Abstract: The Roma (Gypsies) is a transnational minority with a
high degree of consanguineous marriages. Similar to other
genetically isolated founder populations, the Roma harbor a number
of unique or rare genetic disorders. This paper discusses about a rare
form of Charcot-Marie-Tooth disease – type 4G (CMT4G), also
called Hereditary Motor and Sensory Neuropathy type Russe, an
autosomal recessive disease caused by mutation private to Roma
characterized by abnormally increased density of non-myelinated
axons. CMT4G was originally found in Bulgarian Roma and in 2009
two putative causative mutations in the HK1 gene were identified.
Since then, several cases were reported in Roma families mainly
from Bulgaria and Spain. Here we present a Slovak Roma family in
which CMT4G was diagnosed on the basis of clinical examination
and genetic testing. This case is a further proof of the role of the HK1
gene in pathogenesis of the disease. It confirms that mutation in the
HK1 gene is a common cause of autosomal recessive CMT disease in
Roma and should be considered as a common part of a diagnostic
procedure.
Abstract: Monoamine oxidase A gene (MAOA) is suggested to
be a candidate gene implicated in many neuropsychiatric disorders,
including autism spectrum disorder (ASD). This meta-analytic review
evaluates the relationship between ASD and MAOA markers such as
30 bp variable number tandem repeats in the promoter region
(uVNTR) and single nucleotide polymorphisms (SNPs) by using
findings from recently published studies. It seems that in Caucasian
males, the risk of developing ASD increase with the presence of 4-
repeat allele in the promoter region of MAOA gene whereas no
differences were found between autistic patients and controls in
Egyptian, West Bengal and Korean population. Some studies point to
the importance of specific haplotype groups of SNPs and interaction
of MAOA with others genes (e. g. FOXP2 or SRY). The results of
existing studies are insufficient and further research is needed.
Abstract: Environmental impacts of six 3D printers using
various materials were compared to determine if material choice
drove sustainability, or if other factors such as machine type, machine
size, or machine utilization dominate. Cradle-to-grave life-cycle
assessments were performed, comparing a commercial-scale FDM
machine printing in ABS plastic, a desktop FDM machine printing in
ABS, a desktop FDM machine printing in PET and PLA plastics, a
polyjet machine printing in its proprietary polymer, an SLA machine
printing in its polymer, and an inkjet machine hacked to print in salt
and dextrose. All scenarios were scored using ReCiPe Endpoint H
methodology to combine multiple impact categories, comparing
environmental impacts per part made for several scenarios per
machine. Results showed that most printers’ ecological impacts were
dominated by electricity use, not materials, and the changes in
electricity use due to different plastics was not significant compared
to variation from one machine to another. Variation in machine idle
time determined impacts per part most strongly. However, material
impacts were quite important for the inkjet printer hacked to print in
salt: In its optimal scenario, it had up to 1/38th the impacts coreper
part as the worst-performing machine in the same scenario. If salt
parts were infused with epoxy to make them more physically robust,
then much of this advantage disappeared, and material impacts
actually dominated or equaled electricity use. Future studies should
also measure DMLS and SLS processes / materials.
Abstract: One of the major difficulties introduced with wind
power penetration is the inherent uncertainty in production originating
from uncertain wind conditions. This uncertainty impacts many
different aspects of power system operation, especially the balancing
power requirements. For this reason, in power system development
planing, it is necessary to evaluate the potential uncertainty in future
wind power generation. For this purpose, simulation models are
required, reproducing the performance of wind power forecasts.
This paper presents a wind power forecast error simulation models
which are based on the stochastic process simulation. Proposed
models capture the most important statistical parameters recognized
in wind power forecast error time series. Furthermore, two distinct
models are presented based on data availability. First model uses
wind speed measurements on potential or existing wind power plant
locations, while the seconds model uses statistical distribution of wind
speeds.
Abstract: Measurements and quantitative analysis of kinematic
parameters of human hand movements have an important role in
different areas such as hand function rehabilitation, modeling of
multi-digits robotic hands, and the development of machine-man
interfaces. In this paper the assessment and evaluation of the reachto-
grasp movement by using computerized and robot-assisted method
is described. Experiment involved the measurements of hand
positions of seven healthy subjects during grasping three objects of
different shapes and sizes. Results showed that three dominant phases
of reach-to-grasp movements could be clearly identified.
Abstract: It is difficult to study the effect of various variables on
cycle fitting through actual experiment. To overcome such difficulty,
the forward dynamics of a musculoskeletal model was applied to cycle
fitting in this study. The measured EMG data weres compared with the
muscle activities of the musculoskeletal model through forward
dynamics. EMG data were measured from five cyclists who do not
have musculoskeletal diseases during three minutes pedaling with a
constant load (150 W) and cadence (90 RPM). The muscles used for
the analysis were the Vastus Lateralis (VL), Tibialis Anterior (TA),
Bicep Femoris (BF), and Gastrocnemius Medial (GM). Person’s
correlation coefficients of the muscle activity patterns, the peak timing
of the maximum muscle activities, and the total muscle activities were
calculated and compared. BIKE3D model of AnyBody (Anybodytech,
Denmark) was used for the musculoskeletal model simulation. The
comparisons of the actual experiments with the simulation results
showed significant correlations in the muscle activity patterns (VL:
0.789, TA: 0.503, BF: 0.468, GM: 0.670). The peak timings of the
maximum muscle activities were distributed at particular phases. The
total muscle activities were compared with the normalized muscle
activities, and the comparison showed about 10% difference in the VL
(+10%), TA (+9.7%), and BF (+10%), excluding the GM (+29.4%).
Thus, it can be concluded that muscle activities of model &
experiment showed similar results. The results of this study indicated
that it was possible to apply the simulation of further improved
musculoskeletal model to cycle fitting.
Abstract: Alkylated silicon nanocrystals (C11-SiNCs) were
prepared successfully by galvanostatic etching of p-Si(100) wafers
followed by a thermal hydrosilation reaction of 1-undecene in
refluxing toluene in order to extract C11-SiNCs from porous silicon.
Erbium trichloride was added to alkylated SiNCs using a simple
mixing chemical route. To the best of our knowledge, this is the first
investigation on mixing SiNCs with erbium ions (III) by this
chemical method. The chemical characterization of C11-SiNCs and
their mixtures with Er3+(Er/C11-SiNCs) were carried out using X-ray
photoemission spectroscopy (XPS). The optical properties of C11-
SiNCs and their mixtures with Er3+ were investigated using Raman
spectroscopy and photoluminescence (PL). The erbium mixed
alkylated SiNCs shows an orange PL emission peak at around 595
nm that originates from radiative recombination of Si. Er/C11-SiNCs
mixture also exhibits a weak PL emission peak at 1536 nm that
originates from the intra-4f transition in erbium ions (Er3+). The PL
peak of Si in Er/C11-SiNCs mixture is increased in the intensity up to
three times as compared to pure C11-SiNCs. The collected data
suggest that this chemical mixing route leads instead to a transfer of
energy from erbium ions to alkylated SiNCs.
Abstract: Passing the entrance exam to a university is a major
step in one's life. University entrance exam commonly known as
Kankor is the nationwide entrance exam in Afghanistan. This
examination is prerequisite for all public and private higher education
institutions at undergraduate level. It is usually taken by students who
are graduated from high schools. In this paper, we reflect the major
educational school graduates issues and propose ICT-based test
preparation environment, known as ‘Online Kankor Exam Prep
System’ to give students the tools to help them pass the university
entrance exam on the first try. The system is based on Intelligent
Tutoring System (ITS), which introduced an essential package of
educational technology for learners that features: (I) exam-focused
questions and content; (ii) self-assessment environment; and (iii) test
preparation strategies in order to help students to acquire the necessary
skills in their carrier and keep them up-to-date with instruction.
Abstract: This paper identifies limitations of existing two e-
Governance services viz. railway ticket booking and passport service
in India. The comparison has been made as to how in the past these
two citizen services were operating manually and how these services
are taken online via e-Governance. Different e-Governance projects,
investment aspects, and role of corporate are discussed. For Indian
Railway online ticketing a comparison has been made between state
run booking website and popular private firm run booking websites.
For passport service, observations through personal visit to passport
center is described. Suggestions are made to improve these services
further to improve citizen service experiences.
Abstract: This paper describes a novel application of Fiber
Braggs Grating (FBG) sensors in the assessment of human postural
stability and balance on an unstable platform. In this work, FBG
sensor Stability Analyzing Device (FBGSAD) is developed for
measurement of plantar strain to assess the postural stability of
subjects on unstable platforms during different stances in eyes open
and eyes closed conditions on a rocker board. The studies are
validated by comparing the Centre of Gravity (CG) variations
measured on the lumbar vertebra of subjects using a commercial
accelerometer. The results obtained from the developed FBGSAD
depict qualitative similarities with the data recorded by commercial
accelerometer. The advantage of the FBGSAD is that it measures
simultaneously plantar strain distribution and postural stability of the
subject along with its inherent benefits like non-requirement of
energizing voltage to the sensor, electromagnetic immunity and
simple design which suits its applicability in biomechanical
applications. The developed FBGSAD can serve as a tool/yardstick to
mitigate space motion sickness, identify individuals who are
susceptible to falls and to qualify subjects for balance and stability,
which are important factors in the selection of certain unique
professionals such as aircraft pilots, astronauts, cosmonauts etc.
Abstract: We have developed a new computer program in
Fortran 90, in order to obtain numerical solutions of a system
of Relativistic Magnetohydrodynamics partial differential equations
with predetermined gravitation (GRMHD), capable of simulating
the formation of relativistic jets from the accretion disk of matter
up to his ejection. Initially we carried out a study on numerical
methods of unidimensional Finite Volume, namely Lax-Friedrichs,
Lax-Wendroff, Nessyahu-Tadmor method and Godunov methods
dependent on Riemann problems, applied to equations Euler in
order to verify their main features and make comparisons among
those methods. It was then implemented the method of Finite
Volume Centered of Nessyahu-Tadmor, a numerical schemes that
has a formulation free and without dimensional separation of
Riemann problem solvers, even in two or more spatial dimensions,
at this point, already applied in equations GRMHD. Finally, the
Nessyahu-Tadmor method was possible to obtain stable numerical
solutions - without spurious oscillations or excessive dissipation -
from the magnetized accretion disk process in rotation with respect
to a central black hole (BH) Schwarzschild and immersed in a
magnetosphere, for the ejection of matter in the form of jet over a
distance of fourteen times the radius of the BH, a record in terms
of astrophysical simulation of this kind. Also in our simulations,
we managed to get substructures jets. A great advantage obtained
was that, with the our code, we got simulate GRMHD equations in
a simple personal computer.
Abstract: In this article, we have elaborated a study over the
nature of financial intermediation in Islamic banks by comparison to
those of conventional ones. We have found a striking difference
between two kinds of intermediation. We tried, from another side, to
study the relationship between the capital level and deficiency risk
relying on econometric model, and we have obtained a positive and
significant relation between the capital and the deficiency risk for the
conventional banks. This means that when the capital of these banks
increases, the deficiency risk increases as well. In return, since the
Islamic banks are constrained to respect the Sharia Committee as well
as customers’ demands that may, in certain contracts, choose to
invest their capitals in projects they are interested in. These
constraints have as effects to reduce the deficiency risk even when
the capital increases.
Abstract: Nowadays, the successful implementation of ICTs is
vital for almost any kind of organization. Good governance and ICT
management are essential for delivering value, managing
technological risks, managing resources and performance
measurement. In addition, outsourcing is a strategic IT service
solution which complements IT services provided internally in
organizations. This paper proposes the measurement tools of a new
holistic maturity model based on standards ISO/IEC 20000 and
ISO/IEC 38500, and the frameworks and best practices of ITIL and
COBIT, with a specific focus on IT outsourcing. These measurement
tools allow independent validation and practical application in the
field of higher education, using a questionnaire, metrics tables, and
continuous improvement plan tables as part of the measurement
process. Guidelines and standards are proposed in the model for
facilitating adaptation to universities and achieving excellence in the
outsourcing of IT services.
Abstract: Since large part of electricity is generated by using
fossil based resources, energy is an important agenda for countries. In
this context, renewable energy sources are alternative to conventional
sources due to the depletion of fossil resources, increasing awareness
of climate change and global warming concerns. Solar, wind and
hydropower energy are the main renewable energy sources. Among
of them, since installed capacity of wind power has increased
approximately eight times between 2008 - November of 2014, wind
energy is a promising source for Turkey. Furthermore, signing of
Kyoto Protocol can be accepted as a milestone for Turkey's energy
policy. Turkish Government has announced Vision 2023 (energy
targets by 2023) in 2010-2014 Strategic Plan prepared by Ministry of
Energy and Natural Resources (MENR). Energy targets in this plan
can be summarized as follows: Share of renewable energy sources in
electricity generation is 30% of total electricity generation by 2023.
Installed capacity of wind energy will be 20 GW by 2023. Other
renewable energy sources such as solar, hydropower and geothermal
are encouraged with new incentive mechanisms. Dependence on
foreign energy is reduced for sustainability and energy security. On
the other hand, since Turkey is surrounded by three coastal areas,
wind energy potential is convenient for wind power application. As
of November of 2014, total installed capacity of wind power plants is
3.51 GW and a lot of wind power plants are under construction with
capacity 1.16 GW. Turkish government also encourages the locally
manufactured equipments. In this context, one of the projects funded
by private sector, universities and TUBİTAK names as MILRES is
an important project aimed to promote the use wind energy in
electricity generation. Within this project, wind turbine with 500 kW
power has been produced and will be installed at the beginning of the
2015. After that, by using the experience obtained from the first
phase of the project, a wind turbine with 2.5 MW power will be
manufactured in an industrial scale.
Abstract: Due to water shortage, application of saline water for
irrigation is an urgent in agriculture. In this study the effect of
calcium and potassium application as additive in saline root media for
reduce salinity adverse effects was investigated on tomato growth in
a hydroponic system with unequal distribution of salts in the root
media, which was divided in to two equal parts containing full
Johnson nutrient solution and 40 mMNaCl solution, alone or in
combination with KCl (6 mM), CaCl2 (4 mM), K+Ca (3+2 mM) or
half-strength Johnson nutrient solution. The root splits were
exchanged every 7 days. Results showed that addition of calcium,
calcium-potassium and nutrition elements equivalent to half the
concentration of Johnson formula to the saline-half of culture media
minimized the reduction in plant growth caused by NaCl, although
addition of potassium to culture media wasn’t effective. The greatest
concentration of sodium was observed at the shoot of treatments
which had smallest growth. According to the results of this study, in
case of dynamic and non-uniform distribution of salts in the root
media, by addition of additive to the saline solution, it would be
possible to use of saline water with no significant growth reduction.
Abstract: Starting in 2020, an EU-wide CO2-limitation of
95 g/km is scheduled for the average of an OEMs passenger car fleet.
Taking that into consideration additional improvement measures of
the Diesel cycle are necessary in order to reduce fuel consumption
and emissions while boosting, or at the least, keeping performance
values at the same time.
The present article deals with the possibilities of an optimized
air/water charge air cooler, also called iCAC (indirect Charge Air
Cooler) for a Diesel passenger car amongst extreme-boundary
conditions. In this context, the precise objective was to show the
impact of improved intercooling with reference to the engine working
process (fuel consumption and NOx-emissions). Several extremeboundaries
- e.g. varying ambient temperatures or mountainous
routes - that will become very important in the near future regarding
RDE (Real Driving emissions) were subject of the investigation.
With the introduction of RDE in 2017 (EU6c measure), the
controversial NEDC (New European Driving Cycle) will belong to
the past and the OEMs will have to avoid harmful emissions in any
conceivable real life situation.
This is certainly going to lead to optimization-measurements at the
powertrain, which again is going to make the implementation of
iCACs, presently solely used for the premium class, more and more
attractive for compact class cars. The investigations showed a benefit
in FC between 1 and 3% for the iCAC in real world conditions.
Abstract: Water spray cooling is a technique typically used in
heat treatment and other metallurgical processes where controlled
temperature regimes are required. Water spray cooling is used in
static (without movement) or dynamic (with movement of the steel
plate) regimes. The static regime is notable for the fixed position of
the hot steel plate and fixed spray nozzle. This regime is typical for
quenching systems focused on heat treatment of the steel plate. The
second application of spray cooling is the dynamic regime. The
dynamic regime is notable for its static section cooling system and
moving steel plate. This regime is used in rolling and finishing mills.
The fixed position of cooling sections with nozzles and the
movement of the steel plate produce nonhomogeneous water
distribution on the steel plate. The length of cooling sections and
placement of water nozzles in combination with the nonhomogeneity
of water distribution lead to discontinued or interrupted cooling
conditions. The impact of static and dynamic regimes on cooling
intensity and the heat transfer coefficient during the cooling process
of steel plates is an important issue.
Heat treatment of steel is accompanied by oxide scale growth. The
oxide scale layers can significantly modify the cooling properties and
intensity during the cooling. The combination of static and dynamic
(section) regimes with the variable thickness of the oxide scale layer
on the steel surface impact the final cooling intensity. The study of
the influence of the oxide scale layers with different cooling regimes
was carried out using experimental measurements and numerical
analysis. The experimental measurements compared both types of
cooling regimes and the cooling of scale-free surfaces and oxidized
surfaces. A numerical analysis was prepared to simulate the cooling
process with different conditions of the section and samples with
different oxide scale layers.
Abstract: Given the importance of ports as links in the global
supply chains and because they are key elements to induce
competitiveness in their hinterlands, the number of studies devoted to
port governance, management and operations has increased in the last
decades. Some of these studies address the port governance model as
an element to improve coordination among the actors of the portlogistics
chain and to generate a better port performance. In this
context, the present study analyzes the governance of Port of Santos
through individual interviews with port managers, based on a
conceptual model that considers the key dimensions associated with
port governance. The results reinforce the usefulness of the applied
model and highlight some existing improvement opportunities in the
port studied.
Abstract: Strong anion exchange resins with QN+OH-, have the
potential to be developed and employed as heterogeneous catalyst for
transesterification, as they are chemically stable to leaching of the
functional group. Nine different SIERs (SIER1-9) with QN+OH-were
prepared by suspension polymerization of vinylbenzyl chloridedivinylbenzene
(VBC-DVB) copolymers in the presence of n-heptane
(pore-forming agent). The amine group was successfully grafted into
the polymeric resin beads through functionalization with
trimethylamine. These SIERs are then used as a catalyst for the
transesterification of triacetin with methanol. A set of differential
equations that represents the Langmuir-Hinshelwood-Hougen-
Watson (LHHW) and Eley-Rideal (ER) models for the
transesterification reaction were developed. These kinetic models of
LHHW and ER were fitted to the experimental data. Overall, the
synthesized ion exchange resin-catalyzed reaction were welldescribed
by the Eley-Rideal model compared to LHHW models,
with sum of square error (SSE) of 0.742 and 0.996, respectively.
Abstract: Currently, thorium fuel has been especially noticed
because of its proliferation resistance than long half-life alpha emitter
minor actinides, breeding capability in fast and thermal neutron flux
and mono-isotopic naturally abundant. In recent years, efficiency of
minor actinide burning up in PWRs has been investigated. Hence, a
minor actinide-contained thorium based fuel matrix can confront both
proliferation resistance and nuclear waste depletion aims. In the
present work, minor actinide depletion rate in a CANDU-type nuclear
core modeled using MCNP code has been investigated. The obtained
effects of minor actinide load as mixture of thorium fuel matrix on
the core neutronics has been studied with comparing presence and
non-presence of minor actinide component in the fuel matrix.
Depletion rate of minor actinides in the MA-contained fuel has been
calculated using different power loads. According to the obtained
computational data, minor actinide loading in the modeled core
results in more negative reactivity coefficients. The MA-contained
fuel achieves less radial peaking factor in the modeled core. The
obtained computational results showed 140 kg of 464 kg initial load
of minor actinide has been depleted in during a 6-year burn up in 10
MW power.