Abstract: Multipotent mesenchymal stromal cells (MSCs)
possess immunomodulatory properties. The effect of MSCs on the
crucial cellular immunity compartment – T-cells is of a special
interest. It is known that MSC tissue niche and expected milieu of
their interaction with T- cells are characterized by low oxygen
concentration, whereas the in vitro experiments usually are carried
out at a much higher ambient oxygen (20%). We firstly evaluated
immunomodulatory effects of MSCs on T-cells at tissue-related
oxygen (5%) after interaction implied cell-to-cell contacts and
paracrine factors only. It turned out that MSCs under reduced oxygen
can effectively suppress the activation and proliferation of PHAstimulated
T-cells and can provoke decrease in the production of
proinflammatory and increase in anti-inflammatory cytokines. In
hypoxia some effects were amplified (inhibition of proliferation, antiinflammatory
cytokine profile shift). This impact was more evident
after direct cell-to-cell interaction; lack of intercellular contacts could
revoke the potentiating effect of hypoxia.
Abstract: Analysis of real life problems often results in linear
systems of equations for which solutions are sought. The method to
employ depends, to some extent, on the properties of the coefficient
matrix. It is not always feasible to solve linear systems of equations
by direct methods, as such the need to use an iterative method
becomes imperative. Before an iterative method can be employed
to solve a linear system of equations there must be a guaranty that
the process of solution will converge. This guaranty, which must
be determined apriori, involve the use of some criterion expressible
in terms of the entries of the coefficient matrix. It is, therefore,
logical that the convergence criterion should depend implicitly on the
algebraic structure of such a method. However, in deference to this
view is the practice of conducting convergence analysis for Gauss-
Seidel iteration on a criterion formulated based on the algebraic
structure of Jacobi iteration. To remedy this anomaly, the Gauss-
Seidel iteration was studied for its algebraic structure and contrary
to the usual assumption, it was discovered that some property of the
iteration matrix of Gauss-Seidel method is only diagonally dominant
in its first row while the other rows do not satisfy diagonal dominance.
With the aid of this structure we herein fashion out an improved
version of Gauss-Seidel iteration with the prospect of enhancing
convergence and robustness of the method. A numerical section is
included to demonstrate the validity of the theoretical results obtained
for the improved Gauss-Seidel method.
Abstract: The high Peak to Average Power Ratio (PAR) in Filter
Bank Multicarrier with Offset Quadrature Amplitude Modulation
(FBMC-OQAM) can significantly reduce power efficiency and
performance. In this paper, we address the problem of PAPR
reduction for FBMC-OQAM systems using Tone Reservation (TR)
technique. Due to the overlapping structure of FBMCOQAM signals,
directly applying TR schemes of OFDM systems to FBMC-OQAM
systems is not effective. We improve the tone reservation (TR)
technique by employing sliding window with Active Constellation
Extension for the PAPR reduction of FBMC-OQAM signals, called
sliding window tone reservation Active Constellation Extension
(SW-TRACE) technique. The proposed SW-TRACE technique uses
the peak reduction tones (PRTs) of several consecutive data
blocks to cancel the peaks of the FBMC-OQAM signal inside a
window, with dynamically extending outer constellation points in
active(data-carrying) channels, within margin-preserving constraints,
in order to minimize the peak magnitude. Analysis and simulation
results compared to the existing Tone Reservation (TR) technique for
FBMC/OQAM system. The proposed method SW-TRACE has better
PAPR performance and lower computational complexity.
Abstract: It is known that residual welding deformations give
negative effect to processability and operational quality of welded
structures, complicating their assembly and reducing strength.
Therefore, selection of optimal technology, ensuring minimum
welding deformations, is one of the main goals in developing a
technology for manufacturing of welded structures.
Through years, JSC SSTC has been developing a theory for
estimation of welding deformations and practical activities for
reducing and compensating such deformations during welding
process. During long time a methodology was used, based on analytic
dependence. This methodology allowed defining volumetric changes
of metal due to welding heating and subsequent cooling. However,
dependences for definition of structures deformations, arising as a
result of volumetric changes of metal in the weld area, allowed
performing calculations only for simple structures, such as units, flat
sections and sections with small curvature. In case of complex 3D
structures, estimations on the base of analytic dependences gave
significant errors.
To eliminate this shortage, it was suggested to use finite elements
method for resolving of deformation problem. Here, one shall first
calculate volumes of longitudinal and transversal shortenings of
welding joints using method of analytic dependences and further,
with obtained shortenings, calculate forces, which action is
equivalent to the action of active welding stresses. Further, a finiteelements
model of the structure is developed and equivalent forces
are added to this model. Having results of calculations, an optimal
sequence of assembly and welding is selected and special measures to
reduce and compensate welding deformations are developed and
taken.
Abstract: The emergence of the Semantic Web technology
increases day by day due to the rapid growth of multiple web pages.
Many standard formats are available to store the semantic web data.
The most popular format is the Resource Description Framework
(RDF). Querying large RDF graphs becomes a tedious procedure
with a vast increase in the amount of data. The problem of query
optimization becomes an issue in querying large RDF graphs.
Choosing the best query plan reduces the amount of query execution
time. To address this problem, nature inspired algorithms can be used
as an alternative to the traditional query optimization techniques. In
this research, the optimal query plan is generated by the proposed
SAPSO algorithm which is a hybrid of Simulated Annealing (SA)
and Particle Swarm Optimization (PSO) algorithms. The proposed
SAPSO algorithm has the ability to find the local optimistic result
and it avoids the problem of local minimum. Experiments were
performed on different datasets by changing the number of predicates
and the amount of data. The proposed algorithm gives improved
results compared to existing algorithms in terms of query execution
time.
Abstract: High temperature deformation behavior of cast
Fe-20Cr-5Al alloy has been investigated in this study by performing
tensile and compression tests at temperatures from 1100 to 1200oC.
Rectangular ingots of which the dimensions were 300×300×100 in
millimeter were cast using vacuum induction melting. Phase
equilibrium was calculated using the FactSage®, thermodynamic
software and database. Tensile strength of cast Fe-20Cr-5Al alloy was
4 MPa at 1200oC. With temperature decreased, tensile strength
increased rapidly and reached up to 13 MPa at 1100oC. Elongation
also increased from 18 to 80% with temperature decreased from
1200oC to 1100oC. Microstructure observation revealed that M23C6
carbide was precipitated along the grain boundary and within the
matrix.
Abstract: This study investigates the effect of moisture
conditioning on the Indirect Tensile Strength (ITS) of asphalt
concrete. As a first step, cylindrical samples of 100 mm diameter and
50 mm thick were prepared using a Superpave gyratory compactor.
Next, the samples were conditioned using Moisture Induced
Susceptibility Test (MIST) device at different numbers of moisture
conditioning cycles. In the MIST device, samples are subjected water
pressure through the sample pores cyclically. The MIST conditioned
samples were tested for ITS. Results show that the ITS does not
change significantly with MIST conditioning at the specific pressure
and cycles adopted in this study.
Abstract: Second line antiretroviral therapy (ART) regimen is
used when patients fail their first line regimen. There are many
factors such as non-adherence, drug resistance as well as virological
and immunological failure that lead to second line highly active
antiretroviral therapy (HAART) regimen treatment failure. This study
was aimed at determining predictor factors to treatment failure with
second line HAART and analyzing median survival time.
An observational, retrospective study was conducted in Sungai
Buloh Hospital (HSB) to assess current status of HIV patients treated
with second line HAART regimen. Convenience sampling was used
and 104 patients were included based on the study’s inclusion and
exclusion criteria. Data was collected for six months i.e. from July
until December 2013. Data was then analysed using SPSS version 18.
Kaplan-Meier and Cox regression analyses were used to measure
median survival times and predictor factors for treatment failure.
The study population consisted mainly of male subjects, aged 30-
45 years, who were heterosexual, and had HIV infection for less than
6 years. The most common second line HAART regimen given was
lopinavir/ritonavir (LPV/r)-based combination. Kaplan-Meier
analysis showed that patients on LPV/r demonstrated longer median
survival times than patients on indinavir/ritonavir (IDV/r) based
combination (p
Abstract: Construction in Finland is focusing increasingly on
renovation instead of conventional new construction, and this trend
will continue to grow in the coming years and decades. Renovation of
the large number of suburban residential apartment buildings built in
the 1960s and 1970s poses a particular challenge. However,
renovation projects are demanding for the residents of these
buildings, since they usually are uninitiated in construction issues. On
the other hand, renovation projects generally apply the operating
models of new construction.
Nevertheless, the residents of an existing residential apartment
building are some of the best experts on the site. Thus, in this
research project we applied a relational model in developing and
testing at case sites a planning process that employs interactive
planning methods. Current residents, housing company managers, the
city zoning manager, the contractor’s and prefab element supplier’s
representatives, professional designers and researchers all took part in
the planning. The entire interactive planning process progressed
phase by phase as the participants’ and designers’ concerted
discussion and ideation process, so that the end result was a
renovation plan desired by the residents.
Abstract: This paper presents a regression model with
autocorrelated errors in which the inputs are social moods obtained by
analyzing the adjectives in Twitter posts using a document topic
model, where document topics are extracted using LDA. The
regression model predicts Dow Jones Industrial Average (DJIA) more
precisely than autoregressive moving-average models.
Abstract: In the present work, detailed analysis on flow characteristics of a pair of immiscible liquids through horizontal pipeline is simulated by using ANSYS FLUENT 6.2. Moderately viscous oil and water (viscosity ratio = 107, density ratio = 0.89 and interfacial tension = 0.024 N/m) have been taken as system fluids for the study. Volume of Fluid (VOF) method has been employed by assuming unsteady flow, immiscible liquid pair, constant liquid properties, and co-axial flow. Meshing has been done using GAMBIT. Quadrilateral mesh type has been chosen to account for the surface tension effect more accurately. From the grid independent study, we have selected 47037 number of mesh elements for the entire geometry. Simulation successfully predicts slug, stratified wavy, stratified mixed and annular flow, except dispersion of oil in water, and dispersion of water in oil. Simulation results are validated with horizontal literature data and good conformity is observed. Subsequently, we have simulated the hydrodynamics (viz., velocity profile, area average pressure across a cross section and volume fraction profile along the radius) of stratified wavy and annular flow at different phase velocities. The simulation results show that in the annular flow, total pressure of the mixture decreases with increase in oil velocity due to the fact that pipe cross section is completely wetted with water. Simulated oil volume fraction shows maximum at the centre in core annular flow, whereas, in stratified flow, maximum value appears at upper side of the pipeline. These results are in accord with the actual flow configuration. Our findings could be useful in designing pipeline for transportation of crude oil.
Abstract: There is an essential need for obtaining the mathematical representation of fish body undulations, which can be used for designing and building new innovative types of marine propulsion systems with less environmental impact. This research work presents a case study to derive the mathematical model for fish body movement. Observation and capturing image methods were used in this study in order to obtain a mathematical representation of Clariasbatrachus fish (catfish). An experiment was conducted by using an aquarium with dimension 0.609 m x 0.304 m x 0.304 m, and a 0.5 m ruler was attached at the base of the aquarium. Progressive Scan Monochrome Camera was positioned at 1.8 m above the base of the aquarium to provide swimming sequences. Seven points were marked on the fish body using white marker to indicate the fish movement and measuring the amplitude of undulation. Images from video recordings (20 frames/s) were analyzed frame by frame using local coordinate system, with time interval 0.05 s. The amplitudes of undulations were obtained for image analysis from each point that has been marked on fish body. A graph of amplitude of undulations versus time was plotted by using computer to derive a mathematical fit. The function for the graph is polynomial with nine orders.
Abstract: This work studied the ability of adipose tissue-derived
mesenchymal stromal cells (MSCs) to form stroma for expansion of
cord blood hematopoietic cells. We showed that 72-hour interaction
of MSCs with cord blood mononuclear cells (MNCs) in vitro at
atmospheric (20%) and low (5%) O2 conditions increased the
expression of ICAM-1, HCAM (at the beginning of interaction) on
MSCs. Viability of MSCs and MNCs were maintained at high level.
Adhesion of MNCs to MSCs was faster at 20% O2. MSCs promoted
the proliferation of adhered MNCs to form the suspension containing
great number of hematopoietic colony-forming units, and this effect
was more pronounced at 5% O2. Thus, adipose-derived MSCs
supplied sufficient stromal support to cord blood MNCs both at 20%
and 5% О2, providing their adhesion with further expansion of new
generation of different hematopoietic lineages.
Abstract: Analytical expressions of the current and angular errors, as well as the frequency characteristics of an induction converter describing the relation with its structural parameters, the core and winding characteristics are obtained. Based on estimation of the dependences obtained, a mathematical problem of parametric optimization is formulated which can successfully be used for investigating and diagnosing an induction converter.
Abstract: The use of low quality concrete has been identified as one of the main causes of the incessant collapse of buildings in Nigeria. Emphasis has been on the use of poor quality aggregates, poor workmanship and the use of lean concrete mix with low cement quantity as the reasons for the low quality of concrete used for building construction in Nigeria. Surveys conducted revealed that in the construction of most privately owned buildings where concrete trial mixes and concrete compressive strength quality assurance tests are not conducted, concretes used for building constructions are produced using the 1:2:4 mix ratio irrespective of the cement grade/strength class. In this paper, the possible role of the use of inappropriate cement grade/strength class as a cause of the incessant collapse of building in Nigeria is investigated. Investigation revealed that the compressive strengths of concrete cubes produced with Portland-limestone cement grade 32.5 using 1:2:4 and 1:1.5:3 mix ratios are less than the 25MPa and 30MPa cube strengths generally recommended for building superstructures and foundations respectively. Conversely, the compressive strengths of concrete cubes produced with Portland-limestone cement grade 42.5 using 1:2:4 and 1:1.5:3 mix ratios exceed the 25MPa and 30MPa generally recommended for building superstructures and foundations respectively. Thus, it can be concluded that the use of inappropriate cement grade (Portland-limestone cement grade 32.5), particularly for the construction of building foundations is a potential cause of the incessant collapse of buildings in Nigeria. It is recommended that the Standards Organisation of Nigeria should embark on creating awareness for Nigerians, particularly, the home owners and the roadside craftsmen that Portland-limestone cement grade 32.5 should not be used for the construction of building load-carrying members, particularly, building foundations in order to reduce the incessant incidence of collapsed building.
Abstract: The present environmental issues have made aircraft jet noise reduction a crucial problem in aero-acoustics research. Acoustic studies reveal that addition of chevrons to the nozzle reduces the sound pressure level reasonably with acceptable reduction in performance. In this paper comprehensive numerical studies on acoustic characteristics of different types of chevron nozzles have been carried out with non-reacting flows for the shape optimization of chevrons in supersonic nozzles for aerospace applications. The numerical studies have been carried out using a validated steady 3D density based, k-ε turbulence model. In this paper chevron with sharp edge, flat edge, round edge and U-type edge are selected for the jet acoustic characterization of supersonic nozzles. We observed that compared to the base model a case with round-shaped chevron nozzle could reduce 4.13% acoustic level with 0.6% thrust loss. We concluded that the prudent selection of the chevron shape will enable an appreciable reduction of the aircraft jet noise without compromising its overall performance. It is evident from the present numerical simulations that k-ε model can predict reasonably well the acoustic level of chevron supersonic nozzles for its shape optimization.
Abstract: Flow forming is widely used in many industries, especially in defence technology industries. Pressure vessels requirements are high precision, light weight, seamless and optimum strength. For large pressure vessels, flow forming by 3 rollers machine were used. In case of long range rocket motor case flow forming and welding of pressure vessels have been used for manufacturing. Due to complication of welding process, researchers had developed 4 meters length pressure vessels without weldment by 4 rollers flow forming machine. Design and preparation of preform work pieces are performed. The optimization of flow forming parameter such as feed rate, spindle speed and depth of cut will be discussed. The experimental result shown relation of flow forming parameters to quality of flow formed tube and prototype pressure vessels have been made.
Abstract: This article aims to study the effect of pressure on rocket motor case by Finite Element Method simulation to select optimal material in rocket motor manufacturing process. In this study, cylindrical tubes with outside diameter of 122 mm and thickness of 3 mm are used for simulation. Defined rocket motor case materials are AISI4130, AISI1026, AISI1045, AL2024 and AL7075. Internal pressure used for the simulation is 22 MPa.
The result from Finite Element Method shows that at a pressure of 22 MPa rocket motor case produced by AISI4130, AISI1045 and AL7075 can be used. A comparison of the result between AISI4130, AISI1045 and AL7075 shows that AISI4130 has minimum principal stress and confirm the results of Finite Element Method by the used of calculation method found that, the results from Finite Element Method has good reliability.
Abstract: A vacuum fractionation technique was introduced to remove ethanol from fermentation broth. The effect of initial glucose and ethanol concentrations were investigated for specific productivity. The inhibitory ethanol concentration was observed at 100 g/L. In order to increase the fermentation performance, the ethanol product was removed as soon as it is produced. The broth was boiled at 35oC by reducing the pressure to 65 mBar. The ethanol/water vapor was fractionated for up to 90 wt% before leaving the column. Ethanol concentration in the broth was kept lower than 25 g/L, thus minimized the product inhibition effect to the yeast cells. For batch extractive fermentation, a high substrate utilization rate was obtained at 26.6 g/L.h and most of glucose was consumed within 21 h. For repeated-batch extractive fermentation, addition of glucose was carried out up to 9 times and ethanol was produced more than 8-fold higher than batch fermentation.
Abstract: Climate change and poverty are global issues which cannot be waved aside in welfare of the ever increasing population. The causes / consequences are far more elaborate in developing countries, including Nigeria, which poses threats to the existence of man and his environment. The dominant role of agriculture makes it obvious that even minor climate deteriorations can cause devastating socio-economic consequences. Policies to curb the climate change by reducing the consumption of fossil fuels like oil, gas or carbon compounds have significant economical impacts on the producers/suppliers of these fuels. Thus a unified political narrative that advances both agendas is needed, because their components of an environmental coin that needs to be addressed. The developed world should maintain a low-carbon growth & real commitment of 0.7% of gross national income, as aid to developing countries & renewable energy approach should be emphasized, hence global poverty combated.