Abstract: In this paper as showed a non-invasive 3D eye tracker
for optometry clinical applications. Measurements of biomechanical
variables in clinical practice have many font of errors associated with
traditional procedments such cover test (CT), near point of
accommodation (NPC), eye ductions (ED), eye vergences (EG) and,
eye versions (ES). Ocular motility should always be tested but all
evaluations have a subjective interpretations by practitioners, the
results is based in clinical experiences, repeatability and accuracy
don-t exist. Optometric-lab is a tool with 3 (tree) analogical video
cameras triggered and synchronized in one acquisition board AD.
The variables globe rotation angle and velocity can be quantified.
Data record frequency was performed with 27Hz, camera calibration
was performed in a know volume and image radial distortion
adjustments.
Abstract: The worldwide prevalence of H3N2 influenza virus
and its increasing resistance to the existing drugs necessitates for the
development of an improved/better targeting anti-influenza drug.
H3N2 influenza neuraminidase is one of the two membrane-bound
proteins belonging to group-2 neuraminidases. It acts as key player
involved in viral pathogenicity and hence, is an important target of
anti-influenza drugs. Oseltamivir is one of the potent drugs targeting
this neuraminidase. In the present work, we have taken subtype N2
neuraminidase as the receptor and probable analogs of oseltamivir as
drug molecules to study the protein-drug interaction in anticipation of
finding efficient modified candidate compound. Oseltamivir analogs
were made by modifying the functional groups using Marvin Sketch
software and were docked using Schrodinger-s Glide. Oseltamivir
analog 10 was detected to have significant energy value (16% less
compared to Oseltamivir) and could be the probable lead molecule. It
infers that some of the modified compounds can interact in a novel
manner with increased hydrogen bonding at the active site of
neuraminidase and it might be better than the original drug. Further
work can be carried out such as enzymatic inhibition studies;
synthesis and crystallizing the drug-target complex to analyze the
interactions biologically.
Abstract: Article 5(3) of the Brussels I Regulation provides that a person domiciled in a Member State may be sued in another Member State in matters relating to tort, delict or quasi-delict, in the courts for the place where the harmful events occurred or may occur. For a number of years Article 5 (3) of the Brussels I Regulation has been at the centre of the debate regarding the intellectual property rights infringement over the Internet. Nothing has been done to adapt the provisions relating to non-internet cases of infringement of intellectual property rights to the context of the Internet. The author’s findings indicate that in the case of intellectual property rights infringement on the Internet, the plaintiff has the option to sue either: the court of the Member State of the event giving rise to the damage: where the publisher of the newspaper is established; the court of the Member State where the damage occurred: where defamatory article is distributed. However, it must be admitted that whilst infringement over the Internet has some similarity to multi-State defamation by means of newspapers, the position is not entirely analogous due to the cross-border nature of the Internet. A simple example which may appropriately illustrate its contentious nature is a defamatory statement published on a website accessible in different Member States, and available in different languages. Therefore, we need to answer the question: how these traditional jurisdictional rules apply in the case of intellectual property rights infringement over the Internet? Should these traditional jurisdictional rules be modified?
Abstract: This paper study the high-level modelling and design
of delta-sigma (ΔΣ) noise shapers for audio Digital-to-Analog
Converter (DAC) so as to eliminate the in-band Signal-to-Noise-
Ratio (SNR) degradation that accompany one channel mismatch in
audio signal. The converter combines a cascaded digital signal
interpolation, a noise-shaping single loop delta-sigma modulator with
a 5-bit quantizer resolution in the final stage. To reduce sensitivity of
Digital-to-Analog Converter (DAC) nonlinearities of the last stage, a
high pass second order Data Weighted Averaging (R2DWA) is
introduced. This paper presents a MATLAB description modelling
approach of the proposed DAC architecture with low distortion and
swing suppression integrator designs. The ΔΣ Modulator design can
be configured as a 3rd-order and allows 24-bit PCM at sampling rate
of 64 kHz for Digital Video Disc (DVD) audio application. The
modeling approach provides 139.38 dB of dynamic range for a 32
kHz signal band at -1.6 dBFS input signal level.
Abstract: The study of soil for agriculture purposes has
remained the main focus of research since the beginning of civilization as humans- food related requirements remained closely linked with the soil. The study of soil has generated an interest
among the researchers for very similar other reasons including transmission, reflection and refraction of signals for deploying
wireless underground sensor networks or for the monitoring of objects on (or in ) soil in the form of better understanding of soil
electromagnetic characteristics properties. The moisture content has
been very instrumental in such studies as it decides on the resistance of the soil, and hence the attenuation on signals traveling through soil
or the attenuation the signals may suffer upon their impact on soil. This work is related testing and characterizing a measurement circuit
meant for the detection of moisture level content in soil.
Abstract: Tuberculosis (TB) is a bacterial infectious disease caused by the obligate human pathogen, Mycobacterium tuberculosis. Multidrug-resistant tuberculosis (MDR-TB) is a global reality that threatens tuberculosis control. Resistance to antibiotic Rifampicin, occurs in 95% of cases through nucleotide substitutions in an 81-bp core region of the rpoB i.e; beta subunit of DNA dependant RNA polymerase. In this paper, we studied the Rifampicin-rpoB receptor interactions In silico. First, homology modeling was performed to obtain the three dimensional structure of Mycobacterium rpoB. Sixty analogs of Rifampicin were prepared using Marvin sketch software. Both original Rifampicin and the analogs were docked with rpoB and energy values were obtained. Out of sixty analogs, 43 analogs had lesser energy values than conventional Rifampicin and hence are predicted to have greater binding affinity to rpoB. Thus, this study offers a route for the development of Rifampicin analogs against multi drug resistant Mycobacterium rpoB.
Abstract: This paper proposes an efficient finite precision block floating point (BFP) treatment to the fixed coefficient finite impulse response (FIR) digital filter. The treatment includes effective implementation of all the three forms of the conventional FIR filters, namely, direct form, cascaded and par- allel, and a roundoff error analysis of them in the BFP format. An effective block formatting algorithm together with an adaptive scaling factor is pro- posed to make the realizations more simple from hardware view point. To this end, a generic relation between the tap weight vector length and the input block length is deduced. The implementation scheme also emphasises on a simple block exponent update technique to prevent overflow even during the block to block transition phase. The roundoff noise is also investigated along the analogous lines, taking into consideration these implementational issues. The simulation results show that the BFP roundoff errors depend on the sig- nal level almost in the same way as floating point roundoff noise, resulting in approximately constant signal to noise ratio over a relatively large dynamic range.
Abstract: For today-s and future wireless communications applications,
more and more data traffic has to be transmitted with
growing speed and quality demands. The analog front-end of any
mobile device has to cope with very hard specifications regardless
which transmission standard has to be supported. State-of-the-art
analog front-end implementations are reaching the limit of technical
feasibility. For that reason, alternative front-end architectures could
support a continuing development of mobile communications e.g.,
six-port-based front-ends [1], [2].
In this article we propose an analog front-end with high intermediate
frequency and which utilizes additive mixing instead
of multiplicative mixing. The system architecture is presented and
several spurious effects as well as their influence on the system
dimensioning are discussed. Furthermore, several issues concerning
the technical feasibility are provided and some simulation results
are discussed which show the principle functionality of the proposed
superposition heterodyne receiver.
Abstract: The present paper is oriented to problems of simulation of anticipatory systems, namely those that use simulation models for the aid of anticipation. A certain analogy between use of simulation and imagining will be applied to make the explication more comprehensible. The paper will be completed by notes of problems and by some existing applications. The problems consist in the fact that simulation of the mentioned anticipatory systems end is simulation of simulating systems, i.e. in computer models handling two or more modeled time axes that should be mapped to real time flow in a nondescent manner. Languages oriented to objects, processes and blocks can be used to surmount the problems.
Abstract: In this paper a novel high output impedance, low input impedance, wide bandwidth, very simple current mirror with input and output voltage requirements less than that of a simple current mirror is presented. These features are achieved with very simple structure avoiding extra large node impedances to ensure high bandwidth operation. The circuit's principle of operation is discussed and compared to simple and low voltage cascode (LVC) current mirrors. Such outstanding features of this current mirror as high output impedance ~384K, low input impedance~6.4, wide bandwidth~178MHz, low input voltage ~ 362mV, low output voltage ~ 38mV and low current transfer error ~4% (all at 50μA) makes it an outstanding choice for high performance applications. Simulation results in BSIM 0.35μm CMOS technology with HSPICE are given in comparison with simple, and LVC current mirrors to verify and validate the performance of the proposed current mirror.
Abstract: Ten percent of the population will develop plantar
fasciitis (PF) during their lifetime. Two million people are treated
yearly accounting for 11-15% of visits to medical professionals.
Treatment ranges from conservative to surgical intervention. The
purpose of this study was to assess the effects of extracorporeal
shockwave therapy (ECSWT) on heel pain, function, range of motion
(ROM), and strength in patients with PF. One hundred subjects were
treated with ECSWT and measures were taken before and three
months after treatment. There was significant differences in visual
analog scale scores for pain at rest (p=0.0001); after activity (p=
0.0001) and; overall improvement (p=0.0001). There was also
significant improvement in Lower Extremity Functional Scale scores
(p=0.0001); ankle plantarflexion (p=0.0001), dorsiflexion (p=0.001),
and eversion (p=0.017),and first metatarsophalangeal joint flexion
(p=0.002) and extension (p=0.003) ROM. ECSWT is an effective
treatment improving heel pain, function and ROM in patients with
PF.
Abstract: Time interleaved sigma-delta (TIΣΔ) architecture is a
potential candidate for high bandwidth analog to digital converters
(ADC) which remains a bottleneck for software and cognitive radio
receivers. However, the performance of the TIΣΔ architecture is
limited by the unavoidable gain and offset mismatches resulting
from the manufacturing process. This paper presents a novel digital
calibration method to compensate the gain and offset mismatch
effect. The proposed method takes advantage of the reconstruction
digital signal processing on each channel and requires only few logic
components for implementation. The run time calibration is estimated
to 10 and 15 clock cycles for offset cancellation and gain mismatch
calibration respectively.
Abstract: Transpedicular screw fixation in spinal fractures,
degenerative changes, or deformities is a well-established procedure.
However, important rate of fixation failure due to screw bending,
loosening, or pullout are still reported particularly in weak bone stock
in osteoporosis. To overcome the problem, mechanism of failure has
to be fully investigated in vitro. Post-mortem human subjects are less
accessible and animal cadavers comprise limitations due to different
geometry and mechanical properties. Therefore, the development of a
synthetic model mimicking the realistic human vertebra is highly
demanded. A bone surrogate, composed of Polyurethane (PU) foam
analogous to cancellous bone porous structure, was tested for 3
different densities in this study. The mechanical properties were
investigated under uniaxial compression test by minimizing the end
artifacts on specimens. The results indicated that PU foam of 0.32
g.cm-3 density has comparable mechanical properties to human
cancellous bone in terms of young-s modulus and yield strength.
Therefore, the obtained information can be considered as primary
step for developing a realistic cancellous bone of human vertebral
body. Further evaluations are also recommended for other density
groups.
Abstract: This paper presents two prototypes of low power low voltage current mode 9 bit pipelined a/d converters. The first and the second converters are configured of 1.5 bit and 2.5 bit stages, respectively. The a/d converter structures are composed of current mode building blocks and final comparator block which converts the analog current signal into digital voltage signal. All building blocks have been designed in CMOS AMS 0.35μm technology, then simulated to verify proposed concept. The performances of both converters are compared to performances of known current mode and voltage mode switched capacitance converter structures. Low power consumption and small chip area are advantages of the proposed converters.
Abstract: A precision CMOS chopping amplifier is adopted in this work to improve a CMOS temperature sensor high sensitive enough for intracranial temperature monitoring. An amplified temperature sensitivity of 18.8 ± 3*0.2 mV/oC is attained over the temperature range from 20 oC to 80 oC from a given 10 samples of the same wafer. The analog frontend design outputs the temperature dependent and the temperature independent signals which can be directly interfaced to a 10 bit ADC to accomplish an accurate temperature instrumentation system.
Abstract: A digital system is proposed for low power 100-
channel neural recording system in this paper, which consists of 100
amplifiers, 100 analog-to-digital converters (ADC), digital controller
and baseband, transceiver for data link and RF command link. The
proposed system is designed in a 0.18 μm CMOS process and 65 nm
CMOS process.
Abstract: An on chip low drop out voltage regulator that
employs elegant compensation scheme is presented in this paper. The
novelty in this design is that the device parasitic capacitances are
exploited for compensation at different loads. The proposed LDO is
designed to provide a constant voltage of 1.2V and is implemented in
UMC 180 nano meter CMOS technology. The voltage regulator
presented improves stability even at lighter loads and enhances line
and load regulation.
Abstract: To determine if the murine insulinoma, β-TC-6, is a
suitable substitute for primary pancreatic β-cells in the study of β-
cell functional heterogeneity, we used three distinct functional assays
to ascertain the cell line-s response to glucose or a glucose analog.
These assays include: (i) a 2-NBDG uptake assay; (ii) a calcium
influx assay, and; (iii) a quinacrine secretion assay. We show that a
population of β-TC-6 cells endocytoses the glucose analog, 2-
NBDG, at different rates, has non-uniform intracellular calcium ion
concentrations and releases quinacrine at different rates when
challenged with glucose. We also measured the Km for β-TC-6
glucose uptake to be 46.9 mM and the Vm to be 8.36 x 10-5
mmole/million cells/min. These data suggest that β-TC-6 might be
used as an alternative to primary pancreatic β-cells for the study of
glucose-dependent β-cell functional heterogeneity.
Abstract: Thermoacoustic instabilities in combustors have
remained a topic of investigation for over a few decades due to the
challenges it posses to the operation of low emission gas turbines.
For combustors burning liquid fuel, understanding the cause-andeffect
relationship between spray combustion dynamics and
thermoacoustic oscillations is imperative for the successful
development of any control methodology for its mitigation. The
paper presents some very unique operating characteristics of a
kerosene-fueled diffusion type combustor undergoing limit-cycle
oscillations. Combustor stability limits were mapped using three
different-sized injectors. The results show that combustor instability
depends on the characteristics of the fuel spray. A simple analytic
analysis is also reported in support of a plausible explanation for the
unique combustor behavior. The study indicates that high amplitude
acoustic pressure in the combustor may cause secondary breakdown
of fuel droplets resulting in premixed pre-vaporized type burning of
the diffusion type combustor.
Abstract: Implemented 5-bit 125-MS/s successive
approximation register (SAR) analog to digital converter (ADC) on
FPGA is presented in this paper.The design and modeling of a high
performance SAR analog to digital converter are based on monotonic
capacitor switching procedure algorithm .Spartan 3 FPGA is chosen
for implementing SAR analog to digital converter algorithm. SAR
VHDL program writes in Xilinx and modelsim uses for showing
results.