Abstract: pH-sensitive drug targeting using nanoparticles for
cancer chemotherapy have been spotlighted in recent decades. Graft
copolymer composed of poly (L-histidine) (PHS) and dextran
(DexPHS) was synthesized and pH-sensitive nanoparticles were
fabricated for pH-responsive drug delivery of doxorubicin (DOX).
Nanoparticles of DexPHS showed pH-sensitive changes in particle
sizes and drug release behavior, i.e. particle sizes and drug release rate
were increased at acidic pH, indicating that DexPHS nanoparticles
have pH-sensitive drug delivery potentials. Antitumor activity of
DOX-incorporated DexPHS nanoparticles were studied using CT26
colorectal carcinoma cells. Results indicated that fluorescence
intensity was higher at acidic pH than basic pH. These results
indicated that DexPHS nanoparticles have pH-responsive drug
targeting.
Abstract: Finite element method was applied to model damage
development in the femoral neck during a sideways fall. The femoral
failure was simulated using the maximum principal strain criterion.
The evolution of damage was consistent with previous studies. It was
initiated by compressive failure at the junction of the superior aspect
of the femoral neck and the greater trochanter. It was followed by
tensile failure that occurred at the inferior aspect of the femoral neck
before a complete transcervical fracture was observed. The estimated
failure line was less than 50° from the horizontal plane (Pauwels type
II).
Abstract: Chemical industry project management involves
complex decision making situations that require discerning abilities
and methods to make sound decisions. Project managers are faced
with decision environments and problems in projects that are
complex. In this work, case study is Research and Development
(R&D) project selection. R&D is an ongoing process for forward
thinking technology-based chemical industries. R&D project
selection is an important task for organizations with R&D project
management. It is a multi-criteria problem which includes both
tangible and intangible factors. The ability to make sound decisions
is very important to success of R&D projects. Multiple-criteria
decision making (MCDM) approaches are major parts of decision
theory and analysis. This paper presents all of MCDM approaches
for use in R&D project selection. It is hoped that this work will
provide a ready reference on MCDM and this will encourage the
application of the MCDM by chemical engineering management.
Abstract: A hybrid feature based adaptive particle filter algorithm is presented for object tracking in real scenarios with static camera.
The hybrid feature is combined by two effective features: the Grayscale Arranging Pairs (GAP) feature and the color histogram feature. The GAP feature has high discriminative ability even under conditions of severe illumination variation and dynamic background
elements, while the color histogram feature has high reliability to identify the detected objects. The combination of two features covers the shortage of single feature. Furthermore, we adopt an updating
target model so that some external problems such as visual angles can be overcame well. An automatic initialization algorithm is introduced which provides precise initial positions of objects. The experimental
results show the good performance of the proposed method.
Abstract: We study in this paper the effect of the scene
changing on image sequences coding system using Embedded
Zerotree Wavelet (EZW). The scene changing considered here is the
full motion which may occurs. A special image sequence is generated
where the scene changing occurs randomly. Two scenarios are
considered: In the first scenario, the system must provide the
reconstruction quality as best as possible by the management of the
bit rate (BR) while the scene changing occurs. In the second scenario,
the system must keep the bit rate as constant as possible by the
management of the reconstruction quality. The first scenario may be
motivated by the availability of a large band pass transmission
channel where an increase of the bit rate may be possible to keep the
reconstruction quality up to a given threshold. The second scenario
may be concerned by the narrow band pass transmission channel
where an increase of the bit rate is not possible. In this last case,
applications for which the reconstruction quality is not a constraint
may be considered. The simulations are performed with five scales
wavelet decomposition using the 9/7-tap filter bank biorthogonal
wavelet. The entropy coding is performed using a specific defined
binary code book and EZW algorithm. Experimental results are
presented and compared to LEAD H263 EVAL. It is shown that if
the reconstruction quality is the constraint, the system increases the
bit rate to obtain the required quality. In the case where the bit rate
must be constant, the system is unable to provide the required quality
if the scene change occurs; however, the system is able to improve
the quality while the scene changing disappears.
Abstract: One of the major, difficult tasks in automated video
surveillance is the segmentation of relevant objects in the scene.
Current implementations often yield inconsistent results on average
from frame to frame when trying to differentiate partly occluding
objects. This paper presents an efficient block-based segmentation
algorithm which is capable of separating partly occluding objects and
detecting shadows. It has been proven to perform in real time with a
maximum duration of 47.48 ms per frame (for 8x8 blocks on a
720x576 image) with a true positive rate of 89.2%. The flexible
structure of the algorithm enables adaptations and improvements with
little effort. Most of the parameters correspond to relative differences
between quantities extracted from the image and should therefore not
depend on scene and lighting conditions. Thus presenting a
performance oriented segmentation algorithm which is applicable in
all critical real time scenarios.
Abstract: Palestinian cities face the challenges of land scarcity,
high population growth rates, rapid urbanization, uneven
development and territorial fragmentation. Due to geopolitical
constrains and the absence of an effective Palestinian planning
institution, urban development in Palestinian cities has not followed
any discernable planning scheme. This has led to a number of
internal contradictions in the structure of cities, and adversely
affected land use, the provision of urban services, and the quality of
the living environment.
This paper explores these challenges, and the potential that exists
for introducing a more sustainable urban development pattern in
Palestinian cities. It assesses alternative development approaches
with a particular focus on sustainable development, promoting ecodevelopment
imperatives, limiting random urbanization, and meeting
present and future challenges, including fulfilling the needs of the
people and conserving the scarce land and limited natural resources.
This paper concludes by offering conceptual proposals and guidelines
for promoting sustainable physical development in Palestinian cities.
Abstract: Bonding has become a routine procedure in several
dental specialties – from prosthodontics to conservative dentistry and
even orthodontics. In many of these fields it is important to be able to
investigate the bonded interfaces to assess their quality. All currently
employed investigative methods are invasive, meaning that samples
are destroyed in the testing procedure and cannot be used again. We
have investigated the interface between human enamel and bonded
ceramic brackets non-invasively, introducing a combination of new
investigative methods – optical coherence tomography (OCT),
fluorescence OCT and confocal microscopy (CM). Brackets were
conventionally bonded on conditioned buccal surfaces of teeth. The
bonding was assessed using these methods. Three dimensional
reconstructions of the detected material defects were developed using
manual and semi-automatic segmentation. The results clearly prove
that OCT, fluorescence OCT and CM are useful in orthodontic
bonding investigations.
Abstract: The p53 tumor suppressor gene plays two important
roles in genomic stability: blocking cell proliferation after DNA
damage until it has been repaired, and starting apoptosis if the
damage is too critical. Codon 72 exon4 polymorphism (Arg72Pro) of
the P53 gene has been implicated in cancer risk. Various studies have
been done to investigate the status of p53 at codon 72 for arginine
(Arg) and proline (Pro) alleles in different populations and also the
association of this codon 72 polymorphism with various tumors. Our
objective was to investigate the possible association between P53
Arg72Pro polymorphism and susceptibility to colorectal cancer
among Isfahan and Chaharmahal Va Bakhtiari (a part of south west
of Iran) population. We investigated the status of p53 at codon 72 for
Arg/Arg, Arg/Pro and Pro/Pro allele polymorphisms in blood
samples from 145 colorectal cancer patients and 140 controls by
Nested-PCR of p53 exon 4 and digestion with BstUI restriction
enzyme and the DNA fragments were then resolved by
electrophoresis in 2% agarose gel. The Pro allele was 279 bp, while
the Arg allele was restricted into two fragments of 160 and 119 bp.
Among the 145 colorectal cancer cases 49 cases (33.79%) were
homozygous for the Arg72 allele (Arg/Arg), 18 cases (12.41%) were
homozygous for the Pro72 allele (Pro/Pro) and 78 cases (53.8%)
found in heterozygous (Arg/Pro).
In conclusion, it can be said that p53Arg/Arg genotype may be
correlated with possible increased risk of this kind of cancers in south
west of Iran.
Abstract: This paper provides an in-depth study of Wireless
Sensor Network (WSN) application to monitor and control the
swiftlet habitat. A set of system design is designed and developed
that includes the hardware design of the nodes, Graphical User
Interface (GUI) software, sensor network, and interconnectivity for
remote data access and management. System architecture is proposed
to address the requirements for habitat monitoring. Such applicationdriven
design provides and identify important areas of further work
in data sampling, communications and networking. For this
monitoring system, a sensor node (MTS400), IRIS and Micaz radio
transceivers, and a USB interfaced gateway base station of Crossbow
(Xbow) Technology WSN are employed. The GUI of this monitoring
system is written using a Laboratory Virtual Instrumentation
Engineering Workbench (LabVIEW) along with Xbow Technology
drivers provided by National Instrument. As a result, this monitoring
system is capable of collecting data and presents it in both tables and
waveform charts for further analysis. This system is also able to send
notification message by email provided Internet connectivity is
available whenever changes on habitat at remote sites (swiftlet farms)
occur. Other functions that have been implemented in this system
are the database system for record and management purposes; remote
access through the internet using LogMeIn software. Finally, this
research draws a conclusion that a WSN for monitoring swiftlet
habitat can be effectively used to monitor and manage swiftlet
farming industry in Sarawak.
Abstract: Experimental investigations were carried out in the
Manchester Tidal flow Facility (MTF) to study the flow patterns in
the region around and adjacent to a hypothetical headland in tidal
(oscillatory) ambient flow. The Planar laser-induced fluorescence
(PLIF) technique was used for visualization, with fluorescent dye
released at specific points around the headland perimeter and in its
adjacent recirculation zone. The flow patterns can be generalized into
the acceleration, stable flow and deceleration stages for each halfcycle,
with small variations according to location, which are more
distinct for low Keulegan-Carpenter number (KC) cases. Flow
patterns in the mixing region are unstable and complex, especially in
the recirculation zone. The flow patterns are in agreement with
previous visualizations, and support previous results in steady
ambient flow. It is suggested that the headland lee could be a viable
location for siting of pollutant outfalls.
Abstract: Fungal infections are becoming more common and the
range of susceptible individuals has expanded. While Candida
albicans remains the most common infective species, other Candida
spp. are becoming increasingly significant. In a range of large-scale
studies of candidaemia between 1999 and 2006, about 52% of 9717
cases involved C. albicans, about 30% involved either C. glabrata or
C. parapsilosis and less than 15% involved C. tropicalis, C. krusei or
C. guilliermondii. However, the probability of mortality within 30
days of infection with a particular species was at least 40% for C.
tropicalis, C. albicans, C. glabrata and C. krusei and only 22% for
C. parapsilopsis. Clinical isolates of Candida spp. grew at rates
ranging from 1.65 h-1 to 4.9 h-1. Three species (C. krusei, C. albicans
and C. glabrata) had relatively high growth rates (μm > 4 h-1), C.
tropicalis and C. dubliniensis grew moderately quickly (Ôëê 3 h-1) and
C. parapsilosis and C. guilliermondii grew slowly (< 2 h-1). Based
on these data, the log of the odds of mortality within 30 days of
diagnosis was linearly related to μm. From this the underlying
probability of mortality is 0.13 (95% CI: 0.10-0.17) and it increases
by about 0.09 ± 0.02 for each unit increase in μm. Given that the
overall crude mortality is about 0.36, the growth of Candida spp.
approximately doubles the rate, consistent with the results of larger
case-matched studies of candidaemia.
Abstract: High quality requirements analysis is one of the most
crucial activities to ensure the success of a software project, so that
requirements verification for software system becomes more and more
important in Requirements Engineering (RE) and it is one of the most
helpful strategies for improving the quality of software system.
Related works show that requirement elicitation and analysis can be
facilitated by ontological approaches and semantic web technologies.
In this paper, we proposed a hybrid method which aims to verify
requirements with structural and formal semantics to detect
interactions. The proposed method is twofold: one is for modeling
requirements with the semantic web language OWL, to construct a
semantic context; the other is a set of interaction detection rules which
are derived from scenario-based analysis and represented with
semantic web rule language (SWRL). SWRL based rules are working
with rule engines like Jess to reason in semantic context for
requirements thus to detect interactions. The benefits of the proposed
method lie in three aspects: the method (i) provides systematic steps
for modeling requirements with an ontological approach, (ii) offers
synergy of requirements elicitation and domain engineering for
knowledge sharing, and (3)the proposed rules can systematically assist
in requirements interaction detection.
Abstract: Recently studies in area of supply chain network
(SCN) have focused on the disruption issues in distribution systems.
Also this paper extends the previous literature by providing a new biobjective
model for cost minimization of designing a three echelon
SCN across normal and failure scenarios with considering multi
capacity option for manufacturers and distribution centers. Moreover,
in order to solve the problem by means of LINGO software, novel
model will be reformulated through a branch of LP-Metric method
called Min-Max approach.
Abstract: In this study we investigate silica nanoparticle (SiO2- NP) effects on the structure and phase properties of supported lipid monolayers and bilayers, coupling surface pressure measurements, fluorescence microscopy and atomic force microscopy. SiO2-NPs typically in size range of 10nm to 100 nm in diameter are tested. Our results suggest first that lipid molecules organization depends to their nature. Secondly, lipid molecules in the vinicity of big aggregates nanoparticles organize in liquid condensed phase whereas small aggregates are localized in both fluid liquid-expanded (LE) and liquid-condenced (LC). We demonstrated also by atomic force microscopy that by measuring friction forces it is possible to get information as if nanoparticle aggregates are recovered or not by lipid monolayers and bilayers.
Abstract: Sedimentation is a hydraulic phenomenon that is
emerging as a serious challenge in river engineering. When the flow
reaches a certain state that gather potential energy, it shifts the
sediment load along channel bed. The transport of such materials can
be in the form of suspended and bed loads. The movement of these
along the river course and channels and the ways in which this could
influence the water intakes is considered as the major challenges for
sustainable O&M of hydraulic structures. This could be very serious
in arid and semi-arid regions like Iran, where inappropriate watershed
management could lead to shifting a great deal of sediments into the
reservoirs and irrigation systems. This paper aims to investigate
sedimentation in the Western Canal of Dez Diversion Weir in Iran,
identifying factors which influence the process and provide ways in
which to mitigate its detrimental effects by using the SHARC
Software.
For the purpose of this paper, data from the Dezful water authority
and Dezful Hydrometric Station pertinent to a river course of about 6
Km were used.
Results estimated sand and silt bed loads concentrations to be 193
ppm and 827ppm respectively. Given the available data on average
annual bed loads and average suspended sediment loads of 165ppm
and 837ppm, there was a significant statistical difference (16%)
between the sand grains, whereas no significant difference (1.2%)
was find in the silt grain sizes. One explanation for such finding
being that along the 6 Km river course there was considerable
meandering effects which explains recent shift in the hydraulic
behavior along the stream course under investigation. The sand
concentration in downstream relative to present state of the canal
showed a steep descending curve. Sediment trapping on the other
hand indicated a steep ascending curve. These occurred because the
diversion weir was not considered in the simulation model.
Abstract: In a product development process, understanding the functional behavior of the system, the role of components in achieving functions and failure modes if components/subsystem fails its required function will help develop appropriate design validation and verification program for reliability assessment. The integration of these three issues will help design and reliability engineers in identifying weak spots in design and planning future actions and testing program. This case study demonstrate the advantage of unascertained theory described in the subjective cognition uncertainty, and then applies blind number (BN) theory in describing the uncertainty of the mechanical system failure process and the same time used the same theory in bringing out another mechanical reliability system model. The practical calculations shows the BN Model embodied the characters of simply, small account of calculation but betterforecasting capability, which had the value of macroscopic discussion to some extent.
Abstract: In this paper, we proposed an efficient data
compression strategy exploiting the multi-resolution characteristic of
the wavelet transform. We have developed a sensor node called
“Smart Sensor Node; SSN". The main goals of the SSN design are
lightweight, minimal power consumption, modular design and robust
circuitry. The SSN is made up of four basic components which are a
sensing unit, a processing unit, a transceiver unit and a power unit.
FiOStd evaluation board is chosen as the main controller of the SSN
for its low costs and high performance. The software coding of the
implementation was done using Simulink model and MATLAB
programming language. The experimental results show that the
proposed data compression technique yields recover signal with good
quality. This technique can be applied to compress the collected data
to reduce the data communication as well as the energy consumption
of the sensor and so the lifetime of sensor node can be extended.
Abstract: This paper describes a low-voltage and low-power
channel selection analog front end with continuous-time low pass
filters and highly linear programmable gain amplifier (PGA). The
filters were realized as balanced Gm-C biquadratic filters to achieve a
low current consumption. High linearity and a constant wide
bandwidth are achieved by using a new transconductance (Gm) cell.
The PGA has a voltage gain varying from 0 to 65dB, while
maintaining a constant bandwidth. A filter tuning circuit that requires
an accurate time base but no external components is presented.
With a 1-Vrms differential input and output, the filter achieves
-85dB THD and a 78dB signal-to-noise ratio. Both the filter and PGA
were implemented in a 0.18um 1P6M n-well CMOS process. They
consume 3.2mW from a 1.8V power supply and occupy an area of
0.19mm2.
Abstract: In the present work, an attempt is made to understand
electromagnetic field confinement in a subwavelength waveguide
structure using concepts of quantum mechanics. Evanescent field in
the waveguide is looked as inability of the photon to get confined in
the waveguide core and uncertainty of position is assigned to it. The
momentum uncertainty is calculated from position uncertainty.
Schrödinger wave equation for the photon is written by incorporating
position-momentum uncertainty. The equation is solved and field
distribution in the waveguide is obtained. The field distribution and
power confinement is compared with conventional waveguide theory.
They were found in good agreement with each other.