Abstract: Oxidative stress makes up common incidents in
eukaryotic metabolism. The presence of diverse components
disturbing the equilibrium during oxygen metabolism increases
oxidative damage unspecifically in living cells. Body´s own
ubiquinone (Q10) seems to be a promising drug in defending the
heightened appearance of reactive oxygen species (ROS). Though, its
lipophilic properties require a new strategy in drug formulation to
overcome their low bioavailability. Consequently, the manufacture of
heterogeneous nanodispersions is in focus for medical applications.
The composition of conventional nanodispersions is made up of a
drug-consisting core and a surfactive agent, also named as surfactant.
Long-termed encapsulation of the surfactive components into tissues
might be the consequence of the use during medical therapeutics. The
potential of provoking side-effects is given by their nonbiodegradable
properties. Further improvements during fabrication
process use the incorporation of biodegradable components such as
modified γ-polyglutamic acid which decreases the potential of
prospective side-effects.
Abstract: Logistics is part of the supply chain processes that
plans, implements, and controls the efficient and effective forward
and reverse flow and storage of goods, services, and related
information between the point of origin and the point of consumption
in order to meet customer requirements. This research aims to
investigate the current status and future direction of the use of
Information Technology (IT) for logistics, focusing on Supply Chain
Management (SCM) and E-Commerce adoption in Malaysia.
Therefore, this research stresses on the type of technology being
adopted, factors, benefits and barriers affecting the innovation in
SCM and E-Commerce technology adoption among Logistics
Service Providers (LSP). A mailed questionnaire survey was
conducted to collect data from 265 logistics companies in Johor. The
research revealed a high level of SCM technology adoption among
LSP as they had adopted SCM technology in various business
processes while they perceived a high level of benefits from SCM
adoption.
Abstract: The mechanical behavior of porous media is governed by the interaction between its solid skeleton and the fluid existing inside its pores. The interaction occurs through the interface of gains and fluid. The traditional analysis methods of porous media, based on the effective stress and Darcy's law, are unable to account for these interactions. For an accurate analysis, the porous media is represented in a fluid-filled porous solid on the basis of the Biot theory of wave propagation in poroelastic media. In Biot formulation, the equations of motion of the soil mixture are coupled with the global mass balance equations to describe the realistic behavior of porous media. Because of irregular geometry, the domain is generally treated as an assemblage of fmite elements. In this investigation, the numerical formulation for the field equations governing the dynamic response of fluid-saturated porous media is analyzed and employed for the study of transient wave motion. A finite element model is developed and implemented into a computer code called DYNAPM for dynamic analysis of porous media. The weighted residual method with 8-node elements is used for developing of a finite element model and the analysis is carried out in the time domain considering the dynamic excitation and gravity loading. Newmark time integration scheme is developed to solve the time-discretized equations which are an unconditionally stable implicit method Finally, some numerical examples are presented to show the accuracy and capability of developed model for a wide variety of behaviors of porous media.
Abstract: Rice seed expression (cDNA) library in the Lambda
Zap 11® phage constructed from the developing grain 10-20 days
after flowering was transformed into yeast for functional
complementation assays in three salt sensitive yeast mutants S.
cerevisiae strain CY162, G19 and Axt3K. Transformed cells of G19
and Axt3K with pYES vector with cDNA inserts showed enhance
tolerance than those with empty pYes vector. Sequencing of the
cDNA inserts revealed that they encode for the putative proteins with
the sequence homologous to rice putative protein PROLM24
(Os06g31070), a prolamin precursor. Expression of this cDNA did
not affect yeast growth in absence of salt. Axt3k and G19 strains
expressing the PROLM24 were able to grow upto 400 mM and 600
mM of NaCl respectively. Similarly, Axt3k mutant with PROLM24
expression showed comparatively higher growth rate in the medium
with excess LiCl (50 mM). The observation that expression of
PROLM24 rescued the salt sensitive phenotypes of G19 and Axt3k
indicates the existence of a regulatory system that ameliorates the
effect of salt stress in the transformed yeast mutants. However, the
exact function of the cDNA sequence, which shows partial sequence
homology to yeast UTR1 is not clear. Although UTR1 involved in
ferrous uptake and iron homeostasis in yeast cells, there is no
evidence to prove its role in Na+ homeostasis in yeast cells. Absence
of transmembrane regions in Os06g31070 protein indicates that salt
tolerance is achieved not through the direct functional
complementation of the mutant genes but through an alternative
mechanism.
Abstract: This study has investigated the antidiabetic and
antioxidant potential of Pseudovaria macrophylla bark extract on
streptozotocin–nicotinamide induced type 2 diabetic rats. LCMSQTOF
and NMR experiments were done to determine the chemical
composition in the methanolic bark extract. For in vivo experiments,
the STZ (60 mg/kg/b.w, 15 min after 120 mg/kg/1 nicotinamide, i.p.)
induced diabetic rats were treated with methanolic extract of
Pseuduvaria macrophylla (200 and 400 mg/kg·bw) and
glibenclamide (2.5 mg/kg) as positive control respectively.
Biochemical parameters were assayed in the blood samples of all
groups of rats. The pro-inflammatory cytokines, antioxidant status
and plasma transforming growth factor βeta-1 (TGF-β1) were
evaluated. The histological study of the pancreas was examined and
its expression level of insulin was observed by
immunohistochemistry. In addition, the expression of glucose
transporters (GLUT 1, 2 and 4) were assessed in pancreas tissue by
western blot analysis. The outcomes of the study displayed that the
bark methanol extract of Pseuduvaria macrophylla has potentially
normalized the elevated blood glucose levels and improved serum
insulin and C-peptide levels with significant increase in the
antioxidant enzyme, reduced glutathione (GSH) and decrease in the
level of lipid peroxidation (LPO). Additionally, the extract has
markedly decreased the levels of serum pro-inflammatory cytokines
and transforming growth factor beta-1 (TGF-β1). Histopathology
analysis demonstrated that Pseuduvaria macrophylla has the
potential to protect the pancreas of diabetic rats against peroxidation
damage by downregulating oxidative stress and elevated
hyperglycaemia. Furthermore, the expression of insulin protein,
GLUT-1, GLUT-2 and GLUT-4 in pancreatic cells was enhanced.
The findings of this study support the anti-diabetic claims of
Pseudovaria macrophylla bark.
Abstract: This work aims to investigate a potential of
microalgae for utilizing industrial wastewater as a cheap nutrient for
their growth and oil accumulation. Wastewater was collected from
the effluent ponds of agro-industrial factories (cassava and ethanol
production plants). Only 2 microalgal strains were isolated and
identified as Scenedesmus quadricauda and Chlorella sp.. However,
only S. quadricauda was selected to cultivate in various wastewater
concentrations (10%, 20%, 40%, 60%, 80% and 100%). The highest
biomass obtained at 6.6×106 and 6.27×106 cells/ml when 60%
wastewater was used in flask and photo-bioreactor. The cultures gave
the highest lipid content at 18.58 % and 42.86% in cases of S.
quadricauda and S. obliquus. In addition, under salt stress (1.0 M
NaCl), S. obliquus demonstrated the highest lipid content at 50%
which was much more than the case of no NaCl adding. However, the
concentration of NaCl does not affect on lipid accumulation in case
of S. quadricauda.
Abstract: The intention of this study to design the probability optimized sewing sack-s workstation based on ergonomics for productivity improvement and decreasing musculoskeletal disorders. The physical dimensions of two workers were using to design the new workstation. The physical dimensions are (1) sitting height, (2) mid shoulder height sitting, (3) shoulder breadth, (4) knee height, (5) popliteal height, (6) hip breadth and (7) buttock-knee length. The 5th percentile of buttock knee length sitting (51 cm), the 50th percentile of mid shoulder height sitting (62 cm) and the 95th percentile of popliteal height (43 cm) and hip breadth (45 cm) applied to design the workstation for sewing sack-s operator and the others used to adjust the components of this workstation. The risk assessment by RULA before and after using the probability optimized workstation were 7 and 7 scores and REBA scores were 11 and 5, respectively. Body discomfort-abnormal index was used to assess muscle fatigue of operators before adjustment workstation found that neck muscles, arm muscles area, muscles on the back and the lower back muscles fatigue. Therefore, the extension and flexion exercise was applied to relief musculoskeletal stresses. The workers exercised 15 minutes before the beginning and the end of work for 5 days. After that, the capability of flexion and extension muscles- workers were increasing in 3 muscles (arm, leg, and back muscles).
Abstract: Plastics occupy wide place in the applications of
automotive, electronics and house goods. Especially reinforced
plastics become popular because of their high strength besides their
advantages of low weight and easy manufacturability. In this study,
mechanical and morphological properties of polypropylene (PP) and
high density polyethylene (HDPE) matrix composites reinforced with
surface modified nano titan dioxide (TiO2) particles were
investigated. Surface modification was made by coating the nano
powders with maleic anhydride grafted styrene ethylene butylene
styrene (SEBS-g-MA) and silane, respectively. After surface
modification, PP/TiO2 and HDPE/TiO2 composites were obtained by
using twin screw extruder at titan dioxide loading of 1 wt.%, 3 wt.%
and 5 wt.%. Effects of surface modification were determined by
thermal and morphological analysis. SEBS-g-MA provided bridging
effect between TiO2 particles and polymer matrix while silane was
effective as a dispersant. Depending on that, homogenous structures
without agglomeration were obtained. Mechanical tests were
performed on the injection moldings of the composites for obtaining
the impact strength, tensile strength, stress at break, elongation and
elastic modulus. Reinforced HDPE and PP moldings gave higher
tensile strength and elastic modulus due to the rigid structure of TiO2.
Slight increment was seen in stress at break. Elongation and impact
strength decreased due to the stiffness of the nano titan dioxide.
Abstract: In this study the elastic-plastic stress distribution in
weld-bonded joint, fabricated from austenitic stainless steel (AISI
304) sheet of 1.00 mm thickness and Epoxy adhesive Araldite 2011,
subjected to axial loading is investigated. This is needed to improve
design procedures and welding codes, and saving efforts in the
cumbersome experiments and analysis. Therefore, a complete 3-D
finite element modelling and analysis of spot welded, bonded and
weld-bonded joints under axial loading conditions is carried out. A
comprehensive systematic experimental program is conducted to
determine many properties and quantities, of the base metals and the
adhesive, needed for FE modelling, such like the elastic – plastic
properties, modulus of elasticity, fracture limit, the nugget and heat
affected zones (HAZ) properties, etc. Consequently, the finite
element models developed, for each case, are used to evaluate
stresses distributions across the entire joint, in both the elastic and
plastic regions. The stress distribution curves are obtained,
particularly in the elastic regions and found to be consistent and in
excellent agreement with the published data. Furthermore, the
stresses distributions are obtained in the weld-bonded joint and
display the best results with almost uniform smooth distribution
compared to spot and bonded cases. The stress concentration peaks at
the edges of the weld-bonded region, are almost eliminated resulting
in achieving the strongest joint of all processes.
Abstract: Inventory decisional environment of short life-cycle
products is full of uncertainties arising from randomness and
fuzziness of input parameters like customer demand requiring
modeling under hybrid uncertainty. Prior inventory models
incorporating fuzzy demand have unfortunately ignored stochastic
variation of demand. This paper determines an unambiguous optimal
order quantity from a set of n fuzzy observations in a newsvendor
inventory setting in presence of fuzzy random variable demand
capturing both fuzzy perception and randomness of customer
demand. The stress of this paper is in providing solution procedure
that attains optimality in two steps with demand information
availability in linguistic phrases leading to fuzziness along with
stochastic variation. The first step of solution procedure identifies
and prefers one best fuzzy opinion out of all expert opinions and the
second step determines optimal order quantity from the selected
event that maximizes profit. The model and solution procedure is
illustrated with a numerical example.
Abstract: At present, the tendency to implement the conditionbased
maintenance (CBM), which allows the optimization of the
expenses for equipment monitoring, is more and more evident; also,
the transformer substations with remote monitoring are increasingly
used. This paper reviews all the advantages of the on-line monitoring
and presents an equipment for on-line monitoring of bushings, which
is the own contribution of specialists who are the authors of this
paper. The paper presents a study of the temperature field, using the
finite element method. For carrying out this study, the 3D modelling
of the above mentioned bushing was performed. The analysis study is
done taking into account the extreme thermal stresses, focusing at the
level of the first cooling wing section of the ceramic insulator. This
fact enables to justify the tanδ variation in time, depending on the
transformer loading and the environmental conditions. With a view
to reducing the variation of dielectric losses in bushing insulation, the
use of ferrofuids instead of mineral oils is proposed.
Abstract: Nurses in an Armed Force Hospital (AFH) expose to stronger stress than those in a civil hospital, especially in an emergency department (ED). Ironically, stresses of these nurses received few if any attention in academic research in the past. This study collects 227 samples from the emergency departments of four armed force hospitals in central and southern Taiwan. The research indicates that the top five stressors are a massive casualty event, delayed physician support, overloads of routine work, overloads of assignments, and annoying paper work. Excessive work loading was found to be the primary source of stress. Nurses who were perceived to have greater stress levels were more inclined to deploy emotion-oriented approaches and more likely to seek job rotations. Professional stressors and problem-oriented approaches were positively correlated. Unlike other local studies, this study concludes that the excessive work-loading is more stressful in an AFH.
Abstract: This study deals with the phenomena of reflection and transmission (refraction) of qSV-waves, for an incident of quasi transverse vertically waves, at a plane interface of two semi-infinite piezoelectric elastic media under the influence of the initial stresses. The relations governing the reflection and transmission coefficients of these reflected waves for various suitable boundary conditions are derived. We have shown analytically that reflection and transmission coefficients of (qP) and (qSV) waves depend upon the angle of incidence, the parameters of electric potential, the material constants of the medium as will as the initial stresses presented in the media. The numerical calculations of the reflection and transmission amplitude ratios for different values of initial stresses have been carried out by computer for different materials as examples and the results are given in the form of graphs. Finally, some of particular cases are considered.
Abstract: For maintenance of a spine stability during the
postoperative period a transpedicular fixing of its elements is often
used. Usually the transpedicular systems are formed of rods which as
a result form a design of the frame type, fastening by screws to
vertebras. Such design should be rigid and perceive loadings
operating from the spine without essential deformations. From the
perfection point of view of known designs their stress
whole, and each of elements, in particular is of interest. In this study
the modeling of the transpedicular screw is performed and
estimation of its deformations taking into account interaction with a
vertebra body having variable structure is made.
Abstract: Stress analysis of functionally graded composite plates
composed of ceramic, functionally graded material and metal layers is
investigated using 3-D finite element method. In FGM layer, material
properties are assumed to be varied continuously in the thickness
direction according to a simple power law distribution in terms of the
volume fraction of a ceramic and metal. The 3-D finite element model
is adopted by using an 18-node solid element to analyze more
accurately the variation of material properties in the thickness
direction. Numerical results are compared for three types of materials.
In the analysis, the tensile and the compressive stresses are
summarized for various FGM thickness ratios, volume fraction
distributions, geometric parameters and mechanical loads.
Abstract: In production of medicinal plants, seed germination is
very important problem. The treated seeds (control, hydro priming
and ZnSO4) of Cumin (Cuminum cyminum L.) were evaluated at
germination and seedling growth for tolerance to salt (NaCl and
Na2SO4) conditions at the same water potentials of 0.0, -0.3, -0.6, -
0.9 and -1.2MPa. Electrical conductivity (EC) values of the NaCl
solutions were 0.0, 6.5, 12.7, 18.4 and 23.5 dSm-1, respectively. The
objective of the study was to determine factors responsible for
germination and early seedling growth due to salt toxicity or osmotic
effect and to optimize the best priming treatment for these stress
conditions. Results revealed that germination delayed in both
solutions, having variable germination with different priming
treatments. Germination, shoot and weight, root and shoot length
were higher but mean germination time and abnormal germination
percentage were lower in NaCl than Na2SO4 at the same water
potential. The root / shoot weight and R/S length increased with
increase in osmotic potential in both NaCl and Na2SO4 solutions.
NaCl had less inhibitor effect on seedling growth than the
germination. It was concluded that inhibition of germination at the
same water potential of NaCl and Na2SO4 resulted from salt toxicity
rather than osmotic effect. Hydro priming increased germination and
seedling growth under salt stress. This protocol has practical
importance and could be recommended to farmers to achieve higher
germination and uniform emergence under field conditions.
Abstract: This paper discusses the development of a qualitative
simulator (abbreviated QRiOM) for predicting the behaviour of
organic chemical reactions. The simulation technique is based on the
qualitative process theory (QPT) ontology. The modelling constructs
of QPT embody notions of causality which can be used to explain the
behaviour of a chemical system. The major theme of this work is
that, in a qualitative simulation environment, students are able to
articulate his/her knowledge through the inspection of explanations
generated by software. The implementation languages are Java and
Prolog. The software produces explanation in various forms that
stresses on the causal theories in the chemical system which can be
effectively used to support learning.
Abstract: In an effort to understand the preliminary effects of aerodynamic stress on alveolar epithelial cells, we developed a multifluidic cell culture platform capable of supporting alveolar cultures at an air-liquid interface under constant air flow and exposure to varying pressure stimuli on the apical side while providing nourishment on the basolateral plane. Our current study involved utilizing the platform to study the effect of basement membrane coating and addition of dexamethasone on cellular response to pressure in A549 and H441 alveolar epithelial cells.
Abstract: The design of a gravity dam is performed through an
interactive process involving a preliminary layout of the structure
followed by a stability and stress analysis. This study presents a
method to define the optimal top width of gravity dam with genetic
algorithm. To solve the optimization task (minimize the cost of the
dam), an optimization routine based on genetic algorithms (GAs) was
implemented into an Excel spreadsheet. It was found to perform well
and GA parameters were optimized in a parametric study. Using the
parameters found in the parametric study, the top width of gravity
dam optimization was performed and compared to a gradient-based
optimization method (classic method). The accuracy of the results
was within close proximity. In optimum dam cross section, the ratio
of is dam base to dam height is almost equal to 0.85, and ratio of dam
top width to dam height is almost equal to 0.13. The computerized
methodology may provide the help for computation of the optimal
top width for a wide range of height of a gravity dam.
Abstract: In this article an isotropic linear elastic half-space with
a cylindrical cavity of finite length is considered to be under the
effect of a ring shape time-harmonic torsion force applied at an
arbitrary depth on the surface of the cavity. The equation of
equilibrium has been written in a cylindrical coordinate system. By
means of Fourier cosine integral transform, the non-zero
displacement component is obtained in the transformed domain. With
the aid of the inversion theorem of the Fourier cosine integral
transform, the displacement is obtained in the real domain. With the
aid of boundary conditions, the involved boundary value problem for
the fundamental solution is reduced to a generalized Cauchy singular
integral equation. Integral representation of the stress and
displacement are obtained, and it is shown that their degenerated
form to the static problem coincides with existing solutions in the
literature.