Abstract: Candida spp. are common and aggressive pathogens. Because of the growing resistance of Candida spp. to current antifungals, novel targets, found in Candida spp. but not in humans or other flora, have to be identified. The alternative oxidase (AOX) is one such possibility. This enzyme is insensitive to cyanide, but is sensitive to compounds such as salicylhydroxamic acid (SHAM), disulfiram and n-alkyl gallates. The growth each of six Candida spp. was inhibited significantly by ~13 mM SHAM or 2 mM cyanide, albeit to differing extents. In C. dubliniensis, C. krusei and C. tropicalis the rate of O2 uptake was inhibited by 18-36% by 25 mM SHAM, but this had little or no effect on C. glabrata, C. guilliermondii or C. parapsilosis. Although SHAM substantially inhibited the growth of Candida spp., it is unlikely that the inhibition of AOX was the cause. Salicylhydroxamic acid is used therapeutically in the treatment of urinary tract infections and urolithiasis, but it also has some potential in the treatment of Candida spp. infection.
Abstract: We propose a method for discrimination and
classification of ovarian with benign, malignant and normal tissue
using independent component analysis and neural networks. The
method was tested for a proteomic patters set from A database, and
radial basis functions neural networks. The best performance was
obtained with probabilistic neural networks, resulting I 99% success
rate, with 98% of specificity e 100% of sensitivity.
Abstract: Moral decisions are considered as an intuitive process,
while conscious reasoning is mostly used only to justify those
intuitions. This problem is described in few different dual-process
theories of mind, that are being developed e.g. by Frederick and
Kahneman, Stanovich and Evans. Those theories recently evolved
into tri-process theories with a proposed process that makes ultimate
decision or allows to paraformal processing with focal bias..
Presented experiment compares the decision patterns to the
implications of those models.
In presented study participants (n=179) considered different
aspects of trolley dilemma or its footbridge version and decided after
that.
Results show that in the control group 70% of people decided to
use the lever to change tracks for the running trolley, and 20% chose
to push the fat man down the tracks. In contrast, after experimental
manipulation almost no one decided to act. Also the decision time
difference between dilemmas disappeared after experimental
manipulation.
The result supports the idea of three co-working processes:
intuitive (TASS), paraformal (reflective mind) and algorithmic
process.
Abstract: This paper compares the recent transformerless ACDC
power converter architectures and provides an assessment of
each. A prototype of one of the transformerless AC-DC converter
architecture is also presented depicting the feasibility of a small form
factor, power supply design. In this paper component selection
guidelines to achieve high efficiency AC-DC power conversion are
also discussed.
Abstract: The paper shows how the CASMAS modeling language,
and its associated pervasive computing architecture, can be
used to facilitate continuity of care by providing members of patientcentered
communities of care with a support to cooperation and
knowledge sharing through the usage of electronic documents and
digital devices. We consider a scenario of clearly fragmented care to
show how proper mechanisms can be defined to facilitate a better
integration of practices and information across heterogeneous care
networks. The scenario is declined in terms of architectural components
and cooperation-oriented mechanisms that make the support
reactive to the evolution of the context where these communities
operate.
Abstract: Phylogenies ; The evolutionary histories of groups of
species are one of the most widely used tools throughout the life
sciences, as well as objects of research with in systematic,
evolutionary biology. In every phylogenetic analysis reconstruction
produces trees. These trees represent the evolutionary histories of
many groups of organisms, bacteria due to horizontal gene transfer
and plants due to process of hybridization. The process of gene
transfer in bacteria and hybridization in plants lead to reticulate
networks, therefore, the methods of constructing trees fail in
constructing reticulate networks. In this paper a model has been
employed to reconstruct phylogenetic network in honey bee. This
network represents reticulate evolution in honey bee. The maximum
parsimony approach has been used to obtain this reticulate network.
Abstract: The hydrologic time series data display periodic
structure and periodic autoregressive process receives considerable
attention in modeling of such series. In this communication long
term record of monthly waste flow of Lyari river is utilized to
quantify by using PAR modeling technique. The parameters of
model are estimated by using Frances & Paap methodology. This
study shows that periodic autoregressive model of order 2 is the most
parsimonious model for assessing periodicity in waste flow of the
river. A careful statistical analysis of residuals of PAR (2) model is
used for establishing goodness of fit. The forecast by using proposed
model confirms significance and effectiveness of the model.
Abstract: Metal cutting is a severe plastic deformation process
involving large strains, high strain rates, and high temperatures.
Conventional analysis of the chip formation process is based on bulk
material deformation disregarding the inhomogeneous nature of the
material microstructure. A series of orthogonal cutting tests of AISI
1045 and 1144 steel were conducted which yielded similar process
characteristics and chip formations. With similar shear angles and cut
chip thicknesses, shear strains for both chips were found to range
from 2.0 up to 2.8. The manganese-sulfide (MnS) precipitate in the
1144 steel has a very distinct and uniform shape which allows for
comparison before and after chip formation. From close observations
of MnS precipitates in the cut chips it is shown that the conventional
approach underestimates plastic strains in metal cutting.
Experimental findings revealed local shear strains around a value of
6. These findings and their implications are presented and discussed.
Abstract: The kinetic properties of enzymes are often reported
using the apparent KM and Vmax appropriate to the standard
Michaelis-Menten enzyme. However, this model is inappropriate to
enzymes that have more than one substrate or where the rate
expression does not apply for other reasons. Consequently, it is
desirable to have a means of estimating the appropriate kinetic
parameters from the apparent values of KM and Vmax reported for each
substrate. We provide a means of estimating the range within which
the parameters should lie and apply the method to data for glutamate
dehydrogenase from the nematode parasite of sheep Teladorsagia
circumcincta.
Abstract: In this communication a quantitative modeling
approach is applied to construct model for the exchange of gases
from open sewer channel to the atmosphere. The data for the
exchange of gases of the open sewer channel for the year January
1979 to December 2006 is utilized for the construction of the model.
The study reveals that stream flow of the open sewer channel
exchanges the toxic gases continuously with time varying scale. We
find that the quantitative modeling approach is more parsimonious
model for these exchanges. The usual diagnostic tests are applied for
the model adequacy. This model is beneficial for planner and
managerial bodies for the improvement of implemented policies to
overcome future environmental problems.
Abstract: Abu Dhabi is one of the fastest developed cities in the region. On top of all the current and future environmental challenges, Abu Dhabi aims to be among the top governments in the world in sustainable development. Abu Dhabi plans to create an attractive, livable and sustainable managed urban environment in which all necessary services and infrastructure are provided in a sustainable and timely manner. Abu Dhabi is engaged in a difficult challenge to develop credible environmental indicators that would assess the ambitious environmental targets. The aim of those indicators is to provide reliable guidance to decision makers and the public concerning key factors that determine the state of urban environment and identify major areas for policy intervention. In order to ensure sustainable development in UAE in general, and of Abu Dhabi City in particular, relevant and contextual environmental indicators need to be carefully considered. These indicators provide a gauge at a national government scale of how close countries are to establish environmental policy goals. The environment indicators assist city decision-making in such areas as identification of significant environmental aspects and observation of environmental performance trends. Those can help to find ways of reducing environmental pollution and in improving eco-efficiency. This paper outlines recent strategies implemented in Abu Dhabi that aims to improve the sustainable performance of the city-s built environment. The paper explores the variety of current and possible indicators at different levels and their roles in the development of the city.
Abstract: One of the ubiquitous routines in medical practice is searching through voluminous piles of clinical documents. In this paper we introduce a distributed system to search and exchange clinical documents. Clinical documents are distributed peer-to-peer. Relevant information is found in multiple iterations of cross-searches between the clinical text and its domain encyclopedia.
Abstract: This work concerns the evolution and the maintenance
of an ontological resource in relation with the evolution of the corpus
of texts from which it had been built.
The knowledge forming a text corpus, especially in dynamic domains,
is in continuous evolution. When a change in the corpus occurs, the
domain ontology must evolve accordingly. Most methods manage
ontology evolution independently from the corpus from which it is
built; in addition, they treat evolution just as a process of knowledge
addition, not considering other knowledge changes. We propose a
methodology for managing an evolving ontology from a text corpus
that evolves over time, while preserving the consistency and the
persistence of this ontology.
Our methodology is based on the changes made on the corpus to
reflect the evolution of the considered domain - augmented surgery
in our case. In this context, the results of text mining techniques,
as well as the ARCHONTE method slightly modified, are used to
support the evolution process.
Abstract: Every commercial bank optimises its asset portfolio
depending on the profitability of assets and chosen or imposed
constraints. This paper proposes and applies a stylized model for
optimising banks' asset and liability structure, reflecting profitability
of different asset categories and their risks as well as costs associated
with different liability categories and reserve requirements. The level
of detail for asset and liability categories is chosen to create a
suitably parsimonious model and to include the most important
categories in the model. It is shown that the most appropriate
optimisation criterion for the model is the maximisation of the ratio
of net interest income to assets. The maximisation of this ratio is
subject to several constraints. Some are accounting identities or
dictated by legislative requirements; others vary depending on the
market objectives for a particular bank. The model predicts variable
amount of assets allocated to loan provision.
Abstract: Glomerular filtration rate (GFR) is a measure of
kidney function. It is usually estimated from serum concentrations of
cystatin C or creatinine although there has been considerable debate
in the literature about (i) the best equation to use and (ii) the
variability in the correlation between the concentrations of creatinine
and cystatin C. The equations for GFR can be written in a general
form and from these I calculate the error of the GFR estimates
associated with analyte measurement error. These show that the
error of the GFR estimates is such that it is not possible to distinguish
between the equations over much of the concentration range of either
analyte. The general forms of the equations are also used to derive
an expression for the concentration of cystatin C as a function of the
concentration of creatinine. This equation shows that these analyte
concentrations are not linearly related. Clinical reports of cystatin C
and creatinine concentration are consistent with the expression
derived.
Abstract: Based on assumptions of neo-classical economics and
rational choice / public choice theory, this paper investigates the
regulation of industrial land use in Taiwan by homeowners
associations (HOAs) as opposed to traditional government
administration. The comparison, which applies the transaction cost
theory and a polynomial regression analysis, manifested that HOAs
are superior to conventional government administration in terms of
transaction costs and overall efficiency. A case study that compares
Taiwan-s commonhold industrial park, NangKang Software Park, to
traditional government counterparts using limited data on the costs
and returns was analyzed. This empirical study on the relative
efficiency of governmental and private institutions justified the
important theoretical proposition. Numerical results prove the
efficiency of the established model.
Abstract: This paper presents the results of the authors in designing, experimenting, assessing and transferring an innovative approach to energy education in secondary schools, aimed to enhance the quality of learning in terms of didactic curricula and pedagogic methods. The training is online delivered to youngsters via e-Books and portals specially designed for this purpose or by learning by doing via interactive games. An online educational methodology is available teachers.
Abstract: Modular fixtures (MFs) are very important tools in
manufacturing processes in terms of reduction the cost and the
production time. This paper introduces an automated approach for
assembling MFs elements by employing SolidWorks as a powerful
3D CAD software. Visual Basic (VB) programming language was
applied integrating with SolidWorks API (Application programming
interface) functions. This integration allowed creating plug-in file and
generating new menus in the SolidWorks environment. The menus
allow the user to select, insert, and assemble MFs elements.
Abstract: Effective evaluation of software development effort is an important aspect of successful project management. Based on a large database with 4106 projects ever developed, this study statistically examines the factors that influence development effort. The factors found to be significant for effort are project size, average number of developers that worked on the project, type of development, development language, development platform, and the use of rapid application development. Among these factors, project size is the most critical cost driver. Unsurprisingly, this study found that the use of CASE tools does not necessarily reduce development effort, which adds support to the claim that the use of tools is subtle. As many of the current estimation models are rarely or unsuccessfully used, this study proposes a parsimonious parametric model for the prediction of effort which is both simple and more accurate than previous models.
Abstract: Phylogenetic tree is a graphical representation of the
evolutionary relationship among three or more genes or organisms.
These trees show relatedness of data sets, species or genes
divergence time and nature of their common ancestors. Quality of a
phylogenetic tree requires parsimony criterion. Various approaches
have been proposed for constructing most parsimonious trees. This
paper is concerned about calculating and optimizing the changes of
state that are needed called Small Parsimony Algorithms. This paper
has proposed enhanced small parsimony algorithm to give better
score based on number of evolutionary changes needed to produce
the observed sequence changes tree and also give the ancestor of the
given input.