Abstract: Co-crystal is believed to improve the solubility and
dissolution rates and thus, enhanced the bioavailability of poor water
soluble drugs particularly during the oral route of administration.
With the existing of poorly soluble drugs in pharmaceutical industry,
the screening of co-crystal formation using carbamazepine (CBZ) as
a model drug compound with dicarboxylic acids co-crystal formers
(CCF) namely fumaric (FA) and succinic (SA) acids in ethanol has
been studied. The co-crystal formations were studied by varying the
mol ratio values of CCF to CBZ to access the effect of CCF
concentration on the formation of the co-crystal. Solvent evaporation,
slurry and cooling crystallization which representing the solution
based method co-crystal screening were used. Based on the
differential scanning calorimetry (DSC) analysis, the melting point of
CBZ-SA in different ratio was in the range between 188oC-189oC.
For CBZ-FA form A and CBZ-FA form B the melting point in
different ratio were in the range of 174oC-175oC and 185oC-186oC
respectively. The product crystal from the screening was also
characterized using X-ray powder diffraction (XRPD). The XRPD
pattern profile analysis has shown that the CBZ co-crystals with FA
and SA were successfully formed for all ratios studied. The findings
revealed that CBZ-FA co-crystal were formed in two different
polymorphs. It was found that CBZ-FA form A and form B were
formed from evaporation and slurry crystallization methods
respectively. On the other hand, in cooling crystallization method,
CBZ-FA form A was formed at lower mol ratio of CCF to CBZ and
vice versa. This study disclosed that different methods and mol ratios
during the co-crystal screening can affect the outcome of co-crystal
produced such as polymorphic forms of co-crystal and thereof. Thus,
it was suggested that careful attentions is needed during the screening
since the co-crystal formation is currently one of the promising
approach to be considered in research and development for
pharmaceutical industry to improve the poorly soluble drugs.
Abstract: Gypsum (CaSO4.2H2O) is a mineral that is found in
large quantities in the Turkey and in the World. In this study, the
dissolution of this mineral in the diammonium hydrogen phosphate
solutions has been studied. The dissolution and dissolution kinetics of
gypsum in diammonium hydrogen phosphate solutions will be useful
for evaluating of solid wastes containing gypsum. Parameters such as
diammonium hydrogen phosphate concentration, temperature and
stirring speed affecting on the dissolution rate of the gypsum in
diammonium hydrogen phosphate solutions were investigated. In
experimental studies have researched effectiveness of the selected
parameters. The dissolution of gypsum were examined in two parts at
low and high temperatures. The experimental results were
successfully correlated by linear regression using Statistica program.
Dissolution curves were evaluated shrinking core models for solidfluid
systems. The activation energy was found to be 34.58 kJ/mol
and 44.45 kJ/mol for the low and the high temperatures. The
dissolution of gypsum was controlled by chemical reaction both low
temperatures and high temperatures.
Abstract: Rice husk and kenaf filled with calcium carbonate
(CaCO3) and high density polyethylene (HDPE) composite were
prepared separately using twin-screw extruder at 50rpm. Different
filler loading up to 30 parts of rice husk particulate and kenaf fiber
were mixed with the fixed 30% amount of CaCO3 mineral filler to
produce rice husk/CaCO3/HDPE and kenaf/CaCO3/HDPE hybrid
composites. In this study, the effects of natural fiber for both rice
husk and kenaf in CaCO3/HDPE composite on physical, mechanical
and morphology properties were investigated. Field Emission
Scanning Microscope (FeSEM) was used to investigate the impact
fracture surfaces of the hybrid composite. The property analyses
showed that water absorption increased with the presence of kenaf
and rice husk fillers. Natural fibers in composite significantly
influence water absorption properties due to natural characters of
fibers which contain cellulose, hemicellulose and lignin structures.
The result showed that 10% of additional natural fibers into hybrid
composite had caused decreased flexural strength, however additional
of high natural fiber (>10%) filler loading has proved to increase its
flexural strength.
Abstract: Rural tourism is usually associated with rural
development because it has strong linkages to rural resources; but it
remains underdeveloped compared to urban tourism. This
underdevelopment of rural tourism serves as a motivation for this
study whose aim is to examine the factors affecting the perceived
satisfaction of rural tourists. The objectives of this study are: to
identify and design theories and models on rural tourism satisfaction,
and to empirically validate these models and theories through a
survey of tourists from the Malealea Lodge which is located in the
Mafeteng District, in the Mountain Kingdom of Lesotho. Data
generated by the collection of questionnaires used by this survey was
analyzed quantitatively using descriptive statistics and correlations in
SPSS after checking the validity and the reliability of the
questionnaire. The main hypothesis behind this study is the
relationship between the demographics of rural tourists, their
motivation, and their satisfaction, as supported by existing literature;
except that motivation is measured in this study according to three
dimensions: push factors, pull factors, and perceived usefulness of
ICTs in the rural tourism experience. Findings from this study
indicate that among the demographics factors, continent of origin and
marital status influence the satisfaction of rural tourists; and their
occupation affects their perceptions on the use of ICTs in rural
tourism. Moreover, only pull factors were found to influence the
satisfaction of rural tourists.
Abstract: Traditional document representation for classification
follows Bag of Words (BoW) approach to represent the term weights.
The conventional method uses the Vector Space Model (VSM) to
exploit the statistical information of terms in the documents and they
fail to address the semantic information as well as order of the terms
present in the documents. Although, the phrase based approach
follows the order of the terms present in the documents rather than
semantics behind the word. Therefore, a semantic concept based
approach is used in this paper for enhancing the semantics by
incorporating the ontology information. In this paper a novel method
is proposed to forecast the intraday stock market price directional
movement based on the sentiments from Twitter and money control
news articles. The stock market forecasting is a very difficult and
highly complicated task because it is affected by many factors such
as economic conditions, political events and investor’s sentiment etc.
The stock market series are generally dynamic, nonparametric, noisy
and chaotic by nature. The sentiment analysis along with wisdom of
crowds can automatically compute the collective intelligence of
future performance in many areas like stock market, box office sales
and election outcomes. The proposed method utilizes collective
sentiments for stock market to predict the stock price directional
movements. The collective sentiments in the above social media have
powerful prediction on the stock price directional movements as
up/down by using Granger Causality test.
Abstract: Dengue outbreaks are affected by biological,
ecological, socio-economic and demographic factors that vary over
time and space. These factors have been examined separately and still
require systematic clarification. The present study aimed to investigate
the spatial-temporal clustering relationships between these factors and
dengue outbreaks in the northern region of Sri Lanka. Remote sensing
(RS) data gathered from a plurality of satellites were used to develop
an index comprising rainfall, humidity and temperature data. RS data
gathered by ALOS/AVNIR-2 were used to detect urbanization, and a
digital land cover map was used to extract land cover information.
Other data on relevant factors and dengue outbreaks were collected
through institutions and extant databases. The analyzed RS data and
databases were integrated into geographic information systems,
enabling temporal analysis, spatial statistical analysis and space-time
clustering analysis. Our present results showed that increases in the
number of the combination of ecological factor and socio-economic
and demographic factors with above the average or the presence
contribute to significantly high rates of space-time dengue clusters.
Abstract: The adaptation of social networking sites within
higher education has garnered significant interest in the recent years
with numerous researches considering it as a possible shift from the
traditional classroom based learning paradigm. Notwithstanding this
increase in research and conducted studies however, the adaption of
SNS based modules have failed to proliferate within Universities.
This paper commences its contribution by analyzing the various
models and theories proposed in literature and amalgamate together
various effective aspects for the inclusion of social technology within
e-Learning. A three phased framework is further proposed which
details the necessary considerations for the successful adaptation of
SNS in enhancing the students learning experience. This proposal
outlines the theoretical foundations which will be analyzed in
practical implementation across international university campuses.
Abstract: Improved resource efficiency of production is a key
requirement for sustainable growth, worldwide. In this regards, by
considering the energy and tourism as the extra inputs to the classical
Coub-Douglas production function, this study aims at investigating
the efficiency changes in the North African countries. To this end, the
study uses panel data for the period 1995-2010 and adopts the
Malmquist index based on the data envelopment analysis. Results
show that tourism increases technical and scale efficiencies, while it
decreases technological and total factor productivity changes. On the
other hand, when the production function is augmented by the energy
input; technical efficiency change decreases, while the technological
change, scale efficiency change and total factor productivity change
increase. Thus, in order to satisfy the needs for sustainable growth,
North African governments should take some measures for increasing
the contribution that the tourism makes to economic growth and some
others for efficient use of resources in the energy sector.
Abstract: International and domestic environmental law has
evolved quite rapidly in the last few decades. At the international
level the Stockholm and Rio Declarations paved the way for a broad
based consensus of the international community on environmental
issues and principles. At the Domestic level also many states have
incorporated environmental protection in their constitutions and even
more states are doing the same at least in their domestic legislations.
In this process of evolution environmental law has unleashed a
number of novel principles such as; the participatory principle, the
polluter pays principle, the precautionary principle, the intergenerational
and intra-generational principles, the prevention
principle, the sustainable development principle and so on.
Abstract: Nanofibers are effective materials which have
frequently been investigated to produce high quality air filters. As an
environmental approach our aim is to achieve nanofibers by melting.
In spun-bond systems extruder, spin-pump, nozzle package and
attenuator are used. Molten polymer which flows from extruder is
made steady by spin-pump. Regular melt passes through nozzle holes
and forms fibers under high pressure. The fibers pulled from nozzle
are shrunk to micron size by an attenuator; after solidification, they
are collected on a conveyor. In this research different designs of
attenuator system have been studied; and also CFD analysis has been
done on these different designs. Afterwards, one of these designs
tested and finally some optimizations have been done to reduce
pressure loss and increase air velocity.
Abstract: Groundwater inflow to the tunnels is one of the most
important problems in tunneling operation. The objective of this
study is the investigation of model dimension effects on tunnel inflow
assessment in discontinuous rock masses using numerical modeling.
In the numerical simulation, the model dimension has an important
role in prediction of water inflow rate. When the model dimension is
very small, due to low distance to the tunnel border, the model
boundary conditions affect the estimated amount of groundwater flow
into the tunnel and results show a very high inflow to tunnel. Hence,
in this study, the two-dimensional universal distinct element code
(UDEC) used and the impact of different model parameters, such as
tunnel radius, joint spacing, horizontal and vertical model domain
extent has been evaluated. Results show that the model domain extent
is a function of the most significant parameters, which are tunnel
radius and joint spacing.
Abstract: This paper presents system level CMOS solid-state
nanopore techniques enhancement for speedup next generation
molecular recording and high throughput channels. This discussion
also considers optimum number of base-pair (bp) measurements
through channel as an important role to enhance potential read
accuracy. Effective power consumption estimation offered suitable
range of multi-channel configuration. Nanopore bp extraction model
in statistical method could contribute higher read accuracy with
longer read-length (200 < read-length). Nanopore ionic current
switching with Time Multiplexing (TM) based multichannel readout
system contributed hardware savings.
Abstract: This paper examines the effect of the volatility of oil
prices on food price in South Africa using monthly data covering the
period 2002:01 to 2014:09. Food price is measured by the South
African consumer price index for food while oil price is proxied by
the Brent crude oil. The study employs the GARCH-in-mean VAR
model, which allows the investigation of the effect of a negative and
positive shock in oil price volatility on food price. The model also
allows the oil price uncertainty to be measured as the conditional
standard deviation of a one-step-ahead forecast error of the change in
oil price. The results show that oil price uncertainty has a positive
and significant effect on food price in South Africa. The responses of
food price to a positive and negative oil price shocks is asymmetric.
Abstract: This paper reports the worldwide status of building
information modeling (BIM) adoption from the perspectives of the
engagement level, the Hype Cycle model, the technology diffusion
model, and BIM services. An online survey was distributed, and 156
experts from six continents responded. Overall, North America was
the most advanced continent, followed by Oceania and Europe.
Countries in Asia perceived their phase mainly as slope of
enlightenment (mature) in the Hype Cycle model. In the technology
diffusion model, the main BIM-users worldwide were “early majority”
(third phase), but those in the Middle East/Africa and South America
were “early adopters” (second phase). In addition, the more advanced
the country, the more number of BIM services employed in general. In
summary, North America, Europe, Oceania, and Asia were advancing
rapidly toward the mature stage of BIM, whereas the Middle
East/Africa and South America were still in the early phase. The
simple indexes used in this study may be used to track the worldwide
status of BIM adoption in long-term surveys.
Abstract: Recently, the competition between websites becomes
intense. How to make users “adopt” their websites is an issue of urgent
importance for online communities companies. Social procedures
(such as social influence) can possibly explain how and why users’
technologies usage behaviors affect other people to use the
technologies. This study proposes two types of social influences on the
initial usage of Facebook Check In-friends and group members.
Besides, this study combines social influences theory and social
network theory to explore the factors influencing initial usage of
Facebook Check In. This study indicates that Facebook friends’
previous usage of Facebook Check In and Facebook group members’
previous usage of Facebook Check In will positively influence focal
actors’ Facebook Check In adoption intention, and network centrality
will moderate the relationships among Facebook friends’ previous
usage of Facebook Check In, Facebook group members’ previous
usage of Facebook Check In and focal actors’ Facebook Check In
adoption intention. The article concludes with contributions to
academic research and practice.
Abstract: In urban context, urban nodes such as amenity or
hazard will certainly affect house price, while classic hedonic analysis
will employ distance variables measured from each urban nodes.
However, effects from distances to facilities on house prices generally
do not represent the true price of the property. Distance variables
measured on the same surface are suffering a problem called
multicollinearity, which is usually presented as magnitude variance
and mean value in regression, errors caused by instability. In this paper,
we provided a theoretical framework to identify and gather the data
with less bias, and also provided specific sampling method on locating
the sample region to avoid the spatial multicollinerity problem in three
distance variable’s case.
Abstract: This paper aims to investigate the influence of quality
of education and quality of research, provided by local educational
institutions, on the adoption of Information and Communication
Technology (ICT) in managing business operations for companies in
Saudi market. A model was developed and tested using data collected
from 138 Chief Executive Officers (CEOs) of foreign companies in
diverse business sectors. The data is analyzed and managed using
multivariate approaches through standard statistical packages. The
results showed that educational quality has little contribution to the
ICT adoption while research quality seems to play a more prominent
role. These results are analyzed in terms of business environment and
market constraints and further extended to the perceived effectiveness
of applied pedagogical approaches in schools and universities.
Abstract: The feedbacks obtained regarding the sense of
presence from pilot users operating a Mobile Robotic presence
(MRP) system to visit a simulated museum are reported in this paper.
The aim is to investigate how much the perception of system’s
usefulness and ease of use is affected by operators’ sense of social
telepresence (presence) in the remote location. Therefore, scenarios
of visiting a museum are simulated and the user operators are
supposed to perform some regular tasks inside the remote
environment including interaction with local users, navigation and
visiting the artworks. Participants were divided into two groups,
those who had previous experience of operation and interaction with
a MRP system and those who never had experience. Based on the
results, both groups provided different feedbacks. Moreover, there
was a significant association between user’s sense of presence and
their perception of system usefulness and ease of use.
Abstract: We have been grouping and developing various kinds
of practical, promising sensing applied systems concerning
agricultural advancement and technical tradition (guidance). These
include advanced devices to secure real-time data related to worker
motion, and we analyze by methods of various advanced statistics and
human dynamics (e.g. primary component analysis, Ward system
based cluster analysis, and mapping). What is more, we have been
considering worker daily health and safety issues. Targeted fields are
mainly common farms, meadows, and gardens. After then, we
observed and discussed time-line style, changing data. And, we made
some suggestions. The entire plan makes it possible to improve both
the aforementioned applied systems and farms.
Abstract: Soil quality monitoring is a science-based soil
management tool that assesses soil ecosystem health.
A soil monitoring program in Auckland, New Zealand’s largest
city extends from 1995 to the present. The objective of this study was
to firstly determine changes in soil parameters (basic soil properties
and heavy metals) that were assessed from rural land in 1995-2000
and repeated in 2008-2012. The second objective was to determine
differences in soil parameters across various land uses including
native bush, rural (horticulture, pasture and plantation forestry) and
urban land uses using soil data collected in more recent years (2009-
2013).
Across rural land, mean concentrations of Olsen P had
significantly increased in the second sampling period and was
identified as the indicator of most concern, followed by soil
macroporosity, particularly for horticultural and pastoral land. Mean
concentrations of Cd were also greatest for pastoral and horticultural
land and a positive correlation existed between these two parameters,
which highlights the importance of analysing basic soil parameters in
conjunction with heavy metals. In contrast, mean concentrations of
As, Cr, Pb, Ni and Zn were greatest for urban sites. Native bush sites
had the lowest concentrations of heavy metals and were used to
calculate a ‘pollution index’ (PI). The mean PI was classified as high
(PI > 3) for Cd and Ni and moderate for Pb, Zn, Cr, Cu, As and Hg,
indicating high levels of heavy metal pollution across both rural and
urban soils. From a land use perspective, the mean ‘integrated
pollution index’ was highest for urban sites at 2.9 followed by
pasture, horticulture and plantation forests at 2.7, 2.6 and 0.9,
respectively.
It is recommended that soil sampling continues over time because
a longer spanning record will allow further identification of where
soil problems exist and where resources need to be targeted in the
future. Findings from this study will also inform policy and science
direction in regional councils.