Abstract: The biomarker for colorectal cancer (CRC) is CEACAM-6 antigen (C6AG). Therefore, this study aims to develop a novel, simple and low-cost CEACAM-6 antigen immumosensor (C6AG-IMS), based on electrical impedance measurement, for precise determination of C6AG. A low-cost screen-printed graphite electrode was constructed and used as the sensor, with CEACAM-6 antibody (C6AB) immobilized on it. The procedures of sensor fabrication and antibody immobilization are simple and low-cost. Measurement of the electrical impedance at a definite frequency ranges (0.43 – 1.26 MHz) showed that the C6AG-IMS has an excellent linear (r2>0.9) response range (8.125 – 65 pg/mL), covering the normal physiological and pathological ranges of blood C6AG levels. Also, the C6AG-IMS has excellent reliability and validity, with the intraclass correlation coefficient being 0.97. In conclusion, a novel, simple, low-cost and reliable C6AG-IMS was designed and developed, being able to accurately determine blood C6AG levels in the range of pathological and normal physiological regions. The C6AG-IMS can provide a point-of-care and immediate screening results to the user at home.
Abstract: Sickness absence represents a major economic and
social issue. Analysis of sick leave data is a recurrent challenge to analysts because of the complexity of the data structure which is
often time dependent, highly skewed and clumped at zero. Ignoring these features to make statistical inference is likely to be inefficient
and misguided. Traditional approaches do not address these problems. In this study, we discuss model methodologies in terms of statistical techniques for addressing the difficulties with sick leave data. We also introduce and demonstrate a new method by performing a longitudinal assessment of long-term absenteeism using
a large registration dataset as a working example available from the Helsinki Health Study for municipal employees from Finland during the period of 1990-1999. We present a comparative study on model
selection and a critical analysis of the temporal trends, the occurrence
and degree of long-term sickness absences among municipal employees. The strengths of this working example include the large
sample size over a long follow-up period providing strong evidence in supporting of the new model. Our main goal is to propose a way to
select an appropriate model and to introduce a new methodology for analysing sickness absence data as well as to demonstrate model
applicability to complicated longitudinal data.
Abstract: Text categorization (the assignment of texts in natural language into predefined categories) is an important and extensively studied problem in Machine Learning. Currently, popular techniques developed to deal with this task include many preprocessing and learning algorithms, many of which in turn require tuning nontrivial internal parameters. Although partial studies are available, many authors fail to report values of the parameters they use in their experiments, or reasons why these values were used instead of others. The goal of this work then is to create a more thorough comparison of preprocessing parameters and their mutual influence, and report interesting observations and results.
Abstract: This paper describes a computer-aided design for
design of the concave globoidal cam with cylindrical rollers and
swinging follower. Four models with different modeling methods are
made from the same input data. The input data are angular input and
output displacements of the cam and the follower and some other
geometrical parameters of the globoidal cam mechanism. The best
cam model is the cam which has no interference with the rollers
when their motions are simulated in assembly conditions. The
angular output displacement of the follower for the best cam is also
compared with that of in the input data to check errors. In this study,
Pro/ENGINEER® Wildfire 2.0 is used for modeling the cam,
simulating motions and checking interference and errors of the
system.
Abstract: A novel thermo-sensitive superabsorbent hydrogel
with salt- and pH-responsiveness properties was obtained by grafting
of mixtures of acrylic acid (AA) and N-isopropylacrylamide
(NIPAM) monomers onto kappa-carrageenan, kC, using ammonium
persulfate (APS) as a free radical initiator in the presence of
methylene bisacrylamide (MBA) as a crosslinker. Infrared
spectroscopy was carried out to confirm the chemical structure of the
hydrogel. Moreover, morphology of the samples was examined by
scanning electron microscopy (SEM). The effect of MBA
concentration and AA/NIPAM weight ratio on the water absorbency
capacity has been investigated. The swelling variations of hydrogels
were explained according to swelling theory based on the hydrogel
chemical structure. The hydrogels exhibited salt-sensitivity and
cation exchange properties. The temperature- and pH-reversibility
properties of the hydrogels make the intelligent polymers as good
candidates for considering as potential carriers for bioactive agents,
e.g. drugs.
Abstract: This paper proposes a smart design strategy for a sequential detector to reliably detect the primary user-s signal, especially in fast fading environments. We study the computation of the log-likelihood ratio for coping with a fast changing received signal and noise sample variances, which are considered random variables. First, we analyze the detectability of the conventional generalized log-likelihood ratio (GLLR) scheme when considering fast changing statistics of unknown parameters caused by fast fading effects. Secondly, we propose an efficient sensing algorithm for performing the sequential probability ratio test in a robust and efficient manner when the channel statistics are unknown. Finally, the proposed scheme is compared to the conventional method with simulation results with respect to the average number of samples required to reach a detection decision.
Abstract: Rule Discovery is an important technique for mining knowledge from large databases. Use of objective measures for discovering interesting rules lead to another data mining problem, although of reduced complexity. Data mining researchers have studied subjective measures of interestingness to reduce the volume of discovered rules to ultimately improve the overall efficiency of KDD process. In this paper we study novelty of the discovered rules as a subjective measure of interestingness. We propose a hybrid approach that uses objective and subjective measures to quantify novelty of the discovered rules in terms of their deviations from the known rules. We analyze the types of deviation that can arise between two rules and categorize the discovered rules according to the user specified threshold. We implement the proposed framework and experiment with some public datasets. The experimental results are quite promising.
Abstract: Metal stamping die design is a complex, experiencebased
and time-consuming task. Various artificial intelligence (AI)
techniques are being used by worldwide researchers for stamping die
design to reduce complexity, dependence on human expertise and
time taken in design process as well as to improve design efficiency.
In this paper a comprehensive review of applications of AI
techniques in manufacturability evaluation of sheet metal parts, die
design and process planning of metal stamping die is presented.
Further the salient features of major research work published in the
area of metal stamping are presented in tabular form and scope of
future research work is identified.
Abstract: In the present study, fracture behavior of woven
fabric-reinforced glass/epoxy composite laminates under mode III
crack growth was experimentally investigated and numerically
modeled. Two methods were used for the calculation of the strain
energy release rate: the experimental compliance calibration (CC)
method and the Virtual Crack Closure Technique (VCCT). To
achieve this aim ECT (Edge Crack Torsion) was used to evaluate
fracture toughness in mode III loading (out of plane-shear) at
different crack lengths. Load–displacement and associated energy
release rates were obtained for various case of interest. To
calculate fracture toughness JIII, two criteria were considered
including non-linearity and maximum points in load-displacement
curve and it is observed that JIII increases with the crack length
increase. Both the experimental compliance method and the virtual
crack closure technique proved applicable for the interpretation of the
fracture mechanics data of woven glass/epoxy laminates in mode III.
Abstract: In Peer-to-Peer service networks, where peers offer any kind of publicly available services or applications, intuitive navigation through all services in the network becomes more difficult as the number of services increases. In this article, a concept is discussed that enables users to intuitively browse and use large scale P2P service networks. The concept extends the idea of creating virtual 3D-environments solely based on Peer-to-Peer technologies. Aside from browsing, users shall have the possibility to emphasize services of interest using their own semantic criteria. The appearance of the virtual world shall intuitively reflect network properties that may be of interest for the user. Additionally, the concept comprises options for load- and traffic-balancing. In this article, the requirements concerning the underlying infrastructure and the graphical user interface are defined. First impressions of the appearance of future systems are presented and the next steps towards a prototypical implementation are discussed.
Abstract: A Wireless sensor network (WSN) consists of a set of battery-powered nodes, which collaborate to perform sensing tasks in a given environment. Each node in WSN should be capable to act for long periods of time with scrimpy or no external management. One requirement for this independent is: in the presence of adverse positions, the sensor nodes must be capable to configure themselves. Hence, the nodes for determine the existence of unusual events in their surroundings should make use of position awareness mechanisms. This work approaches the problem by considering the possible unusual events as diseases, thus making it possible to diagnose them through their symptoms, namely, their side effects. Considering these awareness mechanisms as a foundation for highlevel monitoring services, this paper also shows how these mechanisms are included in the primal plan of an intrusion detection system.
Abstract: A large number of chemical, bio-chemical and pollution-control processes use heterogeneous fixed-bed reactors. The use of finite hollow cylindrical catalyst pellets can enhance conversion levels in such reactors. The absence of the pellet core can significantly lower the diffusional resistance associated with the solid phase. This leads to a better utilization of the catalytic material, which is reflected in the higher values for the effectiveness factor, leading ultimately to an enhanced conversion level in the reactor. It is however important to develop a rigorous heterogeneous model for the reactor incorporating the two-dimensional feature of the solid phase owing to the presence of the finite hollow cylindrical catalyst pellet. Presently, heterogeneous models reported in the literature invariably employ one-dimension solid phase models meant for spherical catalyst pellets. The objective of the paper is to present a rigorous model of the fixed-bed reactors containing finite hollow cylindrical catalyst pellets. The reaction kinetics considered here is the widely used Michaelis–Menten kinetics for the liquid-phase bio-chemical reactions. The reaction parameters used here are for the enzymatic degradation of urea. Results indicate that increasing the height to diameter ratio helps to improve the conversion level. On the other hand, decreasing the thickness is apparently not as effective. This could however be explained in terms of the higher void fraction of the bed that causes a smaller amount of the solid phase to be packed in the fixed-bed bio-chemical reactor.
Abstract: The trial in the city, located 170 kilometers from the
Iranian city of Ahvaz was Omidiyeh. The main factor in this project
includes 4 levels in control (without hormones), use of hormones in
the seed, vegetative and flowering stage respectively. And sub-plots
included 3 varieties of vetch in three levels, with local names, was the
jewel in the study of light and Auxin in the vegetative and
reproductive different times in different varieties of vetch was
investigated. This test has been taken in the plots in a randomized
complete block with four replications. In order to study the effects of
the hormone Auxin in the growth stages (seed, vegetative and
flowering) to control (no hormone Auxin) on three local varieties of
vetch, the essence of light and plant height, number of pods per plant,
seed number The pods, seeds per plant, grain weight, grain yield,
plant dry weight and protein content were measured. Among the
vetch varieties for plant height, number of pods per plant, a seed per
plant, grain weight, grain yield, and plant dry weight and protein
levels of 1 percent of plant and seed number per pod per plant at 5%
level of There was no significant difference. Interactions for grain
yield per plant, grain yield and protein levels of 1 percent and the
number of seeds per pod and seed weight are significant differences
in levels 5 and plant height and plant dry weight of the interaction
were INFLUENCE There was no significant difference in them.
Abstract: Resins are used in nuclear power plants for water
ultrapurification. Two approaches are considered in this work:
column experiments and simulations. A software called OPTIPUR
was developed, tested and used. The approach simulates the onedimensional
reactive transport in porous medium with convectivedispersive
transport between particles and diffusive transport within
the boundary layer around the particles. The transfer limitation in the
boundary layer is characterized by the mass transfer coefficient
(MTC). The influences on MTC were measured experimentally. The
variation of the inlet concentration does not influence the MTC; on
the contrary of the Darcy velocity which influences. This is consistent
with results obtained using the correlation of Dwivedi&Upadhyay.
With the MTC, knowing the number of exchange site and the relative
affinity, OPTIPUR can simulate the column outlet concentration
versus time. Then, the duration of use of resins can be predicted in
conditions of a binary exchange.
Abstract: In this paper, an estimation accuracy of multiple moving
talker tracking using a microphone array is improved. The tracking
can be achieved by the adaptive method in which two algorithms are integrated, namely, the PAST (Projection Approximation Subspace
Tracking) algorithm and the IPLS (Interior Point Least Square) algorithm. When either talker begins to speak again after a silent
period, an appropriate feasible region for an evaluation function of
the IPLS algorithm might not be set. Then, the tracking fails due to the incorrect updating. Therefore, if an increment of the number of
active talkers is detected, the feasible region must be reset. Then, a low cost realization is required for the high speed tracking and a high
accuracy realization is desired for the precise tracking. In this paper,
the directions roughly estimated using the delayed-sum-array method
are used for the resetting. Several results of experiments performed in
an actual room environment show the effectiveness of the proposed method.
Abstract: Since the one-to-one word translator does not have the
facility to translate pragmatic aspects of Javanese, the parallel text
alignment model described uses a phrase pair combination. The
algorithm aligns the parallel text automatically from the beginning to
the end of each sentence. Even though the results of the phrase pair
combination outperform the previous algorithm, it is still inefficient.
Recording all possible combinations consume more space in the
database and time consuming. The original algorithm is modified by
applying the edit distance coefficient to improve the data-storage
efficiency. As a result, the data-storage consumption is 90% reduced
as well as its learning period (42s).
Abstract: Traditionally, terror groups have been formed by ideologically aligned actors who perceive a lack of options for achieving political or social change. However, terrorist attacks have been increasingly carried out by small groups of actors or lone individuals who may be only ideologically affiliated with larger, formal terrorist organizations. The formation of these groups represents the inverse of traditional organizational growth, whereby structural de-evolution within issue-based organizations leads to the formation of small, independent terror cells. Ideological franchising – the bypassing of formal affiliation to the “parent" organization – represents the de-evolution of traditional concepts of organizational structure in favor of an organic, independent, and focused unit. Traditional definitions of dark networks that are issue-based include focus on an identified goal, commitment to achieving this goal through unrestrained actions, and selection of symbolic targets. The next step in the de-evolution of small dark networks is the miniorganization, consisting of only a handful of actors working toward a common, violent goal. Information-sharing through social media platforms, coupled with civil liberties of democratic nations, provide the communication systems, access to information, and freedom of movement necessary for small dark networks to flourish without the aid of a parent organization. As attacks such as the 7/7 bombings demonstrate the effectiveness of small dark networks, terrorist actors will feel increasingly comfortable aligning with an ideology only, without formally organizing. The natural result of this de-evolving organization is the single actor event, where an individual seems to subscribe to a larger organization-s violent ideology with little or no formal ties.
Abstract: Software reliability prediction gives a great opportunity to measure the software failure rate at any point throughout system test. A software reliability prediction model provides with the technique for improving reliability. Software reliability is very important factor for estimating overall system reliability, which depends on the individual component reliabilities. It differs from hardware reliability in that it reflects the design perfection. Main reason of software reliability problems is high complexity of software. Various approaches can be used to improve the reliability of software. We focus on software reliability model in this article, assuming that there is a time redundancy, the value of which (the number of repeated transmission of basic blocks) can be an optimization parameter. We consider given mathematical model in the assumption that in the system may occur not only irreversible failures, but also a failure that can be taken as self-repairing failures that significantly affect the reliability and accuracy of information transfer. Main task of the given paper is to find a time distribution function (DF) of instructions sequence transmission, which consists of random number of basic blocks. We consider the system software unreliable; the time between adjacent failures has exponential distribution.
Abstract: The world economic crises and budget constraints
have caused authorities, especially those in developing countries, to
rationalize water quality monitoring activities. Rationalization
consists of reducing the number of monitoring sites, the number of
samples, and/or the number of water quality variables measured. The
reduction in water quality variables is usually based on correlation. If
two variables exhibit high correlation, it is an indication that some of
the information produced may be redundant. Consequently, one
variable can be discontinued, and the other continues to be measured.
Later, the ordinary least squares (OLS) regression technique is
employed to reconstitute information about discontinued variable by
using the continuously measured one as an explanatory variable. In
this paper, two record extension techniques are employed to
reconstitute information about discontinued water quality variables,
the OLS and the Line of Organic Correlation (LOC). An empirical
experiment is conducted using water quality records from the Nile
Delta water quality monitoring network in Egypt. The record
extension techniques are compared for their ability to predict
different statistical parameters of the discontinued variables. Results
show that the OLS is better at estimating individual water quality
records. However, results indicate an underestimation of the variance
in the extended records. The LOC technique is superior in preserving
characteristics of the entire distribution and avoids underestimation
of the variance. It is concluded from this study that the OLS can be
used for the substitution of missing values, while LOC is preferable
for inferring statements about the probability distribution.
Abstract: Complex networks have been intensively studied across
many fields, especially in Internet technology, biological engineering,
and nonlinear science. Software is built up out of many interacting
components at various levels of granularity, such as functions, classes,
and packages, representing another important class of complex networks.
It can also be studied using complex network theory. Over the
last decade, many papers on the interdisciplinary research between
software engineering and complex networks have been published.
It provides a different dimension to our understanding of software
and also is very useful for the design and development of software
systems. This paper will explore how to use the complex network
theory to analyze software structure, and briefly review the main
advances in corresponding aspects.