Abstract: Based on the sources- smoothed rank profile (SRP) and modified minimum description length (MMDL) principle, a method for estimation of the source coherency structure (SCS) and the number of wideband sources is proposed in this paper. Instead of focusing, we first use a spatial smoothing technique to pre-process the array covariance matrix of each frequency for de-correlating the sources and then use smoothed rank profile to determine the SCS and the number of wideband sources. We demonstrate the availability of the method by numerical simulations.
Abstract: Severe acute respiratory syndrome (SARS) is a respiratory disease in humans which is caused by the SARS coronavirus. The treatment of coronavirus-associated SARS has been evolving and so far there is no consensus on an optimal regimen. The mainstream therapeutic interventions for SARS involve broad-spectrum antibiotics and supportive care, as well as antiviral agents and immunomodulatory therapy. The Protein- Ligand interaction plays a significant role in structural based drug designing. In the present work we have taken the receptor Angiotensin converting enzyme 2 and identified the drugs that are commonly used against SARS. They are Lopinavir, Ritonavir, Ribavirin, and Oseltamivir. The receptor Angiotensin converting enzyme 2 (ACE-2) was docked with above said drugs and the energy value obtained are as follows, Lopinavir (-292.3), Ritonavir (-325.6), Oseltamivir (- 229.1), Ribavirin (-208.8). Depending on the least energy value we have chosen the best two drugs out of the four conventional drugs. We tried to improve the binding efficiency and steric compatibility of the two drugs namely Ritonavir and Lopinavir. Several modifications were made to the probable functional groups (phenylic, ketonic groups in case of Ritonavir and carboxylic groups in case of Lopinavir respectively) which were interacting with the receptor molecule. Analogs were prepared by Marvin Sketch software and were docked using HEX docking software. Lopinavir analog 8 and Ritonavir analog 11 were detected with significant energy values and are probable lead molecule. It infers that some of the modified drugs are better than the original drugs. Further work can be carried out to improve the steric compatibility of the drug based upon the work done above for a more energy efficient binding of the drugs to the receptor.
Abstract: In this work, position vector of a time-like dual curve
according to standard frame of D31
is investigated. First, it is proven
that position vector of a time-like dual curve satisfies a dual vector
differential equation of fourth order. The general solution of this dual
vector differential equation has not yet been found. Due to this, in
terms of special solutions, position vectors of some special time-like
dual curves with respect to standard frame of D31
are presented.
Abstract: This paper deals with stability analysis for synchronous reluctance motors drive. Special attention is paid to the transient performance with variations in motor's parameters such as Ld and Rs. A study of the dynamic control using d-q model is presented first in order to clarify the stability of the motor drive system. Based on the experimental parameters of the synchronous reluctance motor, this paper gives some simulation results using MATLAB/SIMULINK software packages. It is concluded that the motor parameters, especially Ld, affect the estimator stability and hence the whole drive system.
Abstract: A new reverse phase-high performance liquid chromatography (RP-HPLC) method with fluorescent detector (FLD) was developed and optimized for Norfloxacin determination in human plasma. Mobile phase specifications, extraction method and excitation and emission wavelengths were varied for optimization. HPLC system contained a reverse phase C18 (5 μm, 4.6 mm×150 mm) column with FLD operated at excitation 330 nm and emission 440 nm. The optimized mobile phase consisted of 14% acetonitrile in buffer solution. The aqueous phase was prepared by mixing 2g of citric acid, 2g sodium acetate and 1 ml of triethylamine in 1 L of Milli-Q water was run at a flow rate of 1.2 mL/min. The standard curve was linear for the range tested (0.156–20 μg/mL) and the coefficient of determination was 0.9978. Aceclofenac sodium was used as internal standard. A detection limit of 0.078 μg/mL was achieved. Run time was set at 10 minutes because retention time of norfloxacin was 0.99 min. which shows the rapidness of this method of analysis. The present assay showed good accuracy, precision and sensitivity for Norfloxacin determination in human plasma with a new internal standard and can be applied pharmacokinetic evaluation of Norfloxacin tablets after oral administration in human.
Abstract: The Time-Domain Boundary Element Method (TDBEM)
is a well known numerical technique that handles quite
properly dynamic analyses considering infinite dimension media.
However, when these analyses are also related to nonlinear behavior,
very complex numerical procedures arise considering the TD-BEM,
which may turn its application prohibitive. In order to avoid this
drawback and model nonlinear infinite media, the present work
couples two BEM formulations, aiming to achieve the best of two
worlds. In this context, the regions expected to behave nonlinearly
are discretized by the Domain Boundary Element Method (D-BEM),
which has a simpler mathematical formulation but is unable to deal
with infinite domain analyses; the TD-BEM is employed as in the
sense of an effective non-reflexive boundary. An iterative procedure
is considered for the coupling of the TD-BEM and D-BEM, which is
based on a relaxed renew of the variables at the common interfaces.
Elastoplastic models are focused and different time-steps are allowed
to be considered by each BEM formulation in the coupled analysis.
Abstract: The development of wireless communication technologies has changed our living style in global level. After the international success of mobile telephony standards, the location and time independent voice connection has become a default method in daily telecommunications. As for today, highly advanced multimedia messaging plays a key role in value added service handling. Along with evolving data services, the need for more complex applications can be seen, including the mobile usage of broadcast technologies. Here performance of a system design for terrestrial multimedia content is examined with emphasis on mobile reception. This review paper has accommodated the understanding of physical layer role and the flavour of terrestrial channel effects on the terrestrial multimedia transmission using OFDM keeping DVB-H as benchmark standard.
Abstract: In this paper, we introduce an mobile agent framework
with proactive load balancing for ambient intelligence (AmI) environments.
One of the main obstacles of AmI is the scalability in
which the openness of AmI environment introduces dynamic resource
requirements on agencies. To mediate this scalability problem, our
framework proposes a load balancing module to proactively analyze
the resource consumption of network bandwidth and preferred agencies
to suggest the optimal communication method to its user. The
framework generally formulates an AmI environment that consists
of three main components: (1) mobile devices, (2) hosts or agencies,
and (3) directory service center (DSC). A preliminary implementation
was conducted with NetLogo and the experimental results show that
the proposed approach provides enhanced system performance by
minimizing the network utilization to provide users with responsive
services.
Abstract: This paper presents a cold flow simulation study of a small gas turbine combustor performed using laboratory scale test rig. The main objective of this investigation is to obtain physical insight of the main vortex, responsible for the efficient mixing of fuel and air. Such models are necessary for predictions and optimization of real gas turbine combustors. Air swirler can control the combustor performance by assisting in the fuel-air mixing process and by producing recirculation region which can act as flame holders and influences residence time. Thus, proper selection of a swirler is needed to enhance combustor performance and to reduce NOx emissions. Three different axial air swirlers were used based on their vane angles i.e., 30°, 45°, and 60°. Three-dimensional, viscous, turbulent, isothermal flow characteristics of the combustor model operating at room temperature were simulated via Reynolds- Averaged Navier-Stokes (RANS) code. The model geometry has been created using solid model, and the meshing has been done using GAMBIT preprocessing package. Finally, the solution and analysis were carried out in a FLUENT solver. This serves to demonstrate the capability of the code for design and analysis of real combustor. The effects of swirlers and mass flow rate were examined. Details of the complex flow structure such as vortices and recirculation zones were obtained by the simulation model. The computational model predicts a major recirculation zone in the central region immediately downstream of the fuel nozzle and a second recirculation zone in the upstream corner of the combustion chamber. It is also shown that swirler angles changes have significant effects on the combustor flowfield as well as pressure losses.
Abstract: Reducing energy consumption of embedded systems requires careful memory management. It has been shown that Scratch- Pad Memories (SPMs) are low size, low cost, efficient (i.e. energy saving) data structures directly managed at the software level. In this paper, the focus is on heuristic methods for SPMs management. A method is efficient if the number of accesses to SPM is as large as possible and if all available space (i.e. bits) is used. A Tabu Search (TS) approach for memory management is proposed which is, to the best of our knowledge, a new original alternative to the best known existing heuristic (BEH). In fact, experimentations performed on benchmarks show that the Tabu Search method is as efficient as BEH (in terms of energy consumption) but BEH requires a sorting which can be computationally expensive for a large amount of data. TS is easy to implement and since no sorting is necessary, unlike BEH, the corresponding sorting time is saved. In addition to that, in a dynamic perspective where the maximum capacity of the SPM is not known in advance, the TS heuristic will perform better than BEH.
Abstract: A bond graph model of an electrical transformer
including the nonlinear saturation is presented. A nonlinear observer for the transformer based on multivariable circle
criterion in the physical domain is proposed. In order to show the saturation and hysteresis effects on the electrical transformer,
simulation results are obtained. Finally, the paper describes that convergence of the estimates to the true states is achieved.
Abstract: The various types of frequent pattern discovery
problem, namely, the frequent itemset, sequence and graph mining
problems are solved in different ways which are, however, in certain
aspects similar. The main approach of discovering such patterns can
be classified into two main classes, namely, in the class of the levelwise
methods and in that of the database projection-based methods.
The level-wise algorithms use in general clever indexing structures
for discovering the patterns. In this paper a new approach is proposed
for discovering frequent sequences and tree-like patterns efficiently
that is based on the level-wise issue. Because the level-wise
algorithms spend a lot of time for the subpattern testing problem, the
new approach introduces the idea of using automaton theory to solve
this problem.
Abstract: Textile structures are engineered and fabricated to
meet worldwide structural applications. Nevertheless, research
varying textile structure on natural fibre as composite reinforcement
was found to be very limited. Most of the research is focusing on
short fibre and random discontinuous orientation of the reinforcement
structure. Realizing that natural fibre (NF) composite had been
widely developed to be used as synthetic fibre composite
replacement, this research attempted to examine the influence of
woven and cross-ply laminated structure towards its mechanical
performances. Laminated natural fibre composites were developed
using hand lay-up and vacuum bagging technique. Impact and
flexural strength were investigated as a function of fibre type (coir
and kenaf) and reinforcement structure (imbalanced plain woven,
0°/90° cross-ply and +45°/-45° cross-ply). Multi-level full factorial
design of experiment (DOE) and analysis of variance (ANOVA) was
employed to impart data as to how fibre type and reinforcement
structure parameters affect the mechanical properties of the
composites. This systematic experimentation has led to determination
of significant factors that predominant influences the impact and
flexural properties of the textile composites. It was proven that both
fibre type and reinforcement structure demonstrated significant
difference results. Overall results indicated that coir composite and
woven structure exhibited better impact and flexural strength. Yet,
cross-ply composite structure demonstrated better fracture resistance.
Abstract: This paper presents an algorithm of particle swarm
optimization with reduction for global optimization problems. Particle
swarm optimization is an algorithm which refers to the collective
motion such as birds or fishes, and a multi-point search algorithm
which finds a best solution using multiple particles. Particle
swarm optimization is so flexible that it can adapt to a number
of optimization problems. When an objective function has a lot of
local minimums complicatedly, the particle may fall into a local
minimum. For avoiding the local minimum, a number of particles are
initially prepared and their positions are updated by particle swarm
optimization. Particles sequentially reduce to reach a predetermined
number of them grounded in evaluation value and particle swarm
optimization continues until the termination condition is met. In order
to show the effectiveness of the proposed algorithm, we examine the
minimum by using test functions compared to existing algorithms.
Furthermore the influence of best value on the initial number of
particles for our algorithm is discussed.
Abstract: The image segmentation method described in this
paper has been developed as a pre-processing stage to be used in
methodologies and tools for video/image indexing and retrieval by
content. This method solves the problem of whole objects extraction
from background and it produces images of single complete objects
from videos or photos. The extracted images are used for calculating
the object visual features necessary for both indexing and retrieval
processes.
The segmentation algorithm is based on the cooperation among an
optical flow evaluation method, edge detection and region growing
procedures. The optical flow estimator belongs to the class of
differential methods. It permits to detect motions ranging from a
fraction of a pixel to a few pixels per frame, achieving good results in
presence of noise without the need of a filtering pre-processing stage
and includes a specialised model for moving object detection.
The first task of the presented method exploits the cues from
motion analysis for moving areas detection. Objects and background
are then refined using respectively edge detection and seeded region
growing procedures. All the tasks are iteratively performed until
objects and background are completely resolved.
The method has been applied to a variety of indoor and outdoor
scenes where objects of different type and shape are represented on
variously textured background.
Abstract: The occurrence and removal of trace organic
contaminants in the aquatic environment has become a focus of
environmental concern. For the selective removal of carbamazepine
from loaded waters molecularly imprinted polymers (MIPs) were
synthesized with carbamazepine as template. Parameters varied were
the type of monomer, crosslinker, and porogen, the ratio of starting
materials, and the synthesis temperature. Best results were obtained
with a template to crosslinker ratio of 1:20, toluene as porogen, and
methacrylic acid (MAA) as monomer. MIPs were then capable to
recover carbamazepine by 93% from a 10-5 M landfill leachate
solution containing also caffeine and salicylic acid. By comparison,
carbamazepine recoveries of 75% were achieved using a nonimprinted
polymer (NIP) synthesized under the same conditions, but
without template. In landfill leachate containing solutions
carbamazepine was adsorbed by 93-96% compared with an uptake of
73% by activated carbon. The best solvent for desorption was
acetonitrile, with which the amount of solvent necessary and dilution
with water was tested. Selected MIPs were tested for their reusability
and showed good results for at least five cycles. Adsorption
isotherms were prepared with carbamazepine solutions in the
concentration range of 0.01 M to 5*10-6 M. The heterogeneity index
showed a more homogenous binding site distribution.
Abstract: This article demonstrated development of
controlled release system of an NSAID drug, Diclofenac
sodium employing different ratios of Ethyl cellulose.
Diclofenac sodium and ethyl cellulose in different proportions
were processed by microencapsulation based on phase
separation technique to formulate microcapsules. The
prepared microcapsules were then compressed into tablets to
obtain controlled release oral formulations. In-vitro evaluation
was performed by dissolution test of each preparation was
conducted in 900 ml of phosphate buffer solution of pH 7.2
maintained at 37 ± 0.5 °C and stirred at 50 rpm. At predetermined
time intervals (0, 0.5, 1.0, 1.5, 2, 3, 4, 6, 8, 10, 12,
16, 20 and 24 hrs). The drug concentration in the collected
samples was determined by UV spectrophotometer at 276 nm.
The physical characteristics of diclofenac sodium
microcapsules were according to accepted range. These were
off-white, free flowing and spherical in shape. The release
profile of diclofenac sodium from microcapsules was found to
be directly proportional to the proportion of ethylcellulose and
coat thickness. The in-vitro release pattern showed that with
ratio of 1:1 and 1:2 (drug: polymer), the percentage release of
drug at first hour was 16.91 and 11.52 %, respectively as
compared to 1:3 which is only 6.87 % with in this time. The
release mechanism followed higuchi model for its release
pattern. Tablet Formulation (F2) of present study was found
comparable in release profile the marketed brand Phlogin-SR,
microcapsules showed an extended release beyond 24 h.
Further, a good correlation was found between drug release
and proportion of ethylcellulose in the microcapsules.
Microencapsulation based on coacervation found as good
technique to control release of diclofenac sodium for making
the controlled release formulations.
Abstract: Program slicing is the task of finding all statements in
a program that directly or indirectly influence the value of a variable
occurrence. The set of statements that can affect the value of a
variable at some point in a program is called a program backward
slice. In several software engineering applications, such as program
debugging and measuring program cohesion and parallelism, several
slices are computed at different program points. The existing
algorithms for computing program slices are introduced to compute a
slice at a program point. In these algorithms, the program, or the
model that represents the program, is traversed completely or
partially once. To compute more than one slice, the same algorithm
is applied for every point of interest in the program. Thus, the same
program, or program representation, is traversed several times.
In this paper, an algorithm is introduced to compute all forward
static slices of a computer program by traversing the program
representation graph once. Therefore, the introduced algorithm is
useful for software engineering applications that require computing
program slices at different points of a program. The program
representation graph used in this paper is called Program Dependence
Graph (PDG).
Abstract: A homologous series of aromatic esters, 4-nalkanoyloxybenzylidene-
4--bromoanilines, nABBA,
consisting of two 1,4-disubstituted phenyl cores and a Schiff
base central linkage was synthesized. All the members can be
differed by the number of carbon atoms at terminal
alkanoyloxy chain (CnH2n-1COO-, n = 2, 6, 18). The molecular
structure of nABBA was confirmed with infrared
spectroscopy, nuclear magnetic resonance (NMR)
spectroscopy and electron-ionization mass (EI-MS)
spectrometry. Mesomorphic properties were studied using
differential scanning calorimetry and polarizing optical
microscopy.
Abstract: In this study, an inland metropolitan area, Gwangju, in Korea was selected to assess the amplification potential of earthquake motion and provide the information for regional seismic countermeasure. A geographic information system-based expert system was implemented for reliably predicting the spatial geotechnical layers in the entire region of interesting by building a geo-knowledge database. Particularly, the database consists of the existing boring data gathered from the prior geotechnical projects and the surface geo-knowledge data acquired from the site visit. For practical application of the geo-knowledge database to estimate the earthquake hazard potential related to site amplification effects at the study area, seismic zoning maps on geotechnical parameters, such as the bedrock depth and the site period, were created within GIS framework. In addition, seismic zonation of site classification was also performed to determine the site amplification coefficients for seismic design at any site in the study area. KeywordsEarthquake hazard, geo-knowledge, geographic information system, seismic zonation, site period.