Abstract: Microbubbbles incorporating ultrasound have been used to increase the efficacy of targeted drug delivery, because microstreaming induced by cavitating bubbles affects the drug perfusion into the target cells and tissues. In order to clarify the physical effects of microstreaming on drug perfusion into tissues, a preliminary experimental study of perfusion enhancement by a stably oscillating microbubble was performed. Microstreaming was induced by an oscillating bubble at 15 kHz, and perfusion of dye into an agar phantom was optically measured by histology on agar phantom. Surface color intensity and the penetration length of dye in the agar phantom were increased more than 70% and 30%, respectively, due to the microstreaming induced by an oscillating bubble. The mass of dye perfused into a tissue phantom for 30 s was increased about 80% in the phantom with an oscillating bubble. This preliminary experiment shows the physical effects of steady streaming by an oscillating bubble can enhance the drug perfusion into the tissues while minimizing the biological effects.
Abstract: A lot of recent research have spoken on the relation
between the increase of the homocysteinemia and some kinds of
cancer . For that, our study was based on the research of a possible
relation between the increase of the concentration of this amino-acid
in the plasma and the appearance of the disease of the Acute
Lymphoblastic Leukaemia in a part of Algerian children with Berber
origin in the East of Algeria . The study has done on 47 ill persons
with an average age of (09±06 ) years , with whom the disease has
diagnosed by blood and marrow examination in the hospital of blood
diseases in the CHU of Batna, and on 194 healthy witnesses of the
same age. The two groups were benefited by a dosage of the
concentration of the homocysteine vitamin B9 ,vitamin B12 , and
also of the study of special polymorphisms of indispensable enzymes
in the metabolism of this acid , and that by the use of the method (
Light cycler ) Real time PCR , on the following enzymes : MS (
C2756G ), MSR ( A66G ) ,MTHFR1 ( C677T ) and MTHFR2
(A1298C). The obtained results have revealed that the rate of the
homozygote muted genotype is the less frequent in the two groups ,
and that exist at list one genotype of each enzyme in the ill group and
in which the percentage exceed with remarkable way the same
genotype in the healthy group and we notice specially the muted
genotype GG of -the methionine synthetase-and the form TT of the
enzyme – methyline tetra hydrofolate reductase – We notice the
existence of considerable number of genotypes in the ill group lied
with characteristic increase of this Amino-acid ,and that for the
reduction of the biologic activity of these enzymes which become
inefficient in the transfer of the homocysteine into the methionine
and cause the diminution of the biologic activity of these enzymes
and with consequence the reduction of the percentage of methylic
radicals in the DNA of studied genes and that lead to the increase of
the activity and the capacity of transcription , and it-s so probably
that this last one is one of the factors of this disease especially if we
know that the specific check-up of vitamins is normal and similar in
the two groups , which ovoid the hypothesis of the reduction of
vitamins . We notice also that the heterozygote genotype is the less in
the sick category except the MTHFR2. Wild genotype is more
frequent in the witness group except MSR. Even these results are
partials; they open a new way in the genetic diagnosis of this
malicious disease which allow a precocious diagnosis and the use of
an effective and appropriated treatment in the same time.
Abstract: A Finite Volume method based on Characteristic Fluxes for compressible fluids is developed. An explicit cell-centered resolution is adopted, where second and third order accuracy is provided by using two different MUSCL schemes with Minmod, Sweby or Superbee limiters for the hyperbolic part. Few different times integrator is used and be describe in this paper. Resolution is performed on a generic unstructured Cartesian grid, where solid boundaries are handled by a Cut-Cell method. Interfaces are explicitely advected in a non-diffusive way, ensuring local mass conservation. An improved cell cutting has been developed to handle boundaries of arbitrary geometrical complexity. Instead of using a polygon clipping algorithm, we use the Voxel traversal algorithm coupled with a local floodfill scanline to intersect 2D or 3D boundary surface meshes with the fixed Cartesian grid. Small cells stability problem near the boundaries is solved using a fully conservative merging method. Inflow and outflow conditions are also implemented in the model. The solver is validated on 2D academic test cases, such as the flow past a cylinder. The latter test cases are performed both in the frame of the body and in a fixed frame where the body is moving across the mesh. Adaptive Cartesian grid is provided by Paramesh without complex geometries for the moment.
Abstract: In this study, we present an advanced detection
technique for mass type breast cancer based on texture information
of organs. The proposed method detects the cancer areas in three
stages. In the first stage, the midpoints of mass area are determined
based on AHE (Adaptive Histogram Equalization). In the second
stage, we set the threshold coefficient of homogeneity by using
MLE (Maximum Likelihood Estimation) to compute the uniformity
of texture. Finally, mass type cancer tissues are extracted from the
original image. As a result, it was observed that the proposed
method shows an improved detection performance on dense breast
tissues of Korean women compared with the existing methods. It is
expected that the proposed method may provide additional
diagnostic information for detection of mass-type breast cancer.
Abstract: Equilibrium and rate based models have been applied
in the simulation of methyl tertiary-butyl ether (MTBE) synthesis
through reactive distillation. Temperature and composition profiles
were compared for both the models and found that both the profiles
trends, though qualitatively similar are significantly different
quantitatively. In the rate based method (RBM), multicomponent
mass transfer coefficients have been incorporated to describe
interphase mass transfer. MTBE mole fraction in the bottom stream is
found to be 0.9914 in the Equilibrium Model (EQM) and only 0.9904
for RBM when the same column configuration was preserved. The
individual tray efficiencies were incorporated in the EQM and
simulations were carried out. Dynamic simulation have been also
carried out for the two column configurations and compared.
Abstract: In pressure vessels contain hydrogen, the role of
hydrogen will be important because of hydrogen cracking problem. It
is difficult to predict what is happened in metallurgical field spite of a
lot of studies have been searched. The main role in controlling the
mass diffusion as driving force is related to stress. In this study, finite
element analysis is implemented to estimate material-s behavior
associated with hydrogen embrittlement. For this purpose, one model
of a pressure vessel is introduced that it has definite boundary and
initial conditions. In fact, finite element is employed to solve the
sequentially coupled mass diffusion with stress near a crack front in a
pressure vessel. Modeling simulation intergrarnular fracture of AISI
4135 steel due to hydrogen is investigated. So, distribution of
hydrogen and stress are obtained and they indicate that their
maximum amounts occur near the crack front. This phenomenon is
happened exactly the region between elastic and plastic field.
Therefore, hydrogen is highly mobile and can diffuse through crystal
lattice so that this zone is potential to trap high volume of hydrogen.
Consequently, crack growth and fast fracture will be happened.
Abstract: The pyrolysis characteristics and kinetics of seven marine biomass, which are fixed Enteromorpha clathrata, floating Enteromorpha clathrata, Ulva lactuca L., Zosterae Marinae L., Thallus Laminariae, Asparagus schoberioides kunth and Undaria pinnatifida (Harv.), were studied with thermogravimetric analysis method. Simultaneously, cornstalk, which is a grass biomass, and sawdust, which is a lignocellulosic biomass, were references. The basic pyrolysis characteristics were studied by using TG- DTG-DTA curves. The results showed that there were three stages (dehydration, dramatic weight loss and slow weight loss) during the whole pyrolysis process of samples. The Tmax of marine biomass was significantly lower than two kinds of terrestrial biomass. Zosterae Marinae L. had a relatively high stability of pyrolysis, but floating Enteromorpha clathrata had lowest stability of pyrolysis and a good combustion characteristics. The corresponding activation energy E and frequency factor A were obtained by Coats-Redfern method. It was found that the pyrolysis reaction mechanism functions of three kinds of biomass are different.
Abstract: A new and highly efficient architecture for elliptic curve scalar point multiplication which is optimized for a binary field recommended by NIST and is well-suited for elliptic curve cryptographic (ECC) applications is presented. To achieve the maximum architectural and timing improvements we have reorganized and reordered the critical path of the Lopez-Dahab scalar point multiplication architecture such that logic structures are implemented in parallel and operations in the critical path are diverted to noncritical paths. With G=41, the proposed design is capable of performing a field multiplication over the extension field with degree 163 in 11.92 s with the maximum achievable frequency of 251 MHz on Xilinx Virtex-4 (XC4VLX200) while 22% of the chip area is occupied, where G is the digit size of the underlying digit-serial finite field multiplier.
Abstract: The aim of this work is to investigate on the internalflow
patterns in a plate heat exchanger channel, which affect the
rate of sedimentation fouling on the heat transfer surface of the
plate heat exchanger. The research methodologies were the
computer simulation using Computational Fluid Dynamics (CFD)
and the experimental works. COMSOL MULTIPHYSICS™
Version 3.3 was used to simulate the velocity flow fields to verify
the low and high flow regions. The results from the CFD technique
were then compared with the images obtained from the
experiments in which the fouling test rig was set up with a singlechannel
plate heat exchanger to monitor the fouling of calcium
carbonate. Two parameters were varied i.e., the crossing angle of
the two plate: 55/55, 10/10, and 55/10 degree, and the fluid flow
rate at the inlet: 0.0566, 0.1132 and 0.1698 m/s. The type of plate
“GX-12" (the surface area 0.12 m2, the depth 2.9 mm, the width of
fluid flow 215 mm and the thickness of stainless plate of 0.5 mm)
was used in this study. The results indicated that the velocity
distribution for the case of 55/55 degree seems to be very well
organized when compared with the others. Also, an increase in the
inlet velocity resulted in the reduction of fouling rate on the surface
of plate heat exchangers.
Abstract: In the modern manufacturing systems, the use of
thermal cutting techniques using oxyfuel, plasma and laser have
become indispensable for the shape forming of high quality complex
components; however, the conventional chip removal production
techniques still have its widespread space in the manufacturing
industry. Both these types of machining operations require the
positioning of end effector tool at the edge where the cutting process
commences. This repositioning of the cutting tool in every machining
operation is repeated several times and is termed as non-productive
time or airtime motion. Minimization of this non-productive
machining time plays an important role in mass production with high
speed machining. As, the tool moves from one region to the other by
rapid movement and visits a meticulous region once in the whole
operation, hence the non-productive time can be minimized by
synchronizing the tool movements. In this work, this problem is
being formulated as a general travelling salesman problem (TSP) and
a genetic algorithm approach has been applied to solve the same. For
improving the efficiency of the algorithm, the GA has been
hybridized with a noble special heuristic and simulating annealing
(SA). In the present work a novel heuristic in the combination of GA
has been developed for synchronization of toolpath movements
during repositioning of the tool. A comparative analysis of new Meta
heuristic techniques with simple genetic algorithm has been
performed. The proposed metaheuristic approach shows better
performance than simple genetic algorithm for minimization of nonproductive
toolpath length. Also, the results obtained with the help of
hybrid simulated annealing genetic algorithm (HSAGA) are also
found better than the results using simple genetic algorithm only.
Abstract: The massive proliferation of affordable computers, Internet broadband connectivity and rich education content has created a global phenomenon in which information and communication technology (ICT) is being used to transform education. Therefore, there is a need to redesign the educational system to meet the needs better. The advent of computers with sophisticated software has made it possible to solve many complex problems very fast and at a lower cost. This paper introduces the characteristics of the current E-Learning and then analyses the concept of cloud computing and describes the architecture of cloud computing platform by combining the features of E-Learning. The authors have tried to introduce cloud computing to e-learning, build an e-learning cloud, and make an active research and exploration for it from the following aspects: architecture, construction method and external interface with the model.
Abstract: In this paper, a Smart Home Service Robot, McBot II,
which performs mess-cleanup function etc. in house, is designed much
more optimally than other service robots. It is newly developed in
much more practical system than McBot I which we had developed
two years ago. One characteristic attribute of mobile platforms
equipped with a set of dependent wheels is their omni- directionality
and the ability to realize complex translational and rotational
trajectories for agile navigation in door. An accurate coordination of
steering angle and spinning rate of each wheel is necessary for a
consistent motion. This paper develops trajectory controller of
3-wheels omni-directional mobile robot using fuzzy azimuth estimator.
A specialized anthropomorphic robot manipulator which can be
attached to the housemaid robot McBot II, is developed in this paper.
This built-in type manipulator consists of both arms with 3 DOF
(Degree of Freedom) each and both hands with 3 DOF each. The
robotic arm is optimally designed to satisfy both the minimum
mechanical size and the maximum workspace. Minimum mass and
length are required for the built-in cooperated-arms system. But that
makes the workspace so small. This paper proposes optimal design
method to overcome the problem by using neck joint to move the arms
horizontally forward/backward and waist joint to move them
vertically up/down. The robotic hand, which has two fingers and a
thumb, is also optimally designed in task-based concept. Finally, the
good performance of the developed McBot II is confirmed through
live tests of the mess-cleanup task.
Abstract: Three reactor types were explored and successfully
used for pigment production by Monascus: shake flasks, and shaken
and stirred miniaturized reactors. Also, the use of dielectric
spectroscopy for the on-line measurement of biomass levels was
explored. Shake flasks gave good pigment yields, but scale up is
difficult, and they cannot be automated. Shaken bioreactors were less
successful with pigment production than stirred reactors.
Experiments with different impeller speeds in different volumes of
liquid in the reactor confirmed that this is most likely due oxygen
availability. The availability of oxygen appeared to affect biomass
levels less than pigment production; red pigment production in
particular needed very high oxygen levels. Dielectric spectroscopy
was effectively used to continuously measure biomass levels during
the submerged fungal fermentation in the shaken and stirred
miniaturized bioreactors, despite the presence of the solid substrate
particles. Also, the capacitance signal gave useful information about
the viability of the cells in the culture.
Abstract: This work has been carried out in order to provide an understanding of the physical behaviors of the flow variation of pressure and temperature in a vortex tube. A computational fluid dynamics model is used to predict the flow fields and the associated temperature separation within a Ranque–Hilsch vortex tube. The CFD model is a steady axisymmetric model (with swirl) that utilizes the standard k-ε turbulence model. The second–order numerical schemes, was used to carry out all the computations. Vortex tube with a circumferential inlet stream and an axial (cold) outlet stream and a circumferential (hot) outlet stream was considered. Performance curves (temperature separation versus cold outlet mass fraction) were obtained for a specific vortex tube with a given inlet mass flow rate. Simulations have been carried out for varying amounts of cold outlet mass flow rates. The model results have a good agreement with experimental data.
Abstract: Partial combustion of biomass in the gasifier generates producer gas that can be used for heating purposes and as supplementary or sole fuel in internal combustion engines. In this study, the virgin biomass obtained from hingan shell is used as the feedstock for gasifier to generate producer gas. The gasifier-engine system is operated on diesel and on esters of vegetable oil of hingan in liquid fuel mode operation and then on liquid fuel and producer gas combination in dual fuel mode operation. The performance and emission characteristics of the CI engine is analyzed by running the engine in liquid fuel mode operation and in dual fuel mode operation at different load conditions with respect to maximum diesel savings in the dual fuel mode operation. It was observed that specific energy consumption in the dual fuel mode of operation is found to be in the higher side at all load conditions. The brake thermal efficiency of the engine using diesel or hingan oil methyl ester (HOME) is higher than that of dual fuel mode operation. A diesel replacement in the tune of 60% in dual fuel mode is possible with the use of hingan shell producer gas. The emissions parameters such CO, HC, NOx, CO2 and smoke are higher in the case of dual fuel mode of operation as compared to that of liquid fuel mode.
Abstract: Majority of pepper farmers in Malaysia are using the
open-sun method for drying the pepper berries. This method is time
consuming and exposed the berries to rain and contamination. A
maintenance-friendly and properly enclosed dryer is therefore
desired. A dryer design with a solar collector and a chimney was
studied and adapted to suit the needs of small-scale pepper farmers in
Malaysia. The dryer will provide an environment with an optimum
operating temperature meant for drying pepper berries. The dryer
model was evaluated by using commercially available computational
fluid dynamic (CFD) software in order to understand the heat and
mass transfer inside the dryer. Natural convection was the only mode
of heat transportation considered in this study as in accordance to the
idea of having a simple and maintenance-friendly design. To
accommodate the effect of low buoyancy found in natural convection
driers, a biomass burner was integrated into the solar dryer design.
Abstract: Due to the environmental and price issues of current
energy crisis, scientists and technologists around the globe are
intensively searching for new environmentally less-impact form of
clean energy that will reduce the high dependency on fossil fuel.
Particularly hydrogen can be produced from biomass via thermochemical
processes including pyrolysis and gasification due to the
economic advantage and can be further enhanced through in-situ
carbon dioxide removal using calcium oxide. This work focuses on
the synthesis and development of the flowsheet for the enhanced
biomass gasification process in PETRONAS-s iCON process
simulation software. This hydrogen prediction model is conducted at
operating temperature between 600 to 1000oC at atmospheric
pressure. Effects of temperature, steam-to-biomass ratio and
adsorbent-to-biomass ratio were studied and 0.85 mol fraction of
hydrogen is predicted in the product gas. Comparisons of the results
are also made with experimental data from literature. The
preliminary economic potential of developed system is RM 12.57 x
106 which equivalent to USD 3.77 x 106 annually shows economic
viability of this process.
Abstract: In this study, the designed dual stage membrane
bioreactor (MBR) system was conceptualized for the treatment of
cyanide and heavy metals in electroplating wastewater. The design
consisted of a primary treatment stage to reduce the impact of
fluctuations and the secondary treatment stage to remove the residual
cyanide and heavy metal contaminants in the wastewater under
alkaline pH conditions. The primary treatment stage contained
hydrolyzed Citrus sinensis (C. sinensis) pomace and the secondary
treatment stage contained active Aspergillus awamori (A. awamori)
biomass, supplemented solely with C. sinensis pomace extract from
the hydrolysis process. An average of 76.37%, 95.37%, 93.26 and
94.76% and 99.55%, 99.91%, 99.92% and 99.92% degradation
efficiency for total cyanide (T-CN), including the sorption of nickel
(Ni), zinc (Zn) and copper (Cu) were observed after the first and
second treatment stages, respectively. Furthermore, cyanide
conversion by-products degradation was 99.81% and 99.75 for both
formate (CHOO-) and ammonium (NH4
+) after the second treatment
stage. After the first, second and third regeneration cycles of the C.
sinensis pomace in the first treatment stage, Ni, Zn and Cu removal
achieved was 99.13%, 99.12% and 99.04% (first regeneration cycle),
98.94%, 98.92% and 98.41% (second regeneration cycle) and 98.46
%, 98.44% and 97.91% (third regeneration cycle), respectively.
There was relatively insignificant standard deviation detected in all
the measured parameters in the system which indicated
reproducibility of the remediation efficiency in this continuous
system.
Abstract: Fixed-bed slow pyrolysis experiments of rice husk
have been conducted to determine the effect of pyrolysis
temperature, heating rate, particle size and reactor length on the
pyrolysis product yields. Pyrolysis experiments were performed at
pyrolysis temperature between 400 and 600°C with a constant
heating rate of 60°C/min and particle sizes of 0.60-1.18 mm. The
optimum process conditions for maximum liquid yield from the rice
husk pyrolysis in a fixed bed reactor were also identified. The highest
liquid yield was obtained at a pyrolysis temperature of 500°C,
particle size of
1.18-1.80 mm, with a heating rate of 60°C/min in a 300 mm length
reactor. The obtained yield of, liquid, gas and solid were found be in
the range of 22.57-31.78 %, 27.75-42.26 % and 34.17-42.52 % (all
weight basics) respectively at different pyrolysis conditions. The
results indicate that the effects of pyrolysis temperature and particle
size on the pyrolysis yield are more significant than that of heating
rate and reactor length. The functional groups and chemical
compositions present in the liquid obtained at optimum conditions
were identified by Fourier Transform-Infrared (FT-IR) spectroscopy
and Gas Chromatography/ Mass Spectroscopy (GC/MS) analysis
respectively.
Abstract: In order to optimize annual IT spending and to reduce
the complexity of an entire system architecture, SOA trials have been
started. It is common knowledge that to design an SOA system we
have to adopt the top-down approach, but in reality silo systems are
being made, so these companies cannot reuse newly designed services,
and cannot enjoy SOA-s economic benefits. To prevent this situation,
we designed a generic SOA development process referred to as the
architecture of “mass customization."
To define the generic detail development processes, we did a case
study on an imaginary company. Through the case study, we could
define the practical development processes and found this could vastly
reduce updating development costs.