Abstract: Type 2 diabetes mellitus (T2DM) is a complex
metabolic disorder that characterized by the presence of high glucose
in blood that cause from insulin resistance and insufficiency due to
deterioration β-cell Langerhans functions. T2DM is commonly
caused by the combination of inherited genetic variations as well as
our own lifestyle. Metallothionein (MT) is a known cysteine-rich
protein responsible in helping zinc homeostasis which is important in
insulin signaling and secretion as well as protection our body from
reactive oxygen species (ROS). MT scavenged ROS and free
radicals in our body happen to be one of the reasons of T2DM and its
complications. The objective of this study was to investigate the
association of MT1A and MT2A polymorphisms between T2DM and
control subjects among Malay populations. This study involved 150
T2DM and 120 Healthy individuals of Malay ethnic with mixed
genders. The genomic DNA was extracted from buccal cells and
amplified for MT1A and MT2A loci; the 347bp and 238bp banding
patterns were respectively produced by mean of the Polymerase
Chain Reaction (PCR). The PCR products were digested with Mlucl
and Tsp451 restriction enzymes respectively and producing
fragments lengths of (158/189/347bp) and (103/135/238bp)
respectively. The ANOVA test was conducted and it shown that there
was a significant difference between diabetic and control subjects for
age, BMI, WHR, SBP, FPG, HBA1C, LDL, TG, TC and family
history with (P0.05). The genotype
frequency for AA, AG and GG of MT1A polymorphisms was 72.7%,
22.7% and 4.7% in cases and 15%, 55% and 30% in control
respectively. As for MT2A, genotype frequency of GG, GC and CC
was 42.7%, 27.3% and 30% in case and 5%, 40% and 55% for
control respectively. Both polymorphisms show significant difference
between two investigated groups with (P=0.000). The Post hoc test
was conducted and shows a significant difference between the
genotypes within each polymorphism (P=0. 000). The MT1A and
MT2A polymorphisms were believed to be the reliable molecular
markers to distinguish the T2DM subjects from healthy individuals in
Malay populations.
Abstract: Forming a legal culture among citizens is a
complicated and lengthy process, influencing all spheres of social
life. It includes promoting justice, learning rights and duties, the
introduction of juridical norms and knowledge, and also a process of
developing a system of legal acts and constitutional norms. Currently,
the evaluative and emotional influence of attempts to establish a legal
culture among the citizens of Kazakhstan is limited by real legal
practice. As a result, the values essential to a sound civil society are
absent from the consciousness of the Kazakh people who are thus, in
turn, not able to develop respect for these values. One of the
disadvantages of the modern Kazakh educational system is a
tendency to underrate the actual forces shaping the worldview of
Kazakh youths. The mass-media, which are going through a
personnel crisis, cannot provide society with the legal and political
information necessary to form the sort of legal culture required for a
true civil society.
Abstract: Perhaps no single issue has been cited as either the root
cause and / or the greatest challenge to the restructured power system then the lack of adequate reliable transmission. Probabilistic transmission planning has become increasingly necessary and important in recent
years. The transmission planning analysis carried out by the authors,
spans a 10-year horizon, taking into consideration a value of 2 % load
increase / year at each consumer. Taking into consideration this increased
load, a probabilistic power flow was carried out, all the system components
being regarded from probabilistic point of view. Several contingencies
have been generated, for assessing the security of the power system. The results have been analyzed and several important conclusions were pointed. The objective is to achieve a network that works without limit violations for all (or most of) scenario realizations. The case study is represented by the IEEE 14 buses test power system.
Abstract: The Bayesian Optimization Algorithm (BOA) is an algorithm based on the estimation of distributions. It uses techniques from modeling data by Bayesian networks to estimating the joint distribution of promising solutions. To obtain the structure of Bayesian network, different search algorithms can be used. The key point that BOA addresses is whether the constructed Bayesian network could generate new and useful solutions (strings), which could lead the algorithm in the right direction to solve the problem. Undoubtedly, this ability is a crucial factor of the efficiency of BOA. Varied search algorithms can be used in BOA, but their performances are different. For choosing better ones, certain suitable method to present their ability difference is needed. In this paper, a greedy search algorithm and a stochastic search algorithm are used in BOA to solve certain optimization problem. A method using Kullback-Leibler (KL) Divergence to reflect their difference is described.
Abstract: In this paper we will develop further the sequential
life test approach presented in a previous article by [1] using an
underlying two parameter Weibull sampling distribution. The
minimum life will be considered equal to zero. We will again provide
rules for making one of the three possible decisions as each
observation becomes available; that is: accept the null hypothesis H0;
reject the null hypothesis H0; or obtain additional information by
making another observation. The product being analyzed is a new
type of a low alloy-high strength steel product. To estimate the shape
and the scale parameters of the underlying Weibull model we will use
a maximum likelihood approach for censored failure data. A new
example will further develop the proposed sequential life testing
approach.
Abstract: The Expert Witness Testimony in the Battered
Woman Syndrome Expert witness testimony (EWT) is a kind of
information given by an expert specialized in the field (here in BWS)
to the jury in order to help the court better understand the case. EWT
does not always work in favor of the battered women. Two main
decision-making models are discussed in the paper: the Mathematical
model and the Explanation model. In the first model, the jurors
calculate ″the importance and strength of each piece of evidence″
whereas in the second model they try to integrate the EWT with the
evidence and create a coherent story that would describe the crime.
The jury often misunderstands and misjudges battered women for
their action (or in this case inaction). They assume that these women
are masochists and accept being mistreated for if a man abuses a
woman constantly, she should and could divorce him or simply leave
at any time. The research in the domain found that indeed, expert
witness testimony has a powerful influence on juror’s decisions thus
its quality needs to be further explored. One of the important factors
that need further studies is a bias called the dispositionist worldview
(a belief that what happens to people is of their own doing). This
kind of attributional bias represents a tendency to think that a
person’s behavior is due to his or her disposition, even when the
behavior is clearly attributed to the situation. Hypothesis The
hypothesis of this paper is that if a juror has a dispositionist
worldview then he or she will blame the rape victim for triggering the
assault. The juror would therefore commit the fundamental
attribution error and believe that the victim’s disposition caused the
rape and not the situation she was in. Methods The subjects in the
study were 500 randomly sampled undergraduate students from
McGill, Concordia, Université de Montréal and UQAM.
Dispositional Worldview was scored on the Dispositionist
Worldview Questionnaire. After reading the Rape Scenarios, each
student was asked to play the role of a juror and answer a
questionnaire consisting of 7 questions about the responsibility,
causality and fault of the victim. Results The results confirm the
hypothesis which states that if a juror has a dispositionist worldview
then he or she will blame the rape victim for triggering the assault.
By doing so, the juror commits the fundamental attribution error
because he will believe that the victim’s disposition, and not the
constraints or opportunities of the situation, caused the rape scenario.
Abstract: Reinforced concrete stair slabs with mid landings i.e.
Dog-legged shaped are conventionally designed as per specifications
of standard codes of practices which guide about the effective span
according to the varying support conditions. Presently, the behavior
of such slabs has been investigated using Finite Element method. A
single flight stair slab with landings on both sides and supported at
ends on wall, and a multi flight stair slab with landings and six
different support arrangements have been analyzed. The results
obtained for stresses, strains and deflections are used to describe the
behavior of such stair slabs, including locations of critical moments
and deflections. Values of critical moments obtained by F.E. analysis
have also have been compared with that obtained from conventional
analysis. Analytical results show that the moments are also critical
near the kinks i.e. junction of mid-landing and inclined waist slab.
This change in the behavior of dog-legged stair slab may be due to
continuity of the material in transverse direction in two landings
adjoining the waist slab, hence additional stiffness achieved. This
change in the behavior is generally not taken care of in conventional
method of design.
Abstract: The purpose of this research is to develop a security model for voice eavesdropping protection over digital networks. The proposed model provides an encryption scheme and a personal secret key exchange between communicating parties, a so-called voice data transformation system, resulting in a real-privacy conversation. The operation of this system comprises two main steps as follows: The first one is the personal secret key exchange for using the keys in the data encryption process during conversation. The key owner could freely make his/her choice in key selection, so it is recommended that one should exchange a different key for a different conversational party, and record the key for each case into the memory provided in the client device. The next step is to set and record another personal option of encryption, either taking all frames or just partial frames, so-called the figure of 1:M. Using different personal secret keys and different sets of 1:M to different parties without the intervention of the service operator, would result in posing quite a big problem for any eavesdroppers who attempt to discover the key used during the conversation, especially in a short period of time. Thus, it is quite safe and effective to protect the case of voice eavesdropping. The results of the implementation indicate that the system can perform its function accurately as designed. In this regard, the proposed system is suitable for effective use in voice eavesdropping protection over digital networks, without any requirements to change presently existing network systems, mobile phone network and VoIP, for instance.
Abstract: In this paper the authors propose and verify an approach to control heat flow in machine tool components. Thermal deformations are a main aspect that affects the accuracy of machining. Due to goals of energy efficiency, thermal basic loads should be reduced. This leads to inhomogeneous and time variant temperature profiles. To counteract these negative consequences, material with high melting enthalpy is used as a method for thermal stabilization. The increased thermal capacity slows down the transient thermal behavior. To account for the delayed thermal equilibrium, a control mechanism for thermal flow is introduced. By varying a gap in a heat flow path the thermal resistance of an assembly can be controlled. This mechanism is evaluated in two experimental setups. First to validate the ability to control the thermal resistance and second to prove the possibility of a self-sufficient option based on the selfsensing abilities of thermal shape memory alloys.
Abstract: spherical porous carbon particles with
controllable porosity with a mean size of 2.5m have been
prepared using a spray drying method with organic particle
colloidal template. As a precursor, a mixing solution of carbon
nanopowder and polystyrene (PS) particles as a template was
used. The result showed that the particles with a good porous
structure could be obtained. The pore size and shape (spherical)
were identical to the initial template, giving a potential way for
further developments. The control of particle porosity was also
possible and reported in this paper, in which this control could
be achieved by means of PS concentration.
Abstract: Even it has been recognized that Shape Memory
Alloys (SMA) have a significant potential for deployment actuators,
the number of applications of SMA-based actuators to the present
day is still quite small, due to the need of deep understanding of the
thermo-mechanical behavior of SMA, causing an important need for
a mathematical model able to describe all thermo-mechanical
properties of SMA by relatively simple final set of constitutive
equations. SMAs offer attractive potentials such as: reversible strains
of several percent, generation of high recovery stresses and high
power / weight ratios. The paper tries to provide an overview of the
shape memory functions and a presentation of the designed and
developed temperature control system used for a gripper actuated by
two pairs of differential SMA active springs. An experimental setup
was established, using electrical energy for actuator-s springs heating
process. As for holding the temperature of the SMA springs at certain
level for a long time was developed a control system in order to
avoid the active elements overheating.
Abstract: New Growth Theory helps us make sense of the
ongoing shift from a resource-based economy to a knowledge-based
economy. It underscores the point that the economic processes which
create and diffuse new knowledge are critical to shaping the growth
of nations, communities and individual firms. In all too many
contributions to New (Endogenous) Growth Theory – though not in
all – central reference is made to 'a stock of knowledge', a 'stock of
ideas', etc., this variable featuring centre-stage in the analysis. Yet it
is immediately apparent that this is far from being a crystal clear
concept. The difficulty and uncertainty of being able to capture the
value associated with knowledge is a real problem. The intent of this
paper is introducing new thinking and theorizing about the
knowledge and its measurability in new growth theory. Moreover the
study aims to synthesize various strain of the literature with a
practical bearing on knowledge concept. By contribution of
institution framework which is found within NGT, we can indirectly
measure the knowledge concept. Institutions matter because they
shape the environment for production and employment of new
knowledge
Abstract: Hazardous Material transportation by road is coupled
with inherent risk of accidents causing loss of lives, grievous injuries,
property losses and environmental damages. The most common type
of hazmat road accident happens to be the releases (78%) of
hazardous substances, followed by fires (28%), explosions (14%) and
vapour/ gas clouds (6 %.).
The paper is discussing initially the probable 'Impact Zones'
likely to be caused by one flammable (LPG) and one toxic (ethylene
oxide) chemicals being transported through a sizable segment of a
State Highway connecting three notified Industrial zones in Surat
district in Western India housing 26 MAH industrial units. Three
'hotspots' were identified along the highway segment depending on
the particular chemical traffic and the population distribution within
500 meters on either sides. The thermal radiation and explosion
overpressure have been calculated for LPG / Ethylene Oxide BLEVE
scenarios along with toxic release scenario for ethylene oxide.
Besides, the dispersion calculations for ethylene oxide toxic release
have been made for each 'hotspot' location and the impact zones
have been mapped for the LOC concentrations. Subsequently, the
maximum Initial Isolation and the protective zones were calculated
based on ERPG-3 and ERPG-2 values of ethylene oxide respectively
which are estimated taking the worst case scenario under worst
weather conditions. The data analysis will be helpful to the local
administration in capacity building with respect to rescue /
evacuation and medical preparedness and quantitative inputs to
augment the District Offsite Emergency Plan document.
Abstract: Localized surface plasmon resonance (LSPR) is the
coherent oscillation of conductive electrons confined in noble
metallic nanoparticles excited by electromagnetic radiation, and
nanosphere lithography (NSL) is one of the cost-effective methods to
fabricate metal nanostructures for LSPR. NSL can be categorized
into two major groups: dispersed NSL and closely pack NSL. In
recent years, gold nanocrescents and gold nanoholes with vertical
sidewalls fabricated by dispersed NSL, and silver nanotriangles and
gold nanocaps on silica nanospheres fabricated by closely pack NSL,
have been reported for LSPR biosensing. This paper introduces
several novel gold nanostructures fabricated by NSL in LSPR
applications, including 3D nanostructures obtained by evaporating
gold obliquely on dispersed nanospheres, nanoholes with slant
sidewalls, and patchy nanoparticles on closely packed nanospheres,
all of which render satisfactory sensitivity for LSPR sensing. Since
the LSPR spectrum is very sensitive to the shape of the metal
nanostructures, formulas are derived and software is developed for
calculating the profiles of the obtainable metal nanostructures by
NSL, for different nanosphere masks with different fabrication
conditions. The simulated profiles coincide well with the profiles of
the fabricated gold nanostructures observed under scanning electron
microscope (SEM) and atomic force microscope (AFM), which
proves that the software is a useful tool for the process design of
different LSPR nanostructures.
Abstract: To evaluate genetic variation of wheat (Triticum
aestivum) affected by heat and drought stress on eight Australian
wheat genotypes that are parents of Doubled Haploid (HD) mapping
populations at the vegetative stage, the water stress experiment was
conducted at 65% field capacity in growth room. Heat stress
experiment was conducted in the research field under irrigation over
summer. Result show that water stress decreased dry shoot weight
and RWC but increased osmolarity and means of Fv/Fm values in all
varieties except for Krichauff. Krichauff and Kukri had the
maximum RWC under drought stress. Trident variety was shown
maximum WUE, osmolarity (610 mM/Kg), dry mater, quantum yield
and Fv/Fm 0.815 under water stress condition. However, the
recovery of quantum yield was apparent between 4 to 7 days after
stress in all varieties. Nevertheless, increase in water stress after that
lead to strong decrease in quantum yield. There was a genetic
variation for leaf pigments content among varieties under heat stress.
Heat stress decreased significantly the total chlorophyll content that
measured by SPAD. Krichauff had maximum value of Anthocyanin
content (2.978 A/g FW), chlorophyll a+b (2.001 mg/g FW) and
chlorophyll a (1.502 mg/g FW). Maximum value of chlorophyll b
(0.515 mg/g FW) and Carotenoids (0.234 mg/g FW) content
belonged to Kukri. The quantum yield of all varieties decreased
significantly, when the weather temperature increased from 28 ÔùªC to
36 ÔùªC during the 6 days. However, the recovery of quantum yield
was apparent after 8th day in all varieties. The maximum decrease
and recovery in quantum yield was observed in Krichauff. Drought
and heat tolerant and moderately tolerant wheat genotypes were
included Trident, Krichauff, Kukri and RAC875. Molineux, Berkut
and Excalibur were clustered into most sensitive and moderately
sensitive genotypes. Finally, the results show that there was a
significantly genetic variation among the eight varieties that were
studied under heat and water stress.
Abstract: In this paper, the signal transmission analysis of the
semicircle-shaped via structure for the differential pairs is presented in
the frequency range up to 10 GHz. In order to improve the signal
transmission properties in the differential pairs, single via is separated
centrally into two semicircle-shaped sections, which are
interconnected with the traces of differential pairs respectively. This
via structure make possible to route differential pairs using only one
via. In addition, it can improve impedance discontinuity around its
region and then enhance the signal transmission properties in the
differential pairs. The electrical analysis such as S-parameter
calculation and eye diagram simulation has been performed to
investigate the improvement of the signal transmission property in the
differential pairs with new via structure.
Abstract: In this paper we study a system composed by carbon
nanotube (CNT) and bundle of carbon nanotube (BuCNT) interacting
with a specific fatty acid as molecular probe. Full system is
represented by open nanotube (or nanotubes) and the linoleic acid
(LA) relaxing due the interaction with CNT and BuCNT. The LA has
in his form an asymmetric shape with COOH termination provoking
a close BuCNT interaction mainly by van der Waals force field. The
simulations were performed by classical molecular dynamics with
standard parameterizations.
Our results show that these BuCNT and CNT are dynamically
stable and it shows a preferential interaction position with LA
resulting in three features: (i) when the LA is interacting with CNT
and BuCNT (including both termination, CH2 or COOH), the LA is
repelled; (ii) when the LA terminated with CH2 is closer to open
extremity of BuCNT, the LA is also repelled by the interaction
between them; and (iii) when the LA terminated with COOH is
closer to open extremity of BuCNT, the LA is encapsulated by the
BuCNT. These simulations are part of a more extensive work on
searching efficient selective molecular devices and could be useful to
reach this goal.
Abstract: The social force model which belongs to the
microscopic pedestrian studies has been considered as the supremacy
by many researchers and due to the main feature of reproducing the
self-organized phenomena resulted from pedestrian dynamic. The
Preferred Force which is a measurement of pedestrian-s motivation to
adapt his actual velocity to his desired velocity is an essential term on
which the model was set up. This Force has gone through stages of
development: first of all, Helbing and Molnar (1995) have modeled
the original force for the normal situation. Second, Helbing and his
co-workers (2000) have incorporated the panic situation into this
force by incorporating the panic parameter to account for the panic
situations. Third, Lakoba and Kaup (2005) have provided the
pedestrians some kind of intelligence by incorporating aspects of the
decision-making capability. In this paper, the authors analyze the
most important incorporations into the model regarding the preferred
force. They make comparisons between the different factors of these
incorporations. Furthermore, to enhance the decision-making ability
of the pedestrians, they introduce additional features such as the
familiarity factor to the preferred force to let it appear more
representative of what actually happens in reality.
Abstract: Modeling of Panel Zone (PZ) seismic behavior,
because of its role in overall ductility and lateral stiffness of steel
moment frames, has been considered a challenge for years. There are
some studies regarding the effects of different doubler plates
thicknesses and geometric properties of PZ on its seismic behavior.
However, there is not much investigation on the effects of number of
provided continuity plates in case of presence of one triangular
haunch, two triangular haunches and rectangular haunch (T shape
haunches) for exterior columns. In this research first detailed finite
element models of 12tested connection of SAC joint venture were
created and analyzed then obtained cyclic behavior backbone curves
of these models besides other FE models for similar tests were used
for neural network training. Then seismic behavior of these data is
categorized according to continuity plate-s arrangements and
differences in type of haunches. PZ with one-sided haunches have
little plastic rotation. As the number of continuity plates increases
due to presence of two triangular haunches (four continuity plate),
there will be no plastic rotation, in other words PZ behaves in its
elastic range. In the case of rectangular haunch, PZ show more plastic
rotation in comparison with one-sided triangular haunch and
especially double-sided triangular haunches. Moreover, the models
that will be presented in case of triangular one-sided and double-
sided haunches and rectangular haunches as a result of this study
seem to have a proper estimation of PZ seismic behavior.
Abstract: Jacobs, A.B. (1993) stated that "When I think of a city,
the first thing that comes to mind is the street. If the street is
interesting, the rest of the city is interesting. If the street is mundane,
the city is also mundane." In this statement, he expresses the
importance of the streetscape and the street environment. The
objective of this paper is to analyze the spatial relationships of the
streetscape that affect the general public's preference of the cityscape.
Furthermore, this research focuses on the important role that
streetscape plays in public perception of the city by the pedestrians
who experience it daily. The subject of this paper is eight of the
"Design Seoul Street."The analysis and survey results show the
preference criteria that affect the streetscape and ultimately the
cityscape. This research endeavor shows that differences in physical
form, shape, size, color, locations, and context are important.