Abstract: Transdermal delivery of ondansetron hydrochloride (OdHCl) can prevent the problems encountered with oral ondansetron. In previously conducted studies, effect of amount of polyvinyl pyrrolidone, permeation enhancer and casting solvent on the physicochemical properties on OdHCl were investigated. It is feasible to develop ondansetron transdermal patch by using ethyl cellulose and polyvinyl pyrrolidone with dibutyl pthalate as plasticizer, however, the desired flux is not achieved. The primary aim of this study is to use dimethyl succinate (DMS) and propylene glycol that are not incorporated in previous studies to determine their effect on the physicochemical properties of an OdHCl transdermal patch using ethyl cellulose and polyvinyl pyrrolidone. This study also investigates the effect of permeation enhancer (eugenol and phosphatidylcholine) on the release of OdHCl. The results showed that propylene glycol is a more suitable plasticizer compared to DMS in the fabrication of OdHCl transdermal patch using ethyl cellulose and polyvinyl pyrrolidone as polymers. Propylene glycol containing patch has optimum drug content, thickness, moisture content and water absorption, tensile strength, and a better release profile than DMS. Eugenol and phosphatidylcholine can increase release of OdHCl from the patches. From the physicochemical result and permeation profile, a combination of 350mg of ethyl cellulose, 150mg polyvinyl pyrrolidone, 3% of total polymer weight of eugenol, and 40% of total polymer weight of propylene glycol is the most suitable formulation to develop an OdHCl patch. OdHCl release did not increase with increasing the percentage of plasticiser. DMS 4, PG 4, DMS 9, PG 9, DMS 14, and PG 14 gave better release profiles where using 300mg: 0mg, 300mg: 100mg, and 350mg: 150mg of EC: PVP. Thus, 40% of PG or DMS appeared to be the optimum amount of plasticiser when the above combination where EC: PVP was used. It was concluded from the study that a patch formulation containing 350mg EC, 150mg PVP, 40% PG and 3% eugenol is the best transdermal matrix patch compositions for the uniform and continuous release/permeation of OdHCl over an extended period. This patch design can be used for further pharmacokinetic and pharmacodynamic studies in suitable animal models.
Abstract: The critical period for weed control (CPWC) is the period in the crop growth cycle during which weeds must be controlled to prevent unacceptable yield losses. Field studies were conducted in 2005 and 2006 in the University of Birjand at the south east of Iran to determine CPWC of corn using a randomized complete block design with 14 treatments and four replications. The treatments consisted of two different periods of weed interference, a critical weed-free period and a critical time of weed removal, were imposed at V3, V6, V9, V12, V15, and R1 (based on phonological stages of corn development) with a weedy check and a weed-free check. The CPWC was determined with the use of 2.5, 5, 10, 15 and 20% acceptable yield loss levels by non-linear Regression method and fitting Logistic and Gompertz nonlinear equations to relative yield data. The CPWC of corn was from 5- to 15-leaf stage (19-55 DAE) to prevent yield losses of 5%. This period to prevent yield losses of 2.5, 10 and 20% was 4- to 17-leaf stage (14-59 DAE), 6- to 12-leaf stage (25-47 DAE) and 8- to 9-leaf stage (31-36 DAE) respectively. The height and leaf area index of corn were significantly decreased by weed competition in both weed free and weed infested treatments (P
Abstract: An accurate procedure to determine free vibrations of
beams and plates is presented.
The natural frequencies are exact solutions of governing vibration
equations witch load to a nonlinear homogeny system.
The bilinear and linear structures considered simulate a bridge.
The dynamic behavior of this one is analyzed by using the theory of
the orthotropic plate simply supported on two sides and free on the
two others. The plate can be excited by a convoy of constant or
harmonic loads. The determination of the dynamic response of the
structures considered requires knowledge of the free frequencies and
the shape modes of vibrations. Our work is in this context. Indeed,
we are interested to develop a self-consistent calculation of the Eigen
frequencies.
The formulation is based on the determination of the solution of
the differential equations of vibrations. The boundary conditions
corresponding to the shape modes permit to lead to a homogeneous
system. Determination of the noncommonplace solutions of this
system led to a nonlinear problem in Eigen frequencies.
We thus, develop a computer code for the determination of the
eigenvalues. It is based on a method of bisection with interpolation
whose precision reaches 10 -12. Moreover, to determine the
corresponding modes, the calculation algorithm that we develop uses
the method of Gauss with a partial optimization of the "pivots"
combined with an inverse power procedure. The Eigen frequencies
of a plate simply supported along two opposite sides while
considering the two other free sides are thus analyzed. The results
could be generalized with the case of a beam by regarding it as a
plate with low width.
We give, in this paper, some examples of treated cases. The
comparison with results presented in the literature is completely
satisfactory.
Abstract: Since atmosphere pressure field is an actual envoy of
climatic signal the atmospheric Highs and Lows should be attributed
to the key active focal points within the ocean-atmosphere interplay
system. Here we were set a task to determine how the dynamics of
those centres of action relates to the climate change both on regional
and global scales. For this target the near-surface temperature and
atmospheric pressure differences between the Icelandic Low and the
Azores High were considered. The secular term of phase states of the
system under consideration was found divided into three
nonintersecting subsets. Each of that was put in consequence with
one of three climatic scenarios related to the periods of 1905-1935
(relatively warm phase), 1940-1970 (cold phase) and 1980-2000
(warm phase).
Abstract: This paper presents a simple and effective method for approximate indexing of instances for instance based learning. The method uses an interval tree to determine a good starting search point for the nearest neighbor. The search stops when an early stopping criterion is met. The method proved to be very effective especially when only the first nearest neighbor is required.
Abstract: We propose photo-BJMOSFET (Bipolar Junction Metal-Oxide-Semiconductor Field Effect Transistor) fabricated on SOI film. ITO film is adopted in the device as gate electrode to reduce light absorption. I-V characteristics of photo-BJMOSFET obtained in dark (dark current) and under 570nm illumination (photo current) are studied furthermore to achieve high photo-to-dark-current contrast ratio. Two variables in the calculation were the channel length and the thickness of the film which were set equal to six different values, i.e., L=2, 4, 6, 8, 10, and 12μm and three different values, i.e., dsi =100, 200 and 300nm, respectively. The results indicate that the greatest photo-to-dark-current contrast ratio is achieved with L=10μm and dsi=200 nm at VGK=0.6V.
Abstract: Four phenylurea herbicides (isoproturon, chlortoluron, diuron and linuron) were dissolved in different water matrices in order to study their chemical degradation by using UV radiation, ozone and some advanced oxidation processes (UV/H2O2, O3/H2O2, Fenton reagent and the photo- Fenton system). The waters used were: ultra-pure water, a commercial mineral water, a groundwater and a surface water taken from a reservoir. Elimination levels were established for each herbicide and for several global quality parameters, and a kinetic study was performed in order to determine basic kinetic parameters of each reaction between the target phenylureas and these oxidizing systems.
Abstract: A major goal of any enterprise is to create a ratings
system of customer satisfaction, goods and services. It is obvious that
the company cannot change what is not measured. In order to get a
clearer picture of the preferences of the major consumer groups, this
stage should be based on extensive research, including a variety of
interviews and surveys. It is necessary to know the key benefits,
which determine customer satisfaction in the market segment, of the
properties of certain goods and services. It is important to estimate
the terms of these preferences from the viewpoint of the client. This
article discusses the importance of customer satisfaction, and ways of
assessing it.
Abstract: Nowadays there are many methods for representing
knowledge such as semantic network, neural network, and conceptual
graphs. Nonetheless, these methods are not sufficiently efficient
when applied to perform and deduce on knowledge domains about
supporting in general education such as algebra, analysis or plane
geometry. This leads to the introduction of computational network
which is a useful tool for representation knowledge base, especially
for computational knowledge, especially knowledge domain about
general education. However, when dealing with a practical problem,
we often do not immediately find a new solution, but we search
related problems which have been solved before and then proposing
an appropriate solution for the problem. Besides that, when finding
related problems, we have to determine whether the result of them
can be used to solve the practical problem or not. In this paper, the
extension model of computational network has been presented. In this
model, Sample Problems, which are related problems, will be used
like the experience of human about practical problem, simulate the
way of human thinking, and give the good solution for the practical
problem faster and more effectively. This extension model is applied
to construct an automatic system for solving algebraic problems in
middle school.
Abstract: The flow field over a flat roof model building has been numerically investigated in order to determine threedimensional CFD guidelines for the calculation of the turbulent flow over a structure immersed in an atmospheric boundary layer. To this purpose, a complete validation campaign has been performed through a systematic comparison of numerical simulations with wind tunnel experimental data. Wind tunnel measurements and numerical predictions have been compared for five different vertical positions, respectively from the upstream leading edge to the downstream bottom edge of the analyzed model. Flow field characteristics in the neighborhood of the building model have been numerically investigated, allowing a quantification of the capabilities of the CFD code to predict the flow separation and the extension of the recirculation regions. The proposed calculations have allowed the development of a preliminary procedure to be used as guidance in selecting the appropriate grid configuration and corresponding turbulence model for the prediction of the flow field over a three-dimensional roof architecture dominated by flow separation.
Abstract: Principally, plants grown in soilless culture may be
attacked by the same pests and diseases as cultivated traditionally in
soil. The most destructive phytopathogens are fungi, such as
Phythium, Phytophthora and Fusarium, followed by viruses, bacteria
and nematodes. We investigated effect of carbon nanotube filters on
disease management of soilless culture. Tomato seedlings transplant
in plastic pots filled with a soilless media of vermiculite. The crop
irrigated and fertilized using a hydroponic nutrient solution. We used
carbon nanotube filters for nutrient solution disinfection. Our results
show that carbon nanotube filtration significantly reduces pathogens
on tomato plants. Fungal elimination (Fusarium oxysporum and
Pythium spp.) was usually successful at about 96 to 99.9% all over
the cultural season. It is seem that in tomato soilless culture,
nanofiltration constitutes a reliable method that allows control of the
development of diseases caused by pathogenic fungi
Abstract: Conceptualization strengthens intelligent systems in generalization skill, effective knowledge representation, real-time inference, and managing uncertain and indefinite situations in addition to facilitating knowledge communication for learning agents situated in real world. Concept learning introduces a way of abstraction by which the continuous state is formed as entities called concepts which are connected to the action space and thus, they illustrate somehow the complex action space. Of computational concept learning approaches, action-based conceptualization is favored because of its simplicity and mirror neuron foundations in neuroscience. In this paper, a new biologically inspired concept learning approach based on the probabilistic framework is proposed. This approach exploits and extends the mirror neuron-s role in conceptualization for a reinforcement learning agent in nondeterministic environments. In the proposed method, instead of building a huge numerical knowledge, the concepts are learnt gradually from rewards through interaction with the environment. Moreover the probabilistic formation of the concepts is employed to deal with uncertain and dynamic nature of real problems in addition to the ability of generalization. These characteristics as a whole distinguish the proposed learning algorithm from both a pure classification algorithm and typical reinforcement learning. Simulation results show advantages of the proposed framework in terms of convergence speed as well as generalization and asymptotic behavior because of utilizing both success and failures attempts through received rewards. Experimental results, on the other hand, show the applicability and effectiveness of the proposed method in continuous and noisy environments for a real robotic task such as maze as well as the benefits of implementing an incremental learning scenario in artificial agents.
Abstract: This paper describes a novel approach for deriving
modules from protein-protein interaction networks, which combines
functional information with topological properties of the network.
This approach is based on weighted clustering coefficient, which
uses weights representing the functional similarities between the
proteins. These weights are calculated according to the semantic
similarity between the proteins, which is based on their Gene
Ontology terms. We recently proposed an algorithm for identification
of functional modules, called SWEMODE (Semantic WEights for
MODule Elucidation), that identifies dense sub-graphs containing
functionally similar proteins. The rational underlying this approach is
that each module can be reduced to a set of triangles (protein triplets
connected to each other). Here, we propose considering semantic
similarity weights of all triangle-forming edges between proteins. We
also apply varying semantic similarity thresholds between
neighbours of each node that are not neighbours to each other (and
hereby do not form a triangle), to derive new potential triangles to
include in module-defining procedure. The results show an
improvement of pure topological approach, in terms of number of
predicted modules that match known complexes.
Abstract: In this study four Holstein steers with rumen fistula
fed 7 kg of dry matter (DM) of diets differing in concentrate to
alfalfa hay ratios as 60:40, 70:30, 80:20, and 90:10 in a 4 × 4 latin
square design. The pH of the ruminal fluid was measured before
the morning feeding (0.0 h) to 8 h post feeding. In this study, a
two-layered feed-forward neural network trained by the
Levenberg-Marquardt algorithm was used for modelling of ruminal
pH. The input variables of the network were time, concentrate to
alfalfa hay ratios (C/F), non fiber carbohydrate (NFC) and neutral
detergent fiber (NDF). The output variable was the ruminal pH.
The modeling results showed that there was excellent agreement
between the experimental data and predicted values, with a high
determination coefficient (R2 >0.96). Therefore, we suggest using
these model-derived biological values to summarize continuously
recorded pH data.
Abstract: Improving the reactive power and voltage profile of a
distribution substation is investigated in this paper. The purpose is to
properly determination of the shunt capacitors on/off status and
suitable tap changer (TC) position of a substation transformer. In
addition, the limitation of secondary bus voltage, the maximum
allowable number of switching operation in a day for on load tap
changer and on/off status of capacitors are taken into account. To
achieve these goals, an artificial neural network (ANN) is designed to
provide preliminary scheduling. Input of ANN is active and reactive
powers of transformer and its primary and secondary bus voltages.
The output of ANN is capacitors on/off status and TC position. The
preliminary schedule is further refined by fuzzy dynamic
programming in order to reach the final schedule. The operation of
proposed method in Q/V improving is compared with the results
obtained by operator operation in a distribution substation.
Abstract: Regenerative gas turbine engine cycle is presented that yields higher cycle efficiencies than simple cycle operating under the same conditions. The power output, efficiency and specific fuel consumption are simulated with respect to operating conditions. The analytical formulae about the relation to determine the thermal efficiency are derived taking into account the effected operation conditions (ambient temperature, compression ratio, regenerator effectiveness, compressor efficiency, turbine efficiency and turbine inlet temperature). Model calculations for a wide range of parameters are presented, as are comparisons with simple gas turbine cycle. The power output and thermal efficiency are found to be increasing with the regenerative effectiveness, and the compressor and turbine efficiencies. The efficiency increased with increase the compression ratio to 5, then efficiency decreased with increased compression ratio, but in simple cycle the thermal efficiency always increase with increased in compression ratio. The increased in ambient temperature caused decreased thermal efficiency, but the increased in turbine inlet temperature increase thermal efficiency.
Abstract: Although, all high school students in Japan are required to learn informatics, many of them do not learn this topic sufficiently. In response to this situation, we propose a support package for high school informatics classes. To examine what students learned and if they sufficiently understood the context of the lessons, a questionnaire survey was distributed to 186 students. We analyzed the results of the questionnaire and determined the weakest units, which were “basic computer configuration” and “memory and secondary storage”. We then developed a package for teaching these units. We propose that our package be applied in high school classrooms.
Abstract: In this paper, we intend to study the synthesis of the
multibeam arrays. The synthesis implementation-s method for this
type of arrays permits to approach the appropriated radiance-s
diagram. The used approach is based on neural network that are
capable to model the multibeam arrays, consider predetermined
general criteria-s, and finally it permits to predict the appropriated
diagram from the neural model. Our main contribution in this paper is
the extension of a synthesis model of these multibeam arrays.
Abstract: We report a novel fusion tag for expressing
recombinant proteins in E. coli. The fusion tag is the C-terminus part
of the human GMCSF gene comprising 45 amino acids, which aid in
over expression of otherwise non expressible genes. Expression of
hIFN a2b with this fusion tag also escapes the requirement of rare
codons for expression. This is also a first report of a small fusion tag
of human origin having affinity to heparin sepharose column
facilitating the purification of fusion protein.
Abstract: This paper developed the c-Chart based on a Zero- Inflated Poisson (ZIP) processes that approximated by a geometric distribution with parameter p. The p estimated that fit for ZIP distribution used in calculated the mean, median, and variance of geometric distribution for constructed the c-Chart by three difference methods. For cg-Chart, developed c-Chart by used the mean and variance of the geometric distribution constructed control limits. For cmg-Chart, the mean used for constructed the control limits. The cme- Chart, developed control limits of c-Chart from median and variance values of geometric distribution. The performance of charts considered from the Average Run Length and Average Coverage Probability. We found that for an in-control process, the cg-Chart is superior for low level of mean at all level of proportion zero. For an out-of-control process, the cmg-Chart and cme-Chart are the best for mean = 2, 3 and 4 at all level of parameter.