Abstract: In this paper, an automatic detecting algorithm for
QRS complex detecting was applied for analyzing ECG recordings
and five criteria for dangerous arrhythmia diagnosing are applied for a
protocol type of automatic arrhythmia diagnosing system. The
automatic detecting algorithm applied in this paper detected the
distribution of QRS complexes in ECG recordings and related
information, such as heart rate and RR interval. In this investigation,
twenty sampled ECG recordings of patients with different pathologic
conditions were collected for off-line analysis. A combinative
application of four digital filters for bettering ECG signals and
promoting detecting rate for QRS complex was proposed as
pre-processing. Both of hardware filters and digital filters were
applied to eliminate different types of noises mixed with ECG
recordings. Then, an automatic detecting algorithm of QRS complex
was applied for verifying the distribution of QRS complex. Finally,
the quantitative clinic criteria for diagnosing arrhythmia were
programmed in a practical application for automatic arrhythmia
diagnosing as a post-processor. The results of diagnoses by automatic
dangerous arrhythmia diagnosing were compared with the results of
off-line diagnoses by experienced clinic physicians. The results of
comparison showed the application of automatic dangerous
arrhythmia diagnosis performed a matching rate of 95% compared
with an experienced physician-s diagnoses.
Abstract: The purpose of this paper is to assess the value of neural networks for classification of cancer and noncancer prostate cells. Gauss Markov Random Fields, Fourier entropy and wavelet average deviation features are calculated from 80 noncancer and 80 cancer prostate cell nuclei. For classification, artificial neural network techniques which are multilayer perceptron, radial basis function and learning vector quantization are used. Two methods are utilized for multilayer perceptron. First method has single hidden layer and between 3-15 nodes, second method has two hidden layer and each layer has between 3-15 nodes. Overall classification rate of 86.88% is achieved.
Abstract: Mouse L929 fibroblastic cell line, which is widely
used in many experiment aspects, was tested for their differentiation
potency in osteogenic differentiation and adipogenic differentiation.
Human dermal fibroblasts, which their differentiation potency are
still be in confliction, also be taken in the experiment. The
differentiations were conducted by using the inducing medium
ingredients which is generally used to induce differentiation of stem
cells. By the inducing media used, L929 mouse fibroblasts
successfully underwent osteogenic differentiation and adipogenic
differentiation while human dermal fibroblasts underwent only
osteogenic differentiation but not for adipogenic differentiation.
Human dermal fibroblasts are hard to be differentiated in adipogenic
lineage and need specific proper condition for induction.
Abstract: The ε4 allele of the ε2, ε3 and ε4 protein isoform polymorphism in the gene encoding apolipoprotein E (Apo E) has previously been associated with increased cardiac artery disease (CAD); therefore to investigate the significance of this polymorphism in pathogenesis of CAD in Iranian patients with stenosis and control subjects. To investigate the association between
Apo E polymorphism and coronary artery disease we performed a comparative case control study of the frequency of Apo E
polymorphism in One hundred CAD patients with stenosis who underwent coronary angiography (>50% stenosis) and 100 control subjects (
Abstract: Essential hypertension (HTN) usually clusters with other cardiovascular risk factors such as age, overweight, diabetes, insulin resistance and dyslipidemia. The target organ damage (TOD) such as left ventricular hypertrophy, microalbuminuria (MA), acute coronary syndrome (ACS), stroke and cognitive dysfunction takes place early in course of hypertension. Though the prevalence of hypertension is high in India, the relationship between microalbuminuria and target organ damage in hypertension is not well studied. This study aim at detecting MA in essential hypertension and its relation to severity of HTN, duration of HTN, body mass index (BMI), age and TOD such as HTN retinopathy and acute coronary syndrome The present study was done in 100 patients of essential hypertension non diabetics admitted to B.L.D.E.University-s Sri B.M.Patil Medical College, Bijapur, from October 2008 to April 2011. The patients underwent detailed history and clinical examination. Early morning 5 ml of urine sample was collected & MA was estimated by immunoturbidometry method. The relationship of MA with the duration & severity of HTN, BMI, age, sex and TOD's like hypertensive retinopathy, ACS was assessed by univariate analysis. The prevalence of MA in this study was found to be 63 %. In that 42% were male & 21% were female. In this study a significant association between MA and the duration of hypertension (p = 0.036) & (OR =0.438). Longer the duration of hypertension, more possibility of microalbumin in urine. Also there was a significant association between severity of hypertension and MA (p=0.045) and (OR=0.093). MA was positive in 50 (79.4%) patients out of 63, whose blood pressure was >160/100 mm Hg. In this study a significant association between MA and the grades of hypertensive retinopathy (p =0.011) and acute coronary syndrome (p = 0.041) (OR =2.805). Gender and BMI did not pose high risk for MA in this study.The prevalence of MA in essential hypertension is high in this part of the community and MA will increase the risk of developing target organ damage.Early screening of patients with essential hypertension for MA and aggressive management of positive cases might reduce the burden of chronic kidney diseases and cardiovascular diseases in the community.
Abstract: The research purpose was to evaluate the effect of
Active Imagination Technique (AIT) for bruxism treatment. This
project was approved by the Ethics Committee on Human Research
(CAAE: 05619512.9.0000.0109). Twenty-one volunteers using
interocclusal splint completed the study. Initially they filled in a
questionnaire about their condition, composed of objective questions
on signs and symptoms. Following they were underwent asingle
session of AIT. After 15 days, the volunteers met again the same
initial questionnaire. The results were compared and showed that the
vast majority had pain symptoms, difficulty opening the mouth, pain
when chewing, reduced, some of the participants abandoned the
interocclusal splint during the evaluate period. It is concluded that the
technique can be used in bruxism treatment. Results seem to be
promising and demonstrates the need of highlighting Active
Imagination Technique since it points a possibility of bruxism cure
and that is unprecedented.
Abstract: The Zung self-depression scale and Beck Anxiety Inventory were used both to study the depression and anxiety levels of Armenian Crohn’s disease patients, and to reveal the relation between emotional status and placebo effect of these patients. On the other hand, the blood cell analyses and gut bacteria investigations were used to assess the placebo effect on ESR, and haemoglobin-s and leukocyte-s levels as well as gut commensal E. coli quantities of these patients. Despite of registered high levels of depression and anxiety, the high placebo effect on psychoemotional status for investigated patients during the investigations was described. On the other hand, no positive effect of placebo on measurements of ESP and hemoglobin-s levels of Crohn’s disease patients was revealed. The importance of use of psychotherapies for optimal outcomes during treatments of Crohn’s disease is discussed.
Abstract: Adenylate kinase (AK) catalyse the phosphotransferase
reaction plays an important role in cellular energy homeostasis. The
inhibitors of bacterial AK are useful in the treatment of several
bacterial infections. To the novel inhibitors of AK, docking studies
performed by using the 3D structure of Bacillus stearothermophilus
adenylate kinase from protein data bank (IZIP). 46 Quinoxaline
analogues were docked in 1ZIP and selected the highly interacting
compounds based on their binding energies, for further studies
Abstract: A three-dimensional and pulsatile blood flow in the left ventricle of heart model has been studied numerically. The geometry was derived from a simple approximation of the left ventricle model and the numerical simulations were obtained using a formulation of the Navier-Stokes equations. In this study, simulation was used to investigate the pattern of flow velocity in 3D model of heart with consider the left ventricle based on critical parameter of blood under steady condition. Our results demonstrate that flow velocity focused from mitral valve channel and continuous linearly to left ventricle wall but this skewness progresses into outside wall in atrium through aortic valve with random distribution that is irregular due to force subtract from ventricle wall during cardiac cycle. The findings are the prediction of the behavior of the blood flow velocity pattern in steady flow condition which can assist the medical practitioners in their decision on the patients- treatments.
Abstract: The study of cytokine expression in mice under the
influence of inactivated poliovirus and Imovaks polio vaccine in
combination with derivatives of chitosan shows various kinds of
processes. There is a significant increase in IL-12 in the serum of
immunized animals, which should stimulate the production of IFN-γ
NK-cells and T-cells and polarize the immune response to Th1 type.
Thus, the derivatives of chitosan can promote cell component of the
immune response, providing a full antiviral immunity.
Abstract: Deep Brain Stimulation or DBS is a surgical treatment for Parkinson-s Disease with three stimulation parameters: frequency, pulse width, and voltage. The parameters should be selected appropriately to achieve effective treatment. This selection now, performs clinically. The aim of this research is to study chaotic behavior of recorded tremor of patients under DBS in order to present a computational method to recognize stimulation optimum voltage. We obtained some chaotic features of tremor signal, and discovered embedding space of it has an attractor, and its largest Lyapunov exponent is positive, which show tremor signal has chaotic behavior, also we found out, in optimal voltage, entropy and embedding space variance of tremor signal have minimum values in comparison with other voltages. These differences can help neurologists recognize optimal voltage numerically, which leads to reduce patients' role and discomfort in optimizing stimulation parameters and to do treatment with high accuracy.
Abstract: In this paper, we study the pulsatile flow of blood through stenotic arteries. The inner layer of arterial walls is modeled as a porous medium and human blood is assumed as an incompressible fluid. A numerical algorithm based on the finite element method is developed to simulate the blood flow through both the lumen region and the porous wall. The algorithm is then applied to study the flow behaviour and to investigate the significance of the non-Newtonian effect.
Abstract: Objective: The objective of this paper is to assess the
hospitals preparedness for emergency using WHO standards.
Method: This is a cross-sectional study, consisted of site visit,
questionnaire survey, 16 health facilities were included. The WHO
standard for emergency preparedness of health facilities was used to
evaluate and assess the hospitals preparedness of health facilities.
Result: 13 hospitals were responded. They scored below average
in all measure >75%), while above average score was in 7 out 9 nine
measure with a range of 8%-25%. Un acceptable below average was
noted in two measures only.
Discussion: The biggest challenge facing the hospitals in their
emergency intervention is the lack of pre-emergency and emergency
preparedness plans as well as the coordination of the hospitals
response mechanisms.
Conclusion: The studied hospitals presently are far from
international disasters preparedness protocols. That necessitates
improvements in emergency preparedness, as well as in physician
skills for injury management.
Abstract: Severe heart failure is a common problem that has a significant effect on health expenditures in industrialized countries; moreover it reduces patient-s quality of life. However, current research usually focuses either on detailed modeling of the heart or on detailed modeling of the cardiovascular system. Thus, this paper aims to present a sophisticated model of the heart enhanced with an extensive model of the cardiovascular system. Special interest is on the pressure and flow values close to the heart since these values are critical to accurately diagnose causes of heart failure. The model is implemented in Dymola an object-oriented, physical modeling language. Results achieved with the novel model show overall feasibility of the approach. Moreover, results are illustrated and compared to other models. The novel model shows significant improvements.
Abstract: The error monitoring and processing system, EMPS is
the system located in the substantia nigra of the midbrain, basal
ganglia and cortex of the forebrain, and plays a leading role in error
detection and correction. The main components of EMPS are the
dopaminergic system and anterior cingulate cortex. Although, recent
studies show that alcohol disrupts the EMPS, the ways in which
alcohol affects this system are poorly understood. Based on current
literature data, here we suggest a hypothesis of alcohol-related
glucose-dependent system of error monitoring and processing, which
holds that the disruption of the EMPS is related to the competency of
glucose homeostasis regulation, which in turn may determine the
dopamine level as a major component of EMPS. Alcohol may
indirectly disrupt the EMPS by affecting dopamine level through
disorders in blood glucose homeostasis regulation.
Abstract: Autism Spectrum Disorders (ASDs) are characterized
by abnormalities in social interaction and communication, as well as
repetitive and stereotyped behaviors. Although various studies have
been conducted in ASDs etiology across the world, it seems that they
are still unknown in Middle East. Some scientific researches have
been conducted on ASDs in Middle East (ME) especially in
Kingdom of Saudi Arabia (KSA).
A systematic literature review was performed to identify the ASDs
studies in KSA. Accordingly, PubMed, ISI web of Science and
Google were searched to find KSA and ME studies in ASDs. The
main focus of this review work is to outline an improved
understanding of the underpinnings of ASD in order to achieve
therapeutic interventions and we will discuss the main problem we
waiting for solution with reference with role of Transcranial
Magnetic Stimulation (TMS) to modulate cortical activity improve
understanding ASD.
Abstract: The excessive use of agricultural pesticides and the
resulting contamination of food and beds of rivers have been a
recurring problem nowadays. Some of these substances can cause
changes in endocrine balance and impair reproductive function of
human and animal population. In the present study, we evaluated the
possible effects of the fungicide cuprous copper oxide Sandoz® on
pregnant Wistar rats. They received a daily oral administration of 103
or 3.103 mg/kg of the fungicide from the 6th to the 15th day of
gestation. On day 21 of gestation, the maternal and fetal toxicity
parameters and indices were determined. The administration of
cuprous oxide (Copper Sandoz) in Wistar rats, the period of
organogenesis, revealed no evidence of maternal toxicity or embryo
at the studied doses.
Abstract: The medical data statistical analysis often requires the
using of some special techniques, because of the particularities of
these data. The principal components analysis and the data clustering
are two statistical methods for data mining very useful in the medical
field, the first one as a method to decrease the number of studied
parameters, and the second one as a method to analyze the
connections between diagnosis and the data about the patient-s
condition. In this paper we investigate the implications obtained from
a specific data analysis technique: the data clustering preceded by a
selection of the most relevant parameters, made using the principal
components analysis. Our assumption was that, using the principal
components analysis before data clustering - in order to select and to
classify only the most relevant parameters – the accuracy of
clustering is improved, but the practical results showed the opposite
fact: the clustering accuracy decreases, with a percentage
approximately equal with the percentage of information loss reported
by the principal components analysis.
Abstract: Swietenia mahagoni have been used in traditional
medicine for treatment of different diseases. Present study was
performed to evaluate anti-ulcerogenic activity of ethanol seed
extract against ethanol induced gastric mucosal injury in rats. Six
groups of rats were orally pre-treated respectively with
carboxymethyl cellulose, omeprazole 20 mg/kg, 50, 100, 200 and 400
mg/kg plant extract one hour before oral administration of absolute
ethanol to generate gastric mucosal injury. After additional hour, rats
were sacrificed and ulcer areas of gastric walls were determined.
Grossly, carboxymethyl cellulose group exhibited severe mucosal
injury, whereas pre-treatment with plant extract exhibited significant
protection of gastric mucosa. Histology, carboxymethyl cellulose
group exhibited severe damage of gastric mucosa; edema and
leucocytes infiltration of sub mucosa compared to plant extract which
showed gastric protection. Acute toxicity study did not manifest any
toxicological signs in rats. Conclusions, results suggest that S.
mahagoni promotes ulcer protection as ascertained grossly and
histologically.
Abstract: According to previous studies, some muscles present a non-homogeneous spatial distribution of its muscle fiber types and motor unit types. However, available muscle models only deal with muscles with homogeneous distributions. In this paper, a new architecture muscle model is proposed to permit the construction of non-uniform distributions of muscle fibers within the muscle cross section. The idea behind is the use of a motor unit placement algorithm that controls the spatial overlapping of the motor unit territories of each motor unit type. Results show the capabilities of the new algorithm to reproduce arbitrary muscle fiber type distributions.