental density values. PC-SAFT parameters available in literature especially for ethylene and hydrogen estimated density in supercritical region reasonably well. However, the regressed PC-SAFT parameters performed better in supercritical region than the PC-SAFT parameters from literature.
Abstract: A basic conceptual study of TCSC device on Simulink is a teaching aid and helps in understanding the rudiments of the topic. This paper thus stems out from basics of TCSC device and analyzes the impedance characteristics and associated single & multi resonance conditions. The Impedance characteristics curve is drawn for different values of inductance in MATLAB using M-files. The study is also helpful in estimating the appropriate inductance and capacitance values which have influence on multi resonance point in TCSC device. The capacitor voltage, line current, thyristor current and capacitor current waveforms are discussed briefly as simulation results. Simulink model of TCSC device is given and corresponding waveforms are analyzed. The subsidiary topics e.g. power oscillation damping, SSR mitigation and transient stability is also brought out.
Abstract: In this work, the physical based device model of
AlGaN/GaN high electron mobility transistors (HEMTs) has been
established and the corresponding device operation behavior has
been investigated also by using Sentaurus TCAD from Synopsys.
Advanced AlGaN/GaN hetero-structures with GaN cap layer and AlN
spacer have been considered and the GaN cap layer and AlN spacer
are found taking important roles on the gate leakage blocking and
off-state breakdown voltage enhancement.
Abstract: This paper presents an exact analytical model for
optimizing stability of thin-walled, composite, functionally graded
pipes conveying fluid. The critical flow velocity at which divergence
occurs is maximized for a specified total structural mass in order to
ensure the economic feasibility of the attained optimum designs. The
composition of the material of construction is optimized by defining
the spatial distribution of volume fractions of the material
constituents using piecewise variations along the pipe length. The
major aim is to tailor the material distribution in the axial direction so
as to avoid the occurrence of divergence instability without the
penalty of increasing structural mass. Three types of boundary
conditions have been examined; namely, Hinged-Hinged, Clamped-
Hinged and Clamped-Clamped pipelines. The resulting optimization
problem has been formulated as a nonlinear mathematical
programming problem solved by invoking the MatLab optimization
toolbox routines, which implement constrained function
minimization routine named “fmincon" interacting with the
associated eigenvalue problem routines. In fact, the proposed
mathematical models have succeeded in maximizing the critical flow
velocity without mass penalty and producing efficient and economic
designs having enhanced stability characteristics as compared with
the baseline designs.
Abstract: The exploration of this paper will focus on the Cshaped
transition curve. This curve is designed by using the concept
of circle to circle where one circle lies inside other. The degree of
smoothness employed is curvature continuity. The function used in
designing the C-curve is Bézier-like cubic function. This function has
a low degree, flexible for the interactive design of curves and
surfaces and has a shape parameter. The shape parameter is used to
control the C-shape curve. Once the C-shaped curve design is
completed, this curve will be applied to design spur gear tooth. After
the tooth design procedure is finished, the design will be analyzed by
using Finite Element Analysis (FEA). This analysis is used to find
out the applicability of the tooth design and the gear material that
chosen. In this research, Cast Iron 4.5 % Carbon, ASTM A-48 is
selected as a gear material.
Abstract: In Algeria, some fruit trees produce fruits in free nature. Such trees are Celtis australis, Crataegus azarolus, Crataegus monogyna and Zizyphus lotus. In spite of their appreciable consumption, their nutritional value remains unknown. The objective of this study is the determination of sugars in the pulpe and almond of the above fruits. The biochemical analysis shows that these fruits present interesting contents of soluble sugars which confers significant caloric intakes to them. As well as significant fibres which give them therapeutic and industrial benefits? The analysis of the almonds shows that it contains considerable contents of sugars which enable them to be an energetic food.
Abstract: The paper provides an in-depth tutorial of mathematical
construction of maximal length sequences (m-sequences) via primitive
polynomials and how to map the same when implemented in
shift registers. It is equally important to check whether a polynomial
is primitive or not so as to get proper m-sequences. A fast method to
identify primitive polynomials over binary fields is proposed where
the complexity is considerably less in comparison with the standard
procedures for the same purpose.