Abstract: The scientific achievements coming from molecular
biology depend greatly on the capability of computational
applications to analyze the laboratorial results. A comprehensive
analysis of an experiment requires typically the simultaneous study
of the obtained dataset with data that is available in several distinct
public databases. Nevertheless, developing a centralized access to
these distributed databases rises up a set of challenges such as: what
is the best integration strategy, how to solve nomenclature clashes,
how to solve database overlapping data and how to deal with huge
datasets. In this paper we present GeNS, a system that uses a simple and yet innovative approach to address several biological data integration issues. Compared with existing systems, the main
advantages of GeNS are related to its maintenance simplicity and to its coverage and scalability, in terms of number of supported
databases and data types. To support our claims we present the current use of GeNS in two concrete applications. GeNS currently contains more than 140 million of biological relations and it can be
publicly downloaded or remotely access through SOAP web services.
Abstract: In this paper, a novel associative memory model will be proposed and applied to memory retrievals based on the conventional continuous time model. The conventional model presents memory capacity is very low and retrieval process easily converges to an equilibrium state which is very different from the stored patterns. Genetic Algorithms is well-known with the capability of global optimal search escaping local optimum on progress to reach a global optimum. Based on the well-known idea of Genetic Algorithms, this work proposes a heuristic rule to make a mutation when the state of the network is trapped in a spurious memory. The proposal heuristic associative memory show the stored capacity does not depend on the number of stored patterns and the retrieval ability is up to ~ 1.
Abstract: The research on two-wheeled inverted pendulum (TWIP) mobile robots or commonly known as balancing robots have gained momentum over the last decade in a number of robotic laboratories around the world. This paper describes the hardware design of such a robot. The objective of the design is to develop a TWIP mobile robot as well as MATLAB interfacing configuration to be used as flexible platform comprises of embedded unstable linear plant intended for research and teaching purposes. Issues such as selection of actuators and sensors, signal processing units, MATLAB Real Time Workshop coding, modeling and control scheme will be addressed and discussed. The system is then tested using a wellknown state feedback controller to verify its functionality.
Abstract: The present study is aim to prepare and evaluate the selfnanoemulsifying drug delivery (SNEDDS) system of a poorly water soluble drug valsartan in order to achieve a better dissolution rate which would further help in enhancing oral bioavailability. The present research work describes a SNEDDS of valsartan using labrafil M 1944 CS, Tween 80 and Transcutol HP. The pseudoternary phase diagrams with presence and absence of drug were plotted to check for the emulsification range and also to evaluate the effect of valsartan on the emulsification behavior of the phases. The mixtures consisting of oil (labrafil M 1944 CS) with surfactant (tween 80), co-surfactant (Transcutol HP) were found to be optimum formulations. Prepared formulations were evaluated for its particle size distribution, nanoemulsifying properties, robustness to dilution, self emulsication time, turbidity measurement, drug content and invitro dissolution. The optimized formulations are further evaluated for heating cooling cycle, centrifugation studies, freeze thaw cycling, particle size distribution and zeta potential were carried out to confirm the stability of the formed SNEDDS formulations. The prepared formulation revealed t a significant improvement in terms of the drug solubility as compared with marketed tablet and pure drug.
Abstract: In this paper, the data correction algorithm is suggested
when the environmental air temperature varies. To correct the infrared
data in this paper, the initial temperature or the initial infrared image
data is used so that a target source system may not be necessary. The
temperature data obtained from infrared detector show nonlinear
property depending on the surface temperature. In order to handle this
nonlinear property, Taylor series approach is adopted. It is shown that
the proposed algorithm can reduce the influence of environmental
temperature on the components in the board. The main advantage of
this algorithm is to use only the initial temperature of the components
on the board rather than using other reference device such as black
body sources in order to get reference temperatures.
Abstract: The phase diagrams and compositions of coexisting
phases have been determined for aqueous two-phase systems
containing poly(propylene glycol) with average molecular weight of
425 and sodium citrate at various pH of 3.93, 4.44, 4.6, 4.97, 5.1,
8.22. The effect of pH on the salting-out effect of poly (propylene
glycol) by sodium citrate has been studied. It was found that, an
increasing in pH caused the expansion of two-phase region.
Increasing pH also increases the concentration of PPG in the PPGrich
phase, while the salt-rich phase will be somewhat mole diluted.
Abstract: This paper uses quasi-steady molecular statics model
and diamond tool to carry out simulation temperature rise of nanoscale
orthogonal cutting single-crystal silicon. It further qualitatively
analyzes temperature field of silicon workpiece without considering
heat transfer and considering heat transfer. This paper supposes that
the temperature rise of workpiece is mainly caused by two heat sources:
plastic deformation heat and friction heat. Then, this paper develops a
theoretical model about production of the plastic deformation heat and
friction heat during nanoscale orthogonal cutting. After the increased
temperature produced by these two heat sources are added up, the
acquired total temperature rise at each atom of the workpiece is
substituted in heat transfer finite difference equation to carry out heat
transfer and calculates the temperature field in each step and makes
related analysis.
Abstract: In this work, grinding or microcutting tools in the form of pellets were manufactured using a bounded alumina abrasive grains. The bound used is a vitreous material containing quartz feldspars, kaolinite and a quantity of hematite. The pellets were used in glass grinding process to replace the free abrasive grains lapping process. The study of the elaborated pellets were done to define their effectiveness in the grinding process and to optimize the influence of the pellets elaboration parameters. The obtained results show the existence of an optimal combination of the pellets elaboration parameters for each glass grinding phase (coarse to fine grinding). The final roughness (rms) reached by the elaborated pellets on a BK7 glass surface was about 0.392 μm.
Abstract: An unsupervised classification algorithm is derived
by modeling observed data as a mixture of several mutually
exclusive classes that are each described by linear combinations of
independent non-Gaussian densities. The algorithm estimates the
data density in each class by using parametric nonlinear functions
that fit to the non-Gaussian structure of the data. This improves
classification accuracy compared with standard Gaussian mixture
models. When applied to textures, the algorithm can learn basis
functions for images that capture the statistically significant structure
intrinsic in the images. We apply this technique to the problem of
unsupervised texture classification and segmentation.
Abstract: Model-checking tools such as Symbolic Model Verifier
(SMV) and NuSMV are available for checking hardware designs.
These tools can automatically check the formal legitimacy of a
design. However, NuSMV is too low level for describing a complete
hardware design. It is therefore necessary to translate the system
definition, as designed in a language such as Verilog or VHDL, into
a language such as NuSMV for validation. In this paper, we present
a meta hardware description language, Melasy, that contains a code
generator for existing hardware description languages (HDLs) and
languages for model checking that solve this problem.
Abstract: Network-Centric Air Defense Missile Systems
(NCADMS) represents the superior development of the air defense
missile systems and has been regarded as one of the major research
issues in military domain at present. Due to lack of knowledge and
experience on NCADMS, modeling and simulation becomes an effective
approach to perform operational analysis, compared with
those equation based ones. However, the complex dynamic interactions
among entities and flexible architectures of NCADMS put forward
new requirements and challenges to the simulation framework
and models. ABS (Agent-Based Simulations) explicitly addresses
modeling behaviors of heterogeneous individuals. Agents have capability
to sense and understand things, make decisions, and act on the
environment. They can also cooperate with others dynamically to
perform the tasks assigned to them. ABS proves an effective approach
to explore the new operational characteristics emerging in
NCADMS. In this paper, based on the analysis of network-centric
architecture and new cooperative engagement strategies for
NCADMS, an agent-based simulation framework by expanding the
simulation framework in the so-called System Effectiveness Analysis
Simulation (SEAS) was designed. The simulation framework specifies
components, relationships and interactions between them, the
structure and behavior rules of an agent in NCADMS. Based on scenario
simulations, information and decision superiority and operational
advantages in NCADMS were analyzed; meanwhile some
suggestions were provided for its future development.
Abstract: To realize the vision of ubiquitous computing, it is
important to develop a context-aware infrastructure which can help
ubiquitous agents, services, and devices become aware of their
contexts because such computational entities need to adapt themselves
to changing situations. A context-aware infrastructure manages the
context model representing contextual information and provides
appropriate information. In this paper, we introduce Context-Aware
Middleware for URC System (hereafter CAMUS) as a context-aware
infrastructure for a network-based intelligent robot system and discuss
the ontology-based context modeling and reasoning approach which is
used in that infrastructure.
Abstract: Newcastle Disease Virus (NDV), an avian
paramyxovirus, is a highly contagious, generalised virus disease of
domestic poultry and wild birds characterized by gastro-intestinal,
respiratory and nervous signs. In this study, it was shown that NDV
strain AF2240 and V4-UPM are cytolytic to Human Promyelocytic
Leukemia, HL60 and Human T-lymphoblastic Leukemia, CEM-SS
cells. Results from MTT cytolytic assay showed that CD50 for NDV
AF2240 against HL60 was 130 HAU and NDV V4-UPM against
HL60 and CEM-SS were 110.6 and 150.9 HAU respectively.
Besides, both strains were found to inhibit the proliferation of cells in
a dose dependent manner. The mode of cell death either by apoptosis
or necrosis was further analyzed using acridine orange and propidium
iodide (AO/PI) staining. Our results showed that both NDV strains
induced primarily apoptosis in treated cells at CD50 concentration. In
conclusion, both NDV strains caused cytolytic effects primarily via
apoptosis in leukemia cells.
Abstract: The purpose of Grid computing is to utilize
computational power of idle resources which are distributed in
different areas. Given the grid dynamism and its decentralize
resources, there is a need for an efficient scheduler for scheduling
applications. Since task scheduling includes in the NP-hard problems
various researches have focused on invented algorithms especially
the genetic ones. But since genetic is an inherent algorithm which
searches the problem space globally and does not have the efficiency
required for local searching, therefore, its combination with local
searching algorithms can compensate for this shortcomings. The aim
of this paper is to combine the genetic algorithm and GELS (GAGELS)
as a method to solve scheduling problem by which
simultaneously pay attention to two factors of time and number of
missed tasks. Results show that the proposed algorithm can decrease
makespan while minimizing the number of missed tasks compared
with the traditional methods.
Abstract: In order to enhance the usability of the human computer interface (HCI) on the touchscreen, this study explored the optimal tactile depth and effect of visual cues on the user-s tendency to touch the touchscreen icons. The experimental program was designed on the touchscreen in this study. Results indicated that the ratio of the icon size to the tactile depth was 1:0.106. There were significant effects of experienced users and novices on the tactile feedback depth (p < 0.01). In addition, the results proved that the visual cues provided a feedback that helped to guide the user-s touch icons accurately and increased the capture efficiency for a tactile recognition field. This tactile recognition field was 18.6 mm in length. There was consistency between the experienced users and novices under the visual cue effects. Finally, the study developed an applied design with touch feedback for touchscreen icons.
Abstract: A fuzzy classifier using multiple ellipsoids approximating decision regions for classification is to be designed in this paper. An algorithm called Gustafson-Kessel algorithm (GKA) with an adaptive distance norm based on covariance matrices of prototype data points is adopted to learn the ellipsoids. GKA is able toadapt the distance norm to the underlying distribution of the prototypedata points except that the sizes of ellipsoids need to be determined a priori. To overcome GKA's inability to determine appropriate size ofellipsoid, the genetic algorithm (GA) is applied to learn the size ofellipsoid. With GA combined with GKA, it will be shown in this paper that the proposed method outperforms the benchmark algorithms as well as algorithms in the field.
Abstract: In this work the opportunity of construction of the
qualifiers for face-recognition systems based on conjugation criteria
is investigated. The linkage between the bipartite conjugation, the
conjugation with a subspace and the conjugation with the null-space
is shown. The unified solving rule is investigated. It makes the
decision on the rating of face to a class considering the linkage
between conjugation values. The described recognition method can
be successfully applied to the distributed systems of video control
and video observation.
Abstract: Tumour suppressors are key participants in the
prevention of cancer. Regulation of their expression through
miRNAs is important for comprehensive translation inhibition of
tumour suppressors and elucidation of carcinogenesis mechanisms.
We studies the possibility of 1521 miRNAs to bind with 873 mRNAs
of human tumour suppressors using RNAHybrid 2.1 and ERNAhybrid
programmes. Only 978 miRNAs were found to be
translational regulators of 812 mRNAs, and 61 mRNAs did not have
any miRNA binding sites. Additionally, 45.9% of all miRNA binding
sites were located in coding sequences (CDSs), 33.8% were located
in 3' untranslated region (UTR), and 20.3% were located in the
5'UTR. MiRNAs binding with more than 50 target mRNAs and
mRNAs binding with several miRNAs were selected. Hsa-miR-5096
had 15 perfectly complementary binding sites with mRNAs of 14
tumour suppressors. These newly indentified miRNA binding sites
can be used in the development of medicines (anti-sense therapies)
for cancer treatment.
Abstract: This article investigates a contribution of synthesized visual speech. Synthesis of visual speech expressed by a computer consists in an animation in particular movements of lips. Visual speech is also necessary part of the non-manual component of a sign language. Appropriate methodology is proposed to determine the quality and the accuracy of synthesized visual speech. Proposed methodology is inspected on Czech speech. Hence, this article presents a procedure of recording of speech data in order to set a synthesis system as well as to evaluate synthesized speech. Furthermore, one option of the evaluation process is elaborated in the form of a perceptual test. This test procedure is verified on the measured data with two settings of the synthesis system. The results of the perceptual test are presented as a statistically significant increase of intelligibility evoked by real and synthesized visual speech. Now, the aim is to show one part of evaluation process which leads to more comprehensive evaluation of the sign speech synthesis system.
Abstract: Since large power transformers are the most
expensive and strategically important components of any power
generator and transmission system, their reliability is crucially
important for the energy system operation. Also, Circuit breakers are
very important elements in the power transmission line so monitoring
the events gives a knowledgebase to determine time to the next
maintenance. This paper deals with the introduction of the
comparative method of the state estimation of transformers and
Circuit breakers using continuous monitoring of voltage, current.
This paper gives details a new method based on wavelet to apparatus
insulation monitoring. In this paper to insulation monitoring of
transformer, a new method based on wavelet transformation and
neutral point analysis is proposed. Using the EMTP tools, fault in
transformer winding and the detailed transformer winding model
were simulated. The current of neutral point of winding was analyzed
by wavelet transformation. It is shown that the neutral current of the
transformer winding has useful information about fault in insulation
of the transformer.