Abstract: In this paper, we present user pattern learning
algorithm based MDSS (Medical Decision support system) under
ubiquitous. Most of researches are focus on hardware system, hospital
management and whole concept of ubiquitous environment even
though it is hard to implement. Our objective of this paper is to design
a MDSS framework. It helps to patient for medical treatment and
prevention of the high risk patient (COPD, heart disease, Diabetes).
This framework consist database, CAD (Computer Aided diagnosis
support system) and CAP (computer aided user vital sign prediction
system). It can be applied to develop user pattern learning algorithm
based MDSS for homecare and silver town service. Especially this
CAD has wise decision making competency. It compares current vital
sign with user-s normal condition pattern data. In addition, the CAP
computes user vital sign prediction using past data of the patient. The
novel approach is using neural network method, wireless vital sign
acquisition devices and personal computer DB system. An intelligent
agent based MDSS will help elder people and high risk patients to
prevent sudden death and disease, the physician to get the online
access to patients- data, the plan of medication service priority (e.g.
emergency case).
Abstract: 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) catalyzes the conversion of HMG-CoA to mevalonate using NADPH and the enzyme is involved in rate-controlling step of mevalonate. Inhibition of HMGR is considered as effective way to lower cholesterol levels so it is drug target to treat hypercholesterolemia, major risk factor of cardiovascular disease. To discover novel HMGR inhibitor, we performed structure-based pharmacophore modeling combined with molecular dynamics (MD) simulation. Four HMGR inhibitors were used for MD simulation and representative structure of each simulation were selected by clustering analysis. Four structure-based pharmacophore models were generated using the representative structure. The generated models were validated used in virtual screening to find novel scaffolds for inhibiting HMGR. The screened compounds were filtered by applying drug-like properties and used in molecular docking. Finally, four hit compounds were obtained and these complexes were refined using energy minimization. These compounds might be potential leads to design novel HMGR inhibitor.
Abstract: Mathematical programming has been applied to various
problems. For many actual problems, the assumption that the parameters
involved are deterministic known data is often unjustified. In
such cases, these data contain uncertainty and are thus represented
as random variables, since they represent information about the
future. Decision-making under uncertainty involves potential risk.
Stochastic programming is a commonly used method for optimization
under uncertainty. A stochastic programming problem with recourse
is referred to as a two-stage stochastic problem. In this study, we
consider a stochastic programming problem with simple integer
recourse in which the value of the recourse variable is restricted to a
multiple of a nonnegative integer. The algorithm of a dynamic slope
scaling procedure for solving this problem is developed by using a
property of the expected recourse function. Numerical experiments
demonstrate that the proposed algorithm is quite efficient. The
stochastic programming model defined in this paper is quite useful
for a variety of design and operational problems.
Abstract: In this paper, we discuss the paradigm shift in bank
capital from the “gone concern" to the “going concern" mindset. We
then propose a methodology for pricing a product of this shift called
Contingent Capital Notes (“CoCos"). The Merton Model can
determine a price for credit risk by using the firm-s equity value as a
call option on those assets. Our pricing methodology for CoCos also
uses the credit spread implied by the Merton Model in a subsequent
derivative form created by John Hull et al . Here, a market implied
asset volatility is calculated by using observed market CDS spreads.
This implied asset volatility is then used to estimate the probability of
triggering a predetermined “contingency event" given the distanceto-
trigger (DTT). The paper then investigates the effect of varying
DTTs and recovery assumptions on the CoCo yield. We conclude
with an investment rationale.
Abstract: Due to today-s fierce competition, companies have to
be proactive creators of the future by effectively developing
innovations. Especially radical innovations allow high profit margins
– but they also entail high risks. One possibility to realize radical
innovations and reduce the risk of failure is cross-industry innovation
(CII). CII brings together problems and solution ideas from different
industries. However, there is a lack of systematic ways towards CII.
Bridging this gap, the present paper provides a systematic approach
towards planned CII. Starting with the analysis of potentials, the
definition of promising search strategies is crucial. Subsequently,
identified solution ideas need to be assessed. For the most promising
ones, the adaption process has to be systematically planned –
regarding the risk affinity of a company. The introduced method is
explained on a project from the furniture industry.
Abstract: The trends of design and development of information systems have undergone a variety of ongoing phases and stages. These variations have been evolved due to brisk changes in user requirements and business needs. To meet these requirements and needs, a flexible and agile business solution was required to come up with the latest business trends and styles. Another obstacle in agility of information systems was typically different treatment of same diseases of two patients: business processes and information services. After the emergence of information technology, the business processes and information systems have become counterparts. But these two business halves have been treated under totally different standards. There is need to streamline the boundaries of these both pillars that are equally sharing information system's burdens and liabilities. In last decade, the object orientation has evolved into one of the major solutions for modern business needs and now, SOA is the solution to shift business on ranks of electronic platform. BPM is another modern business solution that assists to regularize optimization of business processes. This paper discusses how object orientation can be conformed to incorporate or embed SOA in BPM for improved information systems.
Abstract: Every organization is continually subject to new damages and threats which can be resulted from their operations or their goal accomplishment. Methods of providing the security of space and applied tools have been widely changed with increasing application and development of information technology (IT). From this viewpoint, information security management systems were evolved to construct and prevent reiterating the experienced methods. In general, the correct response in information security management systems requires correct decision making, which in turn requires the comprehensive effort of managers and everyone involved in each plan or decision making. Obviously, all aspects of work or decision are not defined in all decision making conditions; therefore, the possible or certain risks should be considered when making decisions. This is the subject of risk management and it can influence the decisions. Investigation of different approaches in the field of risk management demonstrates their progress from quantitative to qualitative methods with a process approach.
Abstract: Urban disaster risks and vulnerabilities are great problems for Turkey. The annual loss of life and property through disaster in the world-s major metropolitan areas is increasing. Urban concentrations of the poor and less-informed in environmentally fragile locations suffer the impact of disaster disproportionately. Gecekondu (squatter) developments will compound the inherent risks associated with high-density environments, in appropriate technologies, and inadequate infrastructure. On the other hand, there are many geological disadvantages such as sitting on top of active tectonic plate boundaries, and why having avalanche, flood, and landslide and drought prone areas in Turkey. However, this natural formation is inevitable; the only way to survive in such a harsh geography is to be aware of importance of these natural events and to take political and physical measures. The main aim of this research is to bring up the magnitude of natural hazard risks in Izmir built-up zone, not being taken into consideration adequately. Because the dimensions of the peril are not taken seriously enough, the natural hazard risks, which are commonly well known, are not considered important or they are being forgotten after some time passes. Within this research, the magnitude of natural hazard risks for Izmir is being presented in the scope of concrete and local researches over Izmir risky areas.
Abstract: Nanophotocatalysts such as titanium (TiO2), zinc (ZnO), and iron (Fe2O3) oxides can be used in organic pollutants oxidation, and in many other applications. But among the challenges for technological application (scale-up) of the nanotechnology scientific developments two aspects are still little explored: research on environmental risk of the nanomaterials preparation methods, and the study of nanomaterials properties and/or performance variability. The environmental analysis was performed for six different methods of ZnO nanoparticles synthesis, and showed that it is possible to identify the more environmentally compatible process even at laboratory scale research. The obtained ZnO nanoparticles were tested as photocatalysts, and increased the degradation rate of the Rhodamine B dye up to 30 times.
Abstract: Participation in sporting activities can lead to injury.
Sport injuries have been widely studied in many sports including the
more extreme categories of aquatic board sports. Kitesurfing is a
relatively new water surface action sport, and has not yet been
widely studied in terms of injuries and stress on the body. The aim of
this study was to get information about which injuries that are most
common among kitesurfing participants, where they occur, and their
causes. Injuries were studied using an international open web
questionnaire (n=206).
The results showed that many respondents reported injuries, in
total 251 injuries to knee (24%), ankle (17%), trunk (16%) and
shoulders (10%), often sustained while doing jumps and tricks
(40%). Among the reported injuries were joint injuries (n=101),
muscle/tendon damages (n=47), wounds and cuts (n=36) and bone
fractures (n=28). Also environmental factors and equipment can
influence the risk of injury, or the extent of injury in a hazardous
situation. Conclusively, the information from this retrospective study
supports earlier studies in terms of prevalence and site of injuries.
Suggestively, this information should be used for to build a
foundation of knowledge about the sport for development of
applications for physical training and product development.
Abstract: The traditional Failure Mode and Effects Analysis
(FMEA) uses Risk Priority Number (RPN) to evaluate the risk level
of a component or process. The RPN index is determined by
calculating the product of severity, occurrence and detection indexes.
The most critically debated disadvantage of this approach is that
various sets of these three indexes may produce an identical value of
RPN. This research paper seeks to address the drawbacks in
traditional FMEA and to propose a new approach to overcome these
shortcomings. The Risk Priority Code (RPC) is used to prioritize
failure modes, when two or more failure modes have the same RPN.
A new method is proposed to prioritize failure modes, when there is a
disagreement in ranking scale for severity, occurrence and detection.
An Analysis of Variance (ANOVA) is used to compare means of
RPN values. SPSS (Statistical Package for the Social Sciences)
statistical analysis package is used to analyze the data. The results
presented are based on two case studies. It is found that the proposed
new methodology/approach resolves the limitations of traditional
FMEA approach.
Abstract: This study aims to assess the vulnerability and risk of
the coastal areas of Taijiang to abnormal oceanographic phenomena.
In addition, this study aims to investigate and collect data regarding
the disaster losses, land utilization, and other social, economic, and
environmental issues in these coastal areas to construct a coastal
vulnerability and risk map based on the obtained climate-change risk
assessment results. Considering the indexes of the three coastal
vulnerability dimensions, namely, man-made facilities, environmental
geography, and social economy, this study adopted the equal
weighting process and Analytic Hierarchy Process to analyze the
vulnerability of these coastal areas to disasters caused by climatic
changes. Among the areas with high coastal vulnerability to climatic
changes, three towns had the highest coastal vulnerability and four had
the highest relative vulnerability. Areas with lower disaster risks were
found to be increasingly vulnerable to disasters caused by climatic
changes as time progresses.
Abstract: Technical laboratories are typically considered as
highly hazardous places in the polytechnic institution when
addressing the problems of high incidences and fatality rates. In
conjunction with several topics covered in the technical curricular,
safety and health precaution should be highlighted in order to
connect to few key ideas of being safe. Therefore the assessment of
safety awareness in terms of safety and health about hazardous and
risks at laboratories is needed and has to be incorporated with
technical education and other training programmes. The purpose of
this study was to determine the efficacy of technical laboratory safety
in one of the polytechnics in northern region. The study examined
three related issues that were; the availability of safety material and
equipment, safety practice adopted by technical teachers and
administrator-s safety attitudes in enforcing safety to the students. A
model of efficacy technical laboratory was developed to test the
linear relationship between existing safety material and equipment,
teachers- safety practice and administrators- attitude in enforcing
safety and to identify which of technical laboratory safety issues was
the most pertinent factor to realize safety in technical laboratory.
This was done by analyzing survey-based data sets particularly those
obtained from samples of 210 students in the polytechnic. The
Pearson Correlation was used to measure the association between the
variables and to test the research hypotheses. The result of the study
has found that there was a significant correlation between existing
safety material and equipment, safety practice adopted by teacher
and administrator-s attitude. There was also a significant relationship
between technical laboratory safety and safety practice adopted by
teacher and between technical laboratory safety and administrator
attitude. Hence, safety practice adopted by teacher and administrator
attitude is vital in realizing technical laboratory safety.
Abstract: Outsourcing, a management practice strongly
consolidated within the area of Information Systems, is currently
going through a stage of unstoppable growth. This paper makes a
proposal about the main reasons which may lead firms to adopt
Information Systems Outsourcing. It will equally analyse the
potential risks that IS clients are likely to face. An additional
objective is to assess these reasons and risks in the case of large
Spanish firms, while simultaneously examining their evolution over
time.
Abstract: The parametrical study of Shrouded Contra-rotating
Rotor was done in this paper based on 2D axisymmetric simulations.
The calculations were made with an actuator disk as double rotor
model. It objects to explore and quantify the effects of different shroud
geometry parameters mainly using the performance of power loading
(PL), which could evaluate the whole propulsion system capability as
5 Newtontotal thrust generationfor hover demand. The numerical
results show that:The increase of nozzle radius is desired but limited
by the flow separation, its optimal design is around 1.15 times rotor
radius, the viscosity effects greatly constraint the influence of nozzle
shape, the divergent angle around 10.5° performs best for chosen
nozzle length;The parameters of inlet such as leading edge curvature,
radius and internal shape do not affect thrust great but play an
important role in pressure distribution which could produce most part
of shroud thrust, they should be chosen according to the reduction of
adverse pressure gradients to reduce the risk of boundary separation.
Abstract: Human immunodeficiency virus infection and
acquired immunodeficiency syndrome is a global pandemic with
cases reporting from virtually every country and continues to be a
common infection in developing country like India.
Microalbuminuria is a manifestation of human immunodeficiency
virus associated nephropathy. Therefore, microalbuminuria may be
an early marker of human immunodeficiency virus associated
nephropathy, and screening for its presence may be beneficial. A
strikingly high prevalence of microalbuminuria among human
immunodeficiency virus infected patients has been described in
various studies. Risk factors for clinically significant proteinuria
include African - American race, higher human immunodeficiency
virus ribonucleic acid level and lower CD4 lymphocyte count. The
cardiovascular risk factors of increased systolic blood pressure and
increase fasting blood sugar level are strongly associated with
microalbuminuria in human immunodeficiency virus patient. These
results suggest that microalbuminuria may be a sign of current
endothelial dysfunction and micro-vascular disease and there is
substantial risk of future cardiovascular disease events. Positive
contributing factors include early kidney disease such as human
immunodeficiency virus associated nephropathy, a marker of end
organ damage related to co morbidities of diabetes or hypertension,
or more diffuse endothelial cells dysfunction. Nevertheless after
adjustment for non human immunodeficiency virus factors, human
immunodeficiency virus itself is a major risk factor. The presence of
human immunodeficiency virus infection is independent risk to
develop microalbuminuria in human immunodeficiency virus patient.
Cardiovascular risk factors appeared to be stronger predictors of
microalbuminuria than markers of human immunodeficiency virus
severity person with human immunodeficiency virus infection and
microalbuminuria therefore appear to potentially bear the burden of
two separate damage related to known vascular end organ damage
related to know vascular risk factors, and human immunodeficiency
virus specific processes such as the direct viral infection of kidney
cells.The higher prevalence of microalbuminuria among the human
immunodeficiency virus infected could be harbinger of future
increased risks of both kidney and cardiovascular disease. Further
study defining the prognostic significance of microalbuminuria
among human immunodeficiency virus infected persons will be
essential. Microalbuminuria seems to be a predictor of cardiovascular
disease in diabetic and non diabetic subjects, hence it can also be
used for early detection of micro vascular disease in human
immunodeficiency virus positive patients, thus can help to diagnose
the disease at the earliest.
Abstract: Structural Integrity Management (SIM) is
important for the protection of offshore crew, environment, business assets and company and industry reputation. API RP 2A contained guidelines for assessment of existing platforms mostly for the Gulf
of Mexico (GOM). ISO 19902 SIM framework also does not
specifically cater for Malaysia. There are about 200 platforms in
Malaysia with 90 exceeding their design life. The Petronas Carigali
Sdn Bhd (PCSB) uses the Asset Integrity Management System and
the very subjective Risk based Inspection Program for these
platforms. Petronas currently doesn-t have a standalone Petronas
Technical Standard PTS-SIM. This study proposes a recommended
practice for the SIM process for offshore structures in Malaysia,
including studies by API and ISO and local elements such as the
number of platforms, types of facilities, age and risk ranking. Case
study on SMG-A platform in Sabah shows missing or scattered
platform data and a gap in inspection history. It is to undergo a level
3 underwater inspection in year 2015.
Abstract: Using activity theory, organisational theory and
didactics as theoretical foundations, a comprehensive model of the
organisational dimensions relevant for learning and knowledge
transfer will be developed. In a second step, a Learning Assessment
Guideline will be elaborated. This guideline will be designed to
permit a targeted analysis of organisations to identify the status quo
in those areas crucial to the implementation of learning and
knowledge transfer. In addition, this self-analysis tool will enable
learning managers to select adequate didactic models for e- and
blended learning. As part of the European Integrated Project
"Process-oriented Learning and Information Exchange" (PROLIX),
this model of organisational prerequisites for learning and knowledge
transfer will be empirically tested in four profit and non-profit
organisations in Great Britain, Germany and France (to be finalized
in autumn 2006). The findings concern not only the capability of the
model of organisational dimensions, but also the predominant
perceptions of and obstacles to learning in organisations.
Abstract: This paper provides a key driver-based conceptual framework that can be used to improve a firm-s success in commercializing technology and in new product innovation resulting from collaboration with other organizations through strategic alliances. Based on a qualitative study using an interview approach, strategic alliances of entrepreneurs in the food processing industry in Thailand are explored. This paper describes factors affecting decisions to collaborate through alliances. It identifies four issues: maintaining the efficiency of the value chain for production capability, adapting to present and future competition, careful assessment of value of outcomes, and management of innovation. We consider five driving factors: resource orientation, assessment of risk, business opportunity, sharing of benefits and confidence in alliance partners. These factors will be of interest to entrepreneurs and policy makers with regard to further understanding of the direction of business strategies.
Abstract: The purpose of this article is to briefly review the opportunities that social media present to counselors and psychologists. Particular attention was given to understanding some of the more important common risks inherent in social media and the potential ethical dilemmas which may arise for counselors and psychologists who embrace them in their practice. Key considerations of issues pertinent to an online presence such as multiple relationships, visibility and privacy, maintaining ethical principles and professional boundaries are being discussed.