Abstract: An alarming emergence of multidrug-resistant strains
of the tuberculosis pathogen Mycobacterium tuberculosis and
continuing high worldwide incidence of tuberculosis has invigorated
the search for novel drug targets. The enzyme glutamate racemase
(MurI) in bacteria catalyzes the stereoconversion of L-glutamate to
D-glutamate which is a component of the peptidoglycan cell wall of
the bacterium. The inhibitors targeted against MurI from several
bacterial species have been patented and are advocated as promising
antibacterial agents. However there are none available against MurI
from Mycobacterium tuberculosis, due to the lack of its threedimensional
structure. This work accomplished two major objectives.
First, the tertiary structure of MtMurI was deduced computationally
through homology modeling using the templates from bacterial
homologues. It is speculated that like in other Gram-positive bacteria,
MtMurI exists as a dimer and many of the protein interactions at the
dimer interface are also conserved. Second, potent candidate
inhibitors against MtMurI were identified through docking against
already known inhibitors in other organisms.
Abstract: This article illustrates a model selection management approach for virtual prototypes in interactive simulations. In those numerical simulations, the virtual prototype and its environment are modelled as a multiagent system, where every entity (prototype,human, etc.) is modelled as an agent. In particular, virtual prototyp ingagents that provide mathematical models of mechanical behaviour inform of computational methods are considered. This work argues that selection of an appropriate model in a changing environment,supported by models? characteristics, can be managed by the deter-mination a priori of specific exploitation and performance measures of virtual prototype models. As different models exist to represent a single phenomenon, it is not always possible to select the best one under all possible circumstances of the environment. Instead the most appropriate shall be selecting according to the use case. The proposed approach consists in identifying relevant metrics or indicators for each group of models (e.g. entity models, global model), formulate their qualification, analyse the performance, and apply the qualification criteria. Then, a model can be selected based on the performance prediction obtained from its qualification. The authors hope that this approach will not only help to inform engineers and researchers about another approach for selecting virtual prototype models, but also assist virtual prototype engineers in the systematic or automatic model selection.
Abstract: The daily growing use of agents in software environments, because of many reasons such as independence and intelligence is not a secret anymore. One of such environments in which there is a prominent job for the agents would be emarketplaces in which a user is able to give those agents the responsibility of buying and selling, instead of searching the emarketplace himself. Making up a framework which has sufficient attention to the required roles and their relations, is the first step of achieving such e-markets. In this paper, we suggest a framework in order to establish such e-markets and we will continue investigating the roles such as seller or buyer and the relations in JADE environment in details.
Abstract: Design for Disassembly (DfD) aims to reuse the
structural components instead of demolition followed by recycling of
the demolition debris. This concept preserves the invested embodied
energy of materials, thus reducing inputs of new embodied energy
during materials reprocessing or remanufacturing. Both analytical and
experimental research on a proposed DfD beam-column connection
for use in residential apartments is currently investigated at the
National University of Singapore in collaboration with the Housing
and Development Board of Singapore. The present study reports on
the results of a numerical analysis of the proposed connection utilizing
finite element analysis. The numerical model was calibrated and
validated by comparison against experimental results. Results of a
parametric study will also be presented and discussed.
Abstract: The major aim of this paper is to investigate the opposition politics in Africa. The paper also examines the status and the role, the contributions and the weaknesses of opposition1 political parties in Africa, particularly in transitional democracies that emerged in the 1990s. In Africa, many of the opposition parties appear or become active only during an election, and disappear when the election is over. It is found out that most of the opposition parties in Africa are established around the personalities of individuals, lack internal democracy, suffer from inter-party and intra-party conflicts, have severe shortage of finance, and lack strong base and experience. Their weaknesses also include bad organization and weak connection with the popular constituencies. The paper concludes that most of the weaknesses of the African opposition parties emanate from the incumbents- hostile policies, which are mostly aimed at fragmenting and weakening the opposition groups.
Abstract: Environment-assisted cracking (EAC) is one of the most serious causes of structural failure over a broad range of industrial applications including offshore structures. In EAC condition there is not a definite relation such as Paris equation in Linear Elastic Fracture Mechanics (LEFM). According to studying and searching a lot what the researchers said either a material has contact with hydrogen or any other corrosive environment, phenomenon of electrical and chemical reactions of material with its environment will be happened. In the literature, there are many different works to consider fatigue crack growing and solve it but they are experimental works. Thus, in this paper, authors have an aim to evaluate mathematically the pervious works in LEFM. Obviously, if an environment is more sour and corrosive, the changes of stress intensity factor is more and the calculation of stress intensity factor is difficult. A mathematical relation to deal with the stress intensity factor during the diffusion of sour environment especially hydrogen in a marine pipeline is presented. By using this relation having and some experimental relation an analytical formulation will be presented which enables the fatigue crack growth and critical crack length under cyclic loading to be predicted. In addition, we can calculate KSCC and stress intensity factor in the pipeline caused by EAC.
Abstract: The ultimate goal of this article is to develop a robust and accurate numerical method for solving hyperbolic conservation laws in one and two dimensions. A hybrid numerical method, coupling a cheap fourth order total variation diminishing (TVD) scheme [1] for smooth region and a Robust seventh-order weighted non-oscillatory (WENO) scheme [2] near discontinuities, is considered. High order multi-resolution analysis is used to detect the high gradients regions of the numerical solution in order to capture the shocks with the WENO scheme, while the smooth regions are computed with fourth order total variation diminishing (TVD). For time integration, we use the third order TVD Runge-Kutta scheme. The accuracy of the resulting hybrid high order scheme is comparable with these of WENO, but with significant decrease of the CPU cost. Numerical demonstrates that the proposed scheme is comparable to the high order WENO scheme and superior to the fourth order TVD scheme. Our scheme has the added advantage of simplicity and computational efficiency. Numerical tests are presented which show the robustness and effectiveness of the proposed scheme.
Abstract: The study investigated the 2011 TPGA Ever Rich
Championship – North Bay Open spectators- on-the-site spectating
motivations, experiences, and satisfactions. The research was
conducted on a convenience sample of the on-the-spot spectators at the
North Bay Golf and Country Club. A total of 200 questionnaires were
distributed, of which 185 valid questionnaires were collected,
approaching a 92.5% response rate. The data obtained was analyzed
with statistical techniques. First, the data showed significant
differences in motivations, experiences, and satisfactions relative to
demographic variables among the on-the-spot spectators. Second,
spectating motivation, experience, and satisfaction were significantly
related to one another.
Abstract: In this paper is study the possibility of successfully
implementing of hollow roller concept in order to minimize inertial
mass of the large bearings, with major results in diminution of the
material consumption, increasing of power efficiency (in wind power
station area), increasing of the durability and life duration of the large
bearings systems, noise reduction in working, resistance to
vibrations, an important diminution of losses by abrasion and
reduction of the working temperature. In this purpose was developed
an original solution through which are reduced mass, inertial forces
and moments of large bearings by using of hollow rollers. The
research was made by using the method of finite element analysis
applied on software type Solidworks - Nastran. Also, is study the
possibility of rapidly changing the manufacturing system of solid and
hollow cylindrical rollers.
Abstract: For this study, this researcher conducted a precision
network adjustment with QOCA, the precision network adjustment
software developed by Jet Propulsion Laboratory, to perform an
integrated network adjustment on the Unified Control Points managed
by the National Geographic Information Institute. Towards this end,
275 Unified Control Points observed in 2008 were selected before a
network adjustment is performed on those 275 Unified Control Points.
The RMSE on the discrepancies of coordinates as compared to the
results of GLOBK was ±6.07mm along the N axis, ±2.68mm along the
E axis and ±6.49mm along the U axis.
Abstract: Nowadays, OCR systems have got several
applications and are increasingly employed in daily life. Much
research has been done regarding the identification of Latin,
Japanese, and Chinese characters. However, very little investigation
has been performed regarding Farsi/Arabic characters recognition.
Probably the reason is difficulty and complexity of those characters
identification compared to the others and limitation of IT activities in
Farsi and Arabic speaking countries. In this paper, a technique has
been employed to identify isolated Farsi/Arabic characters. A chain
code based algorithm along with other significant peculiarities such
as number and location of dots and auxiliary parts, and the number of
holes existing in the isolated character has been used in this study to
identify Farsi/Arabic characters. Experimental results show the
relatively high accuracy of the method developed when it is tested on
several standard Farsi fonts.
Abstract: Enhancement of the performance of a reverse osmosis
(RO) unit through periodic control is studied. The periodic control
manipulates the feed pressure and flow rate of the RO unit. To ensure
the periodic behavior of the inputs, the manipulated variables (MV)
are transformed into the form of sinusoidal functions. In this case, the
amplitude and period of the sinusoidal functions become the
surrogate MV and are thus regulated via nonlinear model predictive
control algorithm. The simulation results indicated that the control
system can generate cyclic inputs necessary to enhance the closedloop
performance in the sense of increasing the permeate production
and lowering the salt concentration. The proposed control system can
attain its objective with arbitrary set point for the controlled outputs.
Successful results were also obtained in the presence of modeling
errors.
Abstract: New exact three-wave solutions including periodic two-solitary solutions and doubly periodic solitary solutions for the (2+1)-dimensional asymmetric Nizhnik-Novikov- Veselov (ANNV) system are obtained using Hirota's bilinear form and generalized three-wave type of ansatz approach. It is shown that the generalized three-wave method, with the help of symbolic computation, provides an e¤ective and powerful mathematical tool for solving high dimensional nonlinear evolution equations in mathematical physics.
Abstract: In this paper, a new developed construction model of
the UPFC is proposed. The construction of this model consists of one
shunt compensation block and two series compensation blocks. In
this case, the UPFC with the new construction model will be
investigated when it is installed in multi-machine systems with nonlinear
load model. In addition, the steady–state performance of the
new model operating as impedance compensation will be presented
and compared with that obtained from the system without
compensation.
Abstract: Face Recognition has always been a fascinating research area. It has drawn the attention of many researchers because of its various potential applications such as security systems, entertainment, criminal identification etc. Many supervised and unsupervised learning techniques have been reported so far. Principal Component Analysis (PCA), Self Organizing Maps (SOM) and Independent Component Analysis (ICA) are the three techniques among many others as proposed by different researchers for Face Recognition, known as the unsupervised techniques. This paper proposes integration of the two techniques, SOM and PCA, for dimensionality reduction and feature selection. Simulation results show that, though, the individual techniques SOM and PCA itself give excellent performance but the combination of these two can also be utilized for face recognition. Experimental results also indicate that for the given face database and the classifier used, SOM performs better as compared to other unsupervised learning techniques. A comparison of two proposed methodologies of SOM, Local and Global processing, shows the superiority of the later but at the cost of more computational time.
Abstract: DS-CDMA system is well known wireless
technology. This system suffers from MAI (Multiple Access
Interference) caused by Direct Sequence users. Multi-User Detection
schemes were introduced to detect the users- data in presence of
MAI. This paper focuses on linear multi-user detection schemes used
for data demodulation. Simulation results depict the performance of
three detectors viz-conventional detector, Decorrelating detector and
Subspace MMSE (Minimum Mean Square Error) detector. It is seen
that the performance of these detectors depends on the number of
paths and the length of Gold code used.
Abstract: The time dependent progress of a chemical reaction over a flat horizontal plate is here considered. The problem is solved through the group similarity transformation method which reduces the number of independent by one and leads to a set of nonlinear ordinary differential equation. The problem shows a singularity at the chemical reaction order n=1 and is analytically solved through the perturbation method. The behavior of the process is then numerically investigated for n≠1 and different Schmidt numbers. Graphical results for the velocity and concentration of chemicals based on the analytical and numerical solutions are presented and discussed.
Abstract: Contour filter strips planted with perennial vegetation
can be used to improve surface and ground water quality by reducing
pollutant, such as NO3-N, and sediment outflow from cropland to a
river or lake. Meanwhile, the filter strips of perennial grass with biofuel
potentials also have economic benefits of producing ethanol. In
this study, The Soil and Water Assessment Tool (SWAT) model was
applied to the Walnut Creek Watershed to examine the effectiveness
of contour strips in reducing NO3-N outflows from crop fields to the
river or lake. Required input data include watershed topography,
slope, soil type, land-use, management practices in the watershed and
climate parameters (precipitation, maximum/minimum air
temperature, solar radiation, wind speed and relative humidity).
Numerical experiments were conducted to identify potential
subbasins in the watershed that have high water quality impact, and
to examine the effects of strip size and location on NO3-N reduction
in the subbasins under various meteorological conditions (dry,
average and wet). Variable sizes of contour strips (10%, 20%, 30%
and 50%, respectively, of a subbasin area) planted with perennial
switchgrass were selected for simulating the effects of strip size and
location on stream water quality. Simulation results showed that a
filter strip having 10%-50% of the subbasin area could lead to 55%-
90% NO3-N reduction in the subbasin during an average rainfall
year. Strips occupying 10-20% of the subbasin area were found to be
more efficient in reducing NO3-N when placed along the contour
than that when placed along the river. The results of this study can
assist in cost-benefit analysis and decision-making in best water
resources management practices for environmental protection.
Abstract: Cancer classification to their corresponding cohorts has been key area of research in bioinformatics aiming better prognosis of the disease. High dimensionality of gene data has been makes it a complex task and requires significance data identification technique in order to reducing the dimensionality and identification of significant information. In this paper, we have proposed a novel approach for classification of oral cancer into metastasis positive and negative patients. We have used significance analysis of microarrays (SAM) for identifying significant genes which constitutes gene signature. 3 different gene signatures were identified using SAM from 3 different combination of training datasets and their classification accuracy was calculated on corresponding testing datasets using k-Nearest Neighbour (kNN), Fuzzy C-Means Clustering (FCM), Support Vector Machine (SVM) and Backpropagation Neural Network (BPNN). A final gene signature of only 9 genes was obtained from above 3 individual gene signatures. 9 gene signature-s classification capability was compared using same classifiers on same testing datasets. Results obtained from experimentation shows that 9 gene signature classified all samples in testing dataset accurately while individual genes could not classify all accurately.
Abstract: Due to the non-linear characteristics of photovoltaic
(PV) array, PV systems typically are equipped with the capability of
maximum power point tracking (MPPT) feature. Moreover, in the
case of PV array under partially shaded conditions, hotspot problem
will occur which could damage the PV cells. Partial shading causes
multiple peaks in the P-V characteristic curves. This paper presents a
hybrid algorithm of Particle Swarm Optimization (PSO) and
Artificial Neural Network (ANN) MPPT algorithm for the detection
of global peak among the multiple peaks in order to extract the true
maximum energy from PV panel. The PV system consists of PV
array, dc-dc boost converter controlled by the proposed MPPT
algorithm and a resistive load. The system was simulated using
MATLAB/Simulink package. The simulation results show that the
proposed algorithm performs well to detect the true global peak
power. The results of the simulations are analyzed and discussed.