Abstract: NFκB activation plays a crucial role in anti-apoptotic responses in response to the apoptotic signaling during tumor necrosis factor (TNFa) stimulation in Multiple Myeloma (MM). Although several drugs have been found effective for the treatment of MM by mainly inhibiting NFκB pathway, there are no any quantitative or qualitative results of comparison assessment on inhibition effect between different single drugs or drug combinations. Computational modeling is becoming increasingly indispensable for applied biological research mainly because it can provide strong quantitative predicting power. In this study, a novel computational pathway modeling approach is employed to comparably assess the inhibition effects of specific single drugs and drug combinations on the NFκB pathway in MM, especially the prediction of synergistic drug combinations.
Abstract: Seismic qualification testing for equipments to be
mounted on upper storeys of buildings is very demanding in terms of
floor spectra. The latter is characterized by high accelerations
amplitudes within a narrow frequency band. This article presents a
method which permits to cover specified required response spectra
beyond the shaking table capability by amplifying the acceleration
amplitudes at an appropriate frequency range using a physical
intermediate mounted on the platform of the shaker.
Abstract: Weather disaster events were frequent and caused loss
of lives and property in Taiwan recently. Excessive concentration of
population and lacking of integrated planning led to Taiwanese coastal
zone face the impacts of climate change directly. Comparing to many
countries which have already set up legislation, competent authorities
and national adaptation strategies, the ability of coastal management
adapting to climate change is still insufficient in Taiwan. Therefore, it
is necessary to establish a complete institutional arrangement for
coastal management due to climate change in order to protect
environment and sustain socio-economic development. This paper
firstly reviews the impact of climate change on Taiwanese coastal
zone. Secondly, development of Taiwanese institutional arrangement
of coastal management is introduced. Followed is the analysis of four
dimensions of legal basis, competent authority, scientific and financial
support and international cooperations of institutional arrangement.
The results show that Taiwanese government shall: 1) integrate climate
change issue into Coastal Act, Wetland Act and territorial planning
Act and pass them; 2) establish the high level competent authority for
coastal management; 3) set up the climate change disaster coordinate
platform; 4) link scientific information and decision markers; 5)
establish the climate change adjustment fund; 6) participate in
international climate change organizations and meetings actively; 7)
cooperate with near countries to exchange experiences.
Abstract: The AL-MAJIRI school system is a variant of private
Arabic and Islamic schools which cater for the religious and moral development of Muslims. In the past, the system produced clerics,
scholars, judges, religious reformers, eminent teachers and great men who are worthy of emulation, particularly in northern Nigeria.
Gradually, the system lost its glory but continued to discharge its
educational responsibilities to a certain extent. This paper takes a
look at the activities of the AL-MAJIRI schools. The introduction
provides background information about Nigeria where the schools
operate. This is followed by an overview of the Nigerian educational system, the nature and the features of the AL-MAJIRI school system,
its weaknesses and the current challenges facing the schools. The paper concludes with emphasis on the urgent need for a comprehensive reform of the curriculum content of the schools. The step by step procedure required for the reform is discussed.
Abstract: The Kinetics formation of labile Complex
Ag (I) tetra (p-carboxyphenyl) porphyrin, was investigated at 25oC
and I=0.1M (NaNO3). By spectrophotometric titration, the
composition ratio of the complex was established to be 2:1
(Ag : H2TCPP). The equilibrium constant, K, was found to be
log 10-6.53. Binding of the first Ag (I) was found to be rate
determining step with rate constant, k1= 4.67×102 . A plausible
mechanism is discussed. We discus theoretically why Ag(I)2TCPP is
unstable.
Abstract: Wireless sensor networks (WSN) are currently
receiving significant attention due to their unlimited potential. These
networks are used for various applications, such as habitat
monitoring, automation, agriculture, and security. The efficient nodeenergy
utilization is one of important performance factors in wireless
sensor networks because sensor nodes operate with limited battery
power. In this paper, we proposed the MiSense hierarchical cluster
based routing algorithm (MiCRA) to extend the lifetime of sensor
networks and to maintain a balanced energy consumption of nodes.
MiCRA is an extension of the HEED algorithm with two levels of
cluster heads. The performance of the proposed protocol has been
examined and evaluated through a simulation study. The simulation
results clearly show that MiCRA has a better performance in terms of
lifetime than HEED. Indeed, MiCRA our proposed protocol can
effectively extend the network lifetime without other critical
overheads and performance degradation. It has been noted that there
is about 35% of energy saving for MiCRA during the clustering
process and 65% energy savings during the routing process compared
to the HEED algorithm.
Abstract: As a result of urbanization, the unpredictable growth of industry and transport, production of chemicals, military activities, etc. the concentration of anthropogenic toxicants spread in nature exceeds all the permissible standards. Most dangerous among these contaminants are organic compounds having great persistence, bioaccumulation, and toxicity along with our awareness of their prominent occurrence in the environment and food chain. Among natural ecological tools, plants still occupying above 40% of the world land, until recently, were considered as organisms having only a limited ecological potential, accumulating in plant biomass and partially volatilizing contaminants of different structure. However, analysis of experimental data of the last two decades revealed the essential role of plants in environment remediation due to ability to carry out intracellular degradation processes leading to partial or complete decomposition of carbon skeleton of different structure contaminants. Though, phytoremediation technologies still are in research and development, their various applications have been successfully used. The paper aims to analyze mechanisms of organic contaminants uptake and detoxification in plants, being the less studied issue in evaluation and exploration of plants potential for environment remediation.
Abstract: Fly ash is a significant waste that is released of
thermal power plants and defined as very fine particles that are drifted upward with up taken by the flue gases due to the burning of
used coal [1]. The fly-ash is capable of removing organic
contaminants in consequence of high carbon content, a large surface area per unit volume and contained heavy metals. Therefore, fly ash
is used as an effective coagulant and adsorbent by pelletization [2, 3].
In this study, the possibility of use of fly ash taken from Turkey like low-cost adsorbent for adsorption of zinc ions found in waste
water was investigated. The fly ash taken from Turkey was pelletized with bentonite and molass to evaluate the adsorption capaticity. For
this purpose; analyses such as sieve analysis, XRD, XRF, FTIR and SEM were performed. As a result, it was seen that pellets prepared
from fly ash, bentonite and molass would be used for zinc adsorption.
Abstract: This research was conducted for the first time at the
southeastern coasts of the Caspian Sea in order to evaluate the
performance of osteichthyes cooperatives through production (catch)
function. Using one of the indirect valuation methods in this research,
contributory factors in catch were identified and were inserted into
the function as independent variables. In order to carry out this
research, the performance of 25 Osteichthyes catching cooperatives
in the utilization year of 2009 which were involved in fishing in
Miankale wildlife refuge region. The contributory factors in catch
were divided into groups of economic, ecological and biological
factors. In the mentioned function, catch rate of the cooperative were
inserted into as the dependant variable and fourteen partial variables
in terms of nine general variables as independent variables. Finally,
after function estimation, seven variables were rendered significant at
99 percent reliably level. The results of the function estimation
indicated that human resource (fisherman quantity) had the greatest
positive effect on catch rate with an influence coefficient of 1.7 while
weather conditions had the greatest negative effect on the catch rate
of cooperatives with an influence coefficient of -2.07. Moreover,
factors like member's share, experience and fisherman training and
fishing effort played the main roles in the catch rate of cooperative
with influence coefficients of 0.81, 0.5 and 0.21, respectively.
Abstract: A 10bit, 40 MSps, sample and hold, implemented in 0.18-μm CMOS technology with 3.3V supply, is presented for application in the front-end stage of an analog-to-digital converter. Topology selection, biasing, compensation and common mode feedback are discussed. Cascode technique has been used to increase the dc gain. The proposed opamp provides 149MHz unity-gain bandwidth (wu), 80 degree phase margin and a differential peak to peak output swing more than 2.5v. The circuit has 55db Total Harmonic Distortion (THD), using the improved fully differential two stage operational amplifier of 91.7dB gain. The power dissipation of the designed sample and hold is 4.7mw. The designed system demonstrates relatively suitable response in different process, temperature and supply corners (PVT corners).
Abstract: Choosing the right metadata is a critical, as good
information (metadata) attached to an image will facilitate its
visibility from a pile of other images. The image-s value is enhanced
not only by the quality of attached metadata but also by the technique
of the search. This study proposes a technique that is simple but
efficient to predict a single human image from a website using the
basic image data and the embedded metadata of the image-s content
appearing on web pages. The result is very encouraging with the
prediction accuracy of 95%. This technique may become a great
assist to librarians, researchers and many others for automatically and
efficiently identifying a set of human images out of a greater set of
images.
Abstract: In-core memory requirement is a bottleneck in solving
large three dimensional Navier-Stokes finite element problem
formulations using sparse direct solvers. Out-of-core solution
strategy is a viable alternative to reduce the in-core memory
requirements while solving large scale problems. This study
evaluates the performance of various out-of-core sequential solvers
based on multifrontal or supernodal techniques in the context of
finite element formulations for three dimensional problems on a
Windows platform. Here three different solvers, HSL_MA78,
MUMPS and PARDISO are compared. The performance of these
solvers is evaluated on a 64-bit machine with 16GB RAM for finite
element formulation of flow through a rectangular channel. It is
observed that using out-of-core PARDISO solver, relatively large
problems can be solved. The implementation of Newton and
modified Newton's iteration is also discussed.
Abstract: Nowadays, engineering ceramics have significant
applications in different industries such as; automotive, aerospace,
electrical, electronics and even martial industries due to their
attractive physical and mechanical properties like very high hardness
and strength at elevated temperatures, chemical stability, low friction
and high wear resistance. However, these interesting properties plus
low heat conductivity make their machining processes too hard,
costly and time consuming. Many attempts have been made in order
to make the grinding process of engineering ceramics easier and
many scientists have tried to find proper techniques to economize
ceramics' machining processes. This paper proposes a new diamond
plunge grinding technique using ultrasonic vibration for grinding
Alumina ceramic (Al2O3). For this purpose, a set of laboratory
equipments have been designed and simulated using Finite Element
Method (FEM) and constructed in order to be used in various
measurements. The results obtained have been compared with the
conventional plunge grinding process without ultrasonic vibration
and indicated that the surface roughness and fracture strength
improved and the grinding forces decreased.
Abstract: The dynamics of User Datagram Protocol (UDP) traffic
over Ethernet between two computers are analyzed using nonlinear
dynamics which shows that there are two clear regimes in the data
flow: free flow and saturated. The two most important variables
affecting this are the packet size and packet flow rate. However,
this transition is due to a transcritical bifurcation rather than phase
transition in models such as in vehicle traffic or theorized large-scale
computer network congestion. It is hoped this model will help lay
the groundwork for further research on the dynamics of networks,
especially computer networks.
Abstract: Developing countries are facing a problem of slums and there appears to be no fool proof solution to eradicate them. For improving the quality of life there are three approaches of slum development and In-situ up-gradation approach is found to be the best one, while the relocation approach has proved to be failure. Factors responsible for failure of relocation projects are needed to be assessed, which is the basic aim of the paper. Factors responsible for failure of relocation projects are loss of livelihood, security of tenure and inefficiency of the Government. These factors are traced out & mapped from the examples of Western & Indian cities. National habitat, Resettlement policy emphasized relationship between shelter and work place. SRA has identified 55 slums for relocation due reservation of land uses, security of tenure and non- notified status of slums. The policy guidelines have been suggested for successful relocation projects. KeywordsLivelihood, Relocation, Slums, Urban poor.
Abstract: High speed networks provide realtime variable bit rate
service with diversified traffic flow characteristics and quality
requirements. The variable bit rate traffic has stringent delay and
packet loss requirements. The burstiness of the correlated traffic
makes dynamic buffer management highly desirable to satisfy the
Quality of Service (QoS) requirements. This paper presents an
algorithm for optimization of adaptive buffer allocation scheme for
traffic based on loss of consecutive packets in data-stream and buffer
occupancy level. Buffer is designed to allow the input traffic to be
partitioned into different priority classes and based on the input
traffic behavior it controls the threshold dynamically. This algorithm
allows input packets to enter into buffer if its occupancy level is less
than the threshold value for priority of that packet. The threshold is
dynamically varied in runtime based on packet loss behavior. The
simulation is run for two priority classes of the input traffic –
realtime and non-realtime classes. The simulation results show that
Adaptive Partial Buffer Sharing (ADPBS) has better performance
than Static Partial Buffer Sharing (SPBS) and First In First Out
(FIFO) queue under the same traffic conditions.
Abstract: The necessity of accurate and timely field data is
shared among organizations engaged in fundamentally different
activities, public services or commercial operations. Basically, there
are three major components in the process of the qualitative research:
data collection, interpretation and organization of data, and analytic
process. Representative technological advancements in terms of
innovation have been made in mobile devices (mobile phone, PDA-s,
tablets, laptops, etc). Resources that can be potentially applied on the
data collection activity for field researches in order to improve this
process.
This paper presents and discuss the main features of a mobile
phone based solution for field data collection, composed of basically
three modules: a survey editor, a server web application and a client
mobile application. The data gathering process begins with the
survey creation module, which enables the production of tailored
questionnaires. The field workforce receives the questionnaire(s) on
their mobile phones to collect the interviews responses and sending
them back to a server for immediate analysis.
Abstract: In this paper, we propose a Perceptually Optimized Foveation based Embedded ZeroTree Image Coder (POEFIC) that introduces a perceptual weighting to wavelet coefficients prior to control SPIHT encoding algorithm in order to reach a targeted bit rate with a perceptual quality improvement with respect to a given bit rate a fixation point which determines the region of interest ROI. The paper also, introduces a new objective quality metric based on a Psychovisual model that integrates the properties of the HVS that plays an important role in our POEFIC quality assessment. Our POEFIC coder is based on a vision model that incorporates various masking effects of human visual system HVS perception. Thus, our coder weights the wavelet coefficients based on that model and attempts to increase the perceptual quality for a given bit rate and observation distance. The perceptual weights for all wavelet subbands are computed based on 1) foveation masking to remove or reduce considerable high frequencies from peripheral regions 2) luminance and Contrast masking, 3) the contrast sensitivity function CSF to achieve the perceptual decomposition weighting. The new perceptually optimized codec has the same complexity as the original SPIHT techniques. However, the experiments results show that our coder demonstrates very good performance in terms of quality measurement.
Abstract: The increased number of automobiles in recent years
has resulted in great demand for fossil fuel. This has led to the
development of automobile by using alternative fuels which include
gaseous fuels, biofuels and vegetables oils as fuel. Energy from
biomass and more specific bio-diesel is one of the opportunities that
could cover the future demand of fossil fuel shortage. Biomass in the
form of cashew nut shell represents a new energy source and
abundant source of energy in India. The bio-fuel is derived from
cashew nut shell oil and its blend with diesel are promising
alternative fuel for diesel engine. In this work the pyrolysis Cashew
Nut Shell Liquid (CNSL)-Diesel Blends (CDB) was used to run the
Direct Injection (DI) diesel engine. The experiments were conducted
with various blends of CNSL and Diesel namely B20, B40, B60, B80
and B100. The results are compared with neat diesel operation. The
brake thermal efficiency was decreased for blends of CNSL and
Diesel except the lower blends of B20. The brake thermal efficiency
of B20 is nearly closer to that of diesel fuel. Also the emission level
of the all CNSL and Diesel blends was increased compared to neat
diesel. The higher viscosity and lower volatility of CNSL leads to
poor mixture formation and hence lower brake thermal efficiency and
higher emission levels. The higher emission level can be reduced by
adding suitable additives and oxygenates with CNSL and Diesel
blends.
Abstract: Network layer multicast, i.e. IP multicast, even after
many years of research, development and standardization, is not
deployed in large scale due to both technical (e.g. upgrading of
routers) and political (e.g. policy making and negotiation) issues.
Researchers looked for alternatives and proposed application/overlay
multicast where multicast functions are handled by end hosts, not
network layer routers. Member hosts wishing to receive multicast
data form a multicast delivery tree. The intermediate hosts in the tree
act as routers also, i.e. they forward data to the lower hosts in the
tree. Unlike IP multicast, where a router cannot leave the tree until all
members below it leave, in overlay multicast any member can leave
the tree at any time thus disjoining the tree and disrupting the data
dissemination. All the disrupted hosts have to rejoin the tree. This
characteristic of the overlay multicast causes multicast tree unstable,
data loss and rejoin overhead. In this paper, we propose that each node
sets its leaving time from the tree and sends join request to a number
of nodes in the tree. The nodes in the tree will reject the request if
their leaving time is earlier than the requesting node otherwise they
will accept the request. The node can join at one of the accepting
nodes. This makes the tree more stable as the nodes will join the tree
according to their leaving time, earliest leaving time node being at the
leaf of the tree. Some intermediate nodes may not follow their leaving
time and leave earlier than their leaving time thus disrupting the tree.
For this, we propose a proactive recovery mechanism so that disrupted
nodes can rejoin the tree at predetermined nodes immediately. We
have shown by simulation that there is less overhead when joining
the multicast tree and the recovery time of the disrupted nodes is
much less than the previous works. Keywords