A Chaotic Study on Tremor Behavior of Parkinsonian Patients under Deep Brain Stimulation
Deep Brain Stimulation or DBS is a surgical treatment for Parkinson-s Disease with three stimulation parameters: frequency, pulse width, and voltage. The parameters should be selected appropriately to achieve effective treatment. This selection now, performs clinically. The aim of this research is to study chaotic behavior of recorded tremor of patients under DBS in order to present a computational method to recognize stimulation optimum voltage. We obtained some chaotic features of tremor signal, and discovered embedding space of it has an attractor, and its largest Lyapunov exponent is positive, which show tremor signal has chaotic behavior, also we found out, in optimal voltage, entropy and embedding space variance of tremor signal have minimum values in comparison with other voltages. These differences can help neurologists recognize optimal voltage numerically, which leads to reduce patients' role and discomfort in optimizing stimulation parameters and to do treatment with high accuracy.
[1] H. Yu, J. S. Neimat, "The Treatment of Movement Disorders by Deep
Brain Stimulation", Vol. 5, 26-36, January 2008 ┬® The American
Society for Experimental NeuroTherapeutics, Inc.
[2] S. S. HACISALIHZADE, M. MANSOUR, C. Albani, "Optimization of
Symptomatic Therapy in Parkinson-s Disease", IEEE TRANSACTIONS
ON BIOMEDICAL ENGINEERING, VOL. 36, NO. 3, MARCH 1989.
[3] M. Haeri, Y. Sarbaz, Sh. Gharibzadeh, "Modeling the Parkinson-s
tremor and its treatments", Journal of Theoretical Biology 236, 311-322,
2005.
[4] A. H. V. Schapira, E. Bezard, J. Brotchie, F. Calon, G. L. Collingridge,
B. Ferger, et al.," Novel Pharmacological Targets for the Treatment of
Parkinson-s Disease" NATURE REVIEWS DRUG DISCOVER,
OCTOBER 2008.
[5] C. R. Butson, C. C. McIntyre, "Differences among implanted pulse
generator waveforms cause variations in the neural response to deep
brain stimulation", Clinical Neurophysiology 118 (2007) 1889-1894.
[6] S. Breit, J.B. Schulz , A.-L. Benabid, "Deep brain stimulation", Cell
Tissue Res (2004) 318: 275-288, DOI 10.1007/s00441-004-0936-0.
[7] Th. Wichmann, M.R. DeLong, "Deep Brain Stimulation for Neurologic
and Neuropsychiatric Disorders", Neuron 52, 197-204, October 5,
2006 ª2006 Elsevier Inc. DOI 10.1016/j.neuron.2006.09.022.
[8] D. S. Kern, R. Kumar, "Deep Brain Stimulation", The Neurologist ÔÇó
Volume 13, Number 5, September 2007.
[9] T. Fiegele, G. Feuchtner, F. Sohm, R. Bauer, J. V. Anton, T. Gotwald
and et al "Accuracy of stereotactic electrode placement in deep brain
stimulation by intraoperative computed tomography"., Department of
Neurosurgery, Innsbruck Medical University, Anichstrasse 35, 6020
Innsbruck, Austria b Department of Radiology II, Innsbruck Medical
University, Innsbruck, Austria Received 16 August 2007; received in
revised form 13 November 2007; accepted 3 January 2008
[10] L. Garcia1, G. D-Alessandro2, B. Bioulac1 and C. Hammond2 "Highfrequency
stimulation in Parkinson-s disease: more or less? "
Laboratoire de neurophysiologie (Centre National de la Recherche
Scientifique UMR 5543), Universite' de Bordeaux 2, 146 rue Le'o
Saignat, 33076 Bordeaux Cedex, France 2Institut de Neurobiologie de la
Me' diterrane'e (Institut National de la Recherche Me' dicale U 29), 163
route de Luminy, BP 13, 13273 Marseille Cedex 9, France
[11] J. E. Arle and J. L. Shils "Motor Cortex Stimulation for Pain and
Movement Disorders" Department of Neurosurgery, Lahey Clinic,
Burlington, Massachusetts 01805, and Department of Neurosurgery,
Tufts University School of Medicine, Boston, Massachusetts 02110
[12] A. M. Kuncel, W. M. Grill, "Selection of stimulus parameters for deep
brain stimulation", Clinical Neurophysiology 115 (2004) 2431-2441.
[13] Erwin B. Montgomery Jra,_, John T. Galeb "Mechanisms of action of
deep brain stimulation (DBS)" Department of Neurology, National
Primate Research Center, University of Wisconsin-Madison, H6/538
CSC, 600 Highland Ave., Madison, WI 53792, USA Department of
Neurosurgery, Massachusetts General Hospital/Harvard Medical School,
Edwards Research Building, EDR 410, 50 Blossom St., Boston, MA
02114, USA
[14] J. Y. Chang, L. H. Shi, F. Luo, W.M. Zhang, D.J Woodward, "Studies of
the neural mechanisms of deep brain stimulation in rodent models of
Parkinson-s disease" , Neuroscience and Biobehavioral Reviews 31
(2007) 643-657.
[15] M.S. Titcombe, L. Glass, A. Beuter , "Dynamics of Parkinsonian tremor
during deep brain stimulation", American Institute of Physics,
DECEMBER 2001.
[16] T. O. Videen, M. C. Campbell , S. D. Tabbal, M. Karimi, T. Hershey, J.
S. Perlmutter, "Validation of a fiducial-based atlas localization method
for deep brain stimulation contacts in the area of the subthalamic
nucleus", Department of Neurology, Washington University School of
Medicine, St. Louis, MO 63110, USA Mallinckrodt Institute of
Radiology, Washington University School of Medicine, St. Louis, MO
63110, USA Department of Psychiatry, Washington University School
of Medicine, St. Louis, MO 63110, USA Department of Anatomy &
Neurobiology, Washington University School of Medicine, St. Louis,
MO 63110, USA Program in Physical Therapy, Washington University
School of Medicine, St. Louis, MO 63110, USA Received 7 June 2007;
received in revised form 11 October 2007; accepted 11 October 2007
[17] B. Blad, L. Bertenstam, S. Rehncrona, H. Bjartmarz, A.-L. Törnqvist,
"Measurement of contact impedance of electrodes used for deep brain
stimulation", ITBM-RBM 26 (2005) 344-346.
[18] D. M. Durand, "Electrical Stimulation of Excitable Systems" case
western reserved university
[1] H. Yu, J. S. Neimat, "The Treatment of Movement Disorders by Deep
Brain Stimulation", Vol. 5, 26-36, January 2008 ┬® The American
Society for Experimental NeuroTherapeutics, Inc.
[2] S. S. HACISALIHZADE, M. MANSOUR, C. Albani, "Optimization of
Symptomatic Therapy in Parkinson-s Disease", IEEE TRANSACTIONS
ON BIOMEDICAL ENGINEERING, VOL. 36, NO. 3, MARCH 1989.
[3] M. Haeri, Y. Sarbaz, Sh. Gharibzadeh, "Modeling the Parkinson-s
tremor and its treatments", Journal of Theoretical Biology 236, 311-322,
2005.
[4] A. H. V. Schapira, E. Bezard, J. Brotchie, F. Calon, G. L. Collingridge,
B. Ferger, et al.," Novel Pharmacological Targets for the Treatment of
Parkinson-s Disease" NATURE REVIEWS DRUG DISCOVER,
OCTOBER 2008.
[5] C. R. Butson, C. C. McIntyre, "Differences among implanted pulse
generator waveforms cause variations in the neural response to deep
brain stimulation", Clinical Neurophysiology 118 (2007) 1889-1894.
[6] S. Breit, J.B. Schulz , A.-L. Benabid, "Deep brain stimulation", Cell
Tissue Res (2004) 318: 275-288, DOI 10.1007/s00441-004-0936-0.
[7] Th. Wichmann, M.R. DeLong, "Deep Brain Stimulation for Neurologic
and Neuropsychiatric Disorders", Neuron 52, 197-204, October 5,
2006 ª2006 Elsevier Inc. DOI 10.1016/j.neuron.2006.09.022.
[8] D. S. Kern, R. Kumar, "Deep Brain Stimulation", The Neurologist ÔÇó
Volume 13, Number 5, September 2007.
[9] T. Fiegele, G. Feuchtner, F. Sohm, R. Bauer, J. V. Anton, T. Gotwald
and et al "Accuracy of stereotactic electrode placement in deep brain
stimulation by intraoperative computed tomography"., Department of
Neurosurgery, Innsbruck Medical University, Anichstrasse 35, 6020
Innsbruck, Austria b Department of Radiology II, Innsbruck Medical
University, Innsbruck, Austria Received 16 August 2007; received in
revised form 13 November 2007; accepted 3 January 2008
[10] L. Garcia1, G. D-Alessandro2, B. Bioulac1 and C. Hammond2 "Highfrequency
stimulation in Parkinson-s disease: more or less? "
Laboratoire de neurophysiologie (Centre National de la Recherche
Scientifique UMR 5543), Universite' de Bordeaux 2, 146 rue Le'o
Saignat, 33076 Bordeaux Cedex, France 2Institut de Neurobiologie de la
Me' diterrane'e (Institut National de la Recherche Me' dicale U 29), 163
route de Luminy, BP 13, 13273 Marseille Cedex 9, France
[11] J. E. Arle and J. L. Shils "Motor Cortex Stimulation for Pain and
Movement Disorders" Department of Neurosurgery, Lahey Clinic,
Burlington, Massachusetts 01805, and Department of Neurosurgery,
Tufts University School of Medicine, Boston, Massachusetts 02110
[12] A. M. Kuncel, W. M. Grill, "Selection of stimulus parameters for deep
brain stimulation", Clinical Neurophysiology 115 (2004) 2431-2441.
[13] Erwin B. Montgomery Jra,_, John T. Galeb "Mechanisms of action of
deep brain stimulation (DBS)" Department of Neurology, National
Primate Research Center, University of Wisconsin-Madison, H6/538
CSC, 600 Highland Ave., Madison, WI 53792, USA Department of
Neurosurgery, Massachusetts General Hospital/Harvard Medical School,
Edwards Research Building, EDR 410, 50 Blossom St., Boston, MA
02114, USA
[14] J. Y. Chang, L. H. Shi, F. Luo, W.M. Zhang, D.J Woodward, "Studies of
the neural mechanisms of deep brain stimulation in rodent models of
Parkinson-s disease" , Neuroscience and Biobehavioral Reviews 31
(2007) 643-657.
[15] M.S. Titcombe, L. Glass, A. Beuter , "Dynamics of Parkinsonian tremor
during deep brain stimulation", American Institute of Physics,
DECEMBER 2001.
[16] T. O. Videen, M. C. Campbell , S. D. Tabbal, M. Karimi, T. Hershey, J.
S. Perlmutter, "Validation of a fiducial-based atlas localization method
for deep brain stimulation contacts in the area of the subthalamic
nucleus", Department of Neurology, Washington University School of
Medicine, St. Louis, MO 63110, USA Mallinckrodt Institute of
Radiology, Washington University School of Medicine, St. Louis, MO
63110, USA Department of Psychiatry, Washington University School
of Medicine, St. Louis, MO 63110, USA Department of Anatomy &
Neurobiology, Washington University School of Medicine, St. Louis,
MO 63110, USA Program in Physical Therapy, Washington University
School of Medicine, St. Louis, MO 63110, USA Received 7 June 2007;
received in revised form 11 October 2007; accepted 11 October 2007
[17] B. Blad, L. Bertenstam, S. Rehncrona, H. Bjartmarz, A.-L. Törnqvist,
"Measurement of contact impedance of electrodes used for deep brain
stimulation", ITBM-RBM 26 (2005) 344-346.
[18] D. M. Durand, "Electrical Stimulation of Excitable Systems" case
western reserved university
@article{"International Journal of Medical, Medicine and Health Sciences:64272", author = "M. Sadeghi and A.H. Jafari and S.M.P. Firoozabadi", title = "A Chaotic Study on Tremor Behavior of Parkinsonian Patients under Deep Brain Stimulation", abstract = "Deep Brain Stimulation or DBS is a surgical treatment for Parkinson-s Disease with three stimulation parameters: frequency, pulse width, and voltage. The parameters should be selected appropriately to achieve effective treatment. This selection now, performs clinically. The aim of this research is to study chaotic behavior of recorded tremor of patients under DBS in order to present a computational method to recognize stimulation optimum voltage. We obtained some chaotic features of tremor signal, and discovered embedding space of it has an attractor, and its largest Lyapunov exponent is positive, which show tremor signal has chaotic behavior, also we found out, in optimal voltage, entropy and embedding space variance of tremor signal have minimum values in comparison with other voltages. These differences can help neurologists recognize optimal voltage numerically, which leads to reduce patients' role and discomfort in optimizing stimulation parameters and to do treatment with high accuracy.
", keywords = "Chaos, Deep Brain Stimulation, Parkinson's Disease, Stimulation Parameters, tremor.", volume = "5", number = "2", pages = "78-4", }
