Abstract: Leptospirosis occurs worldwide (except the
poles of the earth), urban and rural areas, developed and
developing countries, especially in Thailand. It can be
transmitted to the human by rats through direct and indirect
ways. Human can be infected by either touching the infected rats
or contacting with water, soil containing urine from the infected
rats through skin, eyes and nose. The data of the people who
are infected with this disease indicates that most of the
patients are adults. The transmission of this disease is studied
through mathematical model. The population is separated into human
and rat. The human is divided into two classes, namely juvenile
and adult. The model equation is constructed for each class. The
standard dynamical modeling method is then used for
analyzing the behaviours of solutions. In addition, the
conditions of the parameters for the disease free and endemic
states are obtained. Numerical solutions are shown to support the
theoretical predictions. The results of this study guide the way to
decrease the disease outbreak.
Abstract: In this study, the Multi-Layer Perceptron (MLP)with Back-Propagation learning algorithm are used to classify to effective diagnosis Parkinsons disease(PD).It-s a challenging problem for medical community.Typically characterized by tremor, PD occurs due to the loss of dopamine in the brains thalamic region that results in involuntary or oscillatory movement in the body. A feature selection algorithm along with biomedical test values to diagnose Parkinson disease.Clinical diagnosis is done mostly by doctor-s expertise and experience.But still cases are reported of wrong diagnosis and treatment. Patients are asked to take number of tests for diagnosis.In many cases,not all the tests contribute towards effective diagnosis of a disease.Our work is to classify the presence of Parkinson disease with reduced number of attributes.Original,22 attributes are involved in classify.We use Information Gain to determine the attributes which reduced the number of attributes which is need to be taken from patients.The Artificial neural networks is used to classify the diagnosis of patients.Twenty-Two attributes are reduced to sixteen attributes.The accuracy is in training data set is 82.051% and in the validation data set is 83.333%.
Abstract: This study presents a mathematical modeling approach to the planning of HIV therapies on an individual basis. The model replicates clinical data from typical-progressors to AIDS for all stages of the disease with good agreement. Clinical data from rapid-progressors and long-term non-progressors is also matched by estimation of immune system parameters only. The ability of the model to reproduce these phenomena validates the formulation, a fact which is exploited in the investigation of effective therapies. The therapy investigation suggests that, unlike continuous therapy, structured treatment interruptions (STIs) are able to control the increase in both the drug-sensitive and drug-resistant virus population and, hence, prevent the ultimate progression from HIV to AIDS. The optimization results further suggest that even patients characterised by the same progression type can respond very differently to the same treatment and that the latter should be designed on a case-by-case basis. Such a methodology is presented here.
Abstract: In this paper we introduce a novel method for
the characterization of synchronziation and coupling effects
in multivariate time series that can be used for the analysis
of EEG or ECoG signals recorded during epileptic seizures.
The method allows to visualize the spatio-temporal evolution
of synchronization and coupling effects that are characteristic
for epileptic seizures. Similar to other methods proposed for
this purpose our method is based on a regression analysis.
However, a more general definition of the regression together
with an effective channel selection procedure allows to use the
method even for time series that are highly correlated, which
is commonly the case in EEG/ECoG recordings with large
numbers of electrodes. The method was experimentally tested
on ECoG recordings of epileptic seizures from patients with
temporal lobe epilepsies. A comparision with the results from
a independent visual inspection by clinical experts showed
an excellent agreement with the patterns obtained with the
proposed method.
Abstract: Vernonia divergens Benth., commonly known as
“Insulin Plant” (Fam: Asteraceae) is a potent sugar killer. Locally the
leaves of the plant, boiled in water are successfully administered to a
large number of diabetic patients. The present study evaluates the
putative anti-diabetic ingredients, isolated from the in vivo and in
vitro grown plantlets of V. divergens for their antimicrobial and
anticancer activities. Sterilized explants of nodal segments were
cultured on MS (Musashige and Skoog, 1962) medium in presence of
different combinations of hormones. Multiple shoots along with
bunch of roots were regenerated at 1mg l-1 BAP and 0.5 mg l-1 NAA.
Micro-plantlets were separated and sub-cultured on the double
strength (2X) of the above combination of hormones leading to
increased length of roots and shoots. These plantlets were
successfully transferred to soil and survived well in nature. The
ethanol extract of plantlets from both in vivo & in vitro sources were
prepared in soxhlet extractor and then concentrated to dryness under
reduced pressure in rotary evaporator. Thus obtainedconcentrated
extracts showed significant inhibitory activity against gram
negative bacteria like Escherichia coli and Pseudomonas
aeruginosa but no inhibition was found against gram positive
bacteria. Further, these ethanol extracts were screened for in vitro
percentage cytotoxicity at different time periods (24 h, 48 h and 72 h)
of different dilutions. The in vivo plant extract inhibited the growth of
EAC mouse cell lines in the range of 65, 66, 78, and 88% at 100, 50,
25 & 12.5μg mL-1 but at 72 h of treatment. In case of the extract of in
vitro origin, the inhibition was found against EAC cell lines even at
48h. During spectrophotometric scanning, the extracts exhibited
different maxima (ʎ) - four peaks in in vitro extracts as against single
in in vivo preparation suggesting the possible change in the nature of
ingredients during micropropagation through tissue culture
techniques.
Abstract: Von Willebrand-s disease is the most common
inherited bleeding disorder in humans, it
caused by qualitative abnormalities of the von Willebrand factor
(vWF). Our objective is to determine the prevalence of this disease at
part of the Algerian population in the East and the South by a
biological diagnosis based on specific biological tests (automated
platelet count, the bleeding time (TS), the time of cephalin + activator
(TCA), measure of the prothrombin rate (TP), vWF rate and factor
VIII rate, Molecular electrophoresis of vWF multimers in agarose gel
in the presence of SDS). Four patients of type III or severe
Willebrand-s disease were found on 200 suspect cases. All cases are
showed a deficit in vWF rate (< 5%), and factor VIII (P
Abstract: Autofluorescence (AF) bronchoscopy is an
established method to detect dysplasia and carcinoma in situ (CIS).
For this reason the “Sotiria" Hospital uses the Karl Storz D-light
system. However, in early tumor stages the visualization is not that
obvious. With the help of a PC, we analyzed the color images we
captured by developing certain tools in Matlab®. We used statistical
methods based on texture analysis, signal processing methods based
on Gabor models and conversion algorithms between devicedependent
color spaces. Our belief is that we reduced the error made
by the naked eye. The tools we implemented improve the quality of
patients' life.
Abstract: Silk sericin (SS) is a glue-like protein from silkworm
cocoon. With its outstanding moisturization and activation collagen
synthesis properties, silk protein is applied for wound healing. Since
wound dressing in film preparation can facilitate patients-
convenience and reduce risk of wound contraction, SS and polyvinyl
alcohol (PVA) films were prepared with various concentrations of
SS. Their physical properties such as surface density, light
transmission, protein dissolution and tensile modulus were
investigated. The results presented that 3% SS with 2% PVA is the
best ingredient for SS film forming.
Abstract: Noise level has critical effects on the diagnostic
performance of signal-averaged electrocardiogram (SAECG), because
the true starting and end points of QRS complex would be masked by
the residual noise and sensitive to the noise level. Several studies and
commercial machines have used a fixed number of heart beats
(typically between 200 to 600 beats) or set a predefined noise level
(typically between 0.3 to 1.0 μV) in each X, Y and Z lead to perform
SAECG analysis. However different criteria or methods used to
perform SAECG would cause the discrepancies of the noise levels
among study subjects. According to the recommendations of 1991
ESC, AHA and ACC Task Force Consensus Document for the use of
SAECG, the determinations of onset and offset are related closely to
the mean and standard deviation of noise sample. Hence this study
would try to perform SAECG using consistent root-mean-square
(RMS) noise levels among study subjects and analyze the noise level
effects on SAECG. This study would also evaluate the differences
between normal subjects and chronic renal failure (CRF) patients in
the time-domain SAECG parameters.
The study subjects were composed of 50 normal Taiwanese and 20
CRF patients. During the signal-averaged processing, different RMS
noise levels were adjusted to evaluate their effects on three time
domain parameters (1) filtered total QRS duration (fQRSD), (2) RMS
voltage of the last QRS 40 ms (RMS40), and (3) duration of the low
amplitude signals below 40 μV (LAS40). The study results
demonstrated that the reduction of RMS noise level can increase
fQRSD and LAS40 and decrease the RMS40, and can further increase
the differences of fQRSD and RMS40 between normal subjects and
CRF patients. The SAECG may also become abnormal due to the
reduction of RMS noise level. In conclusion, it is essential to establish
diagnostic criteria of SAECG using consistent RMS noise levels for
the reduction of the noise level effects.
Abstract: The technological concepts such as wireless hospital
and portable cardiac telemetry system require the development of
physiological signal acquisition devices to be easily integrated into
the hospital database. In this paper we present the low cost, portable
wireless ECG acquisition hardware that transmits ECG signals to a
dedicated computer.The front end of the system obtains and
processes incoming signals, which are then transmitted via a
microcontroller and wireless Bluetooth module. A monitoring
purpose Bluetooth based end user application integrated with patient
database management module is developed for the computers. The
system will act as a continuous event recorder, which can be used to
follow up patients who have been resuscitatedfrom cardiac arrest,
ventricular tachycardia but also for diagnostic purposes for patients
with arrhythmia symptoms. In addition, cardiac information can be
saved into the patient-s database of the hospital.
Abstract: The standard investigational method for obstructive
sleep apnea syndrome (OSAS) diagnosis is polysomnography (PSG),
which consists of a simultaneous, usually overnight recording of
multiple electro-physiological signals related to sleep and
wakefulness. This is an expensive, encumbering and not a readily
repeated protocol, and therefore there is need for simpler and easily
implemented screening and detection techniques. Identification of
apnea/hypopnea events in the screening recordings is the key factor
for the diagnosis of OSAS. The analysis of a solely single-lead
electrocardiographic (ECG) signal for OSAS diagnosis, which may
be done with portable devices, at patient-s home, is the challenge of
the last years. A novel artificial neural network (ANN) based
approach for feature extraction and automatic identification of
respiratory events in ECG signals is presented in this paper. A
nonlinear principal component analysis (NLPCA) method was
considered for feature extraction and support vector machine for
classification/recognition. An alternative representation of the
respiratory events by means of Kohonen type neural network is
discussed. Our prospective study was based on OSAS patients of the
Clinical Hospital of Pneumology from Iaşi, Romania, males and
females, as well as on non-OSAS investigated human subjects. Our
computed analysis includes a learning phase based on cross signal
PSG annotation.
Abstract: Chronic hepatitis B can evolve to cirrhosis and liver
cancer. Interferon is the only effective treatment, for carefully selected
patients, but it is very expensive. Some of the selection criteria are
based on liver biopsy, an invasive, costly and painful medical procedure.
Therefore, developing efficient non-invasive selection systems,
could be in the patients benefit and also save money. We investigated
the possibility to create intelligent systems to assist the Interferon
therapeutical decision, mainly by predicting with acceptable accuracy
the results of the biopsy. We used a knowledge discovery in integrated
medical data - imaging, clinical, and laboratory data. The resulted
intelligent systems, tested on 500 patients with chronic hepatitis
B, based on C5.0 decision trees and boosting, predict with 100%
accuracy the results of the liver biopsy. Also, by integrating the other
patients selection criteria, they offer a non-invasive support for the
correct Interferon therapeutic decision. To our best knowledge, these
decision systems outperformed all similar systems published in the
literature, and offer a realistic opportunity to replace liver biopsy in
this medical context.
Abstract: The need to increase the efficiency of health care
systems is becoming an obligation, and one of area of improvement
is the discharge process. The objective of this work is to minimize
the patients discharge time (for insured patients) to be less than 50
minutes by using six sigma approach, this improvement will also:
lead to an increase in customer satisfaction, increase the number of
admissions and turnover on the rooms, increase hospital
profitability.Three different departments were considered in this
study: Female, Male, and Paediatrics. Six Sigma approach coupled
with simulation has been applied to reduce the patients discharge
time for pediatrics, female, and male departments at hospital. Upon
applying these recommendations at hospital: 60%, 80%, and 22% of
insured female, male, and pediatrics patients respectively will have
discharge time less than the upper specification time i.e. 50 min.
Abstract: The paper is intended to declare and apply ethics, i. e.
moral principles, rules in marketing environment. Ethical behavior of
selected pharmaceutical companies in the Slovak Republic is the
object of our research. The aim of our research is to determine
perception of ethical behavior of the pharmaceutical industry in
Slovakia by the medicine representatives in comparison with the
assessment of doctors and patients. The experimental sample
included 90 participants who were divided into three groups:
medicine representatives of the pharmaceutical companies (N=30),
doctors (N=30) and patients (N=30). The research method was a
Questionnaire of ethical behavior, created by us, that describes
individual areas included in the Code of ethics of the pharmaceutical
industry in Slovakia. The results showed influence of professional
status on ethical behavior perception, not gender. Higher perception
was indicated at patients rather than doctors and medicine
representatives.
Abstract: We analyze hand dexterity in Parkinson-s disease patients (PD) and control subjects using a natural manual transport task (moving an object from one place to another). Eight PD patients and ten control subjects performed the task repeatedly at maximum speed both in OFF and ON medicated status. The movement parameters and the grip and load forces were recorded by a single optoelectronic camera and force transducers built in the especially designed object. Using the force and velocity signals, ten subsequent phases of the transport movement were defined and their durations were measured. The outline of 3D optical measurement is presented to obtain more precise movement trajectory.
Abstract: Hepatitis C is an infectious disease transmitted by
blood and due to hepatitis C virus (HCV), which attacks the liver.
The infection is characterized by liver inflammation (hepatitis) that is
often asymptomatic but can progress to chronic hepatitis and later
cirrhosis and liver cancer. Our problem tends to highlight on the one
hand the prevalence of infectious disease in the population of the
region of Batna and on other hand the biological characteristics of
this disease by a screening and a specific diagnosis based on
serological tests, liver checkup (measurement of haematological and
biochemical parameters).
The results showed:
The serology of hepatitis C establishes the diagnosis of infection
with hepatitis C. In this study and with the serological test, 24 cases
of the disease of hepatitis C were found in 1000 suspected cases (7
cases with normal transaminases and 17 cases with elevated
transaminases). The prevalence of this disease in this study
population was 2.4%.
The presence of hepatitis C disrupts liver function including the
onset of cytolysis, cholestasis, jaundice, thrombocytopenia, and
coagulation disorders.
Abstract: This paper proposes a prototype of a lower-limb
rehabilitation system for recovering and strengthening patients-
injured lower limbs. The system is composed of traction motors for
each leg position, a treadmill as a walking base, tension sensors,
microcontrollers controlling motor functions and a main system with
graphic user interface. For derivation of reference or normal velocity
profiles of the body segment point, kinematic method is applied based
on the humanoid robot model using the reference joint angle data of
normal walking.
Abstract: Gene expression profiling is rapidly evolving into a
powerful technique for investigating tumor malignancies. The
researchers are overwhelmed with the microarray-based platforms
and methods that confer them the freedom to conduct large-scale
gene expression profiling measurements. Simultaneously,
investigations into cross-platform integration methods have started
gaining momentum due to their underlying potential to help
comprehend a myriad of broad biological issues in tumor diagnosis,
prognosis, and therapy. However, comparing results from different
platforms remains to be a challenging task as various inherent
technical differences exist between the microarray platforms. In this
paper, we explain a simple ratio-transformation method, which can
provide some common ground for cDNA and Affymetrix platform
towards cross-platform integration. The method is based on the
characteristic data attributes of Affymetrix- and cDNA- platform. In
the work, we considered seven childhood leukemia patients and their
gene expression levels in either platform. With a dataset of 822
differentially expressed genes from both these platforms, we carried
out a specific ratio-treatment to Affymetrix data, which subsequently
showed an improvement in the relationship with the cDNA data.
Abstract: PARADIGMA (PARticipative Approach to DIsease
Global Management) is a pilot project which aims to develop and
demonstrate an Internet based reference framework to share scientific
resources and findings in the treatment of major diseases.
PARADIGMA defines and disseminates a common methodology and
optimised protocols (Clinical Pathways) to support service functions
directed to patients and individuals on matters like prevention, posthospitalisation
support and awareness. PARADIGMA will provide a
platform of information services - user oriented and optimised
against social, cultural and technological constraints - supporting the
Health Care Global System of the Euro-Mediterranean Community
in a continuous improvement process.
Abstract: Disordered function of maniphalanx and difficulty with
ambulation will occur insofar as a human has a failure in the spinal
marrow. Cervical spondylotic myelopathy as one of the myelopathy
emanates from not only external factors but also increased age. In
addition, the diacrisis is difficult since cervical spondylotic
myelopathy is evaluated by a doctor-s neurological remark and
imaging findings. As a quantitative method for measuring the degree
of disability, hand-operated triangle step test (for short, TST) has
formulated. In this research, a full automatic triangle step counter
apparatus is designed and developed to measure the degree of
disability in an accurate fashion according to the principle of TST. The
step counter apparatus whose shape is a low triangle pole displays the
number of stepping upon each corner. Furthermore, the apparatus has
two modes of operation. Namely, one is for measuring the degree of
disability and the other for rehabilitation exercise. In terms of
usefulness, clinical practice should be executed before too long.