Design of Salbutamol Sulphate Gastroretentive Nanoparticles via Surface Charge Manipulation

In the present study, development of salbutamol sulphate nanoparticles that adhere to gastric mucus was investigated. Salbutamol sulphate has low bioavailability due to short transit time in gastric. It also has a positive surface charge that provides hurdles to be encapsulated by the positively strong mucoadhesive polymer of chitosan. To overcome the difficulties, the surface charge of active ingredient was modified using several nonionic and anionic stomach-specific polymers. The nanoparticles were prepared using ionotropic gelation technique. The evaluation involved determination of particle size, zeta potential, entrapment efficiency, in vitro drug release and in vitro mucoadhesion test. Results exhibited that the use of anionic alginate polymer was more satisfactory than that of nonionic polymer. Characteristics of the particles was nano-size, high encapsulation efficiency, fulfilled the drug release requirements and adhesive towards stomach for around 11 hours. This result shows that the salbutamol sulphate nanoparticles can be utilized for improvement its delivery.

A Comprehensive Study on Phytoextractive Potential of Sri Lankan Mustard (Brassica Juncea (L.) Czern. and Coss) Genotypes

Heavy metal pollution is an environmental concern. Phytoremediation is a low-cost, environmental-friendly approach to solve this problem. Mustard has the potential in reducing heavy metal contents in soils. Among mustard (Brassica juncea (L.) Czern & Coss) genotypes in Sri Lanka, accessions 7788, 8831 and 5088 give significantly a high yield. Therefore, present study was conducted to quantify the phytoextractive potential among these local mustard accessions and to assess the interaction of heavy metals, Pb, Co, Mn on phytoextraction. A pot experiment was designed with acid washed sand (quartz) and a series of heavy metal solutions of 0, 25, 50, 75 and 100 μg/g. Experiment was carried out with factorial experimental design. Mustard accessions were tolerant to heavy metals and could be successfully used in removal of Pb, Co and Mn and they are capable of accumulating significant quantities of heavy metals in vegetative and reproductive organs. The order of the accumulative potential of Pb, Co and Mn in mustard accessions is, root > shoot >seed.

Heavy Metal Contamination of the Landscape at the ─¢ubietová Deposit (Slovakia)

The heavy metal contamination of the technogenous sediments and soils at the investigated dump-field show irregular planar distribution. Also the heavy metal content in the surface water, drainage water and in the groundwater was studied both in the dry as well as during the rainy periods. The cementation process causes substitution of iron by copper. Natural installation and development of plant species was observed at the old mine waste dumps, specific to the local chemical conditions such as low content of essential nutrients and high content of heavy metals. The individual parts of the plant tissues (roots, branches/stems, leaves/needles, flowers/ fruits) are contaminated by heavy metals and tissues are damaged differently, respectively.

An Adverse Model for Price Discrimination in the Case of Monopoly

We consider a Principal-Agent model with the Principal being a seller who does not know perfectly how much the buyer (the Agent) is willing to pay for the good. The buyer-s preferences are hence his private information. The model corresponds to the nonlinear pricing problem of Maskin and Riley. We assume there are three types of Agents. The model is solved using “informational rents" as variables. In the last section we present the main characteristics of the optimal contracts in asymmetric information and some possible extensions of the model.

Internal Loading Distribution in Statically Loaded Ball Bearings Subjected to a Centric Thrust Load: Alternative Approach

An alternative iterative computational procedure is proposed for internal normal ball loads calculation in statically loaded single-row, angular-contact ball bearings, subjected to a known thrust load, which is applied in the inner ring at the geometric bearing center line. An accurate method for curvature radii at contacts with inner and outer raceways in the direction of the motion is used. Numerical aspects of the iterative procedure are discussed. Numerical examples results for a 218 angular-contact ball bearing have been compared with those from the literature. Twenty figures are presented showing the geometrical features, the behavior of the convergence variables and the following parameters as functions of the thrust load: normal ball loads, contact angle, distance between curvature centers, and normal ball and axial deflections.

Estimating European Tourism Demand for Malaysia

Tourism industry is an important sector in Malaysia economy and this motivates the examination of long-run relationships between tourist arrivals from three selected European countries in Malaysia and four possible determinants; relative prices, exchange rates, transportation cost and relative prices of substitute destination. The study utilizes data from January 1999 to September 2008 and employs standard econometric techniques that include unit root test and cointegration test. The estimated demand model indicates that depreciation of local currency and increases in prices at substitute destination have positive impact on tourist arrivals while increase in transportation cost has negative impact on tourist arrivals. In addition, the model suggests that higher rate of increase in local prices relative to prices at tourist country of origin may not deter tourists from coming to Malaysia

Propagation of Viscous Waves and Activation Energy of Hydrocarbon Fluids

The Euler-s equation of motion is extended to include the viscosity stress tensor leading to the formulation of Navier– Stokes type equation. The latter is linearized and applied to investigate the rotational motion or vorticity in a viscous fluid. Relations for the velocity of viscous waves and attenuation parameter are obtained in terms of viscosity (μ) and the density (¤ü) of the fluid. μ and ¤ü are measured experimentally as a function of temperature for two different samples of light and heavy crude oil. These data facilitated to determine the activation energy, velocity of viscous wave and the attenuation parameter. Shear wave velocity in heavy oil is found to be much larger than the light oil, whereas the attenuation parameter in heavy oil is quite low in comparison to light one. The activation energy of heavy oil is three times larger than light oil.

Enhancing Soft Skills through Peer Review Activity in a Technical Writing Class

Peer review is an activity where students review their classmates- writing and then evaluate the content, development, unity and organization. Studies have shown that peer review activities benefit both the reviewer and the writer in developing their reading and writing skills. Furthermore, peer review activities may also enhance students- soft skills. This study was conducted to find out the benefits of peer review activity in a technical writing class based on engineering students- perceptions. The study also highlights how these benefits could improve the students- soft skills. A set of questionnaire was given to 200 undergraduate students of a technical writing course. The results of the study indicate that the activity could help improve their critical thinking skills, written and oral communication skills, as well as team work. This paper further discusses how the implications of these benefits could help enhance students- soft skills.

The Effect of Binahong to Hematoma

In elevating performance in competetive sports, an athlete must continously train in achieving maximum performance,but needs to pay attention to recovery therapy, that is to recover from fatigue as well as injury.The correct recovery therapy will assist in process of recovery and helps in the training in achieving better performace. Binahong (Anredera cordifolia) was proven empirically by the locals in assisting speedy recovery from an injury.Clinical research with lab animals receiving blunt trauma injury, microscopically shown signs of: 1) redness, 2) heatiness, 3) swelling and, 4) lack of activity. There is also microscopic indication of: 1) infiltration of inflame cells (migration of cells to the trauma area), 2) Cells necrosis, 3) Congestion (as a result of dead red blood cells), 4) uedema. On administration of Binahong for 3 days, there is a significant drop of 5% in cell inflammation, 2% increase of fibroblast (cell membrance) count.Conclutin: Binahong do assist in reducing cell inflammation and increase counts of cells fibroblast. Suggestion: In helping athlete's to recover from force injury, we need study about Binahong's roots to inflammation cell and healing of injuried cell.

A Novel Method For evaluating Parameters Of Ongoing Calls In Low Earth Orbit Mobile Satellite System

In order to derive important parameters concerning mobile subscriber MS with ongoing calls in Low Earth Orbit Mobile Satellite Systems LEO MSSs, a positioning system had to be integrated into MSS in order to localize mobile subscribers MSs and track them during the connection. Such integration is regarded as a complex implementation. We propose in this paper a novel method based on advantages of mobility model of Low Earth Orbit Mobile Satellite System LEO MSS called Evaluation Parameters Method EPM which allows for such systems the evaluation of different information concerning a MS with a call in progress even if its location is unknown.

Process Parameter Optimization for the Production of Gentamicin using Micromonouspora Echiniospora

The process parameters, temperature, pH and substrate concentration, were optimized for the production of gentamicin using Micromonouspora echinospora. Experiments were carried out according to central composite design in response surface method. The optimum conditions for the maximum production of gentamicin were found to be: temperature – 31.7oC, pH – 6.8 and substrate concentration – 3%. At these optimized conditions the production of gentamicin was found to be – 1040 mg/L. The R2 value of 0.9465 indicates a good fitness of the model.

Multiple Mental Thought Parametric Classification: A New Approach for Individual Identification

This paper reports a new approach on identifying the individuality of persons by using parametric classification of multiple mental thoughts. In the approach, electroencephalogram (EEG) signals were recorded when the subjects were thinking of one or more (up to five) mental thoughts. Autoregressive features were computed from these EEG signals and classified by Linear Discriminant classifier. The results here indicate that near perfect identification of 400 test EEG patterns from four subjects was possible, thereby opening up a new avenue in biometrics.

Symbolic Analysis of Large Circuits Using Discrete Wavelet Transform

Symbolic Circuit Analysis (SCA) is a technique used to generate the symbolic expression of a network. It has become a well-established technique in circuit analysis and design. The symbolic expression of networks offers excellent way to perform frequency response analysis, sensitivity computation, stability measurements, performance optimization, and fault diagnosis. Many approaches have been proposed in the area of SCA offering different features and capabilities. Numerical Interpolation methods are very common in this context, especially by using the Fast Fourier Transform (FFT). The aim of this paper is to present a method for SCA that depends on the use of Wavelet Transform (WT) as a mathematical tool to generate the symbolic expression for large circuits with minimizing the analysis time by reducing the number of computations.

Developing and Implementing Successful Key Performance Indicators

Measurement and the following evaluation of performance represent important part of management. The paper focuses on indicators as the basic elements of performance measurement system. It emphasizes a necessity of searching requirements for quality indicators so that they can become part of the useful system. It introduces standpoints for a systematic dividing of indicators so that they have as high as possible informative value of background sources for searching, analysis, designing and using of indicators. It draws attention to requirements for indicators' quality and at the same it deals with some dangers decreasing indicator's informative value. It submits a draft of questions that should be answered at the construction of indicator. It is obvious that particular indicators need to be defined exactly to stimulate the desired behavior in order to attain expected results. In the enclosure a concrete example of the defined indicator in the concrete conditions of a small firm is given. The authors of the paper pay attention to the fact that a quality indicator makes it possible to get to the basic causes of the problem and include the established facts into the company information system. At the same time they emphasize that developing of a quality indicator is a prerequisite for the utilization of the system of measurement in management.

An Effective Method for Audio Translation between IAX and RSW Protocols

Nowadays, Multimedia Communication has been developed and improved rapidly in order to enable users to communicate between each other over the Internet. In general, the multimedia communication consists of audio and video communication. However, this paper focuses on audio streams. The audio translation between protocols is a very critical issue due to solving the communication problems between any two protocols, as well as it enables people around the world to talk with each other at anywhere and anytime even they use different protocols. In this paper, a proposed method for an audio translation module between two protocols has been presented. These two protocols are InterAsterisk eXchange Protocol (IAX) and Real Time Switching Control Protocol (RSW), which they are widely used to provide two ways audio transfer feature. The result of this work is to introduce possibility of interworking together.

Hybrid Optimization of Emission and Economic Dispatch by the Sigmoid Decreasing Inertia Weight Particle Swarm Optimization

This paper present an efficient and reliable technique of optimization which combined fuel cost economic optimization and emission dispatch using the Sigmoid Decreasing Inertia Weight Particle Swarm Optimization algorithm (PSO) to reduce the cost of fuel and pollutants resulting from fuel combustion by keeping the output of generators, bus voltages, shunt capacitors and transformer tap settings within the security boundary. The performance of the proposed algorithm has been demonstrated on IEEE 30-bus system with six generating units. The results clearly show that the proposed algorithm gives better and faster speed convergence then linearly decreasing inertia weight.

Formal Verification of a Multicast Protocol in Mobile Networks

As computer network technology becomes increasingly complex, it becomes necessary to place greater requirements on the validity of developing standards and the resulting technology. Communication networks are based on large amounts of protocols. The validity of these protocols have to be proved either individually or in an integral fashion. One strategy for achieving this is to apply the growing field of formal methods. Formal methods research defines systems in high order logic so that automated reasoning can be applied for verification. In this research we represent and implement a formerly announced multicast protocol in Prolog language so that certain properties of the protocol can be verified. It is shown that by using this approach some minor faults in the protocol were found and repaired. Describing the protocol as facts and rules also have other benefits i.e. leads to a process-able knowledge. This knowledge can be transferred as ontology between systems in KQML format. Since the Prolog language can increase its knowledge base every time, this method can also be used to learn an intelligent network.

Development of Low-cost OCDMA Encoder Based On Arrayed Waveguide Gratings(AWGs) and Optical Switches

This paper describes the development of a 16-ports optical code division multiple access (OCDMA) encoder prototype based on Arrayed Waveguide Grating (AWG) and optical switches. It is potentially to provide a high security for data transmission due to all data will be transmitted in binary code form. The output signals from AWG are coded with a binary code that given to an optical switch before it signal modulate with the carrier and transmitted to the receiver. The 16-ports encoder used 16 double pole double throw (DPDT) toggle switches to control the polarization of voltage source from +5 V to -5 V for 16 optical switches. When +5 V is given, the optical switch will give code '1' and vice versa. The experimental results showed the insertion loss, crosstalk, uniformity, and optical signal-noise-ratio (OSNR) for the developed prototype are

Characterization of Liver Leukocyte Infiltrates and Features of Cytokine Profile under Viral Hepatitis-Induced Immunosuppression

The nature, prevalence, cellular composition of leukocyte infiltrates and immunohistochemical characteristics of their constituent cells in the liver of patients with chronic viral hepatitis B and C were investigated. It was found that the area of distribution and cellular composition of infiltrates depended on the virus type and process activity. The expediency of immunohistochemical study using leukocyte infiltrates from liver biopsies of patients with viral hepatitis aimed at clarifying diagnosis, making prognosis, and choice of optimal treatment with elements of immune correction is emphasized.