Abstract: Atherosclerosis was identified as a chronic inflammatory process resulting from interactions between plasma lipoproteins, cellular components (monocyte, macrophages, T lymphocytes, endothelial cells and smooth muscle cells) and the extracellular matrix of the arterial wall. Several types of genes were known to express during formation of atherosclerosis. This study is carried out to identify unknown differentially expressed gene (DEG) in atherogenesis. Rabbit’s aorta tissues were stained by H&E for histomorphology. GeneFishing™ PCR analysis was performed from total RNA extracted from the aorta tissues. The DNA fragment from DEG was cloned, sequenced and validated by Real-time PCR. Histomorphology showed intimal thickening in the aorta. DEG detected from ACP-41 was identified as cathepsin B gene and showed upregulation at week-8 and week-12 of atherogenesis. Therefore, ACP-based GeneFishing™ PCR facilitated identification of cathepsin B gene which was differentially expressed during development of atherosclerosis.
Abstract: The interaction of tunneling or mining with
groundwater has become a very relevant problem not only due to the
need to guarantee the safety of workers and to assure the efficiency of
the tunnel drainage systems, but also to safeguard water resources
from impoverishment and pollution risk. Therefore it is very
important to forecast the drainage processes (i.e., the evaluation of
drained discharge and drawdown caused by the excavation). The aim
of this study was to know better the system and to quantify the flow
drained from the Fontane mines, located in Val Germanasca (Turin,
Italy). This allowed to understand the hydrogeological local changes
in time. The work has therefore been structured as follows: the
reconstruction of the conceptual model with the geological,
hydrogeological and geological-structural study; the calculation of
the tunnel inflows (through the use of structural methods) and the
comparison with the measured flow rates; the water balance at the
basin scale. In this way it was possible to understand what are the
relationships between rainfall, groundwater level variations and the
effect of the presence of tunnels as a means of draining water.
Subsequently, it the effects produced by the excavation of the mining
tunnels was quantified, through numerical modeling. In particular,
the modeling made it possible to observe the drawdown variation as a
function of number, excavation depth and different mines linings.
Abstract: This research aimed to modify pineapple leaf paper
(PALP) for using as wet media in the evaporation cooling system by
improving wet mechanical property (tensile strength) without
compromising water absorption property. Polyamideamineepichorohydrin
resin (PAE) and carboxymethylcellulose (CMC)
were used to strengthen the paper, and the PAE and CMC ratio of
80:20 showed the optimum wet and dry tensile index values, which
were higher than those of the commercial cooling pad (CCP).
Compared with CCP, PALP itself and all the PAE/CMC modified
PALP possessed better water absorption. The PAE/CMC modified
PALP had potential to become a new type of wet media.
Abstract: Leave of absence is important in maintaining a good
status of human resource quality. Allowing the employees temporarily
free from the routine assignments can vitalize the workers- morality
and productivity. This is particularly critical to secure a satisfactory
service quality for healthcare professionals of which were typically
featured with labor intensive and complicated works to perform. As
one of the veteran hospitals that were found and operated by the
Veteran Department of Taiwan, the nursing staff of the case hospital
was squeezed to an extreme minimum level under the pressure of a
tight budgeting. Leave of absence on schedule became extremely
difficult, especially for the intensive care units (ICU), in which
required close monitoring over the cared patients, and that had more
easily driven the ICU nurses nervous. Even worse, the deferred leaves
were more than 10 days at any time in the ICU because of a fluctuating
occupancy. As a result, these had brought a bad setback to this
particular nursing team, and consequently defeated the job
performance and service quality. To solve this problem and
accordingly to strengthen their morality, a project team was organized
across different departments specific for this. Sufficient information
regarding jobs and positions requirements, labor resources, and actual
working hours in detail were collected and analyzed in the team
meetings. Several alternatives were finalized. These included job
rotating, job combination, leave on impromptu and cross-departmental
redeployment. Consequently, the deferred leave days sharply reduced
70% to a level of 3 or less days. This improvement had not only
provided good shelter for the ICU nurses that improved their job
performance and patient safety but also encouraged the nurses active
participating of a project and learned the skills of solving problems
with colleagues.
Abstract: Reinforced concrete crash barriers used in road traffic
must meet a number of criteria. Crash barriers are laid lengthwise,
one behind another, and joined using specially designed steel locks.
While developing BSV reinforced concrete crash barriers (type
ŽPSV), experiments and calculations aimed to optimize the shape of
a newly designed lock and the reinforcement quantity and
distribution in a crash barrier were carried out. The tension carrying
capacity of two parallelly joined locks was solved experimentally.
Based on the performed experiments, adjustments of nonlinear
properties of steel were performed in the calculations. The obtained
results served as a basis to optimize the lock design using a
computational model that takes into account the plastic behaviour of
steel and the influence of the surrounding concrete [6]. The response
to the vehicle impact has been analyzed using a specially elaborated
complex computational model, comprising both the nonlinear model
of the damping wall or crash barrier and the detailed model of the
vehicle [7].
Abstract: Recently, malware attacks have become more serious
over the Internet by e-mail, denial of service (DoS) or distributed
denial of service (DDoS). The Botnets have become a significant part
of the Internet malware attacks. The traditional botnets include three
parts – botmaster, command and control (C&C) servers and bots. The
C&C servers receive commands from botmaster and control the
distributions of computers remotely. Bots use DNS to find the
positions of C&C server. In this paper, we propose an advanced hybrid
peer-to-peer (P2P) botnet 2.0 (AHP2P botnet 2.0) using web 2.0
technology to hide the instructions from botmaster into social sites,
which are regarded as C&C servers. Servent bots are regarded as
sub-C&C servers to get the instructions from social sites. The AHP2P
botnet 2.0 can evaluate the performance of servent bots, reduce DNS
traffics from bots to C&C servers, and achieve harder detection bots
actions than IRC-based botnets over the Internet.
Abstract: The physical methods for RNA secondary structure prediction are time consuming and expensive, thus methods for computational prediction will be a proper alternative. Various algorithms have been used for RNA structure prediction including dynamic programming and metaheuristic algorithms. Musician's behaviorinspired harmony search is a recently developed metaheuristic algorithm which has been successful in a wide variety of complex optimization problems. This paper proposes a harmony search algorithm (HSRNAFold) to find RNA secondary structure with minimum free energy and similar to the native structure. HSRNAFold is compared with dynamic programming benchmark mfold and metaheuristic algorithms (RnaPredict, SetPSO and HelixPSO). The results showed that HSRNAFold is comparable to mfold and better than metaheuristics in finding the minimum free energies and the number of correct base pairs.
Abstract: This paper presents a controller design technique for
Synchronous Reluctance Motor to improve its dynamic performance
with fast response and high accuracy. The sliding mode control is the
most attractive and suitable method to use for this purpose, since it is
simple in design and for its insensitivity to parameter variations or
external disturbances. When this method implemented it yields fast
dynamic response without overshoot and a zero steady-state error.
The current loop control with decentralized sliding mode is presented
in this paper. The mathematical model for the synchronous machine,
the inverter and the controller is developed. The stability of the
sliding mode controller is analyzed. Simulation of synchronous
reluctance motor and the controller with PWM-inverter has been
curried out, using the SIMULINK software package of MATLAB.
Simulation results are presented to show the effectiveness of the
approach.
Abstract: A pilot project was carried out in 2007 by the senior
students of Cyprus International University, aiming to minimize the
total cost of waste collection in Northern Cyprus. Many developed
and developing countries have cut their transportation costs – which
lies between 30-40% – down at a rate of 40% percent, by
implementing network models for their route assignments.
Accordingly, a network model was implemented at Göçmenköy
district, to optimize and standardize waste collection works. The
work environment of the employees were also redesigned to provide
maximum ergonomy and to increase productivity, efficiency and
safety. Following the collection of the required data including waste
densities, lengths of roads and population, a model was constructed
to allocate the optimal route assignment for the waste collection
trucks at Göçmenköy district.
Abstract: The fractal-shaped orifices are assumed to have a
significant effect on the pressure drop downstream pipe flow due to
their edge self-similarity shape which enhances the mixing
properties. Here, we investigate the pressure drop after these fractals
using a digital micro-manometer at different stations downstream a
turbulent flow pipe then a direct comparison has been made with the
pressure drop measured from regular orifices with the same flow
area. Our results showed that the fractal-shaped orifices have a
significant effect on the pressure drop downstream the flow. Also
the pressure drop measured across the fractal-shaped orifices is
noticed to be lower that that from ordinary orifices of the same flow
areas. This result could be important in designing piping systems
from point of view of losses consideration with the same flow
control area. This is promising to use the fractal-shaped orifices as
flowmeters as they can sense the pressure drop across them
accurately with minimum losses than the regular ones.
Abstract: The proper design of RF pulses in magnetic resonance imaging (MRI) has a direct impact on the quality of acquired images, and is needed for many applications. Several techniques have been proposed to obtain the RF pulse envelope given the desired slice profile. Unfortunately, these techniques do not take into account the limitations of practical implementation such as limited amplitude resolution. Moreover, implementing constraints for special RF pulses on most techniques is not possible. In this work, we propose to develop an approach for designing optimal RF pulses under theoretically any constraints. The new technique will pose the RF pulse design problem as a combinatorial optimization problem and uses efficient techniques from this area such as genetic algorithms (GA) to solve this problem. In particular, an objective function will be proposed as the norm of the difference between the desired profile and the one obtained from solving the Bloch equations for the current RF pulse design values. The proposed approach will be verified using analytical solution based RF simulations and compared to previous methods such as Shinnar-Le Roux (SLR) method, and analysis, selected, and tested the options and parameters that control the Genetic Algorithm (GA) can significantly affect its performance to get the best improved results and compared to previous works in this field. The results show a significant improvement over conventional design techniques, select the best options and parameters for GA to get most improvement over the previous works, and suggest the practicality of using of the new technique for most important applications as slice selection for large flip angles, in the area of unconventional spatial encoding, and another clinical use.
Abstract: The current trend of increasing quality and demands
of the final product is affected by time analysis of the entire
manufacturing process. The primary requirement of manufacturing is
to produce as many products as soon as possible, at the lowest
possible cost, but of course with the highest quality. Such
requirements may be satisfied only if all the elements entering and
affecting the production cycle are in a fully functional condition.
These elements consist of sensory equipment and intelligent control
elements that are essential for building intelligent manufacturing
systems. The intelligent manufacturing paradigm includes a new
approach to production system structure design. Intelligent behaviors
are based on the monitoring of important parameters of system and
its environment. The flexible reaction to changes. The realization and
utilization of this design paradigm as an "intelligent manufacturing
system" enables the flexible system reaction to production
requirement as soon as environmental changes too. Results of these
flexible reactions are a smaller layout space, be decreasing of
production and investment costs and be increasing of productivity.
Intelligent manufacturing system itself should be a system that can
flexibly respond to changes in entering and exiting the process in
interaction with the surroundings.
Abstract: The Neuro-Fuzzy hybridization scheme has become
of research interest in pattern classification over the past decade. The
present paper proposes a novel Modified Adaptive Fuzzy Inference
Engine (MAFIE) for pattern classification. A modified Apriori
algorithm technique is utilized to reduce a minimal set of decision
rules based on input output data sets. A TSK type fuzzy inference
system is constructed by the automatic generation of membership
functions and rules by the fuzzy c-means clustering and Apriori
algorithm technique, respectively. The generated adaptive fuzzy
inference engine is adjusted by the least-squares fit and a conjugate
gradient descent algorithm towards better performance with a
minimal set of rules. The proposed MAFIE is able to reduce the
number of rules which increases exponentially when more input
variables are involved. The performance of the proposed MAFIE is
compared with other existing applications of pattern classification
schemes using Fisher-s Iris and Wisconsin breast cancer data sets and
shown to be very competitive.
Abstract: Ten percent of the population will develop plantar
fasciitis (PF) during their lifetime. Two million people are treated
yearly accounting for 11-15% of visits to medical professionals.
Treatment ranges from conservative to surgical intervention. The
purpose of this study was to assess the effects of extracorporeal
shockwave therapy (ECSWT) on heel pain, function, range of motion
(ROM), and strength in patients with PF. One hundred subjects were
treated with ECSWT and measures were taken before and three
months after treatment. There was significant differences in visual
analog scale scores for pain at rest (p=0.0001); after activity (p=
0.0001) and; overall improvement (p=0.0001). There was also
significant improvement in Lower Extremity Functional Scale scores
(p=0.0001); ankle plantarflexion (p=0.0001), dorsiflexion (p=0.001),
and eversion (p=0.017),and first metatarsophalangeal joint flexion
(p=0.002) and extension (p=0.003) ROM. ECSWT is an effective
treatment improving heel pain, function and ROM in patients with
PF.
Abstract: The article analyses historical aspects of the formation
of the Kazakh nation in the conditions of the multicultural society.
The authors underline cultural integration as a significant stage of the
cultural advancement of the Kazakh nation. The transition to the
modern-style houses, the adoption and development of the secular
education gave a rise to the development of the society and culture
on the whole.
Abstract: There have been many variations of technologies that helped educators in teaching & learning. From the past research it is evident that Information Technology significantly increases student participation and interactivity in the classrooms. This research started with a aim to find whether adoption of Wi-Fi environment by Malaysian Higher Educational Institutions (HEI) can benefit students and staff equally. The study was carried out in HEI-s of Klang Valley, Malaysia and the data is gathered through paper based surveys. A sample size of 237 units were randomly selected from 5 higher educational institutions in the Klang Valley using the Stratified Random sampling method and from the analysis of the data, it was found that the implementation of wireless technologies in HEIs have created lot of opportunities and also challenges.
Abstract: In this study, communities of ammonia-oxidizing
archaea (AOA) and ammonia-oxidizing bacteria (AOB) in nitrifying
activated sludge (NAS) prepared by enriching sludge from a
municipal wastewater treatment plant in three continuous-flow
reactors receiving an inorganic medium containing different
ammonium concentrations of 2, 10, and 30 mM NH4
+-N (NAS2,
NAS10, and NAS30, respectively) were investigated using molecular
analysis. Results suggested that almost all AOA clones from NAS2,
NAS10, and NAS30 fell into the same AOA cluster and AOA
communities in NAS2 and NAS10 were more diverse than those of
NAS30. In contrast to AOA, AOB communities obviously shifted
from the seed sludge to enriched NASs and in each enriched NAS,
communities of AOB varied particularly. The seed sludge contained
members of N. communis cluster and N. oligotropha cluster. After it
was enriched under various ammonium loads, members of N.
communis cluster disappeared from all enriched NASs. AOB with
high affinity to ammonia presented in NAS 2, AOB with low affinity
to ammonia presented in NAS 30, and both types of AOB survived in
NAS 10. These demonstrated that ammonium load significantly
influenced AOB communities, but not AOA communities in enriched
NASs.
Abstract: In communication networks where communication nodes are connected with finite capacity transmission links, the packet inter-arrival times are strongly correlated with the packet length and the link capacity (or the packet service time). Such correlation affects the system performance significantly, but little attention has been paid to this issue. In this paper, we propose a mathematical framework to study the impact of the correlation between the packet service times and the packet inter-arrival times on system performance. With our mathematical model, we analyze the system performance, e.g., the unfinished work of the system, and show that the correlation affects the system performance significantly. Some numerical examples are also provided.
Abstract: For a long time as a result of accommodating car
traffic, planning ideologies in the past put a low priority on public
space, pedestrianism and the role of city space as a meeting place for
urban dwellers. In addition, according to authors such as Jan Gehl,
market forces and changing architectural perceptions began to shift
the focus of planning practice from the integration of public space in
various pockets around the contemporary city to individual buildings.
Eventually, these buildings have become increasingly more isolated
and introverted and have turned their backs to the realm of the public
space adjoining them. As a result of this practice, the traditional
function of public space as a social forum for city dwellers has in
many cases been reduced or even phased out. Author Jane Jacobs
published her seminal book “The Death and Life of Great American
Cities" more than fifty years ago, but her observations and
predictions at the time still ring true today, where she pointed out
how the dramatic increase in car traffic and its accommodation by the
urban planning ideology that was brought about by the Modern
movement has prompted a separation of the uses of the city. At the
same time it emphasizes free standing buildings that threaten urban
space and city life and result in underutilized and lifeless urban cores.
In this discussion context, the aim of this paper is to showcase a
reversal of just such a situation in the case of the Dasoupolis
neighborhood in Strovolos, Cyprus, where enlightened urban design
practice has see the reclamation of pedestrian space in a car
dominated area.
Abstract: In this study, the adhesion of ice to solid substrates
with different surface properties is compared. Clear ice, similar to
atmospheric in-flight icing encounters, is accreted on the different
substrates under controlled conditions. The ice adhesion behavior is
investigated by means of a dynamic vibration testing technique with
an electromagnetic shaker initiating ice de-bonding in the interface
between the substrate and the ice. The results of the experiments
reveal that the affinity for ice accretion is significantly influenced by
the water contact angle of the respective sample.