Ultrasensitive Hepatitis B Virus Detection in Blood Using Nano-Porous Silicon Oxide: Towards POC Diagnostics

Early diagnosis of infection like Hep-B virus in blood is important for low cost medical treatment. For this purpose, it is desirable to develop a point of care device which should be able to detect trace quantities of the target molecule in blood. In this paper, we report a nanoporous silicon oxide sensor which is capable of detecting down to 1fM concentration of Hep-B surface antigen in blood without the requirement of any centrifuge or pre-concentration. This has been made possible by the presence of resonant peak in the sensitivity characteristics. This peak is observed to be dependent only on the concentration of the specific antigen and not on the interfering species in blood serum. The occurrence of opposite impedance change within the pores and at the bottom of the pore is responsible for this effect. An electronic interface has also been designed to provide a display of the virus concentration.

Preliminary Chaos Analyses of Explosion Earthquakes Followed by Harmonic Tremors at Semeru Volcano, East Java, Indonesia

Successive event of explosion earthquake and harmonic tremor recorded at Semeru volcano were analyzed to investigate the dynamical system regarding to their eruptive mechanism. The eruptive activity at Semeru volcano East Java, Indonesia is intermittent emission of ash and bombs with Strombolian style which occurred at interval of 15 to 45 minutes. The explosive eruptions accompanied by explosion earthquakes and followed by volcanic tremor which generated by continuous emission of volcanic ash. The spectral and Lyapunov exponent of successive event of explosion and harmonic tremor were analyzed. Peak frequencies of explosion earthquakes range 1.2 to 1.9 Hz and those of the harmonic tremor have peak frequency range 1.5 — 2.2 Hz. The phase space is reconstructed and evaluated based on the Lyapunov exponents. Harmonic tremors have smaller Lyapunov exponent than explosion earthquakes. It can be considerably as correlated complexity of the mechanism from the variance of spectral and fractal dimension and can be concluded that the successive event of harmonic tremor and explosions are chaotic.

Time Domain and Frequency Domain Analyses of Measured Metocean Data for Malaysian Waters

Data of wave height and wind speed were collected from three existing oil fields in South China Sea – offshore Peninsular Malaysia, Sarawak and Sabah regions. Extreme values and other significant data were employed for analysis. The data were recorded from 1999 until 2008. The results show that offshore structures are susceptible to unacceptable motions initiated by wind and waves with worst structural impacts caused by extreme wave heights. To protect offshore structures from damage, there is a need to quantify descriptive statistics and determine spectra envelope of wind speed and wave height, and to ascertain the frequency content of each spectrum for offshore structures in the South China Sea shallow waters using measured time series. The results indicate that the process is nonstationary; it is converted to stationary process by first differencing the time series. For descriptive statistical analysis, both wind speed and wave height have significant influence on the offshore structure during the northeast monsoon with high mean wind speed of 13.5195 knots ( = 6.3566 knots) and the high mean wave height of 2.3597 m ( = 0.8690 m). Through observation of the spectra, there is no clear dominant peak and the peaks fluctuate randomly. Each wind speed spectrum and wave height spectrum has its individual identifiable pattern. The wind speed spectrum tends to grow gradually at the lower frequency range and increasing till it doubles at the higher frequency range with the mean peak frequency range of 0.4104 Hz to 0.4721 Hz, while the wave height tends to grow drastically at the low frequency range, which then fluctuates and decreases slightly at the high frequency range with the mean peak frequency range of 0.2911 Hz to 0.3425 Hz.