Abstract: Kidney cancer is the most lethal urological cancer
accounting for 3% of adult malignancies. VHL, a tumor-suppressor
gene, is best known to be associated with renal cell carcinoma
(RCC). The VHL functions as negative regulator of hypoxia inducible
factors. Recent sequencing efforts have identified several novel
frequent mutations of histone modifying and chromatin remodeling
genes in ccRCC (clear cell RCC) including PBRM1 and SETD2. The
PBRM1 gene encodes the BAF180 protein, which involved in
transcriptional activation and repression of selected genes. SETD2
encodes a histone methyltransferase, which may play a role in
suppressing tumor development. In this study, RNAs of 30 paired
tumor and normal samples that were grouped according to the types
of kidney cancer and clinical characteristics of patients, including
gender and average age were examined by RT-PCR, SSCP and
sequencing techniques. VHL, PBRM1 and SETD2 expressions were
relatively down-regulated. However, statistically no significance was
found (Wilcoxon signed rank test, p>0.05). Interestingly, no mutation
was observed on the contrary of previous studies. Understanding the
molecular mechanisms involved in the pathogenesis of RCC has
aided the development of molecular-targeted drugs for kidney cancer.
Further analysis is required to identify the responsible genes rather
than VHL, PBRM1 and SETD2 in kidney cancer.
Abstract: The problems arising from unbalanced data sets
generally appear in real world applications. Due to unequal class
distribution, many researchers have found that the performance of
existing classifiers tends to be biased towards the majority class. The
k-nearest neighbors’ nonparametric discriminant analysis is a method
that was proposed for classifying unbalanced classes with good
performance. In this study, the methods of discriminant analysis are
of interest in investigating misclassification error rates for classimbalanced
data of three diabetes risk groups. The purpose of this
study was to compare the classification performance between
parametric discriminant analysis and nonparametric discriminant
analysis in a three-class classification of class-imbalanced data of
diabetes risk groups. Data from a project maintaining healthy
conditions for 599 employees of a government hospital in Bangkok
were obtained for the classification problem. The employees were
divided into three diabetes risk groups: non-risk (90%), risk (5%),
and diabetic (5%). The original data including the variables of
diabetes risk group, age, gender, blood glucose, and BMI were
analyzed and bootstrapped for 50 and 100 samples, 599 observations
per sample, for additional estimation of the misclassification error
rate. Each data set was explored for the departure of multivariate
normality and the equality of covariance matrices of the three risk
groups. Both the original data and the bootstrap samples showed nonnormality
and unequal covariance matrices. The parametric linear
discriminant function, quadratic discriminant function, and the
nonparametric k-nearest neighbors’ discriminant function were
performed over 50 and 100 bootstrap samples and applied to the
original data. Searching the optimal classification rule, the choices of
prior probabilities were set up for both equal proportions (0.33: 0.33:
0.33) and unequal proportions of (0.90:0.05:0.05), (0.80: 0.10: 0.10)
and (0.70, 0.15, 0.15). The results from 50 and 100 bootstrap samples
indicated that the k-nearest neighbors approach when k=3 or k=4 and
the defined prior probabilities of non-risk: risk: diabetic as 0.90:
0.05:0.05 or 0.80:0.10:0.10 gave the smallest error rate of
misclassification. The k-nearest neighbors approach would be
suggested for classifying a three-class-imbalanced data of diabetes
risk groups.
Abstract: Press-hardened profiles are used e.g. for automotive
applications in order to improve light weight construction due to the
high reachable strength. The application of interior water-air spray
cooling contributes to significantly reducing the cycle time in the
production of heat-treated tubes. This paper describes a new
manufacturing method for producing press-hardened hollow profiles
by means of an additional interior cooling based on a water-air spray.
Furthermore, this paper provides the results of thorough
investigations on the properties of press-hardened tubes in
dependence of varying spray parameters.
Abstract: The purpose of this study was to develop a descriptive
profile of the adapted physical activity research using single subject
experimental designs. All research articles using single subject
experimental designs published in the journal of Adapted Physical
Activity Quarterly from 1984 to 2013 were employed as the data
source. Each of the articles was coded in a subcategory of seven
categories: (a) the size of sample; (b) the age of participants; (c) the
type of disabilities; (d) the type of data analysis; (e) the type of
designs, (f) the independent variable, and (g) the dependent variable.
Frequencies, percentages, and trend inspection were used to analyze
the data and develop a profile. The profile developed characterizes a
small portion of research articles used single subject designs, in
which most researchers used a small sample size, recruited children
as subjects, emphasized learning and behavior impairments, selected
visual inspection with descriptive statistics, preferred a multiple
baseline design, focused on effects of therapy, inclusion, and
strategy, and measured desired behaviors more often, with a
decreasing trend over years.
Abstract: Microscopic simulation tool kits allow for
consideration of the two processes of railway operations and the
previous timetable production. Block occupation conflicts on both
process levels are often solved by using defined train priorities. These
conflict resolutions (dispatching decisions) generate reactionary
delays to the involved trains. The sum of reactionary delays is
commonly used to evaluate the quality of railway operations, which
describes the timetable robustness. It is either compared to an
acceptable train performance or the delays are appraised
economically by linear monetary functions. It is impossible to
adequately evaluate dispatching decisions without a well-founded
objective function. This paper presents a new approach for the
evaluation of dispatching decisions. The approach uses mode choice
models and considers the behaviour of the end-customers. These
models evaluate the reactionary delays in more detail and consider
other competing modes of transport. The new approach pursues the
coupling of a microscopic model of railway operations with the
macroscopic choice mode model. At first, it will be implemented for
railway operations process but it can also be used for timetable
production. The evaluation considers the possibility for the customer
to interchange to other transport modes. The new approach starts to
look at rail and road, but it can also be extended to air travel. The
result of mode choice models is the modal split. The reactions by the
end-customers have an impact on the revenue of the train operating
companies. Different purposes of travel have different payment
reserves and tolerances towards late running. Aside from changes to
revenues, longer journey times can also generate additional costs.
The costs are either time- or track-specific and arise from required
changes to rolling stock or train crew cycles. Only the variable values
are summarised in the contribution margin, which is the base for the
monetary evaluation of delays. The contribution margin is calculated
for different possible solutions to the same conflict. The conflict
resolution is optimised until the monetary loss becomes minimal. The
iterative process therefore determines an optimum conflict resolution
by monitoring the change to the contribution margin. Furthermore, a
monetary value of each dispatching decision can also be derived.
Abstract: Roadway planning and design is a very complex
process involving five key phases before a project is completed;
planning, project development, final design, right-of-way, and
construction. The planning phase for a new roadway transportation
project is a very critical phase as it greatly affects all latter phases of
the project. A location study is usually performed during the
preliminary planning phase in a new roadway project. The objective
of the location study is to develop alignment alternatives that are cost
efficient considering land acquisition and construction costs. This
paper describes a methodology to develop optimal preliminary
roadway alignments utilizing spatial-data. Four optimization criteria
are taken into consideration; roadway length, land cost, land slope,
and environmental impacts. The basic concept of the methodology is
to convert the proposed project area into a grid, which represents the
search space for an optimal alignment. The aforementioned
optimization criteria are represented in each of the grid’s cells. A
spatial-data optimization technique is utilized to find the optimal
alignment in the search space based on the four optimization criteria.
Two case studies for new roadway projects in Duval County in the
State of Florida are presented to illustrate the methodology. The
optimization output alignments are compared to the proposed Florida
Department of Transportation (FDOT) alignments. The comparison is
based on right-of-way costs for the alignments. For both case studies,
the right-of-way costs for the developed optimal alignments were
found to be significantly lower than the FDOT alignments.
Abstract: One of the main challenges in using the Discrete
Element Method (DEM) is to specify the correct input parameter
values. In general, the models are sensitive to the input parameter
values and accurate results can only be achieved if the correct values
are specified. For the linear contact model, micro-parameters such as
the particle density, stiffness, coefficient of friction, as well as the
particle size and shape distributions are required. There is a need for
a procedure to accurately calibrate these parameters before any
attempt can be made to accurately model a complete bulk materials
handling system. Since DEM is often used to model applications in
the mining and quarrying industries, a calibration procedure was
developed for materials that consist of relatively large (up to 40 mm
in size) particles. A coarse crushed aggregate was used as the test
material. Using a specially designed large shear box with a diameter
of 590 mm, the confined Young’s modulus (bulk stiffness) and
internal friction angle of the material were measured by means of the
confined compression test and the direct shear test respectively. DEM
models of the experimental setup were developed and the input
parameter values were varied iteratively until a close correlation
between the experimental and numerical results was achieved. The
calibration process was validated by modelling the pull-out of an
anchor from a bed of material. The model results compared well with
experimental measurement.
Abstract: During the post-Civil War era, the city of Nashville,
Tennessee, had the highest mortality rate in the United States. The
elevated death and disease rates among former slaves were
attributable to lack of quality healthcare. To address the paucity of
healthcare services, Meharry Medical College, an institution with the
mission of educating minority professionals and serving the
underserved population, was established in 1876.
Purpose: The social ecological framework and partial least squares
(PLS) path modeling were used to quantify the impact of
socioeconomic status and adverse health outcome on primary care
professionals serving the disadvantaged community. Thus, the study
results could demonstrate the accomplishment of the College’s
mission of training primary care professionals to serve in underserved
areas.
Methods: Various statistical methods were used to analyze alumni
data from 1975 – 2013. K-means cluster analysis was utilized to
identify individual medical and dental graduates in the cluster groups
of the practice communities (Disadvantaged or Non-disadvantaged
Communities). Discriminant analysis was implemented to verify the
classification accuracy of cluster analysis. The independent t-test was
performed to detect the significant mean differences of respective
clustering and criterion variables. Chi-square test was used to test if
the proportions of primary care and non-primary care specialists are
consistent with those of medical and dental graduates practicing in
the designated community clusters. Finally, the PLS path model was
constructed to explore the construct validity of analytic model by
providing the magnitude effects of socioeconomic status and adverse
health outcome on primary care professionals serving the
disadvantaged community.
Results: Approximately 83% (3,192/3,864) of Meharry Medical
College’s medical and dental graduates from 1975 to 2013 were
practicing in disadvantaged communities. Independent t-test confirmed the content validity of the cluster analysis model. Also, the
PLS path modeling demonstrated that alumni served as primary care
professionals in communities with significantly lower socioeconomic
status and higher adverse health outcome (p < .001). The PLS path
modeling exhibited the meaningful interrelation between primary
care professionals practicing communities and surrounding
environments (socioeconomic statues and adverse health outcome),
which yielded model reliability, validity, and applicability.
Conclusion: This study applied social ecological theory and
analytic modeling approaches to assess the attainment of Meharry
Medical College’s mission of training primary care professionals to
serve in underserved areas, particularly in communities with low
socioeconomic status and high rates of adverse health outcomes. In
summary, the majority of medical and dental graduates from Meharry
Medical College provided primary care services to disadvantaged
communities with low socioeconomic status and high adverse health
outcome, which demonstrated that Meharry Medical College has
fulfilled its mission. The high reliability, validity, and applicability of
this model imply that it could be replicated for comparable
universities and colleges elsewhere.
Abstract: Big Data and analytics have gained a huge momentum
in recent years. Big Data feeds into the field of Learning Analytics
(LA) that may allow academic institutions to better understand the
learners’ needs and proactively address them. Hence, it is important
to have an understanding of Big Data and its applications. The
purpose of this descriptive paper is to provide an overview of Big
Data, the technologies used in Big Data, and some of the applications
of Big Data in education. Additionally, it discusses some of the
concerns related to Big Data and current research trends. While Big
Data can provide big benefits, it is important that institutions
understand their own needs, infrastructure, resources, and limitation
before jumping on the Big Data bandwagon.
Abstract: This study attempts to identify the factors influencing
on women empowerment of rural area in Sri Lanka through micro
finance services. Data were collected from one hundred (100) rural
women involving self-employment activities through a questionnaire
using direct personal interviews. Judgment and Convenience Random
sampling technique was used to select the sample size from three
Divisional Secretariat divisions of Kandawalai, Poonakari and
Karachchi in Kilinochchi District. The factor analysis was performed
on fourteen (14) variables for screening and reducing the variables to
identify the influencing factors on empowerment. Multiple regression
analysis was used to identify the relationship between the three
empowerment factors and the impact of micro finance on overall
empowerment of rural women. The result of this study summarized
the variables into three factors namely decision making, freedom to
mobility and family support and which are positively associated with
empowerment. In addition to this the value of adjusted R2 is 0.248
indicates that all the variables extracted can be explained 24.8% of
the variation in the women empowerment through microfinance.
Independent variables of these three factors have positive correlation
with women empowerment as well as significant values at 5 percent
level.
Abstract: Quality of Service (QoS) attributes as part of the
service description is an important factor for service attribute. It is not
easy to exactly quantify the weight of each QoS conditions since
human judgments based on their preference causes vagueness. As
web services selection requires optimization, evolutionary computing
based on heuristics to select an optimal solution is adopted. In this
work, the evolutionary computing technique Particle Swarm
Optimization (PSO) is used for selecting a suitable web services
based on the user’s weightage of each QoS values by optimizing the
QoS weight vector and thereby finding the best weight vectors for
best services that is being selected. Finally the results are compared
and analyzed using static inertia weight and deterministic inertia
weight of PSO.
Abstract: The following article presents Technology Centre of
Ostrava (TCO) in the Czech Republic describing the structure and
main research areas realized by the project ENET - Energy Units for
Utilization of non Traditional Energy Sources. More details are
presented from the research program dealing with transformation,
accumulation and distribution of electric energy. Technology Centre
has its own energy mix consisting of alternative sources of fuel
sources that use of process gases from the storage part and also the
energy from distribution network. The article will be focus on the
properties and application possibilities SiC semiconductor devices for
power semiconductor converter for photovoltaic systems.
Abstract: This paper shows in detail the mathematical model of
direct and inverse kinematics for a robot manipulator (welding type)
with four degrees of freedom. Using the D-H parameters, screw
theory, numerical, geometric and interpolation methods, the
theoretical and practical values of the position of robot were
determined using an optimized algorithm for inverse kinematics
obtaining the values of the particular joints in order to determine the
virtual paths in a relatively short time.
Abstract: The advent of social networking technologies has been
met with mixed reactions in academic and corporate circles around
the world. This study explored the influence of social network in
current era, the relation being maintained between the Social
networking site and its user by the extent of use, benefits and latest
technologies. The study followed a descriptive research design
wherein a questionnaire was used as the main research tool. The data
collected was analyzed using SPSS 16. Data was gathered from 1205
users and analyzed in accordance with the objectives of the study.
The analysis of the results seem to suggest that the majority of users
were mainly using Facebook, despite of concerns raised about the
disclosure of personal information on social network sites, users
continue to disclose huge quantity of personal information, they find
that reading privacy policy is time consuming and changes made can
result into improper settings.
Abstract: Present paper describes method of obtaining clay
ceramic foam (CCF) and foam concrete (FC), by direct foaming with
high speed mixer-disperser (HSMD). Three foaming agents (FA) are
compared for the FC and CCF production: SCHÄUMUNGSMITTEL
W 53 FLÜSSIG (Zschimmer & Schwarz Gmbh, Germany), SCF-
1245 (Sika, test sample, Latvia) and FAB-12 (Elade, Latvija). CCF
were obtained at 950, 1000°C, 1150°C and 1150°C firing temperature
and have mechanical compressive strength 1.2, 2.55 and 4.3 MPa and
porosity 79.4, 75.1, 71.6%, respectively. Obtained FC has 6-14 MPa
compressive strength and porosity 44-55%. The goal of this work
was development of a sustainable and durable ceramic cellular
structures using HSMD.
Abstract: Breast cancer is considered as a substantial health
concern and practicing mammography screening [MS] is important in
minimizing its related morbidity. So it is essential to have a better
understanding of breast cancer screening behaviors of women and
factors that influence utilization of them. The aim of this study is to
identify the factors that are linked to MS behaviors among the
Egyptian women. A cross-sectional descriptive design was carried
out to provide a snapshot of the factors that are linked to MS
behaviors. A convenience sample of 311 women was utilized and all
eligible participants admitted to the Women Imaging Unit who are 40
years of age or above, coming for mammography assessment, not
pregnant or breast feeding and who accepted to participate in the
study were included. A structured questionnaire was developed by
the researchers and contains three parts; Socio-demographic data;
Motivating factors associated with MS; and association between MS
and model of behavior change. The analyzed data indicated that most
of the participated women (66.6%) belonged to the age group of 40-
49.A high proportion of participants (58.1%) of group having
previous MS influenced by their neighbors to practice MS, whereas
32.7 % in group not having previous MS were influenced by family
members which indicated significant differences (P
Abstract: This paper is part of a study to develop robots for
farming. As such power requirement to operate equipment attach to
such robots become an important factor. Soil-tool interaction plays
major role in power consumption, thus predicting accurately the
forces which act on the blade during the farming is very important for
optimal designing of farm equipment. In this paper, a finite element
investigation for tillage tools and soil interaction is described by
using an inelastic constitutive material law for agriculture
application. A 3-dimensional (3D) nonlinear finite element analysis
(FEA) is developed to examine behavior of a blade with different
rake angles moving in a block of soil, and to estimate the blade force.
The soil model considered is an elastic-plastic with non-associated
Drucker-Prager material model. Special use of contact elements are
employed to consider connection between soil-blade and soil-soil
surfaces. The FEA results are compared with experimental ones,
which show good agreement in accurately predicting draft forces
developed on the blade when it moves through the soil. Also a very
good correlation was obtained between FEA results and analytical
results from classical soil mechanics theories for straight blades.
These comparisons verified the FEA model developed. For analyzing
complicated soil-tool interactions and for optimum design of blades,
this method will be useful.
Abstract: The aims of this study were to determine the factor
structure and psychometric properties (i.e., reliability and convergent
validity) of the Malaysian Multi-Ethnic Discrimination Scale
(MMEDS). It consists of 71-items measure experience, strategies
used and consequences of ethnic discrimination. A sample of 649
university students from one of the higher education institution in
Malaysia was asked to complete MMEDS, as well as Perceived
Ethnic and Racial Discrimination. The exploratory factor analysis on
ethnic discrimination experience extracted two factors labeled ‘unfair
treatment’ (15 items) and ‘Denial of the ethnic right’ (12 items)
which accounted for 60.92% of the total variance. The two sub scales
demonstrated clear reliability with internal consistency above .70.
The convergent validity of the Scale was supported by an expected
pattern of correlations (positive and significant correlation) between
the score of unfair treatment and denial of the ethnic right and the
score of Perceived Ethnic and Racial Discrimination by Peers Scale.
The results suggest that the MMEDS is a reliable and valid measure.
However, further studies need to be carried out in other groups of
sample as to validate the Scale.
Abstract: We report the microstructural and magnetic properties
of Ni50Mn39Sn11 and Ni50Mn36Sn14 ribbon Heusler alloys.
Experimental results were obtained by differential scanning
calorymetry, X-ray diffraction and vibrating sample magnetometry
techniques. The Ni-Mn-Sn system undergoes a martensitic structural
transformation in a wide temperature range. For example, for
Ni50Mn39Sn11 the start and finish temperatures of the martensitic and
austenite phase transformation for ribbon alloy were Ms=336K,
Mf=328K, As=335K and Af=343K whereas no structural
transformation is observed for Ni50Mn36Sn14 alloys. Magnetic
measurements show the typical ferromagnetic behavior with Curie
temperature 207 K at low applied field of 50 Oe. The complex
behavior exhibited by these Heusler alloys should be ascribed to the
strong coupling between magnetism and structure, being their
magnetic behavior determined by the distance between Mn atoms.
Abstract: Availability of different genetic tests after completion
of Human Genome Project increases the physicians’ responsibility to
keep themselves update on the potential implementation of these
genetic tests in their daily practice. However, due to numbers of
barriers, still many of physicians are not either aware of these tests or
are not willing to offer or refer their patients for genetic tests. This
study was conducted an anonymous, cross-sectional, mailed-based
survey to develop a primary data of Malaysian physicians’ level of
knowledge and perception of gene profiling. Questionnaire had 29
questions. Total scores on selected questions were used to assess the
level of knowledge. The highest possible score was 11. Descriptive
statistics, one way ANOVA and chi-squared test was used for
statistical analysis. Sixty three completed questionnaires were
returned by 27 general practitioners (GPs) and 36 medical specialists.
Responders’ age ranges from 24 to 55 years old (mean 30.2 ± 6.4).
About 40% of the participants rated themselves as having poor level
of knowledge in genetics in general whilst 60% believed that they
have fair level of knowledge; however, almost half (46%) of the
respondents felt that they were not knowledgeable about available
genetic tests. A majority (94%) of the responders were not aware of
any lab or company which is offering gene profiling services in
Malaysia. Only 4% of participants were aware of using gene profiling
for detection of dosage of some drugs. Respondents perceived greater
utility of gene profiling for breast cancer (38%) compared to the
colorectal familial cancer (3%). The score of knowledge ranged from
2 to 8 (mean 4.38 ± 1.67). Non- significant differences between score
of knowledge of GPs and specialists were observed, with score of
4.19 and 4.58 respectively. There was no significant association
between any demographic factors and level of knowledge. However,
those who graduated between years 2001 to 2005 had higher level of
knowledge. Overall, 83% of participants showed relatively high level
of perception on value of gene profiling to detect patient’s risk of
disease. However, low perception was observed for both statements
of using gene profiling for general population in order to alter their
lifestyle (25%) as well as having the full sequence of a patient
genome for the purpose of determining a patient’s best match for
treatment (18%). The lack of clinical guidelines, limited provider
knowledge and awareness, lack of time and resources to educate
patients, lack of evidence-based clinical information and cost of tests
were the most barriers of ordering gene profiling mentioned by
physicians. In conclusion Malaysian physicians who participate in
this study had mediocre level of knowledge and awareness in gene
profiling. The low exposure to the genetic questions and problems
might be a key predictor of lack of awareness and knowledge on
available genetic tests. Educational and training workshop might be useful in helping Malaysian physicians incorporate genetic profiling
into practice for eligible patients.