Abstract: Segmenting the lungs in medical images is a
challenging and important task for many applications. In particular,
automatic segmentation of lung cavities from multiple magnetic
resonance (MR) images is very useful for oncological applications
such as radiotherapy treatment planning. However, distinguishing of
the lung areas is not trivial due to largely changing lung shapes, low
contrast and poorly defined boundaries. In this paper, we address
lung segmentation problem from pulmonary magnetic resonance
images and propose an automated method based on a robust regionaided
geometric snake with a modified diffused region force into the
standard geometric model definition. The extra region force gives the
snake a global complementary view of the lung boundary
information within the image which along with the local gradient
flow, helps detect fuzzy boundaries. The proposed method has been
successful in segmenting the lungs in every slice of 30 magnetic
resonance images with 80 consecutive slices in each image. We
present results by comparing our automatic method to manually
segmented lung cavities provided by an expert radiologist and with
those of previous works, showing encouraging results and high
robustness of our approach.
Abstract: To investigate the applicability of the EDR-2 film for
clinical radiation dosimetry, percentage depth-doses, profiles and
distributions in open and dynamically wedged fields were measured
using film and compared with data from a Treatment Planning
system.The validity of the EDR2 film to measure dose in a plane
parallel to the beam was tested by irradiating 10 cm×10 cm and 4
cm×4 cm fields from a Siemens, primus linac with a 6MV beam and
a source-to-surface distance of 100 cm. The film was placed
Horizontally between solid water phantom blocks and marked
with pin holes at a depth of 10 cm from the incident beam surface.
The film measurement results, in absolute dose, were compared with
ion chamber measurements using a Welhoffer scanning water tank
system and Treatment Planning system. Our results indicate a
maximum underestimate of calculated dose of 8 % with Treatment
Planning system.
Abstract: In medical therapy, laser has been widely used to conduct cosmetic, tumor and other treatments. During the process of laser irradiation, there may be thermal damage caused by excessive laser exposure. Thus, the establishment of a complete thermal analysis model is clinically helpful to physicians in reference data. In this study, porcine liver in place of tissue was subjected to laser irradiation to set up the experimental data considering the explored impact on surface thermal field and thermal damage region under different conditions of power, laser irradiation time, and distance between laser and porcine liver. In the experimental process, the surface temperature distribution of the porcine lever was measured by the infrared thermal imager. In the part of simulation, the bio heat transfer Pennes-s equation was solved by software SYSWELD applying in welding process. The double ellipsoid function as a laser source term is firstly considered in the prediction for surface thermal field and internal tissue damage. The simulation results are compared with the experimental data to validate the mathematical model established here in.
Abstract: Aiming the application of localized hyperthermia, a
magnetic induction system with new approaches is proposed. The techniques in this system for improving the effectiveness of localized hyperthermia are that using magnetic circuit and the multiple-coil array instead of a giant coil for generating magnetic field. Specially, amorphous metal is adopted as the material of magnetic circuit. Detail
design parameters of hardware are well described. Simulation tool is
employed for this work and experiment result is reported as well.
Abstract: Healthcare providers sometimes use the power of
humor as a treatment and therapy for buffering mental health or easing
mental disorders because humor can provide relief from distress and
conflict. Humor is also very suitable for advertising because of similar
benefits. This study carefully examines humor's widespread use in
advertising and identifies relationships among humor mechanisms,
female depictions, and product types. The purpose is to conceptualize
how humor theories can be used not only to successfully define a
product as fitting within one of four color categories of the product
color matrix, but also to identify compelling contemporary female
depictions through humor in ads. The results can offer an idealization
for marketing managers and consumers to help them understand how
female role depictions can be effectively used with humor in ads. The
four propositions developed herein are derived from related literature,
through the identification of marketing strategy formulations that
achieve product memory enhancement by adopting humor
mechanisms properly matched with female role depictions.
Abstract: Increased physical fitness participation has been
paralleled by increasedoveruse injuries such as insertional Achilles
tendinosis (AT). Treatment has provided inconsistentresults. The use
of extracorporeal shockwave therapy (ECSWT) offers a new
treatment consideration.The purpose of this study was to assess the
effects of ECSWTon pain, function, range of motion (ROM), joint
mobility and strength in patients with AT. Thirty subjects were
treated with ECSWT and measures were takenbefore and three
months after treatment. There was significant differences in visual
analog scale (VAS) scores for pain at rest (p=0.002); after activity
(p= 0.0001); overall improvement(p=0.0001); Lower Extremity
Functional Scale (LEFS) scores (p=0.002); dorsiflexion range of
motion (ROM) (p=0.0001); plantarflexion strength (p=0.025);
talocrural joint anterior glide (p=0.046); and subtalar joint medial and
lateral glide (p=0.025).ECSWT offers a new intervention that may
limit the progression of the disorder and the long term healthcare
costs associated with AT.
Abstract: Previous studies have shown that there are arguments
regarding the reliability and validity of the Ashworth and Modified
Ashworth Scale towards evaluating patients diagnosed with upper
limb disorders. These evaluations depended on the raters’ experiences.
This initiated us to develop an upper limb disorder part-task trainer
that is able to simulate consistent upper limb disorders, such as
spasticity and rigidity signs, based on the Modified Ashworth Scale to
improve the variability occurring between raters and intra-raters
themselves. By providing consistent signs, novice therapists would be
able to increase training frequency and exposure towards various
levels of signs. A total of 22 physiotherapists and occupational
therapists participated in the study. The majority of the therapists
agreed that with current therapy education, they still face problems
with inter-raters and intra-raters variability (strongly agree 54%; n =
12/22, agree 27%; n = 6/22) in evaluating patients’ conditions. The
therapists strongly agreed (72%; n = 16/22) that therapy trainees
needed to increase their frequency of training; therefore believe that
our initiative to develop an upper limb disorder training tool will help
in improving the clinical education field (strongly agree and agree
63%; n = 14/22).
Abstract: This paper presents an overview of the design and
implementation of an online rule-based Expert Systems for Islamic
medication. T his Online Islamic Medication Expert System (OIMES)
focuses on physical illnesses only. Knowledge base of this Expert
System contains exhaustively the types of illness together with their
related cures or treatments/therapies, obtained exclusively from the
Quran and Hadith. Extensive research and study are conducted to
ensure that the Expert System is able to provide the most suitable
treatment with reference to the relevant verses cited in Quran or
Hadith. These verses come together with their related 'actions'
(bodily actions/gestures or some acts) to be performed by the patient
to treat a particular illness/sickness. These verses and the instructions
for the 'actions' are to be displayed unambiguously on the computer
screen. The online platform provides the advantage for patient getting
treatment practically anytime and anywhere as long as the computer
and Internet facility exist. Patient does not need to make appointment
to see an expert for a therapy.
Abstract: The small interfering RNA (siRNA) alters the
regulatory role of mRNA during gene expression by translational
inhibition. Recent studies show that upregulation of mRNA because
serious diseases like cancer. So designing effective siRNA with good
knockdown effects plays an important role in gene silencing. Various
siRNA design tools had been developed earlier. In this work, we are
trying to analyze the existing good scoring second generation siRNA
predicting tools and to optimize the efficiency of siRNA prediction
by designing a computational model using Artificial Neural Network
and whole stacking energy (%G), which may help in gene silencing
and drug design in cancer therapy. Our model is trained and tested
against a large data set of siRNA sequences. Validation of our results
is done by finding correlation coefficient of experimental versus
observed inhibition efficacy of siRNA. We achieved a correlation
coefficient of 0.727 in our previous computational model and we
could improve the correlation coefficient up to 0.753 when the
threshold of whole tacking energy is greater than or equal to -32.5
kcal/mol.
Abstract: The paper proposes a methodology to process the signals coming from the Transcranial Magnetic Stimulation (TMS) in order to identify the pathology and evaluate the therapy to treat the patients affected by demency diseases. In particular, a fuzzy model is developed to identify the demency of the patients affected by Subcortical Ischemic Vascular Dementia (SIVD) and to measure the effect of a repetitive TMS on their motor performances. A tool is also presented to support the mentioned analysis.
Abstract: Huge losses in apple production are caused by pathogens that cannot be seen shortly after harvest. After-harvest thermotherapy treatments can considerably improve control of storage diseases on apples and become an alternative to chemical pesticides. In the years 2010-2012 carried out research in this area. Apples of 'Topaz' cultivar were harvested at optimal maturity time for long storage and subject to water bath treatment at 45, 50, 52, 55°C for 60, 120, 180 and 240 seconds. The control was untreated fruits. After 12 and 24 weeks and during so called simulated trade turnover the fruits were checked for their condition and the originators of diseases were determined by using the standard phytopathological methods. The most common originator of 'Topaz' apple infection during storage were the fungi of genus Gloeosporium. In this paper it was proven that for effective protection of 'Topaz' apples against diseases, thermotherapy by using water treatments at temperature range of 50-52°C is quite sufficient.
Abstract: This paper presents a model for the characterization
and selection of beeswaxes for use as base substitute tissue for the
manufacture of objects suitable for external radiotherapy using
megavoltage photon beams. The model of characterization was
divided into three distinct stages: 1) verification of aspects related to
the origin of the beeswax, the bee species, the flora in the vicinity of
the beehives and procedures to detect adulterations; 2) evaluation of
physical and chemical properties; and 3) evaluation of beam
attenuation capacity. The chemical composition of the beeswax
evaluated in this study was similar to other simulators commonly
used in radiotherapy. The behavior of the mass attenuation coefficient
in the radiotherapy energy range was comparable to other simulators.
The proposed model is efficient and enables convenient assessment
of the use of any particular beeswax as a base substitute tissue for
radiotherapy.
Abstract: Dexamethasone (Dex) is a synthetic glucocorticoid
that is used in therapy. However prolonged treatments with high
doses are often required. This causes side effects that interfere with
the activity of several endocrine systems, including the gonadotropic
axis.
The aim of our study is to determine the effect of Dex on testicular
function in prepubertal Wistar rats.
Newborn Wistar rats are submitted to intraperitoneal injection of
Dex (1μg of Dex dissolved in NaCl 0.9% / 5g bw) for 20 days and
then sacrificed at the age of 40days. A control group received NaCl
0.9%. The rat is weighed daily. The plasmatic levels of testosterone,
LH and FSH were measured by radioimmunoassay. A histomorphometric
study was performed on sections of testis.
Treated groups showed a significant decrease in body weight (p
Abstract: In elevating performance in competetive sports, an
athlete must continously train in achieving maximum
performance,but needs to pay attention to recovery therapy, that is to
recover from fatigue as well as injury.The correct recovery therapy
will assist in process of recovery and helps in the training in
achieving better performace. Binahong (Anredera cordifolia) was
proven empirically by the locals in assisting speedy recovery from an
injury.Clinical research with lab animals receiving blunt trauma
injury, microscopically shown signs of: 1) redness, 2) heatiness, 3)
swelling and, 4) lack of activity. There is also microscopic indication
of: 1) infiltration of inflame cells (migration of cells to the trauma
area), 2) Cells necrosis, 3) Congestion (as a result of dead red blood
cells), 4) uedema. On administration of Binahong for 3 days, there is
a significant drop of 5% in cell inflammation, 2% increase of
fibroblast (cell membrance) count.Conclutin: Binahong do assist in
reducing cell inflammation and increase counts of cells fibroblast.
Suggestion: In helping athlete's to recover from force injury, we need
study about Binahong's roots to inflammation cell and healing of
injuried cell.
Abstract: Asthma is a condition that causing chronic health problems in children. In addition to basic therapy against disease, we must try to reduce the impact of chronic health problems and also optimize their medical aspect of growth and development. A boy with mild asthma attack frequent episode did not showed any improvement with medical treatment and his asthma control test was 11. From radiologic examination he got hyperaerated lung and billateral sinusitis maxillaris; skin test results were house dust, food and pet allergy; an overweight body; bad school grades; psychological and environmental problem. We followed and evaluated this boy in 6 months, treated holistically. Even we could not do much on environmental but no more psychological and school problems, his on a good bodyweight and his asthma control test was 22. A case of a child with mild asthma attack frequent episode was reported. Asthma clinical course show no significant improvement when other predisposing factor is not well-controlled and a child’s growth and development may be affected. Improving condition of the patient can be created with the help of loving and caring way of nurturing from the parents and supportive peer group. Therefore, continuous and consistent monitoring is required because prognosis of asthma is generally good when regularly and properly controlled.
Abstract: This study presents a mathematical modeling approach to the planning of HIV therapies on an individual basis. The model replicates clinical data from typical-progressors to AIDS for all stages of the disease with good agreement. Clinical data from rapid-progressors and long-term non-progressors is also matched by estimation of immune system parameters only. The ability of the model to reproduce these phenomena validates the formulation, a fact which is exploited in the investigation of effective therapies. The therapy investigation suggests that, unlike continuous therapy, structured treatment interruptions (STIs) are able to control the increase in both the drug-sensitive and drug-resistant virus population and, hence, prevent the ultimate progression from HIV to AIDS. The optimization results further suggest that even patients characterised by the same progression type can respond very differently to the same treatment and that the latter should be designed on a case-by-case basis. Such a methodology is presented here.
Abstract: In order to alleviate the mental and physical problems
of persons with disabilities, animal-assisted therapy (AAT) is one of
the possible modalities that employs the merit of the human-animal
interaction. Nevertheless, to achieve the purpose of AAT for persons
with severe disabilities (e.g. spinal cord injury, stroke, and
amyotrophic lateral sclerosis), real-time animal language
interpretation is desirable. Since canine behaviors can be visually
notable from its tail, this paper proposes the automatic real-time
interpretation of canine tail language for human-canine interaction in
the case of persons with severe disabilities. Canine tail language is
captured via two 3-axis accelerometers. Directions and frequencies
are selected as our features of interests. The novel fuzzy rules based
on Gaussian-Trapezoidal model and center of gravity (COG)-based
defuzzification method are proposed in order to interpret the features
into four canine emotional behaviors, i.e., agitate, happy, scare and
neutral as well as its blended emotional behaviors. The emotional
behavior model is performed in the simulated dog and has also been
evaluated in the real dog with the perfect recognition rate.
Abstract: The focal spot of a high intensity focused ultrasound
transducer is small. To heat a large target volume, multiple treatment spots are required. If the power of each treatment spot is fixed, it could
results in insufficient heating of initial spots and over-heating of later ones, which is caused by the thermal diffusion. Hence, to produce a
uniform heated volume, the delivered energy of each treatment spot
should be properly adjusted. In this study, we proposed an iterative, extrapolation technique to adjust the required ultrasound energy of
each treatment spot. Three different scanning pathways were used to evaluate the performance of this technique. Results indicate that by using the proposed technique, uniform heating volume could be obtained.
Abstract: A therapeutic success is the aim of any therapeutic
intervention, but a therapeutic failure is the other side of the same
coin. The purpose of this study is to present the activity of a personal
development group, composed of 14 participants (psychologists,
doctors and a priest) registered for a 2 days course of integrative
psychotherapy. The objectives of this study are centred on: the
management of the personal development group breaking moment
realized by the therapist/trainer; the analysis of the trainer’s personal
situation and of some group participants and the brief presentation of
the main work methods applied on participants in the repairing of the
therapeutic relation and in the counter transfer management. The
therapist’s orientation is an integrative one and the demarche realized
includes T.A. techniques, role play, Gestalt and family systemic
psychotherapy. The conclusions obtained represent landmarks for the
future activity within that group and strengthen the therapeutic
relation with the group.
Abstract: Breast cancer is the most common malignancy in the
world among women. Many therapies have been designed to treat
this disease. Mamectomy, chemotherapy and radiotherapy are still
the main therapies of breast cancer. However, the results were
unsatisfactory and still far from the ideal treatment.
PM 701is a natural product, has anticancer activity. The bioactive
fraction PMF and subfraction PMFK had been isolated from PM701.
PM 701 and its fractions were proved to have a cytotoxic properties
against different cancer cell lines. This article is directed for the
further examination of lyophilized PM701 and its active fractions on
the growth of breast cancer cells (MCF-7). PM 701, PMF or PMFK
were adding to the cultural medium, where MCF-7 is incubated.
PM 701, PMF or PMFK were able to inhibit significantly the
proliferation of MCF-7 cells, Moreover these new agents were
proved to induce apoptosis of the breast cancer cells; through its
direct effect on the nuclei.