Abstract: Mycophenolic acid (MPA) is a secondary metabolite
produced by Penicillium brevicompactum, which has antibiotic and
immunosuppressive properties. In this study, the first, mycophenolic
acid was produced in a fermentation process by Penicillium
brevicompactum MUCL 19011 in shake flask using a base medium.
The maximum MPA production, product yield and productivity of
process were 1.379 g/L, 18.6 mg/g glucose and 4.9 mg/L. h,
respectively. Also the glucose consumption, biomass and MPA
production profiles were investigated during batch cultivation.
Obtained results showed that MPA production starts approximately
after 180 hours and reaches to a maximum at 280 h. In the next step,
the effects of some various concentrations of enzymatically
hydrolyzed casein on MPA production were evaluated. Maximum
MPA production, product yield and productivity as 3.63 g/L, 49
mg/g glucose and 12.96 mg/L.h, respectively were obtained with
using 30 g/L enzymatically hydrolyzed casein in culture medium.
These values show an enhanced MPA production, product yield and
process productivity pr as 116.8%, 132.8% and 163.2%, respectively.
Abstract: This paper aims to present the design, fabrication and test of a novel piezoelectric actuated, check-valves embedded micropump having the advantages of miniature size, light weight and low power consumption. This device is designed to pump gases and liquids with the capability of performing the self-priming and bubble-tolerant work mode by maximizing the stroke volume of the membrane as well as the compression ratio via minimization of the dead volume of the micropump chamber and channel. By experiment apparatus setup, we can get the real-time values of the flow rate of micropump, the displacement of the piezoelectric actuator and the deformation of the check valve, simultaneously. The micropump with check valve 0.4 mm in thickness obtained higher output performance under the sinusoidal waveform of 120 Vpp. The micropump achieved the maximum pumping rates of 42.2 ml/min and back pressure of 14.0 kPa at the corresponding frequency of 28 and 20 Hz. The presented micropump is able to pump gases with a pumping rate of 196 ml/min at operating frequencies of 280 Hz under the sinusoidal waveform of 120 Vpp.
Abstract: At present the process of formation of corporate
values in Kazakh universities is under the influence of a whole range
of socio-economic and cultural changes: on the one hand universities
must maintain and transmit traditional cultural values of education,
on the other, to improve quality of service and to involve young
people to science, providing thus own competitiveness. Thus, this
article presents some results of two cycles of sociological research
conducted in 2012 and aimed at identifying possible ways to
popularize science and readiness to participate of youth in given
activities, expectations of young scientists and the prospects of future
development of the Kazakh science.
Abstract: Finding suitable non-supersingular elliptic curves for
pairing-based cryptosystems becomes an important issue for the
modern public-key cryptography after the proposition of id-based
encryption scheme and short signature scheme. In previous work
different algorithms have been proposed for finding such elliptic
curves when embedding degree k ∈ {3, 4, 6} and cofactor h ∈ {1, 2, 3,
4, 5}. In this paper a new method is presented to find more
non-supersingular elliptic curves for pairing-based cryptosystems with
general embedding degree k and large values of cofactor h. In
addition, some effective parameters of these non-supersingular elliptic
curves are provided in this paper.
Abstract: The technique of k-anonymization has been proposed to obfuscate private data through associating it with at least k identities. This paper investigates the basic tabular structures that
underline the notion of k-anonymization using cell suppression.
These structures are studied under idealized conditions to identify the
essential features of the k-anonymization notion. We optimize data kanonymization
through requiring a minimum number of anonymized
values that are balanced over all columns and rows. We study the
relationship between the sizes of the anonymized tables, the value k, and the number of attributes. This study has a theoretical value through contributing to develop a mathematical foundation of the kanonymization
concept. Its practical significance is still to be
investigated.
Abstract: Inferring the network structure from time series data
is a hard problem, especially if the time series is short and noisy.
DNA microarray is a technology allowing to monitor the mRNA
concentration of thousands of genes simultaneously that produces
data of these characteristics. In this study we try to investigate the
influence of the experimental design on the quality of the result.
More precisely, we investigate the influence of two different types of
random single gene perturbations on the inference of genetic networks
from time series data. To obtain an objective quality measure for
this influence we simulate gene expression values with a biologically
plausible model of a known network structure. Within this framework
we study the influence of single gene knock-outs in opposite to
linearly controlled expression for single genes on the quality of the
infered network structure.
Abstract: Researches on the general rules of temperature field
changing and their effects on the bridge in construction are necessary.
This paper investigated the rules of temperature field changing and its
effects on bridge using onsite measurement and computational
analysis. Guanyinsha Bridge was used as a case study in this research.
The temperature field was simulated in analyses. The effects of certain
boundary conditions such as sun radiance, wind speed, and model
parameters such as heat factor and specific heat on temperature field
are investigated. Recommended values for these parameters are
proposed. The simulated temperature field matches the measured
observations with high accuracy. At the same time, the stresses and
deflections of the bridge computed with the simulated temperature
field matches measured values too. As a conclusion, the temperature
effect analysis of reinforced concrete box girder can be conducted
directly based on the reliable weather data of the concerned area.
Abstract: Higher education has an important role to play in
advocating environmentalism. Given this responsibility, the goal of
higher education should therefore be to develop graduates with the
knowledge, skills and values related to environmentalism. However,
research indicates that there is a lack of consciousness amongst
graduates on the need to be more environmentally aware, especially
when it comes to applying the appropriate knowledge and skills
related to environmentalism. Although institutions of higher learning
do include environmental parameters within their undergraduate and
postgraduate academic programme structures, the environmental
boundaries are usually confined to specific engineering majors within
an engineering programme. This makes environmental knowledge,
skills and values exclusive to certain quarters of the higher education
system. The incorporation of environmental literacy within higher
education institutions as a whole is of utmost pertinence if a nation-s
human capital is to be nurtured to become change agents for the
preservation of environment. This paper discusses approaches that
can be adapted by institutions of higher learning to include
environmental literacy within the graduate-s higher learning
experience.
Abstract: Evapotranspiration (ET) is a major component of the hydrologic cycle and its accurate estimation is essential for hydrological studies. In past, various estimation methods have been developed for different climatological data, and the accuracy of these methods varies with climatic conditions. Reference crop evapotranspiration (ET0) is a key variable in procedures established for estimating evapotranspiration rates of agricultural crops. Values of ET0 are used with crop coefficients for many aspects of irrigation and water resources planning and management. Numerous methods are used for estimating ET0. As per internationally accepted procedures outlined in the United Nations Food and Agriculture Organization-s Irrigation and Drainage Paper No. 56(FAO-56), use of Penman-Monteith equation is recommended for computing ET0 from ground based climatological observations. In the present study, seven methods have been selected for performance evaluation. User friendly software has been developed using programming language visual basic. The visual basic has ability to create graphical environment using less coding. For given data availability the developed software estimates reference evapotranspiration for any given area and period for which data is available. The accuracy of the software has been checked by the examples given in FAO-56.The developed software is a user friendly tool for estimating ET0 under different data availability and climatic conditions.
Abstract: The objective of this study is to present the test
results of variable air volume (VAV) air conditioning system
optimized by two objective genetic algorithm (GA). The objective
functions are energy savings and thermal comfort. The optimal set
points for fuzzy logic controller (FLC) are the supply air temperature
(Ts), the supply duct static pressure (Ps), the chilled water
temperature (Tw), and zone temperature (Tz) that is taken as the
problem variables. Supply airflow rate and chilled water flow rate are
considered to be the constraints. The optimal set point values are
obtained from GA process and assigned into fuzzy logic controller
(FLC) in order to conserve energy and maintain thermal comfort in
real time VAV air conditioning system. A VAV air conditioning
system with FLC installed in a software laboratory has been taken for
the purpose of energy analysis. The total energy saving obtained in
VAV GA optimization system with FLC compared with constant air
volume (CAV) system is expected to achieve 31.5%. The optimal
duct static pressure obtained through Genetic fuzzy methodology
attributes to better air distribution by delivering the optimal quantity
of supply air to the conditioned space. This combination enhanced
the advantages of uniform air distribution, thermal comfort and
improved energy savings potential.
Abstract: The African Great Lakes Region refers to the zone
around lakes Victoria, Tanganyika, Albert, Edward, Kivu, and
Malawi. The main source of electricity in this region is hydropower
whose systems are generally characterized by relatively weak,
isolated power schemes, poor maintenance and technical deficiencies
with limited electricity infrastructures. Most of the hydro sources are
rain fed, and as such there is normally a deficiency of water during
the dry seasons and extended droughts. In such calamities fossil fuels
sources, in particular petroleum products and natural gas, are
normally used to rescue the situation but apart from them being nonrenewable,
they also release huge amount of green house gases to our
environment which in turn accelerates the global warming that has at
present reached an amazing stage. Wind power is ample, renewable,
widely distributed, clean, and free energy source that does not
consume or pollute water. Wind generated electricity is one of the
most practical and commercially viable option for grid quality and
utility scale electricity production. However, the main shortcoming
associated with electric wind power generation is fluctuation in its
output both in space and time. Before making a decision to establish
a wind park at a site, the wind speed features there should therefore
be known thoroughly as well as local demand or transmission
capacity. The main objective of this paper is to utilise monthly
average wind speed data collected from one prospective site within
the African Great Lakes Region to demonstrate that the available
wind power there is high enough to generate electricity. The mean
monthly values were calculated from records gathered on hourly
basis for a period of 5 years (2001 to 2005) from a site in Tanzania.
The documentations that were collected at a height of 2 m were
projected to a height of 50 m which is the standard hub height of
wind turbines. The overall monthly average wind speed was found to
be 12.11 m/s whereas June to November was established to be the
windy season as the wind speed during the session is above the
overall monthly wind speed. The available wind power density
corresponding to the overall mean monthly wind speed was evaluated
to be 1072 W/m2, a potential that is worthwhile harvesting for the
purpose of electric generation.
Abstract: This paper investigates the impact of the hand-hold
positions on both antenna performance and the specific absorption
rate (SAR) induced in the user-s head. A cellular handset with
external antenna operating at GSM-900 frequency is modeled and
simulated using a finite difference time-domain (FDTD)-based
platform SEMCAD-X. A specific anthropomorphic mannequin
(SAM) is adopted to simulate the user-s head, whereas a semirealistic
CAD-model of three-tissues is designed to simulate the
user-s hand. The results show that in case of the handset in hand close
to head at different positions; the antenna total efficiency gets
reduced to (14.5% - 5.9%) at cheek-position and to (27.5% to 11.8%)
at tilt-position. The peak averaged SAR1g values in head close to
handset without hand, are 4.67 W/Kg and 2.66 W/Kg at cheek and
tilt-position, respectively. Due to the presence of hand, the SAR1g in
head gets reduced to (3.67-3.31 W/Kg) at cheek-position and to
(1.84-1.64 W/Kg) at tilt-position, depending on the hand-hold
position.
Abstract: A statistical optimization was studied to design a media composition to produce optimum cellulolytic enzyme where palm oil mill effluent (POME) as a basal medium and filamentous fungus, Trichoderma reesei RUT-C30 were used in the liquid state bioconversion(LSB). 2% (w/v) total suspended solid, TSS, of the POME supplemented with 1% (w/v) cellulose, 0.5%(w/v) peptone and 0.02% (v/v) Tween 80 was estimated to produce the optimum CMCase activity of 18.53 U/ml through the statistical analysis followed by the faced centered central composite design(FCCCD). The probability values of cellulose (
Abstract: A new design approach for three-stage operational
amplifiers (op-amps) is proposed. It allows to actually implement a
symmetrical push-pull class-AB amplifier output stage for wellestablished
three-stage amplifiers using a feedforward
transconductance stage. Compared with the conventional design
practice, the proposed approach leads to a significant
improvement of the symmetry between the positive and the
negative op-amp step response, resulting in similar values of the
positive/negative settling time. The new approach proves to be very
useful in order to fully exploit the potentiality allowed by the op-amp
in terms of speed performances. Design examples in a commercial
0.35-μm CMOS prove the effectiveness of theproposed strategy.
Abstract: In data mining, the association rules are used to search
for the relations of items of the transactions database. Following the
data is collected and stored, it can find rules of value through
association rules, and assist manager to proceed marketing strategy
and plan market framework. In this paper, we attempt fuzzy partition
methods and decide membership function of quantitative values of
each transaction item. Also, by managers we can reflect the
importance of items as linguistic terms, which are transformed as
fuzzy sets of weights. Next, fuzzy weighted frequent pattern growth
(FWFP-Growth) is used to complete the process of data mining. The
method above is expected to improve Apriori algorithm for its better
efficiency of the whole association rules. An example is given to
clearly illustrate the proposed approach.
Abstract: HIV-1 genome is highly heterogeneous. Due to this
variation, features of HIV-I genome is in a wide range. For this
reason, the ability to infection of the virus changes depending on
different chemokine receptors. From this point of view, R5 HIV
viruses use CCR5 coreceptor while X4 viruses use CXCR5 and
R5X4 viruses can utilize both coreceptors. Recently, in
Bioinformatics, R5X4 viruses have been studied to classify by using
the experiments on HIV-1 genome.
In this study, R5X4 type of HIV viruses were classified using
Auto Regressive (AR) model through Artificial Neural Networks
(ANNs). The statistical data of R5X4, R5 and X4 viruses was
analyzed by using signal processing methods and ANNs. Accessible
residues of these virus sequences were obtained and modeled by AR
model since the dimension of residues is large and different from
each other. Finally the pre-processed data was used to evolve various
ANN structures for determining R5X4 viruses. Furthermore ROC
analysis was applied to ANNs to show their real performances. The
results indicate that R5X4 viruses successfully classified with high
sensitivity and specificity values training and testing ROC analysis
for RBF, which gives the best performance among ANN structures.
Abstract: The fluid flow and the properties of the hydraulic
fluid inside a torque converter are the main topics of interest in this
research. The primary goal is to investigate the applicability of
various viscous fluids inside the torque converter. The Taguchi
optimization method is adopted to analyse the fluid flow in a torque
converter from a design perspective. Calculations are conducted in
maximizing the pressure since greater the pressure, greater the torque
developed. Using the values of the S/N ratios obtained, graphs are
plotted. Computational Fluid Dynamics (CFD) analysis is also
conducted.
Abstract: Severe heart failure is a common problem that has a significant effect on health expenditures in industrialized countries; moreover it reduces patient-s quality of life. However, current research usually focuses either on detailed modeling of the heart or on detailed modeling of the cardiovascular system. Thus, this paper aims to present a sophisticated model of the heart enhanced with an extensive model of the cardiovascular system. Special interest is on the pressure and flow values close to the heart since these values are critical to accurately diagnose causes of heart failure. The model is implemented in Dymola an object-oriented, physical modeling language. Results achieved with the novel model show overall feasibility of the approach. Moreover, results are illustrated and compared to other models. The novel model shows significant improvements.
Abstract: Severe acute respiratory syndrome (SARS) is a respiratory disease in humans which is caused by the SARS coronavirus. The treatment of coronavirus-associated SARS has been evolving and so far there is no consensus on an optimal regimen. The mainstream therapeutic interventions for SARS involve broad-spectrum antibiotics and supportive care, as well as antiviral agents and immunomodulatory therapy. The Protein- Ligand interaction plays a significant role in structural based drug designing. In the present work we have taken the receptor Angiotensin converting enzyme 2 and identified the drugs that are commonly used against SARS. They are Lopinavir, Ritonavir, Ribavirin, and Oseltamivir. The receptor Angiotensin converting enzyme 2 (ACE-2) was docked with above said drugs and the energy value obtained are as follows, Lopinavir (-292.3), Ritonavir (-325.6), Oseltamivir (- 229.1), Ribavirin (-208.8). Depending on the least energy value we have chosen the best two drugs out of the four conventional drugs. We tried to improve the binding efficiency and steric compatibility of the two drugs namely Ritonavir and Lopinavir. Several modifications were made to the probable functional groups (phenylic, ketonic groups in case of Ritonavir and carboxylic groups in case of Lopinavir respectively) which were interacting with the receptor molecule. Analogs were prepared by Marvin Sketch software and were docked using HEX docking software. Lopinavir analog 8 and Ritonavir analog 11 were detected with significant energy values and are probable lead molecule. It infers that some of the modified drugs are better than the original drugs. Further work can be carried out to improve the steric compatibility of the drug based upon the work done above for a more energy efficient binding of the drugs to the receptor.
Abstract: This paper deals with modeling and parameter
identification of nonlinear systems described by Hammerstein model
having Piecewise nonlinear characteristics such as Dead-zone
nonlinearity characteristic. The simultaneous use of both an easy
decomposition technique and the triangular basis functions leads to a
particular form of Hammerstein model. The approximation by using
Triangular basis functions for the description of the static nonlinear
block conducts to a linear regressor model, so that least squares
techniques can be used for the parameter estimation. Singular Values
Decomposition (SVD) technique has been applied to separate the
coupled parameters. The proposed approach has been efficiently
tested on academic examples of simulation.