Abstract: Semiconductor nanomaterials like TiO2 nanoparticles
(TiO2-NPs) approximately less than 100 nm in diameter have become
a new generation of advanced materials due to their novel and
interesting optical, dielectric, and photo-catalytic properties. With the
increasing use of NPs in commerce, to date few studies have
investigated the toxicological and environmental effects of NPs.
Motivated by the importance of TiO2-NPs that may contribute to the
cancer research field especially from the treatment prospective
together with the fractal analysis technique, we have investigated the
effect of TiO2-NPs on colony morphology in the dark condition
using fractal dimension as a key morphological characterization
parameter. The aim of this work is mainly to investigate the cytotoxic
effects of TiO2-NPs in the dark on the growth of human cervical
carcinoma (HeLa) cell colonies from morphological aspect. The in
vitro studies were carried out together with the image processing
technique and fractal analysis. It was found that, these colonies were
abnormal in shape and size. Moreover, the size of the control
colonies appeared to be larger than those of the treated group. The
mean Df +/- SEM of the colonies in untreated cultures was
1.085±0.019, N= 25, while that of the cultures treated with TiO2-NPs
was 1.287±0.045. It was found that the circularity of the control
group (0.401±0.071) is higher than that of the treated group
(0.103±0.042). The same tendency was found in the diameter
parameters which are 1161.30±219.56 μm and 852.28±206.50 μm
for the control and treated group respectively. Possible explanation of
the results was discussed, though more works need to be done in
terms of the for mechanism aspects. Finally, our results indicate that
fractal dimension can serve as a useful feature, by itself or in
conjunction with other shape features, in the classification of cancer
colonies.
Abstract: The various applications of VLSI circuits in highperformance
computing, telecommunications, and consumer
electronics has been expanding progressively, and at a very hasty
pace. This paper describes a new model for partitioning a circuit
using DBSCAN and fuzzy ARTMAP neural network. The first step
is concerned with feature extraction, where we had make use
DBSCAN algorithm. The second step is the classification and is
composed of a fuzzy ARTMAP neural network. The performance of
both approaches is compared using benchmark data provided by
MCNC standard cell placement benchmark netlists. Analysis of the
investigational results proved that the fuzzy ARTMAP with
DBSCAN model achieves greater performance then only fuzzy
ARTMAP in recognizing sub-circuits with lowest amount of
interconnections between them The recognition rate using fuzzy
ARTMAP with DBSCAN is 97.7% compared to only fuzzy
ARTMAP.
Abstract: Scaffolds play a key role in tissue engineering and can be produced in many different ways depending on the applications and the materials used. Most researchers used an experimental trialand- error approach into new biomaterials but computer simulation applied to tissue engineering can offer a more exhaustive approach to test and screen out biomaterials. This paper develops the model of scaffolds and Computational Fluid Dynamics that show the value of computer simulations in determining the influence of the geometrical scaffold parameter porosity, pore size and shape on the permeability of scaffolds, magnitude of velocity, drop pressure, shear stress distribution and level and the proper design of the geometry of the scaffold. This creates a need for more advanced studies that include aspects of dynamic conditions of a micro fluid passing through the scaffold were characterized for tissue engineering applications and differentiation of tissues within scaffolds.
Abstract: Dietary macro and micro nutrients in their respective proportion and fractions present a practical potential tool to fabricate milk constituents since cells of lactating mammary glands obtain about 80 % of milk synthesis nutrients from blood, reflecting the existence of an isotonic equilibrium between blood and milk. Diverting milk biosynthetic activities through manipulation of nutrients towards producing milk not only keeping in view its significance as natural food but also as food item which prevents or dilutes the adverse effects of some diseases (like cardiovascular problem by saturated milk fat intake) has been area of interest in the last decade. Nutritional modification / supplementation has been reported to enhance conjugated linoleic acid, fatty acid type and concentration, essential fatty acid concentration, vitamin B12& C, Se, Cu, I and Fe which are involved to counter the health threats to human well being. Synchronizing dietary nutrients aimed to modify rumen dynamics towards synthesis of nutrients or their precursors to make their drive towards formulated milk constituents presents a practical option. Formulating dietary constituents to design milk constituents will let the farmers, consumers and investors know about the real potential and profit margins associated with this enterprise. This article briefly recapitulates the ways and means to modify milk constituents keeping an eye on human health and well being issues, which allows milk to serve more than a food item.
Abstract: In this paper, a simple heuristic genetic algorithm is
used for Multistage Multiuser detection in fast fading environments.
Multipath channels, multiple access interference (MAI) and near far
effect cause the performance of the conventional detector to degrade.
Heuristic Genetic algorithms, a rapidly growing area of artificial
intelligence, uses evolutionary programming for initial search, which
not only helps to converge the solution towards near optimal
performance efficiently but also at a very low complexity as
compared with optimal detector. This holds true for Additive White
Gaussian Noise (AWGN) and multipath fading channels.
Experimental results are presented to show the superior performance
of the proposed techque over the existing methods.
Abstract: Complex assemblies of interacting proteins carry out
most of the interesting jobs in a cell, such as metabolism, DNA
synthesis, mitosis and cell division. These physiological properties
play out as a subtle molecular dance, choreographed by underlying
regulatory networks that control the activities of cyclin-dependent
kinases (CDK). The network can be modeled by a set of nonlinear
differential equations and its behavior predicted by numerical
simulation. In this paper, an innovative approach has been proposed
that uses genetic algorithms to mine a set of behavior data output by
a biological system in order to determine the kinetic parameters of
the system. In our approach, the machine learning method is
integrated with the framework of existent biological information in a
wiring diagram so that its findings are expressed in a form of system
dynamic behavior. By numerical simulations it has been illustrated
that the model is consistent with experiments and successfully shown
that such application of genetic algorithms will highly improve the
performance of mathematical model of the cell division cycle to
simulate such a complicated bio-system.
Abstract: The issue of real-time and reliable report delivery is extremely important for taking effective decision in a real world mission critical Wireless Sensor Network (WSN) based application. The sensor data behaves differently in many ways from the data in traditional databases. WSNs need a mechanism to register, process queries, and disseminate data. In this paper we propose an architectural framework for data placement and management. We propose a reliable and real time approach for data placement and achieving data integrity using self organized sensor clusters. Instead of storing information in individual cluster heads as suggested in some protocols, in our architecture we suggest storing of information of all clusters within a cell in the corresponding base station. For data dissemination and action in the wireless sensor network we propose to use Action and Relay Stations (ARS). To reduce average energy dissipation of sensor nodes, the data is sent to the nearest ARS rather than base station. We have designed our architecture in such a way so as to achieve greater energy savings, enhanced availability and reliability.
Abstract: In this study rack systems that are structural storage
units of warehouses have been analyzed as structural with Finite
Element Method (FEA). Each cell of discussed rack system storages
pallets which have from 800 kg to 1000 kg weights and
0.80x1.15x1.50 m dimensions. Under this load, total deformations
and equivalent stresses of structural elements and principal stresses,
tensile stresses and shear stresses of connection elements have been
analyzed. The results of analyses have been evaluated according to
resistance limits of structural and connection elements. Obtained
results have been presented as visual and magnitude.
Abstract: In vitro gastro-duodenal digestion model was used to investigate the changes of emulsions under digestion conditions. Oil in water emulsions stabilized by whey proteins (2%) and stabilized by whey proteins (2%) with addition of carboxymethyl cellulose (0.75%) as gelling agent of continuous phase were prepared at pH7. Both emulsions were destabilized under gastric conditions; however the protective role of carboxymethyl cellulose was indicated by recording delay of fat digestibility of this emulsion. In the presence of carboxymethyl cellulose whey proteins on the interfacial surface of droplets were more resistant to gastric degradation causing limited hydrolysis of fat due to the poor acceptability of lipids for the enzymes. Studies of emulsions using in vivo model supported results from in vitro studies. Lower content of triglycerides in blood serum and higher amount of fecal fat of rats were determined when rats were fed by diet containing emulsion made with whey proteins and carboxymethyl cellulose.
Abstract: Mutations of the telomeric copy of the survival motor neuron 1 (SMN1) gene cause spinal muscular atrophy. A deletion of the Eef1a2 gene leads to lower motor neuron degeneration in wasted mice. Indirect evidences have been shown that the eEF1A protein family may interact with SMN, and our previous study showed that abnormalities of neuromuscular junctions in wasted mice were similar to those of Smn mutant mice. To determine potential colocalization between SMN and tissue-specific translation elongation factor 1A2 (eEF1A2), an immunochemical analysis of HeLa cells transfected with the plasmid pcDNA3.1(+)C-hEEF1A2- myc and a new quantitative test of colocalization by intensity correlation analysis (ICA) was used to explore the association of SMN and eEF1A2. Here the results showed that eEF1A2 redistributed from the cytoplasm to the nucleus in response to serum and epidermal growth factor. In the cytoplasm, compelling evidence showed that staining for myc-tagged eEF1A2 varied in synchrony with that for SMN, consistent with the formation of a SMN-eEF1A2 complex in the cytoplasm of HeLa cells. These findings suggest that eEF1A2 may colocalize with SMN in the cytoplasm and may be a component of the SMN complex. However, the limitation of the ICA method is an inability to resolve colocalization in components of small organelles such as the nucleus.
Abstract: Relevant agricultural information disseminator
(extension agent) ratio of 1:3500 farm families which become a
menace to agricultural production capacity in developing countries
necessitate this study. Out of 4 zones in the state, 24 extension agents
in each zone, 4 extension agents using cell phones and 120 farmers
using cell phone and 120 other farmers not using cell phone were
purposively selected to give 240 farmers that participated in the
research. Data were collected using interview guide and analysized
using frequency, percentage and t-test.. Frequency of contact with
agricultural information centers revealed that cell phone user farmers
had greater means score of X 41.43 contact as against the low mean
X19.32 contact recorded by farmers receiving agricultural
information from extension agents not using cell phone and their
production was statistically significant at P < 0.05. Usage of cell
phone increase extension agent contact and increase farmers-
production capacity.
Abstract: As the fossil fuels kept on depleting, intense research in developing hydrogen (H2) as the alternative fuel has been done to cater our tremendous demand for fuel. The potential of H2 as the ultimate clean fuel differs with the fossil fuel that releases significant amounts of carbon dioxide (CO2) into the surrounding and leads to the global warming. The experimental work was carried out to study the production of H2 from palm kernel shell steam gasification at different variables such as heating rate, steam to biomass ratio and adsorbent to biomass ratio. Maximum H2 composition which is 61% (volume basis) was obtained at heating rate of 100oCmin-1, steam/biomass of 2:1 ratio, and adsorbent/biomass of 1:1 ratio. The commercial adsorbent had been modified by utilizing the alcoholwater mixture. Characteristics of both adsorbents were investigated and it is concluded that flowability and floodability of modified CaO is significantly improved.
Abstract: A study was carried out to determine the effect of water quality on flotation performance. The experimental test work comprised of batch flotation tests using Denver lab cell for a period of 10 minutes. Nine different test runs were carried out in triplicates to ensure reproducibility using different water types from different thickener overflows, return and sewage effluent water (process water) and portable water. The water sources differed in pH, total dissolved solids, total suspended solids and conductivity. Process water was found to reduce the concentrate recovery and mass pull, while portable water increased the concentrate recovery and mass pull. Portable water reduced the concentrate grade while process water increased the concentrate grade. It is proposed that a combination of process water and portable water supply be used in flotation circuits to balance the different effects that the different water types have on the flotation efficiency.
Abstract: Structural representation and technology mapping of
a Boolean function is an important problem in the design of nonregenerative
digital logic circuits (also called combinational logic
circuits). Library aware function manipulation offers a solution to
this problem. Compact multi-level representation of binary networks,
based on simple circuit structures, such as AND-Inverter Graphs
(AIG) [1] [5], NAND Graphs, OR-Inverter Graphs (OIG), AND-OR
Graphs (AOG), AND-OR-Inverter Graphs (AOIG), AND-XORInverter
Graphs, Reduced Boolean Circuits [8] does exist in
literature. In this work, we discuss a novel and efficient graph
realization for combinational logic circuits, represented using a
NAND-NOR-Inverter Graph (NNIG), which is composed of only
two-input NAND (NAND2), NOR (NOR2) and inverter (INV) cells.
The networks are constructed on the basis of irredundant disjunctive
and conjunctive normal forms, after factoring, comprising terms with
minimum support. Construction of a NNIG for a non-regenerative
function in normal form would be straightforward, whereas for the
complementary phase, it would be developed by considering a virtual
instance of the function. However, the choice of best NNIG for a
given function would be based upon literal count, cell count and
DAG node count of the implementation at the technology
independent stage. In case of a tie, the final decision would be made
after extracting the physical design parameters.
We have considered AIG representation for reduced disjunctive
normal form and the best of OIG/AOG/AOIG for the minimized
conjunctive normal forms. This is necessitated due to the nature of
certain functions, such as Achilles- heel functions. NNIGs are found
to exhibit 3.97% lesser node count compared to AIGs and
OIG/AOG/AOIGs; consume 23.74% and 10.79% lesser library cells
than AIGs and OIG/AOG/AOIGs for the various samples considered.
We compare the power efficiency and delay improvement achieved
by optimal NNIGs over minimal AIGs and OIG/AOG/AOIGs for
various case studies. In comparison with functionally equivalent,
irredundant and compact AIGs, NNIGs report mean savings in power
and delay of 43.71% and 25.85% respectively, after technology
mapping with a 0.35 micron TSMC CMOS process. For a
comparison with OIG/AOG/AOIGs, NNIGs demonstrate average
savings in power and delay by 47.51% and 24.83%. With respect to
device count needed for implementation with static CMOS logic
style, NNIGs utilize 37.85% and 33.95% lesser transistors than their
AIG and OIG/AOG/AOIG counterparts.
Abstract: Transpedicular screw fixation in spinal fractures,
degenerative changes, or deformities is a well-established procedure.
However, important rate of fixation failure due to screw bending,
loosening, or pullout are still reported particularly in weak bone stock
in osteoporosis. To overcome the problem, mechanism of failure has
to be fully investigated in vitro. Post-mortem human subjects are less
accessible and animal cadavers comprise limitations due to different
geometry and mechanical properties. Therefore, the development of a
synthetic model mimicking the realistic human vertebra is highly
demanded. A bone surrogate, composed of Polyurethane (PU) foam
analogous to cancellous bone porous structure, was tested for 3
different densities in this study. The mechanical properties were
investigated under uniaxial compression test by minimizing the end
artifacts on specimens. The results indicated that PU foam of 0.32
g.cm-3 density has comparable mechanical properties to human
cancellous bone in terms of young-s modulus and yield strength.
Therefore, the obtained information can be considered as primary
step for developing a realistic cancellous bone of human vertebral
body. Further evaluations are also recommended for other density
groups.
Abstract: In this paper, we have proposed a novel FinFET with
extended body under the poly gate, which is called EB-FinFET, and
its characteristic is demonstrated by using three-dimensional (3-D)
numerical simulation. We have analyzed and compared it with
conventional FinFET. The extended body height dependence on the
drain induced barrier lowering (DIBL) and subthreshold swing (S.S)
have been also investigated. According to the 3-D numerical
simulation, the proposed structure has a firm structure, an acceptable
short channel effect (SCE), a reduced series resistance, an increased
on state drain current (I
on) and a large normalized I
DS. Furthermore,
the structure can also improve corner effect and reduce self-heating
effect due to the extended body. Our results show that the EBFinFET
is excellent for nanoscale device.
Abstract: Hydrogen is considered to be the most promising
candidate as a future energy carrier. One of the most used
technologies for the electrolytic hydrogen production is alkaline
water electrolysis. However, due to the high energy requirements, the
cost of hydrogen produced in such a way is high. In continuous
search to improve this process using advanced electrocatalytic
materials for the hydrogen evolution reaction (HER), Ni type Raney
and macro-porous Ni-Co electrodes were prepared on AISI 304
stainless steel substrates by electrodeposition. The developed
electrodes were characterized by SEM and confocal laser scanning
microscopy. HER on these electrodes was evaluated in 30 wt.% KOH
solution by means of hydrogen discharge curves and galvanostatic
tests. Results show that the developed electrodes present a most
efficient behaviour for HER when comparing with the smooth Ni
cathode. It has been reported a reduction in the energy consumption
of the electrolysis cell of about 25% by using the developed coatings
as cathodes.
Abstract: This paper presents an equivalent circuit model based on piecewise linear parallel branches (PLPB) to study solar cell modules which are partially shaded. The PLPB model can easily be used in circuit simulation software such as the ElectroMagnetic Transients Program (EMTP). This PLPB model allows the user to simulate several different configurations of solar cells, the influence of partial shadowing on a single or multiple cells, the influence of the number of solar cells protected by a bypass diode and the effect of the cell connection configuration on partial shadowing.
Abstract: The inhibition effect of brazilin to human bladder
tumor cell line T24 in vitro and in vivo was studied. The results of the
in vitro experiments showed that brazilin has strong inhibition activity
on the target cells. The inhibition ratio of 100 μg/mL brazilin and 100
μg/mL mitomycin to the target cells was 90.90 % and 63.24 %
respectively, which showed that brazilin has higher inhibition activity
than mitomycin under the same concentration. Brazilin could induce
cell apoptosis in T24 cells. Significant antitumor activity of brazilin
was also showed in the animals experiments. The life extention rate of
200 mg/mL, 300 mg/kg, and 400 mg/kg brazilin intraperitoneally
injected into Balb/c-nu-nu nude mice that with human bladder cancer
were 51.50 %, 56.90 %, and 58.42 %（P
Abstract: This study describes a micro device integrated with
multi-chamber for polymerase chain reaction (PCR) with different
annealing temperatures. The device consists of the reaction
polydimethylsiloxane (PDMS) chip, a cover glass chip, and is
equipped with cartridge heaters, fans, and thermocouples for
temperature control. In this prototype, commercial software is utilized
to determine the geometric and operational parameters those are
responsible for creating the denaturation, annealing, and extension
temperatures within the chip. Two cartridge heaters are placed at two
sides of the chip and maintained at two different temperatures to
achieve a thermal gradient on the chip during the annealing step. The
temperatures on the chip surface are measured via an infrared imager.
Some thermocouples inserted into the reaction chambers are used to
obtain the transient temperature profiles of the reaction chambers
during several thermal cycles. The experimental temperatures
compared to the simulated results show a similar trend. This work
should be interesting to persons involved in the high-temperature
based reactions and genomics or cell analysis.