Features of the Immune Response in Mice were Immunized with Polio Vaccine in Combination with Chitosan Preparations as Adjuvants

Year: 2012 Volume: 6 Issue: 12 743 - 745 Pages

• Authors:
• Nelly К. Akhmatova
• Оlga V. Lebedinskaya
• Stanislav G. Markushin
• Elvin А. Akhmatov
• Lidiya A. Geiderova
• Еlena А. Lebedinskaya
• Vera M. Axenova
• Аnatoliy P. Godovalov

Abstract: The study of cytokine expression in mice under the influence of inactivated poliovirus and Imovaks polio vaccine in combination with derivatives of chitosan shows various kinds of processes. There is a significant increase in IL-12 in the serum of immunized animals, which should stimulate the production of IFN-γ NK-cells and T-cells and polarize the immune response to Th1 type. Thus, the derivatives of chitosan can promote cell component of the immune response, providing a full antiviral immunity.

• Keywords:
• Poliovirus
• chitosan
• cytokine expression
• antiviral immunity.

Immune Responce in Mice Immunized with Live Cold-Adapted Influenza Vaccine in Combination with Chitosan-Based Adjuvants

Year: 2012 Volume: 6 Issue: 12 706 - 709 Pages

• Authors:
• Nelly К. Akhmatova
• Оlga V. Lebedinskaya
• Ancha V. Baranova
• Еlena А. Lebedinskaya
• Ekaterina V. Sorokina
• Elvin А. Akhmatov
• Аnatoliy P. Godovalov
• Stanislav G. Markushin

Abstract: An influence of intranasal combined injection of live cold-adapted influenza vaccine with chitosan derivatives as adjuvants on the subpopulation structure of mononuclear leukocytes of mouse spleen which reflects the orientation of the immune response was studied. It is found that the inclusion of chitosan preparations promotes activation of cellular-level of immune response.

• Keywords:
• Immunophenotype
• chitosan
• cold-adapted vaccine
• intranasal injection.