Abstract: The goal of Gene Expression Analysis is to understand the processes that underlie the regulatory networks and pathways controlling inter-cellular and intra-cellular activities. In recent times microarray datasets are extensively used for this purpose. The scope of such analysis has broadened in recent times towards reconstruction of gene networks and other holistic approaches of Systems Biology. Evolutionary methods are proving to be successful in such problems and a number of such methods have been proposed. However all these methods are based on processing of genotypic information. Towards this end, there is a need to develop evolutionary methods that address phenotypic interactions together with genotypic interactions. We present a novel evolutionary approach, called Phenomic algorithm, wherein the focus is on phenotypic interaction. We use the expression profiles of genes to model the interactions between them at the phenotypic level. We apply this algorithm to the yeast sporulation dataset and show that the algorithm can identify gene networks with relative ease.
Abstract: In this paper we are interested in Moufang-Klingenberg
planesM(A) defined over a local alternative ring A of dual numbers.
We introduce two new collineations of M(A).
Abstract: COPD is characterized by loss of elastic fibers from
small airways and alveolar walls, with the decrease in elastin
increasing with disease severity. It is unclear why there is a lack of
repair of elastic fibers. We have examined fibroblasts cultured from
lung tissue from normal and COPD subjects to determine if the
secretory profile explains lack of tissue repair. In this study,
fibroblasts were cultured from lung parenchyma of bronchial
carcinoma patients with varying degrees of COPD; controls
(non-COPD, n=5), mild COPD (GOLD 1, n=5) and moderate-severe
COPD (GOLD 2-3, n=12). Measurements were made of proliferation,
senescence-associated beta-galactosidase-1, mRNA expression of
IL-6, IL-8, MMP-1, tropoelastin and versican, and protein levels for
IL-6, IL-8, PGE2, tropoelastin, insoluble elastin, and versican. It was
found that GOLD 2-3 fibroblasts proliferated more slowly (p
Abstract: Recently, there has been a considerable increase in the
number of procedures carried out under regional anesthesia.
However, percutaneous nephrolithotomy (PCNL) procedures are
usually performed under general anesthesia. The aim of this study
was to assess the safety and efficacy of PCNL under spinal anesthesia
in patients with renal calculi. We describe our 9 years experience of
performing PCNL under spinal anesthesia for 387 patients with large
stones of the upper urinary tract, with regard to the effectiveness and
side effects. All patients received spinal anesthetics (Lidocain 5%, or
Bupivacaine 0.75%) and underwent PCNL in prone position. The
success rate was 94.1%. The incidence of complications was 11.6%.
PCNL under spinal anesthesia is feasible, safe, and well-tolerated in
management of patients with renal stones.
Abstract: Fundamental sensor-motor couplings form the backbone
of most mobile robot control tasks, and often need to be implemented
fast, efficiently and nevertheless reliably. Machine learning
techniques are therefore often used to obtain the desired sensor-motor
competences.
In this paper we present an alternative to established machine
learning methods such as artificial neural networks, that is very fast,
easy to implement, and has the distinct advantage that it generates
transparent, analysable sensor-motor couplings: system identification
through nonlinear polynomial mapping.
This work, which is part of the RobotMODIC project at the
universities of Essex and Sheffield, aims to develop a theoretical understanding
of the interaction between the robot and its environment.
One of the purposes of this research is to enable the principled design
of robot control programs.
As a first step towards this aim we model the behaviour of the
robot, as this emerges from its interaction with the environment, with
the NARMAX modelling method (Nonlinear, Auto-Regressive, Moving
Average models with eXogenous inputs). This method produces
explicit polynomial functions that can be subsequently analysed using
established mathematical methods.
In this paper we demonstrate the fidelity of the obtained NARMAX
models in the challenging task of robot route learning; we present a
set of experiments in which a Magellan Pro mobile robot was taught
to follow four different routes, always using the same mechanism to
obtain the required control law.
Abstract: Oxidative stress is considered to be the cause for onset
and the progression of type 2 diabetes mellitus (T2DM) and
complications including neuropathy. It is a deleterious process that
can be an important mediator of damage to cell structures: protein,
lipids and DNA. Data suggest that in patients with diabetes and
diabetic neuropathy DNA repair is impaired, which prevents effective
removal of lesions. Objective: The aim of our study was to evaluate
the association of the hOGG1 (326 Ser/Cys) and XRCC1 (194
Arg/Trp, 399 Arg/Gln) gene polymorphisms whose protein is
involved in the BER pathway with DNA repair efficiency in patients
with diabetes type 2 and diabetic neuropathy compared to the healthy
subjects. Genotypes were determined by PCR-RFLP analysis in 385
subjects, including 117 with type 2 diabetes, 56 with diabetic
neuropathy and 212 with normal glucose metabolism. The
polymorphisms studied include codon 326 of hOGG1 and 194, 399
of XRCC1 in the base excision repair (BER) genes. Comet assay was
carried out using peripheral blood lymphocytes from the patients and
controls. This test enabled the evaluation of DNA damage in cells
exposed to hydrogen peroxide alone and in the combination with the
endonuclease III (Nth). The results of the analysis of polymorphism
were statistically examination by calculating the odds ratio (OR) and
their 95% confidence intervals (95% CI) using the ¤ç2-tests. Our data
indicate that patients with diabetes mellitus type 2 (including those
with neuropathy) had higher frequencies of the XRCC1 399Arg/Gln
polymorphism in homozygote (GG) (OR: 1.85 [95% CI: 1.07-3.22],
P=0.3) and also increased frequency of 399Gln (G) allele (OR: 1.38
[95% CI: 1.03-1.83], P=0.3). No relation to other polymorphisms
with increased risk of diabetes or diabetic neuropathy. In T2DM
patients complicated by neuropathy, there was less efficient repair of
oxidative DNA damage induced by hydrogen peroxide in both the
presence and absence of the Nth enzyme. The results of our study
suggest that the XRCC1 399 Arg/Gln polymorphism is a significant
risk factor of T2DM in Polish population. Obtained data suggest a
decreased efficiency of DNA repair in cells from patients with
diabetes and neuropathy may be associated with oxidative stress.
Additionally, patients with neuropathy are characterized by even
greater sensitivity to oxidative damage than patients with diabetes,
which suggests participation of free radicals in the pathogenesis of
neuropathy.
Abstract: The use of new technologies such internet (e-mail, chat
rooms) and cell phones has steeply increased in recent years.
Especially among children and young people, use of technological
tools and equipments is widespread. Although many teachers and
administrators now recognize the problem of school bullying, few are
aware that students are being harassed through electronic
communication. Referred to as electronic bullying, cyber bullying, or
online social cruelty, this phenomenon includes bullying through email,
instant messaging, in a chat room, on a website, or through
digital messages or images sent to a cell phone. Cyber bullying is
defined as causing deliberate/intentional harm to others using internet
or other digital technologies. It has a quantitative research design nd
uses relational survey as its method. The participants consisted of
300 secondary school students in the city of Konya, Turkey. 195
(64.8%) participants were female and 105 (35.2%) were male. 39
(13%) students were at grade 1, 187 (62.1%) were at grade 2 and 74
(24.6%) were at grade 3. The “Cyber Bullying Question List"
developed by Ar─▒cak (2009) was given to students. Following
questions about demographics, a functional definition of cyber
bullying was provided. In order to specify students- human values,
“Human Values Scale (HVS)" developed by Dilmaç (2007) for
secondary school students was administered. The scale consists of 42
items in six dimensions. Data analysis was conducted by the primary
investigator of the study using SPSS 14.00 statistical analysis
software. Descriptive statistics were calculated for the analysis of
students- cyber bullying behaviour and simple regression analysis was
conducted in order to test whether each value in the scale could
explain cyber bullying behaviour.
Abstract: The segmentation of mouth and lips is a fundamental
problem in facial image analyisis. In this paper we propose a method
for lip segmentation based on rg-color histogram. Statistical analysis
shows, using the rg-color-space is optimal for this purpose of a pure
color based segmentation. Initially a rough adaptive threshold selects
a histogram region, that assures that all pixels in that region are
skin pixels. Based on that pixels we build a gaussian model which
represents the skin pixels distribution and is utilized to obtain a
refined, optimal threshold. We are not incorporating shape or edge
information. In experiments we show the performance of our lip pixel
segmentation method compared to the ground truth of our dataset and
a conventional watershed algorithm.
Abstract: This study shows palynomorphological description of
pollen grains of Lamium garganicum, species of the family Labiatae.
Fresh material of this plant is taken in Mount Llogara, in Albania. By
comparison made between palinomorphological characteristics of
pollen grains of Lamium garganicum with those of Lamium
maculatum and Lamium purpureum, showed that granules have
similarities in the number of furrows. The pollen grains of Lamium
garganicum were larger in length and width than those of Lamium
maculatum and almost equal with those of Lamium purpureum.
Furrows are longer than those of pollen grains in Lamium maculatum
and shorter than those of Lamium purpureum. The layer of exine of
Lamium garganicum was thinner than that of two others. The
sculpture of exine was fine reticulate, where reticulas were uniform
whereas in Lamium purpureum was verrucate, with small verrucae; in
Lamium maculatum was reticulate.
Abstract: Cement, the most widely used construction material
is very brittle and characterized by low tensile strength and strain
capacity. Macro to nano fibers are added to cement to provide
tensile strength and ductility to it. Carbon Nanotube (CNT), one of
the nanofibers, has proven to be a promising reinforcing material in
the cement composites because of its outstanding mechanical
properties and its ability to close cracks at the nano level. The
experimental investigations for CNT reinforced cement is costly,
time consuming and involves huge number of trials. Mathematical
modeling of CNT reinforced cement can be done effectively and
efficiently to arrive at the mechanical properties and to reduce the
number of trials in the experiments. Hence, an attempt is made to
numerically study the effective mechanical properties of CNT
reinforced cement numerically using Representative Volume
Element (RVE) method. The enhancement in its mechanical
properties for different percentage of CNTs is studied in detail.
Abstract: Heat transfer from two cam shape cylinder in side-byside
arrangement had been studied numerically.
The transverse gap between the centers of cylinders (T) is allowed
to vary to change the pitch ratio (T/Deq). The equivalent diameter of
the cylinder (Deq) is 27.6 mm and pitch ratio varies in range of
1≤T/Deq≤3. The Reynolds numbers based on equivalent circular
cylinder are within 50≤ Reeq≤150. Results show that Nusselt number
of cylinders increases about 1 to 36 percent when pitch ratio
increases from 1 to 3.
Abstract: This paper reports on an effort to address the issue of
inequality in girls- and women-s access to science, engineering and
technology (SET) education and careers through raising awareness on
SET among secondary school girls in South Africa. Girls participated
in hands-on high-tech rapid prototyping environment of a fabrication
laboratory that was aimed at stimulating creativity and innovation as
part of a Fab Kids initiative. The Fab Kids intervention is about
creating a SET pipeline as part of the Young Engineers and Scientists
of Africa Initiative.The methodology was based on a real world
situation and a hands-on approach. In the process, participants
acquired a number of skills including computer-aided design,
research skills, communication skills, teamwork skills, technical
drawing skills, writing skills and problem-solving skills. Exposure to
technology enhanced the girls- confidence in being able to handle
technology-related tasks.
Abstract: Many natural language expressions are ambiguous, and
need to draw on other sources of information to be interpreted.
Interpretation of the e word تعاون to be considered as a noun or a verb
depends on the presence of contextual cues. To interpret words we
need to be able to discriminate between different usages. This paper
proposes a hybrid of based- rules and a machine learning method for
tagging Arabic words. The particularity of Arabic word that may be
composed of stem, plus affixes and clitics, a small number of rules
dominate the performance (affixes include inflexional markers for
tense, gender and number/ clitics include some prepositions,
conjunctions and others). Tagging is closely related to the notion of
word class used in syntax. This method is based firstly on rules (that
considered the post-position, ending of a word, and patterns), and
then the anomaly are corrected by adopting a memory-based learning
method (MBL). The memory_based learning is an efficient method to
integrate various sources of information, and handling exceptional
data in natural language processing tasks. Secondly checking the
exceptional cases of rules and more information is made available to
the learner for treating those exceptional cases. To evaluate the
proposed method a number of experiments has been run, and in
order, to improve the importance of the various information in
learning.
Abstract: There are a number of different cars for transferring hundreds of close contacts of swine influenza patients to hospital, and we need to carefully assign the passengers to those cars in order to minimize the risk of influenza spreading during transportation. The paper presents an approach to straightforward obtain the optimal solution of the relaxed problems, and develops two iterative improvement algorithms to effectively tackle the general problem.
Abstract: Video-on-demand (VOD) is designed by using content delivery networks (CDN) to minimize the overall operational cost and to maximize scalability. Estimation of the viewing pattern (i.e., the relationship between the number of viewings and the ranking of VOD contents) plays an important role in minimizing the total operational cost and maximizing the performance of the VOD systems. In this paper, we have analyzed a large body of commercial VOD viewing data and found that the viewing rank distribution fits well with the parabolic fractal distribution. The weighted linear model fitting function is used to estimate the parameters (coefficients) of the parabolic fractal distribution. This paper presents an analytical basis for designing an optimal hierarchical VOD contents distribution system in terms of its cost and performance.
Abstract: In mechanical and environmental engineering, mixed
convection is a frequently encountered thermal fluid phenomenon
which exists in atmospheric environment, urban canopy flows, ocean
currents, gas turbines, heat exchangers, and computer chip cooling
systems etc... . This paper deals with a numerical investigation of
mixed convection in a vertical heated channel. This flow results from
the mixing of the up-going fluid along walls of the channel with the
one issued from a flat nozzle located in its entry section. The fluiddynamic
and heat-transfer characteristics of vented vertical channels
are investigated for constant heat-flux boundary conditions, a
Rayleigh number equal to 2.57 1010, for two jet Reynolds number
Re=3 103 and 2104 and the aspect ratio in the 8-20 range. The system
of governing equations is solved with a finite volumes method and an
implicit scheme. The obtained results show that the turbulence and
the jet-wall interaction activate the heat transfer, as does the drive of
ambient air by the jet. For low Reynolds number Re=3 103, the
increase of the aspect Ratio enhances the heat transfer of about 3%,
however; for Re=2 104, the heat transfer enhancement is of about
12%. The numerical velocity, pressure and temperature fields are
post-processed to compute the quantities of engineering interest such
as the induced mass flow rate, and average Nusselt number, in terms
of Rayleigh, Reynolds numbers and dimensionless geometric
parameters are presented.
Abstract: Bond graph models of an electrical transformer
including the nonlinear saturation are presented. These models
determine the relation between self and mutual inductances, and
the leakage and magnetizing inductances of power transformers
with two and three windings using the properties of a bond
graph. The modelling and analysis using this methodology to
three phase power transformers or transformers with internal
incipient faults can be extended.
Abstract: The steady-state temperature for one-dimensional transpiration cooling system has been conducted experimentally and numerically to investigate the heat transfer characteristics of combined convection and radiation. The Nickel –Chrome (Ni-Cr) open-cellular porous material having porosity of 0.93 and pores per inch (PPI) of 21.5 was examined. The upper surface of porous plate was heated by the heat flux of incoming radiation varying from 7.7 - 16.6 kW/m2 whereas air injection velocity fed into the lower surface was varied from 0.36 - 1.27 m/s, and was then rearranged as Reynolds number (Re). For the report of the results in the present study, two efficiencies including of temperature and conversion efficiency were presented. Temperature efficiency indicating how close the mean temperature of a porous heat plate to that of inlet air, and increased rapidly with the air injection velocity (Re). It was then saturated and had a constant value at Re higher than 10. The conversion efficiency, which was regarded as the ability of porous material in transferring energy by convection after absorbed from heat radiation, decreased with increasing of the heat flux and air injection velocity. In addition, it was then asymptotic to a constant value at the Re higher than 10. The numerical predictions also agreed with experimental data very well.
Abstract: In-place sorting algorithms play an important role in many fields such as very large database systems, data warehouses, data mining, etc. Such algorithms maximize the size of data that can be processed in main memory without input/output operations. In this paper, a novel in-place sorting algorithm is presented. The algorithm comprises two phases; rearranging the input unsorted array in place, resulting segments that are ordered relative to each other but whose elements are yet to be sorted. The first phase requires linear time, while, in the second phase, elements of each segment are sorted inplace in the order of z log (z), where z is the size of the segment, and O(1) auxiliary storage. The algorithm performs, in the worst case, for an array of size n, an O(n log z) element comparisons and O(n log z) element moves. Further, no auxiliary arithmetic operations with indices are required. Besides these theoretical achievements of this algorithm, it is of practical interest, because of its simplicity. Experimental results also show that it outperforms other in-place sorting algorithms. Finally, the analysis of time and space complexity, and required number of moves are presented, along with the auxiliary storage requirements of the proposed algorithm.
Abstract: This article considers the positional buckling of
composite thick plates under thermal loading . For this purpose , the
complex finite strip method is used . In analysis of complex finite
strip, harmonic complex function in longitudinal direction , cubic
functions in transversal direction and parabola distribution of
transverse shear strain in thickness of thick plate based on higherorder
shear deformation theory are used . In given examples , the
effect of angles of stratification , number of layers , dimensions ratio
and length – to – thick ratio across critical temperature are
considered.