Abstract: It is the patient compliance and stability in
combination with controlled drug delivery and biocompatibility that
forms the core feature in present research and development of
sustained biodegradable patch formulation intended for wound
healing. The aim was to impart sustained degradation, sterile
formulation, significant folding endurance, elasticity,
biodegradability, bio-acceptability and strength. The optimized
formulation comprised of polymers including Hydroxypropyl methyl
cellulose, Ethylcellulose, and Gelatin, and Citric Acid PEG Citric
acid (CPEGC) triblock dendrimers and active Curcumin. Polymeric
mixture dissolved in geometric order in suitable medium through
continuous stirring under ambient conditions. With continued stirring
Curcumin was added with aid of DCM and Methanol in optimized
ratio to get homogenous dispersion. The dispersion was sonicated
with optimum frequency and for given time and later casted to form a
patch form. All steps were carried out under strict aseptic conditions.
The formulations obtained in the acceptable working range were
decided based on thickness, uniformity of drug content, smooth
texture and flexibility and brittleness. The patch kept on stability
using butter paper in sterile pack displayed folding endurance in
range of 20 to 23 times without any evidence of crack in an
optimized formulation at room temperature (RT) (24 ± 2°C). The
patch displayed acceptable parameters after stability study conducted
in refrigerated conditions (8±0.2°C) and at RT (24 ± 2°C) up to 90
days. Further, no significant changes were observed in critical
parameters such as elasticity, biodegradability, drug release and drug
content during stability study conducted at RT 24±2°C for 45 and 90
days. The drug content was in range 95 to 102%, moisture content
didn’t exceeded 19.2% and patch passed the content uniformity test.
Percentage cumulative drug release was found to be 80% in 12h and
matched the biodegradation rate as drug release with correlation
factor R2>0.9. The biodegradable patch based formulation developed
shows promising results in terms of stability and release profiles.
Abstract: In this paper numerical studies have been carried out
to examine the pre-ignition flow features of high-performance solid
propellant rocket motors with two different port geometries but with
same propellant loading density. Numerical computations have been
carried out using a validated 3D, unsteady, 2nd-order implicit, SST k-
ω turbulence model. In the numerical study, a fully implicit finite
volume scheme of the compressible, Reynolds-Averaged, Navier-
Stokes equations is employed. We have observed from the numerical
results that in solid rocket motors with highly loaded propellants
having divergent port geometry the hot igniter gases can create preignition
pressure oscillations leading to thrust oscillations due to the
flow unsteadiness and recirculation. We have also observed that the
igniter temperature fluctuations are diminished rapidly thereby
reaching the steady state value faster in the case of solid propellant
rocket motors with convergent port than the divergent port
irrespective of the igniter total pressure. We have concluded that the
prudent selection of the port geometry, without altering the propellant
loading density, for damping the total temperature fluctuations within
the motor is a meaningful objective for the suppression and control of
instability and/or thrust oscillations often observed in solid propellant
rocket motors with non-uniform port geometry.
Abstract: This survey paper shows the recent state of model
comparison as it’s applies to Model Driven engineering. In Model
Driven Engineering to calculate the difference between the models is
a very important and challenging task. There are number of tasks
involved in model differencing that firstly starts with identifying and
matching the elements of the model. In this paper, we discuss how
model matching is accomplished, the strategies, techniques and the
types of the model. We also discuss the future direction. We found
out that many of the latest model comparison strategies are geared
near enabling Meta model and similarity based matching. Therefore
model versioning is the most dominant application of the model
comparison. Recently to work on comparison for versioning has
begun to deteriorate, giving way to different applications. Ultimately
there is wide change among the tools in the measure of client exertion
needed to perform model comparisons, as some require more push to
encourage more sweeping statement and expressive force.
Abstract: Twin steel plates-concrete composite shear walls are
composed of a pair of steel plate layers and a concrete layer
sandwiched between them, which have the characteristics of both
reinforced concrete shear walls and steel plate shear walls. Twin steel
plates-composite shear walls contain very high ultimsate bearing
capacity and ductility, which have great potential to be applied in the
super high-rise buildings and special structures. In this paper, we
analyzed the basic characteristics and stress mechanism of the twin
steel plates-composite shear walls. Specifically, we analyzed the
effects of the steel plate thickness, wall thickness and concrete
strength on the bearing capacity of the twin steel plates-composite
shear walls. The analysis results indicate that: (1) the initial shear
stiffness and ultimate shear-carrying capacity is not significantly
affected by the thickness of concrete wall but by the class of concrete,
(2) both factors significantly impact the shear distribution of the
shear walls in ultimate shear-carrying capacity. The technique of twin
steel plates-composite shear walls has been successfully applied in
the construction of an 88-meter Huge Statue of Buddha located in
Hunan Province, China. The analysis results and engineering
experiences showed that the twin steel plates-composite shear walls
have great potential for future research and applications.
Abstract: Consumers are demanding novel beverages that are
healthier, convenient and have appealing consumer acceptance. The
objectives of this study were to investigate the effects of adding grape
polyphenols and the influence of presenting health claims on the
sensory acceptability of wines. Fresh red sorrel calyces were
fermented into wines. The total soluble solids of the pectinase-treated
sorrel puree were from 4°Brix to 23.8°Brix. Polyphenol in the form
of grape pomace extract was added to sorrel wines (w/v) in specified
levels to give 0. 25. 50 and 75 ppm. A focus group comprising of 12
panelists was use to select the level of polyphenol to be added to
sorrel wines for sensory preference The sensory attributed of the
wines which were evaluated were colour, clarity, aroma, flavor,
mouth-feel, sweetness, astringency and overall preference. The sorrel
wine which was most preferred from focus group evaluation was
presented for hedonic rating. In the first stage of hedonic testing, the
sorrel wine was served chilled at 7°C for 24 h prior to sensory
evaluation. Each panelist was provided with a questionnaire and was
asked to rate the wines on colour, aroma, flavor, mouth-feel,
sweetness, astringency and overall acceptability using a 9-point
hedonic scale. In the second stage of hedonic testing, the panelist
were instructed to read a health abstract on the health benefits of
polyphenolic compounds and again to rate sorrel wine with added 25
ppm polyphenol. Paired t-test was used for the analysis of the
influence of presenting health information on polyphenols on hedonic
scoring of sorrel wines. Focus groups found that the addition of
polyphenol addition had no significant effect on sensory color and
aroma but affected clarity and flavor. A 25 ppm wine was liked
moderately in overall acceptability. The presentation of information
on the health benefit of polyphenols in sorrel wines to panelists had
no significant influence on the sensory acceptance of wine. More
than half of panelists would drink this wine now and then. This wine
had color L 19.86±0.68, chroma 2.10±0.12, hue° 16.90 ±3.10 and
alcohol content of 13.0%. The sorrel wine was liked moderately in
overall acceptability with the added polyphenols.
Abstract: Batch production plants provide a wide range of
scheduling problems. In pharmaceutical industries a batch process
is usually described by a recipe, consisting of an ordering of tasks
to produce the desired product. In this research work we focused
on pharmaceutical production processes requiring the culture of
a microorganism population (i.e. bacteria, yeasts or antibiotics).
Several sources of uncertainty may influence the yield of the culture
processes, including (i) low performance and quality of the cultured
microorganism population or (ii) microbial contamination. For
these reasons, robustness is a valuable property for the considered
application context. In particular, a robust schedule will not collapse
immediately when a cell of microorganisms has to be thrown away
due to a microbial contamination. Indeed, a robust schedule should
change locally in small proportions and the overall performance
measure (i.e. makespan, lateness) should change a little if at all.
In this research work we formulated a constraint programming
optimization (COP) model for the robust planning of antibiotics
production. We developed a discrete-time model with a multi-criteria
objective, ordering the different criteria and performing a
lexicographic optimization. A feasible solution of the proposed
COP model is a schedule of a given set of tasks onto available
resources. The schedule has to satisfy tasks precedence constraints,
resource capacity constraints and time constraints. In particular
time constraints model tasks duedates and resource availability
time windows constraints. To improve the schedule robustness, we
modeled the concept of (a, b) super-solutions, where (a, b) are input
parameters of the COP model. An (a, b) super-solution is one in
which if a variables (i.e. the completion times of a culture tasks)
lose their values (i.e. cultures are contaminated), the solution can be
repaired by assigning these variables values with a new values (i.e.
the completion times of a backup culture tasks) and at most b other
variables (i.e. delaying the completion of at most b other tasks).
The efficiency and applicability of the proposed model is
demonstrated by solving instances taken from a real-life
pharmaceutical company. Computational results showed that
the determined super-solutions are near-optimal.
Abstract: This research presents the main ideas to implement an
intelligent system composed by communicating wireless sensors
measuring environmental data linked to drought indicators (such as
air temperature, soil moisture , etc...). On the other hand, the setting
up of a spatio temporal database communicating with a Web mapping
application for a monitoring in real time in activity 24:00 /day, 7
days/week is proposed to allow the screening of the drought
parameters time evolution and their extraction. Thus this system
helps detecting surfaces touched by the phenomenon of drought.
Spatio-temporal conceptual models seek to answer the users who
need to manage soil water content for irrigating or fertilizing or other
activities pursuing crop yield augmentation. Effectively, spatiotemporal
conceptual models enable users to obtain a diagram of
readable and easy data to apprehend. Based on socio-economic
information, it helps identifying people impacted by the phenomena
with the corresponding severity especially that this information is
accessible by farmers and stakeholders themselves. The study will be
applied in Siliana watershed Northern Tunisia.
Abstract: The influence of physicochemical water quality
parameters on the abundance and diversity of caddisfly larvae was
studied in seven sampling stations in Mae Tao and Mae Ku
watersheds, Mae Sot District, Tak Province, northern Thailand. The
streams: MK2 and MK8 as reference site, and impacted streams
(MT1-MT5) were sampled bi-monthly during July 2011 to May
2012. A total of 4,584 individual of caddisfly larvae belonging to 10
family and 17 genera were found. The larvae of family
Hydropsychidae were the most abundance, followed by
Philopotamidae, Odontoceridae, and Leptoceridae, respectively. The
genus Cheumatopsyche, Hydropsyche, and Chimarra were the most
abundance genera in this study. Results of CCA ordination showed
the total dissolved solids, sulfate, water temperature, dissolved
oxygen and pH were the most important physicochemical factors to
affect distribution of caddisflies communities. Changes in the
caddisfly fauna may indicate changes in physicochemical factors
owing to agricultural pollution, urbanization, or other human
activities. Results revealed that the order Trichoptera, identified to
species or genus, can be potentially used to assess environmental
water quality status in freshwater ecosystems.
Abstract: The composite flour blend consisting of corn, pearl
millet, black gram and wheat bran in the ratio of 80:5:10:5 was taken
to prepare the extruded product and their effect on physical properties
of extrudate was studied. The extrusion process was conducted in
laboratory by using twin screw extruder. The physical characteristics
evaluated include lateral expansion, bulk density, water absorption
index, water solubility index, and rehydration ratio and moisture
retention. The Central Composite Rotatable Design (CCRD) was
used to decide the level of processing variables i.e. feed moisture
content (%), screw speed (rpm), and barrel temperature (oC) for the
experiment. The data obtained after extrusion process were analyzed
by using response surface methodology. A second order polynomial
model for the dependent variables was established to fit the
experimental data. The numerical optimization studies resulted in
127°C of barrel temperature, 246 rpm of screw speed, and 14.5% of
feed moisture as optimum variables to produce acceptable extruded
product. The responses predicted by the software for the optimum
process condition resulted in lateral expansion 126%, bulk density
0.28 g/cm3, water absorption index 4.10 g/g, water solubility index
39.90%, rehydration ratio 544% and moisture retention 11.90% with
75% desirability.
Abstract: Public space is essential to strengthen the social and
urban fabric and the social cohesion; there lies the importance of its
study. Hence, the aim of this paper is to analyze the quality of public
space in the XXI century in both quantitative and qualitative terms. In
this article, the concept of public space includes open spaces such as
parks, public squares and walking areas. To make this analysis, we
take Mexico City as the case study. It has a population of nearly 9
million inhabitants and is composed of sixteen boroughs. For this
analysis, we consider both existing public spaces and the government
intervention for building and improving new and existent public
spaces. Results show that on the one hand, quantitatively there is not
an equitable distribution of public spaces due to both the growth of
the city itself as well as due to the absence of political will to create
public spaces. Another factor is the evolution of this city, which has
been growing merely in a “patched pattern”, where public space has
played no role at all with a total absence of urban design. On the
other hand, qualitatively, even the boroughs with the most public
spaces have not shown interest in making these spaces qualitatively
inclusive and open to the general population aiming for integration.
Therefore, urban projects that privatize public space seem to be the
rule, rather than a rehabilitation effort of the existent public spaces.
Hence, state intervention should reinforce its role as an agent of
social change acting in benefit of the majority of the inhabitants with
the promotion of more inclusive public spaces.
Abstract: In this communication, a low-cost circularly
polarized wire antenna exhibiting improved gain performance for
Dedicated Short Range Communications (DSRC), vehicle-to-vehicle
(V2V) and vehicle-to-infrastructure (V2I) communications is
presented. The proposed antenna comprises a Y-shaped quarterwavelength
monopole antenna surrounded by two iterations of eight
conductive arched walls acting as parasitic elements to enhance the
overall antenna gain and to shape the radiation pattern in the H-plane.
A hemispherical radome shell is added to protect the antenna
structure and its effect on the antenna performance is discussed. The
designed antenna demonstrates antenna gain of 8.2 dB with
omnidirectional far-field radiation pattern in the H-plane. The gain of
the proposed antenna is also compared with the characteristic of the
stand-alone Y-shaped monopole to highlight the advantages of the
proposed approach.
Abstract: This study analyzes the critical gaps in the
architecture of European stability and the expected role of the
banking union as the new important step towards completing the
Economic and Monetary Union that should enable the creation of
safe and sound financial sector for the euro area market. The single
rulebook together with the Single Supervisory Mechanism and the
Single Resolution Mechanism - as two main pillars of the banking
union, should provide a consistent application of common rules and
administrative standards for supervision, recovery and resolution of
banks – with the final aim of replacing the former bail-out practice
with the bail-in system through which possible future bank failures
would be resolved by their own funds, i.e. with minimal costs for
taxpayers and real economy. In this way, the vicious circle between
banks and sovereigns would be broken. It would also reduce the
financial fragmentation recorded in the years of crisis as the result of
divergent behaviors in risk premium, lending activities and interest
rates between the core and the periphery. In addition, it should
strengthen the effectiveness of monetary transmission channels, in
particular the credit channels and overflows of liquidity on the money
market which, due to the fragmentation of the common financial
market, has been significantly disabled in period of crisis. However,
contrary to all the positive expectations related to the future
functioning of the banking union, major findings of this study
indicate that characteristics of the economic system in which the
banking union will operate should not be ignored. The euro area is an
integration of strong and weak entities with large differences in
economic development, wealth, assets of banking systems, growth
rates and accountability of fiscal policy. The analysis indicates that
low and unbalanced economic growth remains a challenge for the
maintenance of financial stability and this problem cannot be
resolved just by a single supervision. In many countries bank assets
exceed their GDP by several times and large banks are still a matter
of concern, because of their systemic importance for individual
countries and the euro zone as a whole. The creation of the Single
Supervisory Mechanism and the Single Resolution Mechanism is a
response to the European crisis, which has particularly affected
peripheral countries and caused the associated loop between the
banking crisis and the sovereign debt crisis, but has also influenced
banks’ balance sheets in the core countries, as the result of crossborder
capital flows. The creation of the SSM and the SRM should
prevent the similar episodes to happen again and should also provide
a new opportunity for strengthening of economic and financial
systems of the peripheral countries. On the other hand, there is a
potential threat that future focus of the ECB, resolution mechanism
and other relevant institutions will be extremely oriented towards
large and significant banks (whereby one half of them operate in the
core and most important euro area countries), and therefore it remains
questionable to what extent will the common resolution funds will be used for rescue of less important institutions. Recent geopolitical
developments will be the optimal indicator to show whether the
previously established mechanisms are sufficient enough to maintain
the adequate financial stability in the euro area market.
Abstract: The purpose of this study is the discrimination of 28
postmenopausal with osteoporotic femoral fractures from an agematched
control group of 28 women using texture analysis based on
fractals. Two pre-processing approaches are applied on radiographic
images; these techniques are compared to highlight the choice of the
pre-processing method. Furthermore, the values of the fractal
dimension are compared to those of the fractal signature in terms of
the classification of the two populations. In a second analysis, the
BMD measure at proximal femur was compared to the fractal
analysis, the latter, which is a non-invasive technique, allowed a
better discrimination; the results confirm that the fractal analysis of
texture on calcaneus radiographs is able to discriminate osteoporotic
patients with femoral fracture from controls. This discrimination was
efficient compared to that obtained by BMD alone. It was also
present in comparing subgroups with overlapping values of BMD.
Abstract: A lower consumption of thermal energy will
contribute not only to a reduction in the running costs, but also in the
reduction of pollutant emissions that contribute to the greenhouse
effect. Cogeneration or CHP (Combined Heat and Power) is the
system that produces power and usable heat simultaneously by
decreasing the pollutant emissions and increasing the efficiency.
Combined production of mechanical or electrical and thermal energy
using a simple energy source, such as oil, coal, natural or liquefied
gas, biomass or the sun; affords remarkable energy savings and
frequently makes it possible to operate with greater efficiency when
compared to a system producing heat and power separately. This
study aims to bring out the contributions of cogeneration systems to
the environment and sustainability by saving the energy and reducing
the emissions. In this way we made a comprehensive investigation in
the literature by focusing on the environmental aspects of the
cogeneration systems. In the light of these studies we reached that,
cogeneration systems must be consider in sustainability and their
benefits on protecting the ecology must be investigated.
Abstract: Workflow scheduling is an important part of cloud
computing and based on different criteria it decides cost, execution
time, and performances. A cloud workflow system is a platform
service facilitating automation of distributed applications based on
new cloud infrastructure. An aspect which differentiates cloud
workflow system from others is market-oriented business model, an
innovation which challenges conventional workflow scheduling
strategies. Time and Cost optimization algorithm for scheduling
Hybrid Clouds (TCHC) algorithm decides which resource should be
chartered from public providers is combined with a new De-De
algorithm considering that every instance of single and multiple
workflows work without deadlocks. To offset this, two new concepts
- De-De Dodging Algorithm and Priority Based Decisive Algorithm -
combine with conventional deadlock avoidance issues by proposing
one algorithm that maximizes active (not just allocated) resource use
and reduces Makespan.
Abstract: Based on application requirements, nodes are static or
mobile in Wireless Sensor Networks (WSNs). Mobility poses
challenges in protocol design, especially at the link layer requiring
mobility adaptation algorithms to localize mobile nodes and predict
link quality to be established with them. This study implements
XMAC and Berkeley Media Access Control (BMAC) routing
protocols to evaluate performance under WSN’s static and mobility
conditions. This paper gives a comparative study of mobility-aware
MAC protocols. Routing protocol performance, based on Average
End to End Delay, Average Packet Delivery Ratio, Average Number
of hops, and Jitter is evaluated.
Abstract: Cross-linked konjac glucomannan and kappa
carrageenan film were prepared by chemical crosslinking using
glutaraldehyde (GA) as the crosslinking agent. The effect
crosslinking on the swelling degree was investigated. Konjac
glucomannan and its mixture with kappa carrageenan film was
immersed in GA solution and then thermally cured. The obtained
cross-linked film was washed and soaked in the ethanol to remove
the unreacted GA. The obtained film was air dried at room
temperature to a constant weight. The infrared spectra and the value
of swelling degree of obtained crosslinked film showed that
glucomannan and kappa carrageenan was able to be cross-linked
using glutaraldehyde by film immersion and curing method without
catalyst. The cross-linked films were found to be pH sensitive,
indicating a potential to be used in drug delivery polymer system.
Abstract: A Rice Sheller is used for obtaining polished white
rice from paddy. There are about 3000 Rice Shellers in Punjab and
50000 in India. During the process of shelling lot of dust is emitted
from different unit operations like paddy silo, paddy shaker, bucket
elevators, huskers, paddy separator etc. These dust emissions have
adverse effect on the health of the workers and the wear and tear of
the shelling machinery is fast. All the dust emissions spewing out of
these unit operations of a rice Sheller were contained by providing
suitable hoods and enclosures while ensuring their workability. These
were sucked by providing an induced draft fan followed by a high
efficiency cyclone separator that has got an overall dust collection
efficiency of more than 90%. This cyclone separator replaced two
cyclone separators and a filter bag house, which the Rice Sheller was
already having. The dust concentration in the stack after the
installation of cyclone separator is well within the stipulated
standards. Besides controlling pollution, there is improvement in the
quality of products like bran and the life of shelling machinery has
enhanced. The payback period of this technology is less than four
shelling months.
Abstract: The output error of the globoidal cam mechanism can
be considered as a relevant indicator of mechanism performance,
because it determines kinematic and dynamical behavior of
mechanical transmission. Based on the differential geometry and the
rigid body transformations, the mathematical model of surface
geometry of the globoidal cam is established. Then we present the
analytical expression of the output error (including the transmission
error and the displacement error along the output axis) by considering
different manufacture and assembly errors. The effects of the center
distance error, the perpendicular error between input and output axes
and the rotational angle error of the globoidal cam on the output error
are systematically analyzed. A globoidal cam mechanism which is
widely used in automatic tool changer of CNC machines is applied for
illustration. Our results show that the perpendicular error and the
rotational angle error have little effects on the transmission error but
have great effects on the displacement error along the output axis. This
study plays an important role in the design, manufacture and assembly
of the globoidal cam mechanism.
Abstract: Ceramic Waste Aggregates (CWAs) were made from
electric porcelain insulator wastes supplied from an electric power
company, which were crushed and ground to fine aggregate sizes. In
this study, to develop the CWA mortar as an eco–efficient, ground
granulated blast–furnace slag (GGBS) as a Supplementary
Cementitious Material (SCM) was incorporated. The water–to–binder
ratio (W/B) of the CWA mortars was varied at 0.4, 0.5, and 0.6. The
cement of the CWA mortar was replaced by GGBS at 20 and 40% by
volume (at about 18 and 37% by weight). Mechanical properties of
compressive and splitting tensile strengths, and elastic modulus were
evaluated at the age of 7, 28, and 91 days. Moreover, the chloride
ingress test was carried out on the CWA mortars in a 5.0% NaCl
solution for 48 weeks. The chloride diffusion was assessed by using an
electron probe microanalysis (EPMA). To consider the relation of the
apparent chloride diffusion coefficient and the pore size, the pore size
distribution test was also performed using a mercury intrusion
porosimetry at the same time with the EPMA. The compressive
strength of the CWA mortars with the GGBS was higher than that
without the GGBS at the age of 28 and 91 days. The resistance to the
chloride ingress of the CWA mortar was effective in proportion to the
GGBS replacement level.