Abstract: This paper presents system level CMOS solid-state
nanopore techniques enhancement for speedup next generation
molecular recording and high throughput channels. This discussion
also considers optimum number of base-pair (bp) measurements
through channel as an important role to enhance potential read
accuracy. Effective power consumption estimation offered suitable
range of multi-channel configuration. Nanopore bp extraction model
in statistical method could contribute higher read accuracy with
longer read-length (200 < read-length). Nanopore ionic current
switching with Time Multiplexing (TM) based multichannel readout
system contributed hardware savings.