Abstract: Hyperglycaemia is a key factor that contributes to the
development of diabetes-related microvascular disease and a major
risk factor for endothelial dysfunction. In the current study, we have
explored glucose-induced abnormal intracellular calcium (Ca2+
i)
homeostasis in mouse microvessel endothelial cells (MMECs) in
high glucose (HG) (40mmol/L) versus control (low glucose, LG) (11
mmol/L). We demonstrated that the exposure of MMECs to HG for 3
days did not change basal Ca2+
i, however, there was a significant
increase of acetylcholine-induced Ca2+ entry. Western blots
illustrated that exposure to HG also increased STIM1 (Stromal
Interaction Molecule 1), but not Orai1 (the pore forming subunit),
protein expression levels. Although the link between HG-induced
changes in STIM1 expression, enhanced Ca2+ entry and endothelial
dysfunction requires further study, the current data are suggestive
that targeting these pathways may reduce the impact of HG on
endothelial function.
Abstract: In the last few years, the Semantic Web gained scientific acceptance as a means of relationships identification in knowledge base, widely known by semantic association. Query about complex relationships between entities is a strong requirement for many applications in analytical domains. In bioinformatics for example, it is critical to extract exchanges between proteins. Currently, the widely known result of such queries is to provide paths between connected entities from data graph. However, they do not always give good results while facing the user need by the best association or a set of limited best association, because they only consider all existing paths but ignore the path evaluation. In this paper, we present an approach for supporting association discovery queries. Our proposal includes (i) a query language PmSPRQL which provides a multiparadigm query expressions for association extraction and (ii) some quantification measures making easy the process of association ranking. The originality of our proposal is demonstrated by a performance evaluation of our approach on real world datasets.
Abstract: This paper describes Clinical Document Architecture Release Two (CDA R2) standard and a client application for messaging with SAĞLIK-NET project developed by The Ministry of Health of Turkey. CDA R2 , developed by Health Level 7 (HL7) organization and approved by American National Standards Institute (ANSI) in 2004, to standardize medical information to be able to share semantically and syntactically. In this study, a client application compatible with HL7 V3 for a project named SAĞLIKNET, aimed to build a National Health Information System by Turkey. Moreover, CDA conformance of this application will also be evaluated.
Abstract: Tandem mass spectrometry (MS/MS) is the engine
driving high-throughput protein identification. Protein mixtures possibly
representing thousands of proteins from multiple species are
treated with proteolytic enzymes, cutting the proteins into smaller
peptides that are then analyzed generating MS/MS spectra. The
task of determining the identity of the peptide from its spectrum
is currently the weak point in the process. Current approaches to de
novo sequencing are able to compute candidate peptides efficiently.
The problem lies in the limitations of current scoring functions. In this
paper we introduce the concept of proteome signature. By examining
proteins and compiling proteome signatures (amino acid usage) it is
possible to characterize likely combinations of amino acids and better
distinguish between candidate peptides. Our results strongly support
the hypothesis that a scoring function that considers amino acid usage
patterns is better able to distinguish between candidate peptides. This
in turn leads to higher accuracy in peptide prediction.
Abstract: This research presents a system for post processing of
data that takes mined flat rules as input and discovers crisp as well as
fuzzy hierarchical structures using Learning Classifier System
approach. Learning Classifier System (LCS) is basically a machine
learning technique that combines evolutionary computing,
reinforcement learning, supervised or unsupervised learning and
heuristics to produce adaptive systems. A LCS learns by interacting
with an environment from which it receives feedback in the form of
numerical reward. Learning is achieved by trying to maximize the
amount of reward received. Crisp description for a concept usually
cannot represent human knowledge completely and practically. In the
proposed Learning Classifier System initial population is constructed
as a random collection of HPR–trees (related production rules) and
crisp / fuzzy hierarchies are evolved. A fuzzy subsumption relation is
suggested for the proposed system and based on Subsumption Matrix
(SM), a suitable fitness function is proposed. Suitable genetic
operators are proposed for the chosen chromosome representation
method. For implementing reinforcement a suitable reward and
punishment scheme is also proposed. Experimental results are
presented to demonstrate the performance of the proposed system.
Abstract: This study aims to investigate how much both son and
daughter trust their father and what are the underlying reasons they
trust their father. The results revealed five main reasons why
Malaysian adolescents trust their father. Those reasons are related to
the role of father, father-child relationship, father-s characteristics,
father-s nurturing nature and father-s attitude and behavior. A total of
1022 students (males = 241, females = 781) from one of public
university in Sabah, Malaysia participated in the study. The
participants completed open-ended questionnaires developed by Kim
(2008), asking how much the adolescents trust their father, and the
reasons why they trust their father. The data was analysed by using
the indigenous psychology method proposed by [1] Findings of this
study revealed the pattern of trust towards father for both Malaysian
male and female adolescents. The results contributed new
information about Malaysian adolescents- trust towards their father
form the indigenous context. The implications of finding will be
discussed.
Abstract: Let G be a Hamiltonian graph. A factor F of G is called
a Hamiltonian factor if F contains a Hamiltonian cycle. In this paper,
two sufficient conditions are given, which are two neighborhood
conditions for a Hamiltonian graph G to have a Hamiltonian factor.
Abstract: Mega urban transport projects (MUTPs) are
increasingly being used in urban environments to ameliorate the
problem of congestion. However, a number of problems with regard
to mega projects have been identified. In particular the seemingly
institutionalised over estimation of economic benefits and persistent
cost over runs, could mean that the wrong projects are selected, and
that the projects that are selected cost more than they should. Studies
to date have produced a number of solutions to these problems,
perhaps most notably, the various methods for the inclusion of the
private sector in project provision. However the problems have
shown significant intractability in the face of these solutions. This
paper provides a detailed examination of some of the problems
facing mega projects and then examines Foucault-s theory of
'governmentality' as a possible frame of analysis which might shed
light on the intractability of the problems that have been identified,
through an identification of the art of government in which MUTPs
occur.
Abstract: In manufacturing industries, development of measurement leads to increase the number of monitoring variables and eventually the importance of multivariate control comes to the fore. Statistical process control (SPC) is one of the most widely used as multivariate control chart. Nevertheless, SPC is restricted to apply in processes because its assumption of data as following specific distribution. Unfortunately, process data are composed by the mixture of several processes and it is hard to estimate as one certain distribution. To alternative conventional SPC, therefore, nonparametric control chart come into the picture because of the strength of nonparametric control chart, the absence of parameter estimation. SVDD based control chart is one of the nonparametric control charts having the advantage of flexible control boundary. However,basic concept of SVDD has been an oversight to the important of data characteristic, density distribution. Therefore, we proposed DW-SVDD (Density Weighted SVDD) to cover up the weakness of conventional SVDD. DW-SVDD makes a new attempt to consider dense of data as introducing the notion of density Weight. We extend as control chart using new proposed SVDD and a simulation study of various distributional data is conducted to demonstrate the improvement of performance.
Abstract: Fractional Fourier Transform is a generalization of the classical Fourier Transform which is often symbolized as the rotation in time- frequency plane. Similar to the product of time and frequency span which provides the Uncertainty Principle for the classical Fourier domain, there has not been till date an Uncertainty Principle for the Fractional Fourier domain for a generalized class of finite energy signals. Though the lower bound for the product of time and Fractional Fourier span is derived for the real signals, a tighter lower bound for a general class of signals is of practical importance, especially for the analysis of signals containing chirps. We hence formulate a mathematical derivation that gives the lower bound of time and Fractional Fourier span product. The relation proves to be utmost importance in taking the Fractional Fourier Transform with adaptive time and Fractional span resolutions for a varied class of complex signals.
Abstract: The fault current levels through the electric devices
have a significant impact on failure probability. New fault current
results in exceeding the rated capacity of circuit breaker and switching
equipments and changes operation characteristic of overcurrent relay.
In order to solve these problems, SFCL (Superconducting Fault
Current Limiter) has rising as one of new alternatives so as to improve
these problems. A fault current reduction differs depending on
installed location. Therefore, a location of SFCL is very important.
Also, SFCL decreases the fault current, and it prevents surrounding
protective devices to be exposed to fault current, it then will bring a
change of reliability. In this paper, we propose method which
determines the optimal location when SFCL is installed in power
system. In addition, the reliability about the power system which
SFCL was installed is evaluated. The efficiency and effectiveness of
this method are also shown by numerical examples and the reliability
indices are evaluated in this study at each load points. These results
show a reliability change of a system when SFCL was installed.
Abstract: Tasks of the work were study the possible E.coli
contamination in red deer meat, identify pathogenic strains from
isolated E.coli, determine their incidence in red deer meat and
determine the presence of VT1, VT2 and eaeA genes for the
pathogenic E.coli. 8 (10%) samples were randomly selected from 80
analysed isolates of E.coli and PCR reaction was performed on them.
PCR was done both on initial materials – samples of red deer meat -
and for already isolated liqueurs. Two of analysed venison samples
contain verotoxin-producing strains of E. coli. It means that this meat
is not safe to consumer. It was proven by the sequestration reaction of
E. coli and by comparison of the obtained results with the database of
microorganism genome available on the internet that the isolated
culture corresponds to region 16S rDNS of E. coli thus presenting
correctness of the microbiological methods.
Abstract: Recordings from recent earthquakes have provided evidence that ground motions in the near field of a rupturing fault differ from ordinary ground motions, as they can contain a large energy, or “directivity" pulse. This pulse can cause considerable damage during an earthquake, especially to structures with natural periods close to those of the pulse. Failures of modern engineered structures observed within the near-fault region in recent earthquakes have revealed the vulnerability of existing RC buildings against pulse-type ground motions. This may be due to the fact that these modern structures had been designed primarily using the design spectra of available standards, which have been developed using stochastic processes with relatively long duration that characterizes more distant ground motions. Many recently designed and constructed buildings may therefore require strengthening in order to perform well when subjected to near-fault ground motions. Fiber Reinforced Polymers are considered to be a viable alternative, due to their relatively easy and quick installation, low life cycle costs and zero maintenance requirements. The objective of this paper is to investigate the adequacy of Artificial Neural Networks (ANN) to determine the three dimensional dynamic response of FRP strengthened RC buildings under the near-fault ground motions. For this purpose, one ANN model is proposed to estimate the base shear force, base bending moments and roof displacement of buildings in two directions. A training set of 168 and a validation set of 21 buildings are produced from FEA analysis results of the dynamic response of RC buildings under the near-fault earthquakes. It is demonstrated that the neural network based approach is highly successful in determining the response.
Abstract: The changing economic climate has made global
manufacturing a growing reality over the last decade, forcing
companies from east and west and all over the world to
collaborate beyond geographic boundaries in the design,
manufacture and assemble of products. The ISO10303 and
ISO14649 Standards (STEP and STEP-NC) have been
developed to introduce interoperability into manufacturing
enterprises so as to meet the challenge of responding to
production on demand. This paper describes and illustrates a
STEP compliant CAD/CAPP/CAM System for the manufacture
of rotational parts on CNC turning centers. The information
models to support the proposed system together with the data
models defined in the ISO14649 standard used to create the NC
programs are also described. A structured view of a STEP
compliant CAD/CAPP/CAM system framework supporting the
next generation of intelligent CNC controllers for turn/mill
component manufacture is provided. Finally a proposed
computational environment for a STEP-NC compliant system
for turning operations (SCSTO) is described. SCSTO is the
experimental part of the research supported by the specification
of information models and constructed using a structured
methodology and object-oriented methods. SCSTO was
developed to generate a Part 21 file based on machining
features to support the interactive generation of process plans
utilizing feature extraction. A case study component has been
developed to prove the concept for using the milling and turning
parts of ISO14649 to provide a turn-mill CAD/CAPP/CAM
environment.
Abstract: The demand on High voltage (HV) infrastructures is growing due to the corresponding growth in industries and population. New or upgraded HV infrastructure has safety implications since Transmission mains usually occupy the same easement in the vicinity of neighbouring residents. Transmission mains consist of underground (UG) and overhead (OH) sections and the transition between the UG and OH section is known as the UGOH pole. The existence of two transmission mains in the same easement can dictate to resort to more complicated earthing design in order to mitigate the effect of AC interference, and in some cases it can also necessitates completing a Split Study of the system. This paper provides an overview of the AC interference, Split Study and the earthing of an underground feeder including the UGOH pole .In addition, this paper discusses the use of different link boxes on the UG feeder and presents a case study that represent a clear example of the Ac interference and Split factor. Finally, a few recommendations are provided to achieve a safety zone in the area beyond the boundary of the HV system.
Abstract: This paper presents an iterative algorithm to find a
inverse kinematic solution of 5-DOF robot. The algorithm is to
minimize the iteration number. Since the 5-DOF robot cannot give full
orientation of tool. Only z-direction of tool is satisfied while rotation
of tool is determined by kinematic constraint. This work therefore
described how to specify the tool direction and let the tool rotation free.
The simulation results show that this algorithm effectively worked.
Using the proposed iteration algorithm, error due to inverse kinematics
converged to zero rapidly in 5 iterations. This algorithm was applied in
real welding robot and verified through various practical works.
Abstract: Decision Support System (DSS) are interactive
software systems that are built to assist the management of an
organization in the decision making process when faced with nonroutine
problems in a specific application domain. Non-functional
requirements (NFRs) for a DSS deal with the desirable qualities and
restrictions that the DSS functionalities must satisfy. Unlike the
functional requirements, which are tangible functionalities provided
by the DSS, NFRs are often hidden and transparent to DSS users but
affect the quality of the provided functionalities. NFRs are often
overlooked or added later to the system in an ad hoc manner, leading
to a poor overall quality of the system. In this paper, we discuss the
development of NFRs as part of the requirements engineering phase
of the system development life cycle of DSSs. To help eliciting
NFRs, we provide a comprehensive taxonomy of NFRs for DSSs.
Abstract: The performance of modified Fenton (MF) treatment
to promote PAH oxidation in artificially contaminated soil was
investigated in packed soil column with a hydrogen peroxide (H2O2)
delivery system simulating in situ injection. Soil samples were spiked
with phenanthrene (low molecular weight PAH) and fluoranthene
(high molecular weight PAH) to an initial concentration of 500
mg/kg dried soil each. The effectiveness of process parameters
H2O2/soil, iron/soil, chelating agent/soil weight ratios and reaction
time were studied using a 24 three level factorial design experiments.
Statistically significant quadratic models were developed using
Response Surface Methodology (RSM) for degrading PAHs from the
soil samples. Optimum operating condition was achieved at mild
range of H2O2/soil, iron/soil and chelating agent/soil weight ratios,
indicating cost efficient method for treating highly contaminated
lands.
Abstract: This paper examines the role of telecommunications in sustainable development of urban, rural and remote communities in the Northern Territory of Australia through the theoretical lens of Social Capital. Social Capital is a relatively new construct and is rapidly gaining interest among policy makers, politicians and researchers as a means to both describe and understand social and economic development. Increasingly, the concept of Social Capital, as opposed to the traditional economic indicators, is seen as a more accurate measure of well-being. Whilst the essence of Social Capital is quality social relations, the concept intersects with telecommunications and Information Communications Technology (ICT) in a number of ways. The potential of ICT to disseminate information quickly, to reach vast numbers of people simultaneously and to include the previously excluded, is immense. However, the exact nature of the relationship is not clearly defined. This paper examines the nexus between social relations of mutual benefit, telecommunications access and sustainable development. A mixed methodological approach was used to test the hypothesis that No relationship exists between Social Capital and access to telecommunications services and facilities. Four communities, which included two urban, a rural and a remote Indigenous community in the Northern Territory of Australia are the focus of this research paper.
Abstract: Microwave energy can be used for drying purpose. It is unique process. It is distinctly different from conventional drying process. It is advantageous over conventional drying / heating processes. When microwave energy is used for drying purpose, the process can be accelerated with a better control to achieve uniform heating, more conversion efficiency, selective drying and ultimately improved product quality of the output. Also, less floor space and compact system are the added advantages. Existing low power microwave drying system is to be modified with suitable applicator. Appropriate sensors are to be used to measure parameters like moisture, temperature, weight of sample. Suitable high tech controller is to be used to control microwave power continuously from minimum to maximum. Phase - controller, cycle - controller and PWM - controller are some of the advanced power control techniques. It has been proposed to work on turmeric using high-tech phase controller to control the microwave power conveniently. The drying of turmeric with microwave energy employing phase controller gives better results as formulated in this paper and hence new approach of processing turmeric will open future doors of profit making to allied industries and the farmers.