Abstract: pH-sensitive drug targeting using nanoparticles for
cancer chemotherapy have been spotlighted in recent decades. Graft
copolymer composed of poly (L-histidine) (PHS) and dextran
(DexPHS) was synthesized and pH-sensitive nanoparticles were
fabricated for pH-responsive drug delivery of doxorubicin (DOX).
Nanoparticles of DexPHS showed pH-sensitive changes in particle
sizes and drug release behavior, i.e. particle sizes and drug release rate
were increased at acidic pH, indicating that DexPHS nanoparticles
have pH-sensitive drug delivery potentials. Antitumor activity of
DOX-incorporated DexPHS nanoparticles were studied using CT26
colorectal carcinoma cells. Results indicated that fluorescence
intensity was higher at acidic pH than basic pH. These results
indicated that DexPHS nanoparticles have pH-responsive drug
targeting.
Abstract: Cognizant of the fact that enterprise systems involve
organizational change and their implementation is over shadowed by a
high failure rate, it is argued that there is the need to focus attention on
employees- perceptions of such organizational change when
explaining adoption behavior of enterprise systems. For this purpose,
the research incorporates a conceptual constructo fattitude toward
change that captures views about the need for organizational change.
Centered on this conceptual construct, the research model includes
beliefs regarding the system and behavioral intention as its
consequences, and the personal characteristics of organizational
commitment and perceived personal competence as its antecedents.
Structural equation analysis using LISREL provides significant
support for the proposed relationships. Theoretical and practical
implications are discussed along with limitations.
Abstract: A mathematical model of the surface roughness
has been developed by using response surface methodology
(RSM) in grinding of AISI D2 cold work tool steels. Analysis
of variance (ANOVA) was used to check the validity of the
model. Low and high value for work speed and feed rate are
decided from design of experiment. The influences of all
machining parameters on surface roughness have been
analyzed based on the developed mathematical model. The
developed prediction equation shows that both the feed rate
and work speed are the most important factor that influences
the surface roughness. The surface roughness was found to be
the lowers with the used of low feed rate and low work speed.
Accuracy of the best model was proved with the testing data.
Abstract: Finite element method was applied to model damage
development in the femoral neck during a sideways fall. The femoral
failure was simulated using the maximum principal strain criterion.
The evolution of damage was consistent with previous studies. It was
initiated by compressive failure at the junction of the superior aspect
of the femoral neck and the greater trochanter. It was followed by
tensile failure that occurred at the inferior aspect of the femoral neck
before a complete transcervical fracture was observed. The estimated
failure line was less than 50° from the horizontal plane (Pauwels type
II).
Abstract: Recent advancements in sensor technologies and
Wireless Body Area Networks (WBANs) have led to the
development of cost-effective healthcare devices which can be used
to monitor and analyse a person-s physiological parameters from
remote locations. These advancements provides a unique opportunity
to overcome current healthcare challenges of low quality service
provisioning, lack of easy accessibility to service varieties, high costs
of services and increasing population of the elderly experienced
globally. This paper reports on a prototype implementation of an
architecture that seamlessly integrates Wireless Body Area Network
(WBAN) with Web services (WS) to proactively collect
physiological data of remote patients to recommend diagnostic
services. Technologies based upon WBAN and WS can provide
ubiquitous accessibility to a variety of services by allowing
distributed healthcare resources to be massively reused to provide
cost-effective services without individuals physically moving to the
locations of those resources. In addition, these technologies can
reduce costs of healthcare services by allowing individuals to access
services to support their healthcare. The prototype uses WBAN body
sensors implemented on arduino fio platforms to be worn by the
patient and an android smart phone as a personal server. The
physiological data are collected and uploaded through GPRS/internet
to the Medical Health Server (MHS) to be analysed. The prototype
monitors the activities, location and physiological parameters such as
SpO2 and Heart Rate of the elderly and patients in rehabilitation.
Medical practitioners would have real time access to the uploaded
information through a web application.
Abstract: Palm shell obtained from coastal part of southern
India was studied for the removal for the adsorption of Hg (II) ions.
Batch adsorption experiments were carried out as a function of pH,
concentration of Hg (II) ions, time, temperature and adsorbent dose.
Maximum removal was seen in the range pH 4.0- pH 7.0. The palm
shell powder used as adsorbent was characterized for its surface area,
SEM, PXRD, FTIR, ion exchange capacity, moisture content, and
bulk density, soluble content in water and acid and pH. The
experimental results were analyzed using Langmuir I, II, III, IV and
Freundlich adsorption isotherms. The batch sorption kinetics was
studied for the first order reversible reaction, pseudo first order;
pseudo second order reaction and the intra-particle diffusion reaction.
The biomass was successfully used for removal Hg (II) from
synthetic and industrial effluents and the technique appears
industrially applicable and viable.
Abstract: We theoretically demonstrate modulation of light
polarization by a crossed rectangular hole array with asymmetric arm
lengths. There are two waveguide modes that can modulate the x- and
y- polarized incident waves independently. A specific structure is
proposed to convert a left-hand incident wave to a right-hand outgoing
wave by transmission.
Abstract: In this paper, we investigate two parallel alternating methods for solving the system of linear equations Ax = b and give convergence theorems for the parallel alternating methods when the coefficient matrix is a nonsingular H-matrix. Furthermore, we give one example to show our results.
Abstract: The literature reports a large number of approaches for
measuring the similarity between protein sequences. Most of these
approaches estimate this similarity using alignment-based techniques
that do not necessarily yield biologically plausible results, for two
reasons.
First, for the case of non-alignable (i.e., not yet definitively aligned
and biologically approved) sequences such as multi-domain, circular
permutation and tandem repeat protein sequences, alignment-based
approaches do not succeed in producing biologically plausible results.
This is due to the nature of the alignment, which is based on the
matching of subsequences in equivalent positions, while non-alignable
proteins often have similar and conserved domains in non-equivalent
positions.
Second, the alignment-based approaches lead to similarity measures
that depend heavily on the parameters set by the user for the alignment
(e.g., gap penalties and substitution matrices). For easily alignable
protein sequences, it's possible to supply a suitable combination of
input parameters that allows such an approach to yield biologically
plausible results. However, for difficult-to-align protein sequences,
supplying different combinations of input parameters yields different
results. Such variable results create ambiguities and complicate the
similarity measurement task.
To overcome these drawbacks, this paper describes a novel and
effective approach for measuring the similarity between protein
sequences, called SAF for Substitution and Alignment Free. Without
resorting either to the alignment of protein sequences or to substitution
relations between amino acids, SAF is able to efficiently detect the
significant subsequences that best represent the intrinsic properties of
protein sequences, those underlying the chronological dependencies of
structural features and biochemical activities of protein sequences.
Moreover, by using a new efficient subsequence matching scheme,
SAF more efficiently handles protein sequences that contain similar
structural features with significant meaning in chronologically
non-equivalent positions. To show the effectiveness of SAF, extensive
experiments were performed on protein datasets from different
databases, and the results were compared with those obtained by
several mainstream algorithms.
Abstract: This work proposes a novel market-based air traffic flow control model considering competitive airlines in air traffic network. In the flow model, an agent based framework for resources (link/time pair) pricing is described. Resource agent and auctioneer for groups of resources are also introduced to simulate the flow management in Air Traffic Control (ATC). Secondly, the distributed group pricing algorithm is introduced, which efficiently reflect the competitive nature of the airline industry. Resources in the system are grouped according to the degree of interaction, and each auctioneer adjust s the price of one group of resources respectively until the excess demand of resources becomes zero when the demand and supply of resources of the system changes. Numerical simulation results show the feasibility of solving the air traffic flow control problem using market mechanism and pricing algorithms on the air traffic network.
Abstract: MATCH project [1] entitle the development of an
automatic diagnosis system that aims to support treatment of colon
cancer diseases by discovering mutations that occurs to tumour
suppressor genes (TSGs) and contributes to the development of
cancerous tumours. The constitution of the system is based on a)
colon cancer clinical data and b) biological information that will be
derived by data mining techniques from genomic and proteomic
sources The core mining module will consist of the popular, well
tested hybrid feature extraction methods, and new combined
algorithms, designed especially for the project. Elements of rough
sets, evolutionary computing, cluster analysis, self-organization maps
and association rules will be used to discover the annotations
between genes, and their influence on tumours [2]-[11].
The methods used to process the data have to address their high
complexity, potential inconsistency and problems of dealing with the
missing values. They must integrate all the useful information
necessary to solve the expert's question. For this purpose, the system
has to learn from data, or be able to interactively specify by a domain
specialist, the part of the knowledge structure it needs to answer a
given query. The program should also take into account the
importance/rank of the particular parts of data it analyses, and adjusts
the used algorithms accordingly.
Abstract: In this paper, we introduce GODYS-PC software
package for modeling, simulating and analyzing dynamic systems.
To illustrate the use of GODYS-PC we present a few examples
which concern modeling and simulating of engineering systems. In
order to compare GODYS-PC with widely used in academia and
industry Simulink®, the same examples are provided both in
GODYS-PC and Simulink®.
Abstract: Literature reveals that many investors rely on technical trading rules when making investment decisions. If stock markets are efficient, one cannot achieve superior results by using these trading rules. However, if market inefficiencies are present, profitable opportunities may arise. The aim of this study is to investigate the effectiveness of technical trading rules in 34 emerging stock markets. The performance of the rules is evaluated by utilizing White-s Reality Check and the Superior Predictive Ability test of Hansen, along with an adjustment for transaction costs. These tests are able to evaluate whether the best model performs better than a buy-and-hold benchmark. Further, they provide an answer to data snooping problems, which is essential to obtain unbiased outcomes. Based on our results we conclude that technical trading rules are not able to outperform a naïve buy-and-hold benchmark on a consistent basis. However, we do find significant trading rule profits in 4 of the 34 investigated markets. We also present evidence that technical analysis is more profitable in crisis situations. Nevertheless, this result is relatively weak.
Abstract: A cancelable palmprint authentication system
proposed in this paper is specifically designed to overcome the
limitations of the contemporary biometric authentication system. In
this proposed system, Geometric and pseudo Zernike moments are
employed as feature extractors to transform palmprint image into a
lower dimensional compact feature representation. Before moment
computation, wavelet transform is adopted to decompose palmprint
image into lower resolution and dimensional frequency subbands.
This reduces the computational load of moment calculation
drastically. The generated wavelet-moment based feature
representation is used to generate cancelable verification key with a
set of random data. This private binary key can be canceled and
replaced. Besides that, this key also possesses high data capture
offset tolerance, with highly correlated bit strings for intra-class
population. This property allows a clear separation of the genuine
and imposter populations, as well as zero Equal Error Rate
achievement, which is hardly gained in the conventional biometric
based authentication system.
Abstract: Reducing the risk of information leaks is one of
the most important functions of identity management systems. To
achieve this purpose, Dey et al. have already proposed an account
management method for a federated login system using a blind
signature scheme. In order to ensure account anonymity for the
authentication provider, referred to as an IDP (identity provider),
a blind signature scheme is utilized to generate an authentication
token on an authentication service and the token is sent to an IDP.
However, there is a problem with the proposed system. Malicious
users can establish multiple accounts on an IDP by requesting such
accounts. As a measure to solve this problem, in this paper, the
authors propose an account checking method that is performed before
account generation.
Abstract: The new concept of two–dimensional (2D) image
processing implementation for auto-guiding system is shown in this
paper. It is dedicated to astrophotography and operates with
astronomy CCD guide cameras or with self-guided dual-detector
CCD cameras and ST4 compatible equatorial mounts. This idea was
verified by MATLAB model, which was used to test all procedures
and data conversions. Next the circuit prototype was implemented at
Altera MAX II CPLD device and tested for real astronomical object
images. The digital processing speed of CPLD prototype board was
sufficient for correct equatorial mount guiding in real-time system.
Abstract: The harmonic Arnoldi method can be used to find interior eigenpairs of large matrices. However, it has been shown that this method may converge erratically and even may fail to do so. In this paper, we present a new method for computing interior eigenpairs of large nonsymmetric matrices, which is called weighted harmonic Arnoldi method. The implementation of the method has been tested by numerical examples, the results show that the method converges fast and works with high accuracy.
Abstract: In this work, the physical based device model of
AlGaN/GaN high electron mobility transistors (HEMTs) has been
established and the corresponding device operation behavior has
been investigated also by using Sentaurus TCAD from Synopsys.
Advanced AlGaN/GaN hetero-structures with GaN cap layer and AlN
spacer have been considered and the GaN cap layer and AlN spacer
are found taking important roles on the gate leakage blocking and
off-state breakdown voltage enhancement.
Abstract: This paper presents an exact analytical model for
optimizing stability of thin-walled, composite, functionally graded
pipes conveying fluid. The critical flow velocity at which divergence
occurs is maximized for a specified total structural mass in order to
ensure the economic feasibility of the attained optimum designs. The
composition of the material of construction is optimized by defining
the spatial distribution of volume fractions of the material
constituents using piecewise variations along the pipe length. The
major aim is to tailor the material distribution in the axial direction so
as to avoid the occurrence of divergence instability without the
penalty of increasing structural mass. Three types of boundary
conditions have been examined; namely, Hinged-Hinged, Clamped-
Hinged and Clamped-Clamped pipelines. The resulting optimization
problem has been formulated as a nonlinear mathematical
programming problem solved by invoking the MatLab optimization
toolbox routines, which implement constrained function
minimization routine named “fmincon" interacting with the
associated eigenvalue problem routines. In fact, the proposed
mathematical models have succeeded in maximizing the critical flow
velocity without mass penalty and producing efficient and economic
designs having enhanced stability characteristics as compared with
the baseline designs.
Abstract: As part of national epidemiological survey on bovine
viral diarrhea virus (BVDV), a total of 274 dejecta samples were
collected from 14 cattle farms in 8 areas of Xinjiang Uygur
Autonomous Region in northwestern China. Total RNA was extracted
from each sample, and 5--untranslated region (UTR) of BVDV
genome was amplified by using two-step reverse
transcriptase-polymerase chain reaction (RT-PCR). The PCR products
were subsequently sequenced to study the genetic variations of BVDV
in these areas. Among the 274 samples, 33 samples were found
virus-positive. According to sequence analysis of the PCR products,
the 33 samples could be arranged into 16 groups. All the sequences,
however, were highly conserved with BVDV Osloss strains. The virus
possessed theses sequences belonged to BVDV-1b subtype by
phylogenetic analysis. Based on these data, we established a typing
tree for BVDV in these areas. Our results suggested that BVDV-1b
was a predominant subgenotype in northwestern China and no
correlation between the genetic and geographical distances could be
observed above the farm level.