Abstract: Pressures for urban redevelopment are intensifying in
all large cities. A new logic for urban development is required –
green urbanism – that provides a spatial framework for directing
population and investment inwards to brownfields and greyfields
precincts, rather than outwards to the greenfields. This represents
both a major opportunity and a major challenge for city planners in
pluralist liberal democracies. However, plans for more compact
forms of urban redevelopment are stalling in the face of community
resistance. A new paradigm and spatial planning platform is required
that will support timely multi-level and multi-actor stakeholder
engagement, resulting in the emergence of consensus plans for
precinct-level urban regeneration capable of more rapid
implementation. Using Melbourne, Australia as a case study, this
paper addresses two of the urban intervention challenges – where and
how – via the application of a 21st century planning tool ENVISION
created for this purpose.
Abstract: COPD is characterized by loss of elastic fibers from
small airways and alveolar walls, with the decrease in elastin
increasing with disease severity. It is unclear why there is a lack of
repair of elastic fibers. We have examined fibroblasts cultured from
lung tissue from normal and COPD subjects to determine if the
secretory profile explains lack of tissue repair. In this study,
fibroblasts were cultured from lung parenchyma of bronchial
carcinoma patients with varying degrees of COPD; controls
(non-COPD, n=5), mild COPD (GOLD 1, n=5) and moderate-severe
COPD (GOLD 2-3, n=12). Measurements were made of proliferation,
senescence-associated beta-galactosidase-1, mRNA expression of
IL-6, IL-8, MMP-1, tropoelastin and versican, and protein levels for
IL-6, IL-8, PGE2, tropoelastin, insoluble elastin, and versican. It was
found that GOLD 2-3 fibroblasts proliferated more slowly (p
Abstract: In this article we explore how computer assisted exercises may allow for bridging the traditional gap between theory and practice in professional education. To educate officers able to master the complexity of the battlefield the Norwegian Military Academy needs to develop a learning environment that allows for creating viable connections between the educational environment and the field of practice. In response to this challenge we explore the conditions necessary to make computer assisted training systems (CATS) a useful tool to create structural similarities between an educational context and the field of military practice. Although, CATS may facilitate work procedures close to real life situations, this case do demonstrate how professional competence also must build on viable learning theories and environments. This paper explores the conditions that allow for using simulators to facilitate professional competence from within an educational setting. We develop a generic didactic model that ascribes learning to participation in iterative cycles of action and reflection. The development of this model is motivated by the need to develop an interdisciplinary professional education rooted in the pattern of military practice.
Abstract: Fundamental sensor-motor couplings form the backbone
of most mobile robot control tasks, and often need to be implemented
fast, efficiently and nevertheless reliably. Machine learning
techniques are therefore often used to obtain the desired sensor-motor
competences.
In this paper we present an alternative to established machine
learning methods such as artificial neural networks, that is very fast,
easy to implement, and has the distinct advantage that it generates
transparent, analysable sensor-motor couplings: system identification
through nonlinear polynomial mapping.
This work, which is part of the RobotMODIC project at the
universities of Essex and Sheffield, aims to develop a theoretical understanding
of the interaction between the robot and its environment.
One of the purposes of this research is to enable the principled design
of robot control programs.
As a first step towards this aim we model the behaviour of the
robot, as this emerges from its interaction with the environment, with
the NARMAX modelling method (Nonlinear, Auto-Regressive, Moving
Average models with eXogenous inputs). This method produces
explicit polynomial functions that can be subsequently analysed using
established mathematical methods.
In this paper we demonstrate the fidelity of the obtained NARMAX
models in the challenging task of robot route learning; we present a
set of experiments in which a Magellan Pro mobile robot was taught
to follow four different routes, always using the same mechanism to
obtain the required control law.
Abstract: The aim of this study is to find out and analyze the
role of gender and age on the perceptions of students to the distant
online program offered by Vocational High School in Sakarya
University. The research is based on a questionnaire as a mean of
data collection method to find out the role of age and gender on the
student-s perceptions toward online education, and the study
progressed through finding relationships between the variables used
in the data collection instrument. The findings of the analysis
revealed that although the students registered to the online program
by will, they preferred the traditional face-to-face education due to
the difficulty of the nonverbal communication, their incompetence of
using the technology required, and their belief in traditional face-toface
learning more than online education.
Regarding gender, the results showed that the female students
have a better perception of the online education as opposed to the
male students. Regarding age, the results showed that the older the
students are the more is their preference towards attending face-toface
classes.
Abstract: A camera in the building site is exposed to different
weather conditions. Differences between images of the same scene
captured with the same camera arise also due to temperature variations.
The influence of temperature changes on camera parameters
were modelled and integrated into existing analytical camera model.
Modified camera model enables quantitatively assessing the influence
of temperature variations.
Abstract: Shadoo protein (Sho) was described in 2003 as the newest member of Prion protein superfamily [1]. Sho has similar structural motifs like prion protein (PrP) that is known for its central role in transmissible spongiform enchephalopathies. Although a great number of functions have been proposed, the exact physiological function of PrP is not known yet. Investigation of the function and localization of Sho may help us to understand the function of the Prion protein superfamily. Analyzing the subcellular localization of YFP-tagged forms of Sho, we detected the protein in the plasma membrane and in the nucleus of various cell lines. To reveal the localization of the endogenous protein we generated antibodies against Shadoo as well as employed commercially available anti-Shadoo antibodies: i) EG62 anti-mouse Shadoo antibody generated by Eurogentec Ltd.; ii) S-12 anti-human Shadoo antibody by Santa Cruz Biotechnology Inc.; iii) R-12 anti-mouse Shadoo antibody by Santa Cruz Biotechnology Inc.; iv) SPRN antibody against human Shadoo by Abgent Inc. We carried out immunocytochemistry on non-transfected HeLa, Zpl 2-1, Zw 3-5, GT1-1, GT1-7 and SHSY5Y cells as well as on YFP-Sho, Sho-YFP, and YFP-GPI transfected HeLa cells. Their specificity (in antibody-peptide competition assay) and co-localization (with the YFP signal) were assessed.
Abstract: To analyze the behavior of Petri nets, the accessibility
graph and Model Checking are widely used. However, if the
analyzed Petri net is unbounded then the accessibility graph becomes
infinite and Model Checking can not be used even for small Petri
nets. ECATNets [2] are a category of algebraic Petri nets. The main
feature of ECATNets is their sound and complete semantics based on
rewriting logic [8] and its language Maude [9]. ECATNets analysis
may be done by using techniques of accessibility analysis and Model
Checking defined in Maude. But, these two techniques supported by
Maude do not work also with infinite-states systems. As a category
of Petri nets, ECATNets can be unbounded and so infinite systems.
In order to know if we can apply accessibility analysis and Model
Checking of Maude to an ECATNet, we propose in this paper an
algorithm allowing the detection if the ECATNet is bounded or not.
Moreover, we propose a rewriting logic based tool implementing this
algorithm. We show that the development of this tool using the
Maude system is facilitated thanks to the reflectivity of the rewriting
logic. Indeed, the self-interpretation of this logic allows us both the
modelling of an ECATNet and acting on it.
Abstract: The preparation of good-quality Environmental Impact Assessment (EIA) reports contribute to enhancing overall effectiveness of EIA. This component of the EIA process becomes more important in situation where public participation is weak and there is lack of expertise on the part of the competent authority. In Pakistan, EIA became mandatory for every project likely to cause adverse environmental impacts from July 1994. The competent authority also formulated guidelines for preparation and review of EIA reports in 1997. However, EIA is yet to prove as a successful decision support tool to help in environmental protection. One of the several reasons of this ineffectiveness is the generally poor quality of EIA reports. This paper critically reviews EIA reports of some randomly selected projects. Interviews of EIA consultants, project proponents and concerned government officials have also been conducted to underpin the root causes of poor quality of EIA reports. The analysis reveals several inadequacies particularly in areas relating to identification, evaluation and mitigation of key impacts and consideration of alternatives. The paper identifies some opportunities and suggests measures for improving the quality of EIA reports and hence making EIA an effective tool to help in environmental protection.
Abstract: This work involved the use of phytoremediation to
remediate an aged soil contaminated with polychlorinated biphenyls
(PCBs). At microcosm scale, tests were prepared using soil samples
that have been collected in an industrial area with a total PCBs
concentration of about 250 μg kg-1. Medicago sativa and Lolium
italicum were the species selected in this study that is used as
“feasibility test" for full scale remediation. The experiment was
carried out with the addition of a mixture of randomly methylatedbeta-
cyclodextrins (RAMEB). At the end of the experiment analysis
of soil samples showed that in general the presence of plants has led
to a higher degradation of most congeners with respect to not
vegetated soil. The two plant species efficiencies were comparable
and improved by RAMEB addition with a final reduction of total
PCBs near to 50%. With increasing the chlorination of the congeners
the removal percentage of PCBs progressively decreased.
Abstract: Automatic detection of syllable repetition is one of the
important parameter in assessing the stuttered speech objectively.
The existing method which uses artificial neural network (ANN)
requires high levels of agreement as prerequisite before attempting to
train and test ANNs to separate fluent and nonfluent. We propose
automatic detection method for syllable repetition in read speech for
objective assessment of stuttered disfluencies which uses a novel
approach and has four stages comprising of segmentation, feature
extraction, score matching and decision logic. Feature extraction is
implemented using well know Mel frequency Cepstra coefficient
(MFCC). Score matching is done using Dynamic Time Warping
(DTW) between the syllables. The Decision logic is implemented by
Perceptron based on the score given by score matching. Although
many methods are available for segmentation, in this paper it is done
manually. Here the assessment by human judges on the read speech
of 10 adults who stutter are described using corresponding method
and the result was 83%.
Abstract: Cardiovascular disease mostly in the form of atherosclerosis is responsible for 30% of all world deaths amounting to 17 million people per year. Atherosclerosis is due to the formation of plaque. The fatty plaque may be at risk of rupture, leading typically to stroke and heart attack. The plaque is usually associated with a high degree of lumen reduction, called a stenosis. The initiation and progression of the disease is strongly linked to the hemodynamic environment near the vessel wall. The aim of this study is to validate the flow of blood mimic through an arterial stenosis model with computational fluid dynamics (CFD) package. In experiment, an axisymmetric model constructed consists of contraction and expansion region that follow a mathematical form of cosine function. A 30% diameter reduction was used in this study. Particle image velocimetry (PIV) was used to characterize the flow. The fluid consists of rigid spherical particles suspended in waterglycerol- NaCl mixture. The particles with 20 μm diameter were selected to follow the flow of fluid. The flow at Re=155, 270 and 390 were investigated. The experimental result is compared with FLUENT simulated flow that account for viscous laminar flow model. The results suggest that laminar flow model was sufficient to predict flow velocity at the inlet but the velocity at stenosis throat at Re =390 was overestimated. Hence, a transition to turbulent regime might have been developed at throat region as the flow rate increases.
Abstract: Conventional materials like glass, wood or metals
replacement with polymer materials is still continuing. More simple
thus cheaper production is the main reason. However due to high
energy and petrochemical prices are polymer prices increasing too.
That´s why various kinds of fillers are used to make polymers
cheaper. Of course target is to maintain or improve properties of
these compounds. In this paper are solved rheology issues of
polymers compounded with vegetal origin fibers.
Abstract: The exhaustive quality control is becoming more and
more important when commercializing competitive products in the
world's globalized market. Taken this affirmation as an undeniable
truth, it becomes critical in certain sector markets that need to offer
the highest restrictions in quality terms. One of these examples is the
percussion cap mass production, a critical element assembled in
firearm ammunition. These elements, built in great quantities at a
very high speed, must achieve a minimum tolerance deviation in
their fabrication, due to their vital importance in firing the piece of
ammunition where they are built in. This paper outlines a machine
vision development for the 100% inspection of percussion caps
obtaining data from 2D and 3D simultaneous images. The acquisition
speed and precision of these images from a metallic reflective piece
as a percussion cap, the accuracy of the measures taken from these
images and the multiple fabrication errors detected make the main
findings of this work.
Abstract: There are three main ways of categorizing capital in banking operations: accounting, regulatory and economic capital. However, the 2008-2009 global crisis has shown that none of these categories adequately reflects the real risks of bank operations, especially in light of the failures Bear Stearns, Lehman Brothers or Northern Rock. This paper deals with the economic capital allocation of global banks. In theory, economic capital should reflect the real risks of a bank and should be publicly available. Yet, as discovered during the global financial crisis, even when economic capital information was publicly disclosed, the underlying assumptions rendered the information useless. Specifically, some global banks that reported relatively high levels of economic capital before the crisis went bankrupt or had to be bailed-out by their government. And, only 15 out of 50 global banks reported their economic capital during the 2007-2010 period. In this paper, we analyze the changes in reported bank economic capital disclosure during this period. We conclude that relative shares of credit and business risks increased in 2010 compared to 2007, while both operational and market risks decreased their shares on the total economic capital of top-rated global banks. Generally speaking, higher levels of disclosure and transparency of bank operations are required to obtain more confidence from stakeholders. Moreover, additional risks such as liquidity risks should be included in these disclosures.
Abstract: The mathematical modeling of different biological
processes is usually used to predict or assess behavior of systems in
which these processes take place. This study deals with mathematical
and computer modeling of bi-substrate enzymatic reactions with
ping-pong mechanism, which play an important role in different
biochemical pathways. Besides that, three models of competitive
inhibition were designed using different software packages. The main
objective of this study is to represent the results from in silico
investigation of bi-substrate enzymatic reactions with ordered pingpong
mechanism in the presence of competitive inhibitors, as well as
to describe in details the inhibition effects. The simulation of the
models with certain kinetic parameters allowed investigating the
behavior of reactions as well as determined some interesting aspects
concerning influence of different cases of competitive inhibition.
Simultaneous presence of two inhibitors, competitive to the S1 and S2
substrates have been studied. Moreover, we have found the pattern of
simultaneous influence of both inhibitors.
Abstract: Aeration by a plunging water jet is an energetically attractive way to effect oxygen-transfer than conventional oxygenation systems. In the present study, a new type of conical shaped plunging aeration device is fabricated to generate hollow inclined ined plunging jets (jet plunge angle of π/3 ) to investigate its oxygen transfer capacity. The results suggest that the volumetric oxygen-transfer coefficient and oxygen-transfer efficiency of the conical plunging jet aerator are competitive with other types of aeration systems. Relationships of volumetric oxygen-transfer coefficient with jet power per unit volume and jet parameters are also proposed. The suggested relationships predict the volumetric oxygentransfer coefficient within a scatter of ± 15% . Further, the application of Support Vector Machines on the experimental data revealed its utility in the prediction of volumetric oxygen-transfer coefficient and development of conical plunging jet aerators.
Abstract: Deciding the numerous parameters involved in
designing a competent artificial neural network is a complicated task.
The existence of several options for selecting an appropriate
architecture for neural network adds to this complexity, especially
when different applications of heterogeneous natures are concerned.
Two completely different applications in engineering and medical
science were selected in the present study including prediction of
workpiece's surface roughness in ultrasonic-vibration assisted turning
and papilloma viruses oncogenicity. Several neural network
architectures with different parameters were developed for each
application and the results were compared. It was illustrated in this
paper that some applications such as the first one mentioned above
are apt to be modeled by a single network with sufficient accuracy,
whereas others such as the second application can be best modeled
by different expert networks for different ranges of output.
Development of knowledge about the essentials of neural networks
for different applications is regarded as the cornerstone of
multidisciplinary network design programs to be developed as a
means of reducing inconsistencies and the burden of the user
intervention.
Abstract: Radiolabeled cyclic RGD peptides targeting integrin αvβ3 are reported as promising agents for the early diagnosis of metastatic tumors. With an aim to improve tumor uptake and retention of the peptide, cyclic RGD peptide dimer E[c (RGDfK)] 2 (E = Glutamic acid, f = phenyl alanine, K = lysine) coupled to the bifunctional chelator DOTA was custom synthesized and radiolabelled with 68Ga. Radiolabelling of cyclic RGD peptide dimer with 68Ga was carried out using HEPES buffer and biological evaluation of the complex was done in nude mice bearing HT29 tumors.
Abstract: The small interfering RNA (siRNA) alters the
regulatory role of mRNA during gene expression by translational
inhibition. Recent studies show that upregulation of mRNA because
serious diseases like cancer. So designing effective siRNA with good
knockdown effects plays an important role in gene silencing. Various
siRNA design tools had been developed earlier. In this work, we are
trying to analyze the existing good scoring second generation siRNA
predicting tools and to optimize the efficiency of siRNA prediction
by designing a computational model using Artificial Neural Network
and whole stacking energy (%G), which may help in gene silencing
and drug design in cancer therapy. Our model is trained and tested
against a large data set of siRNA sequences. Validation of our results
is done by finding correlation coefficient of experimental versus
observed inhibition efficacy of siRNA. We achieved a correlation
coefficient of 0.727 in our previous computational model and we
could improve the correlation coefficient up to 0.753 when the
threshold of whole tacking energy is greater than or equal to -32.5
kcal/mol.