Abstract: Early diagnosis of infection like Hep-B virus in blood
is important for low cost medical treatment. For this purpose, it is
desirable to develop a point of care device which should be able to
detect trace quantities of the target molecule in blood. In this paper,
we report a nanoporous silicon oxide sensor which is capable of
detecting down to 1fM concentration of Hep-B surface antigen in
blood without the requirement of any centrifuge or pre-concentration.
This has been made possible by the presence of resonant peak in the
sensitivity characteristics. This peak is observed to be dependent only
on the concentration of the specific antigen and not on the interfering
species in blood serum. The occurrence of opposite impedance
change within the pores and at the bottom of the pore is responsible
for this effect. An electronic interface has also been designed to
provide a display of the virus concentration.
Abstract: The design philosophy of building structure has been
changing time to time. The reason for this is because of an increase of
human inertest, an improved building materials and technology that
will impact how we live, to speed up construction period and natural
effect which includes earthquake disasters and environmental effect.
One technique which takes in to account the above case is using a
prefabricable structural system. In which each and every structural
element is designed and prefabricated and assembled on a site so that
the construction speed is increased and the environmental impact is
also enhanced. This system has an immense advantage such as: reduce
construction cost, reusable, recyclable, speed up construction period
and less environmental effect. In this study, it is tried to present some
of the developed and evaluated structural elements of building
structures.
Abstract: Today’s VLSI networks demands for high speed. And
in this work the compact form mathematical model for current mode
signalling in VLSI interconnects is presented.RLC interconnect line
is modelled using characteristic impedance of transmission line and
inductive effect. The on-chip inductance effect is dominant at lower
technology node is emulated into an equivalent resistance. First order
transfer function is designed using finite difference equation, Laplace
transform and by applying the boundary conditions at the source and
load termination. It has been observed that the dominant pole
determines system response and delay in the proposed model. The
novel proposed current mode model shows superior performance as
compared to voltage mode signalling. Analysis shows that current
mode signalling in VLSI interconnects provides 2.8 times better
delay performance than voltage mode. Secondly the damping factor
of a lumped RLC circuit is shown to be a useful figure of merit.
Abstract: Epidermal Growth Factor (EGF, Mw=6,045) has been
reported to have high efficiency of wound repair and anti-wrinkle
effect. However, the half-life of EGF in the body is too short to exert
the biological activity effectively when applied in free form. Growth
Factors can be stabilized by immobilization with carbohydrates from
thermal and proteolytic degradation. Low molecular weight chitosan
(LMCS) and its derivate prepared by hydrogen peroxide has high
solubility. LM6A6DC was successfully prepared as a reactive
carbohydrate for the stabilization of EGF by the reactions of LMCS
with alkalization, tosylation, azidation and reduction. The structure of
LM6A6DC was confirmed by FT-IR, 1H NMR and elementary
analysis. For enhancing the stability of free EGF, EGF was attached
with LM6A6DC by using water-soluble carbodiimide.
EGF-LM6A6DC conjugates did not show any cytotoxicity on the
Normal Human Dermal Fibroblast (NHDF) 3T3 proliferation at least
under 100 μg/ml. In the result, it was considered that LM6A6DC is
suitable to immobilize of growth factor.
Abstract: This study aims to investigate the possibility of crime
prevention through CCTV by analyzing the appropriateness of the
CCTV location, whether it is installed in the hotspot of crime-prone
areas, and exploring the crime prevention effect and transition effect.
The real crime and CCTV locations of case city were converted into
the spatial data by using GIS. The data was analyzed by hotspot
analysis and weighted displacement quotient (WDQ). As study
methods, it analyzed existing relevant studies for identifying the trends
of CCTV and crime studies based on big data from 1800 to 2014 and
understanding the relation between CCTV and crime. Second, it
investigated the current situation of nationwide CCTVs and analyzed
the guidelines of CCTV installation and operation to draw attention to
the problems and indicating points of CCTV use. Third, it investigated
the crime occurrence in case areas and the current situation of CCTV
installation in the spatial aspects, and analyzed the appropriateness and
effectiveness of CCTV installation to suggest a rational installation of
CCTV and the strategic direction of crime prevention. The results
demonstrate that there was no significant effect in the installation of
CCTV on crime prevention in the case area. This indicates that CCTV
should be installed and managed in a more scientific way reflecting
local crime situations. In terms of CCTV, the methods of spatial
analysis such as GIS, which can evaluate the installation effect, and the
methods of economic analysis like cost-benefit analysis should be
developed. In addition, these methods should be distributed to local
governments across the nation for the appropriate installation of
CCTV and operation. This study intended to find a design guideline of
the optimum CCTV installation. In this regard, this study is
meaningful in that it will contribute to the creation of a safe city.
Abstract: It has become an increasing evident that large
development influences the climate. There are concerns that rising
temperature over developed areas could have negative impact and
increase living discomfort within city boundaries. Temperature trends
in Ibadan city have received little attention, yet the area has
experienced heavy urban expansion between 1972 and 2014. This
research aims at examining the impact of landuse change on surface
temperature knowing that the built-up environment absorb and store
solar energy, resulting into the Urban Heat Island (UHI) effect. The
Landsat imagery was used to examine the landuse change for a
period of 42 years (1972-2014). Land Surface Temperature (LST)
was obtained by converting the thermal band to a surface temperature
map and zonal statistic analyses was used to examine the relationship
between landuse and temperature emission. The results showed that
the settlement area increased to a large extent while the area covered
by vegetation reduced during the study period. The spatial and
temporal trends of surface temperature are related to the gradual
change in urban landuse/landcover and the settlement area has the
highest emission. This research provides useful insight into the
temporal behavior of the Ibadan city.
Abstract: The present work aims to throw light on the effects of
arcing in air on the surface state of contact pastilles made of silvernickel
Ag-Ni (60/40). Also, the photoelectric emission from these
electrical contacts has been investigated in the spectral range of 196-
256 nm. In order to study the effects of arcing on the EWF, the
metallic samples were subjected to electrical arcs in air, at
atmospheric pressure and room temperature, after that, they have
been introduced into the vacuum chamber of an experimental UHV
set-up for EWF measurements. Both Fowler method of isothermal
curves and linearized Fowler plots were used for the measurement of
the EWF by the photoelectric effect.
It has been found that the EWF varies with the number of applied
arcs. Thus, after 500 arcs in air, the observed EWF increasing is
probably due to progressive inclusion of oxide on alloy surface.
Microscopic examination is necessary to get better understandings on
EWF of silver alloys, for both virgin and arced electrical contacts.
Abstract: There exists some time lag between the consumption of
inputs and the production of outputs. This time lag effect should be
considered in calculating efficiency of decision making units (DMU).
Recently, a couple of DEA models were developed for considering
time lag effect in efficiency evaluation of research activities. However,
these models can’t discriminate efficient DMUs because of the nature
of basic DEA model in which efficiency scores are limited to ‘1’. This
problem can be resolved a super-efficiency model. However, a super
efficiency model sometimes causes infeasibility problem. This paper
suggests an output oriented super-efficiency model for efficiency
evaluation under the consideration of time lag effect. A case example
using a long term research project is given to compare the suggested
model with the MpO model.
Abstract: Heavy metals are one of the major groups of
contaminants in the environment and many of them are toxic even at
very low concentration in plants and animals. However, some metals
play important roles in the biological function of many enzymes in
living organisms. Metals such as zinc, iron, and cooper are important
for survival and activity of enzymes in plants, however heavy metals
can inhibit enzyme which is responsible for defense system of plants.
Polyphenol oxidase (PPO) is a copper-containing metalloenzyme
which is responsible for enzymatic browning reaction of plants.
Enzymatic browning is a major problem for the handling of
vegetables and fruits in food industry. It can be increased and
effected with many different futures such as metals in the nature and
ground. In the present work, PPO was isolated and characterized
from green leaves of red poppy plant (Papaverr hoeas). Then, the
effect of some known antibrowning agents which can form
complexes with metals and metals were investigated on the red poppy
PPO activity. The results showed that glutathione was the most
potent inhibitory effect on PPO activity. Cu(II) and Fe(II) metals
increased the enzyme activities however, Sn(II) had the maximum
inhibitory effect and Zn(II) and Pb(II) had no significant effect on the
enzyme activity. In order to reduce the effect of heavy metals, the
effects of metal-antibrowning agent complexes on the PPO activity
were determined. EDTA and metal complexes had no significant
effect on the enzyme. L-ascorbic acid and metal complexes decreased
but L-ascorbic acid-Cu(II)-complex had no effect. Glutathione–metal
complexes had the best inhibitory effect on Red poppy leaf PPO
activity.
Abstract: Natural antimicrobials are used to preserve foods that
can be found in plants, animals, and microorganisms. Antimicrobial
substances are natural or artificial agents that produced by
microorganisms or obtained semi/total chemical synthesis are used at
low concentrations to inhibit the growth of other microorganisms.
Food borne pathogens and spoilage microorganisms are inactivated
by the use of antagonistic microorganisms and their metabolites.
Yeasts can produce toxic proteins or glycoproteins (toxins) that cause
inhibition of sensitive bacteria and yeast species. Antimicrobial
substance producing phenotypes belonging different yeast genus
were isolated from different sources. Toxins secreted by many yeast
strains inhibiting the growth of other yeast strains. These strains show
antimicrobial activity, inhibiting the growth of mold and bacteria.
The effect of antimicrobial agents produced by yeasts can be
extremely fast, and therefore may be used in various treatment
procedures. Rapid inhibition of microorganisms is possibly caused by
microbial cell membrane lipopolysaccharide binding and in
activation (neutralization) effect. Antimicrobial agents inhibit the
target cells via different mechanisms of action.
Abstract: Azadirachta excelsa or locally known as sentang are
frequently used as a traditional medicine by diabetes patients in
Malaysia. However, less attention has been given to their toxicity
effect. Thus, the study is an attempt to examine the protective effect
of A. excelsa on the pancreas and to determine possible toxicity
mediated by the extract. Diabetes was induced experimentally in rats
by high-fat-diet for 16 weeks followed by intraperitoneal injection of
streptozotocin at dosage of 35 mg/kg of body weight. Declination of
the fasting blood glucose level was observed after continuous
administration of A. excelsa for 14 days twice daily. This is due to the
refining structure of the pancreas. However, surprisingly, the plant
extract reduced the leukocytes, erythrocytes, hemoglobin, MCHC and
lymphocytes. In addition, the rat treated with the plant extract
exhibited increment in AST and eosinocytes level. Overall, the
finding shows that A. excelsa possesses antidiabetic activity by
improving the structure of pancreatic islet of Langerhans but
involved in ameliorating of hematology and biochemical parameters.
Abstract: Because of high thermal efficiency and low CO2
emission, diesel engines are being used widely in many industrial
fields although it makes many PM and NOx which give both human
health and environment a negative effect. NOx regulations for diesel
engines, however, are being strengthened and it is impossible to meet
the emission standard without NOx reduction devices such as SCR
(Selective Catalytic Reduction), LNC (Lean NOx Catalyst), and LNT
(Lean NOx Trap). Among the NOx reduction devices, urea-SCR
system is known as the most stable and efficient method to solve the
problem of NOx emission. But this device has some issues associated
with the ammonia slip phenomenon which is occurred by shortage of
evaporation and thermolysis time, and that makes it difficult to achieve
uniform distribution of the injected urea in front of monolith.
Therefore, this study has focused on the mixing enhancement between
urea and exhaust gases to enhance the efficiency of the SCR catalyst
equipped in catalytic muffler by changing inlet gas temperature and
spray conditions to improve the spray uniformity of the urea water
solution. Finally, it can be found that various parameters such as inlet
gas temperature and injector and injection angles significantly affect
the evaporation and mixing of the urea water solution with exhaust
gases, and therefore, optimization of these parameters are required.
Abstract: An optimisation method using both global and local
optimisation is implemented to determine the flapping profile which
will produce the most lift for an experimental wing-actuation system.
The optimisation method is tested using a numerical quasi-steady
analysis. Results of an optimised flapping profile show a 20% increase
in lift generated as compared to flapping profiles obtained by high
speed cinematography of a Sympetrum frequens dragonfly. Initial
optimisation procedures showed 3166 objective function evaluations.
The global optimisation parameters - initial sample size and stage
one sample size, were altered to reduce the number of function
evaluations. Altering the stage one sample size had no significant
effect. It was found that reducing the initial sample size to 400
would allow a reduction in computational effort to approximately
1500 function evaluations without compromising the global solvers
ability to locate potential minima. To further reduce the optimisation
effort required, we increase the local solver’s convergence tolerance
criterion. An increase in the tolerance from 0.02N to 0.05N decreased
the number of function evaluations by another 20%. However, this
potentially reduces the maximum obtainable lift by up to 0.025N.
Abstract: Photoacoustic imaging (PAI) is a non-invasive and
non-ionizing imaging modality that combines the absorption contrast
of light with ultrasound resolution. Laser is used to deposit optical
energy into a target (i.e., optical fluence). Consequently, the target
temperature rises, and then thermal expansion occurs that leads to
generating a PA signal. In general, most image reconstruction
algorithms for PAI assume uniform fluence within an imaging object.
However, it is known that optical fluence distribution within the
object is non-uniform. This could affect the reconstruction of PA
images. In this study, we have investigated the influence of optical
fluence distribution on PA back-propagation imaging using finite
element method. The uniform fluence was simulated as a triangular
waveform within the object of interest. The non-uniform fluence
distribution was estimated by solving light propagation within a
tissue model via Monte Carlo method. The results show that the PA
signal in the case of non-uniform fluence is wider than the uniform
case by 23%. The frequency spectrum of the PA signal due to the
non-uniform fluence has missed some high frequency components in
comparison to the uniform case. Consequently, the reconstructed
image with the non-uniform fluence exhibits a strong smoothing
effect.
Abstract: The extracellular proteins secreted by bacteria may be increased in stressful surroundings, such as in the presence of antibiotics. It appears that many antibiotics, when used at low concentrations, have in common the ability to activate or repress gene transcription, which is distinct from their inhibitory effect. There have been comparatively few studies on the potential of antibiotics as a specific chemical signal that can trigger a variety of biological functions. Therefore, this study was carried out to determine the effect of Streptomycin Sulfate in regulating extracellular proteins secreted by Bacillus subtilis ATCC21332. Results of Microdilution assay showed that the Minimum Inhibition Concentration (MIC) of Streptomycin Sulfate on B. subtilis ATCC21332 was 2.5 mg/ml. The bacteria cells were then exposed to Streptomycin Sulfate at concentration of 0.01 MIC before being further incubated for 48h to 72 h. The extracellular proteins secreted were then isolated and analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Proteins profile revealed that three additional bands with approximate sizes of 30 kDa, 22 kDa and 23 kDa were appeared for the treated bacteria with Streptomycin Sulfate. Thus, B. subtilis ATCC21332 in stressful condition with the presence of Streptomycin Sulfate at low concentration could induce the extracellular proteins secretion.
Abstract: Two new algorithms for nonparametric estimation of errors-in-variables models are proposed. The first algorithm is based on penalized regression spline. The spline is represented as a piecewise-linear function and for each linear portion orthogonal regression is estimated. This algorithm is iterative. The second algorithm involves locally weighted regression estimation. When the independent variable is measured with error such estimation is a complex nonlinear optimization problem. The simulation results have shown the advantage of the second algorithm under the assumption that true smoothing parameters values are known. Nevertheless the use of some indexes of fit to smoothing parameters selection gives the similar results and has an oversmoothing effect.
Abstract: Social media refers to the means of interactions
among people in which they create share, exchange and comment
contents among themselves in virtual communities and networks.
Social media or "social networking" has almost become part of our
daily lives and being tossed around over the past few years. It is like
any other media such as newspaper, radio and television but it is far
more than just about sharing information and ideas. Social
networking tools like Twitter, Facebook, Flickr and Blogs have
facilitated creation and exchange of ideas so quickly and widely than
the conventional media. This paper shows the choices,
communication, feeling comfort, time saving and effects of social
media among the people.
Abstract: Historically, actuators’ redundancy was used to deal
with faults occurring suddenly in flight systems. This technique was
generally expensive, time consuming and involves increased weight
and space in the system. Therefore, nowadays, the on-line fault
diagnosis of actuators and accommodation plays a major role in the
design of avionic systems. These approaches, known as Fault
Tolerant Flight Control systems (FTFCs) are able to adapt to such
sudden faults while keeping avionics systems lighter and less
expensive. In this paper, a (FTFC) system based on the Geometric
Approach and a Reconfigurable Flight Control (RFC) are presented.
The Geometric approach is used for cosmic ray fault reconstruction,
while Sliding Mode Control (SMC) based on Lyapunov stability
theory is designed for the reconfiguration of the controller in order to
compensate the fault effect. Matlab®/Simulink® simulations are
performed to illustrate the effectiveness and robustness of the
proposed flight control system against actuators’ faulty signal caused
by cosmic rays. The results demonstrate the successful real-time
implementation of the proposed FTFC system on a non-linear 6 DOF
aircraft model.
Abstract: The inhibition of SH2 domain regulated protein-protein interactions is an attractive target for developing an effective chemotherapeutic approach in the treatment of disease. Molecular simulation is a useful tool for developing new drugs and for studying molecular recognition. In this study, we searched potential drug compounds for the inhibition of SH2 domain by performing structural similarity search in PubChem Compound Database. A total of 37 compounds were screened from the database, and then we used the LibDock docking program to evaluate the inhibition effect. The best three compounds (AP22408, CID 71463546 and CID 9917321) were chosen for MD simulations after the LibDock docking. Our results show that the compound CID 9917321 can produce a more stable protein-ligand complex compared to other two currently known inhibitors of Src SH2 domain. The compound CID 9917321 may be useful for the inhibition of SH2 domain based on these computational results. Subsequently experiments are needed to verify the effect of compound CID 9917321 on the SH2 domain in the future studies.
Abstract: The aim of this study was to find out if the special type of exercise with elastic cord can improve the level of postural stability. The exercise programme was conducted twice a week for 3 months. The participants were randomly divided into an experimental group and a control group. The electronic balance board was used for testing of postural stability. All participants trained for 18 hours at the time of experiment without any special form of coordination programme. The experimental group performed 90 minutes plus of coordination exercise. The result showed that differences between pre-test and post-test occurred in the experimental group. It was used the nonparametric Wilcoxon t-test for paired samples (p=0.012; the significance level 95%). We calculated effect size by Cohen´s d. In the experimental group d is 1.96 which indicates a large effect. In the control group d is 0.04 which confirms no significant improvement.